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Cited by 18Muscle metabolism and nutritionSports Performance and TrainingExercise and Physiological Responses

Glycogen resynthesis and exercise performance with the addition of fenugreek extract (4-hydroxyisoleucine) to post-exercise carbohydrate feeding

Slivka, D., Cuddy, J., Hailes, W., Harger, S., Ruby, B.·2008·Amino Acids
DOI 10.1007/s00726-007-0580-6
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Abstract

The purpose of this study was to determine the effect of adding fenugreek extract (FG) to post-exercise carbohydrate feeding on glycogen resynthesis and subsequent exercise performance in normoglycemic male endurance athletes. A muscle biopsy sample was obtained from the vastus lateralis from subjects prior to exercise for 5 h at 50% of peak cycling power (52.1 +/- 3.3% of VO(2) peak). A second muscle biopsy sample was obtained immediately after exercise. Immediately after and 2 h after the second biopsy subjects ingested either an oral dose of dextrose (GLU) (1.8 g x kg BW(-1)) or GLU with FG containing 1.99 +/- 0.20 mg x kg(-1) 4-hydroxyisoleucine (GLU + FG) in a randomized, cross-over, double blind design. At 4 h post-exercise a third biopsy was taken and subjects received a standardised meal along with FG or a placebo capsule. At 15 h post-exercise subjects underwent their final muscle biopsy before completing a simulated 40 km cycling time trial. There was no difference in muscle glycogen at any time between GLU and GLU + FG. Additionally, 40 km time trial performance was similar for average power output (221 +/- 28 vs. 213 +/- 16 watts) and for time to completion (69.7 +/- 3.7 vs. 70.5 +/- 2.2 min) for the GLU and GLU + FG, respectively. Despite earlier data to the contrary, the present results do not support an effect of fenugreek supplementation on glycogen resynthesis, even though this may have been the result of differences in experimental protocol.

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  • A subsequent investigation from the same group found no refuelling advantages after 4 or 15 h of postexercise recovery when fenugreek product was consumed with CHO.

    “a subsequent investigation from the same group failed to find any refuelling advantages after 4 or 15 h of post-exercise recovery when this product was consumed in combination with CHO (99).”

    From Postexercise muscle glycogen resynthesis in humans. (2017) · cites this paper as [99]

  • In trained cyclists, fenugreek extract (providing 4 mg/kg 4-hydroxy-leucine) added to carbohydrate feeding (0.9 g/kg/h) during 0-4 h and 4-15 h recovery after glycogen-depleting exercise did not increase muscle glycogen synthesis at 4 h or 15 h compared with carbohydrate alone.

    “No difference in muscle glycogen synthesis at 4 h or 15 h with CHO+Fenugreek vs CHO trials.”

    From Postexercise muscle glycogen resynthesis in humans. (2017) · cites this paper as Slivka et al. 2008 (99)

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Authors
Slivka, D., Cuddy, J., Hailes, W., Harger, S., & Ruby, B.
Affiliations
University of Montana (US)
Corresponding author
Ruby, B.
ORCID
Venue
Amino Acids
Publisher
Springer Science and Business Media LLC
Published
2007-08-21
Volume
35
Issue
2
Pages
439-444
ISSN
  • 0939-4451 (ISSN-L)
  • 1438-2199
DOI
10.1007/s00726-007-0580-6
OpenAlex
W1965144447
Cited by
18
References
36
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2021: 4 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 1
FWCI
0.28
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Amino Acids (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
glycogen resynthesis, fenugreek extract, 4-hydroxyisoleucine, endurance exercise performance, muscle glycogen, dextrose supplementation, cycling time trial, vastus lateralis, endurance athletes
MeSH terms
Adult, Amino Acids, Blood Glucose, Dietary Carbohydrates, Glycogen, Humans, Isoleucine, Male, Plant Extracts, Seeds, Exercise, Muscle, Skeletal, Trigonella

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