Nitric Oxide as a Determinant of Human Longevity and Health Span
Open accessPreprint — published as 10.3390/ijms241914533
Abstract
The master molecular regulators and mechanisms determining longevity and health span include nitric oxide (NO) and superoxide anion radicals (SOR). L-arginine, the NO synthase (NOS) substrate, can restore a healthy ratio between the dangerous SOR and the protective NO radical to promote healthy aging. Antioxidant supplementation orchestrates protection against oxidative stress and damage—L-arginine and antioxidants such as vitamin C increase NO production and bioavailability. Uncoupling of NO generation with the appearance of SOR can be induced by asymmetric dimethylarginine (ADMA). L-arginine can displace ADMA from the site of NO formation if sufficient amounts of the amino acid are available. Antioxidants such as ascorbic acids can scavenge SOR and increase the bioavailability of NO. The topics of this review are the complex interactions of antioxidant agents with L-arginine, which determine NO bioactivity and protection against age-related degeneration.
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Dietary antioxidants may further support mitochondrial effects, providing a mechanistic explanation for the greater efficacy of whole-food nitrate sources.
“Dietary antioxidants may further support these effects, providing a mechanistic explanation for the greater efficacy of whole-food nitrate sources [50,58].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [58]
Elevated oxidative stress accelerates NO degradation.
“Concurrently, elevated oxidative stress accelerates NO degradation [58].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [58]
Cites
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., et al. (2003) · Science · doi:10.1126/science.1079368 · Cited by 1,243 · see citing works
Protein content and amino acid composition of commercially available plant-based protein isolates
Gorissen, S. H. M., Crombag, J. J. R., Senden, J. M. G., Waterval, W. A. H., Bierau, J., Verdijk, L. B., & van Loon, L. J. C. (2018) · Amino Acