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Cited by 61Muscle metabolism and nutritionMetabolism, Diabetes, and CancerSports Performance and Training

The addition of fenugreek extract (Trigonella foenum-graecum) to glucose feeding increases muscle glycogen resynthesis after exercise

Ruby, B. C., Gaskill, S. E., Slivka, D., Harger, S. G.·2005·Amino Acids
DOI 10.1007/s00726-004-0143-z
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Abstract

The purpose of this study was to determine the effects of ingesting an oral supplement containing 4-Hydroxyisoleucine (4-OH-Ile, isolated from fenugreek seeds [Trigonella foenum-graecum]) with a glucose beverage on rates of post-exercise muscle glycogen resynthesis in trained male cyclists. Following an overnight fast (12 hr), subjects completed a 90-minute glycogen depletion ride after which a muscle biopsy was obtained from the vastus lateralis. Immediately and 2 hours after the muscle biopsy, subjects ingested either an oral dose of dextrose (Glu) (1.8 g.kg BW(-1)) or 4-OH-Ile supplement (Glu+4-OH-Ile, including 2.0 mg.kg(-1) 4-OH-Ile with the same oral dose of dextrose) with a second muscle biopsy 4 hours after exercise. Post exercise muscle glycogen concentration was similar for both trials. Overall, there was a significant increase in glucose and insulin concentrations from time 0 throughout the majority of the 4-hour recovery period, with no significant differences between the two trials at any time point. Although muscle glycogen concentration significantly increased from immediately post exercise to 4 hr of recovery for both trials, the net rate of muscle glycogen resynthesis was 63% greater during Glu+4-OH-Ile (10.6+/-3.3 vs. 6.5+/-2.6 g.kg wet wt.(-1).hr.(-1) for the Glu+4-OH-Ile and Glu trials, respectively). These data demonstrate that when the fenugreek extract supplement (4-OH-Ile) is added to a high oral dose of dextrose, rates of post-exercise glycogen resynthesis are enhanced above dextrose alone.

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  • Fenugreek extract added to high-dose dextrose enhanced muscle glycogen synthesis during 4 h of recovery.

    “although muscle glycogen synthesis during 4 h of recovery was found to be enhanced when an extract isolated from fenugreek was added to a high dose of dextrose (92)”

    From Postexercise muscle glycogen resynthesis in humans. (2017) · cites this paper as [92]

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Authors
Ruby, B. C., Gaskill, S. E., Slivka, D., & Harger, S. G.
Affiliations
University of Montana (US)
ORCID
Venue
Amino Acids
Publisher
Springer Science and Business Media LLC
Published
2004-12-02
Volume
28
Issue
1
Pages
71-76
ISSN
  • 0939-4451 (ISSN-L)
  • 1438-2199
DOI
10.1007/s00726-004-0143-z
OpenAlex
W2030400950
Cited by
61
References
25
Citations by year
2024: 3 · 2023: 5 · 2022: 1 · 2021: 8 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 3
FWCI
0.90
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Amino Acids (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
fenugreek extract, fenugreek, 4-hydroxyisoleucine, muscle glycogen resynthesis, post-exercise recovery, glucose supplementation, D-glucose, insulin, glycogen depletion, cyclists, vastus lateralis
MeSH terms
Adult, Bicycling, Blood Glucose, Glucose, Glycogen, Humans, Insulin, Isoleucine, Male, Plant Extracts, Exercise, Muscle, Skeletal, Dietary Supplements, Trigonella

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