Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 124

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review

Khatri, Mishti, Naughton, Robert J., Clifford, Tom, Harper, Liam D., Corr, Liam·2021·Amino Acids
DOI 10.1007/s00726-021-03072-x
Open this paper in CoChat — free account

Abstract

Collagen peptide supplementation (COL), in conjunction with exercise, may be beneficial for the management of degenerative bone and joint disorders. This is likely due to stimulatory effects of COL and exercise on the extracellular matrix of connective tissues, improving structure and load-bearing capabilities. This systematic review aims to evaluate the current literature available on the combined impact of COL and exercise. Following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, a literature search of three electronic databases—PubMed, Web of Science and CINAHL—was conducted in June 2020. Fifteen randomised controlled trials were selected after screening 856 articles. The study populations included 12 studies in recreational athletes, 2 studies in elderly participants and 1 in untrained pre-menopausal women. Study outcomes were categorised into four topics: (i) joint pain and recovery from joint injuries, (ii) body composition, (iii) muscle soreness and recovery from exercise, and (iv) muscle protein synthesis (MPS) and collagen synthesis. The results indicated that COL is most beneficial in improving joint functionality and reducing joint pain. Certain improvements in body composition, strength and muscle recovery were present. Collagen synthesis rates were elevated with 15 g/day COL but did not have a significant impact on MPS when compared to isonitrogenous higher quality protein sources. Exact mechanisms for these adaptations are unclear, with future research using larger sample sizes, elite athletes, female participants and more precise outcome measures such as muscle biopsies and magnetic imagery.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00726-021-03072-x

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 7 references

Research works printed but not linked: 41

  1. Bello AE, Oesser S (2006) Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin 22(11):2221–2232 · DOI
  2. Bennell K, Hunter DJ, Vicenzino B (2012) Long-term effects of sport: preventing and managing OA in the athlete. Nat Rev Rheumatol 8(12):747–752 · DOI
  3. Chiang TI, Chang IC, Lee HH, Hsieh KH, Chiu YW, Lai TJ, Kao SH (2016) Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate. Int J Med Sci 13(11):853–857. https://doi.org/10.7150/ijms.16706 · DOI
  4. Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, Albert A (2008) 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin 24(5):1485–1496. https://doi.org/10.1185/030079908x291967 · DOI
  5. Clifford T, Ventress M, Allerton DM, Stansfield S, Tang JCY, Fraser WD, Stevenson E (2019) The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial. Amino Acids 51(4):691–704. https://doi.org/10.1007/s00726-019-02706-5 · DOI
  6. Dressler P, Gehring D, Zdzieblik D, Oesser S, Gollhofer A, König D (2018) Improvement of functional ankle properties following supplementation with specific collagen peptides in athletes with chronic ankle instability. J Sports Sci Med 17(2):298–304
  7. Ferreira AM, Gentile P, Chiono V, Ciardelli G (2012) Collagen for bone tissue regeneration. Acta Biomater 8(9):3191–3200. https://doi.org/10.1016/j.actbio.2012.06.014 · DOI · Paper page
  8. Field A, Naughton RJ, Haines M, Lui S, Corr LD, Russell M, Harper LD (2020) The demands of the extra-time period of soccer: a systematic review. J Sport Health Sci. https://doi.org/10.1016/j.jshs.2020.03.008 · DOI
  9. Frantz C, Stewart KM, Weaver VM (2010) The extracellular matrix at a glance. J Cell Sci 123(24):4195. https://doi.org/10.1242/jcs.023820 · DOI · Paper page
  10. García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, Acosta-Olivo CA, Vilchez-Cavazos F, Simental-Mendía LE, Simental-Mendía M (2019) Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop 43(3):531–538. https://doi.org/10.1007/s00264-018-4211-5 · DOI
  11. Goes RA, Lopes LR, Cossich VRA, de Miranda VAR, Coelho ON, do Carmo Bastos R, Perini JA (2020) Musculoskeletal injuries in athletes from five modalities: a cross-sectional study. BMC Musculoskelet Disord 21(1):122. https://doi.org/10.1186/s12891-020-3141-8 · DOI
  12. Hartog A, Cozijnsen M, de Vrij G, Garssen J (2013) Collagen hydrolysate inhibits zymosan-induced inflammation. Exp Biol Med 238(7):798–802. https://doi.org/10.1177/1535370213480740 · DOI
  13. Hayes A, Easton K, Devanaboyina PT, Wu J-P, Kirk TB, Lloyd D (2019) A review of methods to measure tendon dimensions. J Orthop Surg Res 14(1):18. https://doi.org/10.1186/s13018-018-1056-y · DOI
  14. Holm L, Rahbek SK, Farup J, Vendelbo MH, Vissing K (2017) Contraction mode and whey protein intake affect the synthesis rate of intramuscular connective tissue. Muscle Nerve 55(1):128–130. https://doi.org/10.1002/mus.25398 · DOI
  15. Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, Ohtsuki K (2005) Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J agri food chem 53(16):6531–6536 · DOI · Paper page
  16. Kannus P (2000) Structure of the tendon connective tissue. Scand J Med Sci Sports 10(6):312–320. https://doi.org/10.1034/j.1600-0838.2000.010006312.x · DOI · Paper page
  17. Kitakaze T, Sakamoto T, Kitano T, Inoue N, Sugihara F, Harada N, Yamaji R (2016) The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy. Biochem Biophys Res Commun 478(3):1292–1297. https://doi.org/10.1016/j.bbrc.2016.08.114 · DOI
  18. Kjaer M, Magnusson P, Krogsgaard M, Boysen Møller J, Olesen J, Heinemeier K, Langberg H (2006) Extracellular matrix adaptation of tendon and skeletal muscle to exercise. J Anat 208(4):445–450. https://doi.org/10.1111/j.1469-7580.2006.00549.x · DOI
  19. León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G (2019) Hydrolyzed collagen-sources and applications. Molecules. https://doi.org/10.3390/molecules24224031 · DOI · Paper page
  20. Levene CI, Shoshan S, Bates CJ (1972) The effect of ascorbic acid on the cross-linking of collagen during its synthesis by cultured 3T6 fibroblasts. Biochem Biophys Acta 257(2):384–388. https://doi.org/10.1016/0005-2795(72)90290-5 · DOI
  21. Lian ØB, Engebretsen L, Bahr R (2005) Prevalence of Jumper’s knee among elite athletes from different sports: a cross-sectional study. Am J Sports Med 33(4):561–567. https://doi.org/10.1177/0363546504270454 · DOI · Paper page
  22. Lis DM, Baar K (2019) Effects of different vitamin C-enriched collagen derivatives on collagen synthesis. Int J Sport Nutr Exerc Metab 29(5):526–531. https://doi.org/10.1123/ijsnem.2018-0385 · DOI · Paper page
  23. Lopez HL, Ziegenfuss TN, Park J (2015) Evaluation of the effects of biocell collagen, a novel cartilage extract, on connective tissue support and functional recovery from exercise. Integr Med (encinitas) 14(3):30–38
  24. Mackey AL, Donnelly AE, Turpeenniemi-Hujanen T, Roper HP (2004) Skeletal muscle collagen content in humans after high-force eccentric contractions. J Appl Physiol 97(1):197–203. https://doi.org/10.1152/japplphysiol.01174.2003 · DOI
  25. Magnusson SP, Hansen M, Langberg H, Miller B, Haraldsson B, Westh EK, Kjaer M (2007) The adaptability of tendon to loading differs in men and women. Int J Exp Pathol 88(4):237–240. https://doi.org/10.1111/j.1365-2613.2007.00551.x · DOI
  26. Moher D, Liberati A., Tetzlaff J, Altman DG, Prisma Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097 · DOI · Paper page
  27. Moskowitz RW (2000) Role of collagen hydrolysate in bone and joint disease. In: Seminars in arthritis and rheumatism, Vol. 30, No. 2. WB Saunders, pp 87–99 · DOI · Paper page
  28. Oertzen-Hagemann V, Kirmse M, Eggers B, Pfeiffer K, Marcus K, de Marées M, Platen P (2019) Effects of 12 weeks of hypertrophy resistance exercise training combined with collagen peptide supplementation on the skeletal muscle proteome in recreationally active men. Nutrients. https://doi.org/10.3390/nu11051072 · DOI
  29. Oesser S, Seifert J (2003) Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res 311(3):393–399. https://doi.org/10.1007/s00441-003-0702-8 · DOI
  30. Ohberg L, Alfredson H (2004) Effects on neovascularisation behind the good results with eccentric training in chronic mid-portion Achilles tendinosis? Knee Surg Sports Traumatol Arthrosc 12(5):465–470. https://doi.org/10.1007/s00167-004-0494-8 · DOI · Paper page
  31. Oikawa SY, Kamal MJ, Webb EK, McGlory C, Baker SK, Phillips SM (2020a) Whey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: a randomized controlled trial. Am J Clin Nutr 111(3):708–718. https://doi.org/10.1093/ajcn/nqz332 · DOI · Paper page
  32. Oikawa SY, Macinnis MJ, Tripp TR, McGlory C, Baker SK, Phillips SM (2020b) Lactalbumin, not collagen, augments muscle protein synthesis with aerobic exercise. Med Sci Sports Exerc 52(6):1394–1403. https://doi.org/10.1249/mss.0000000000002253 · DOI · Paper page
  33. Paxton JZ, Grover LM, Baar K (2010) Engineering an in vitro model of a functional ligament from bone to bone. Tissue Eng Part A 16(11):3515–3525. https://doi.org/10.1089/ten.TEA.2010.0039 · DOI
  34. Pinnell SR, Murad S, Darr D (1987) Induction of collagen synthesis by ascorbic acid: a possible mechanism. Arch Dermatol 123(12):1684–1686. https://doi.org/10.1001/archderm.1987.01660360122023 · DOI
  35. Praet SFE, Purdam CR, Welvaert M, Vlahovich N, Lovell G, Burke LM, Waddington G (2019) Oral supplementation of specific collagen peptides combined with calf-strengthening exercises enhances function and reduces pain in achilles tendinopathy patients. Nutrients. https://doi.org/10.3390/nu11010076 · DOI
  36. Ricard-Blum S (2011) The collagen family. Cold Spring Harb Perspect Biol 3(1):a004978. https://doi.org/10.1101/cshperspect.a004978 · DOI · Paper page
  37. Schunck M, Oesser S (2013) Specific collagen peptides benefit the biosynthesis of matrix molecules of tendons and ligaments. J Int Soc Sports Nutr 10(Suppl 1):P23–P23. https://doi.org/10.1186/1550-2783-10-S1-P23 · DOI
  38. Shaw G, Lee-Barthel A, Ross ML, Wang B, Baar K (2017) Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. Am J Clin Nutr 105(1):136–143. https://doi.org/10.3945/ajcn.116.138594 · DOI · Paper page
  39. Svensson RB, Heinemeier KM, Couppé C, Kjaer M, Magnusson SP (2016) Effect of aging and exercise on the tendon. J Appl Physiol (1985) 121(6):1237–1246. https://doi.org/10.1152/japplphysiol.00328.2016 · DOI
  40. Vieira CP, Viola M, Carneiro GD, D’Angelo ML, Vicente CP, Passi A, Pimentel ER (2018) Glycine improves the remodelling process of tenocytes in vitro. Cell Biol Int 42(7):804–814. https://doi.org/10.1002/cbin.10937 · DOI
  41. Zdzieblik D, Oesser S, Gollhofer A, König D (2017) Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab 42(6):588–595. https://doi.org/10.1139/apnm-2016-0390 · DOI

Cited by

See all 124

Metadata

Authors
Khatri, M., Naughton, R. J., Clifford, T., Harper, L. D., & Corr, L.
ORCID
Venue
Amino Acids
Publisher
Springer Science and Business Media LLC
Published
2021-09-07
Volume
53
Issue
10
Pages
1493-1506
ISSN
  • 0939-4451
  • 1438-2199
DOI
10.1007/s00726-021-03072-x
Cited by
124
References
7
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. https://app.cochat.ai/papers/10.1007/s00726-021-03072-x
The paper
Khatri, M., Naughton, R. J., Clifford, T., Harper, L. D., & Corr, L. (2021). The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. https://doi.org/10.1007/s00726-021-03072-x

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.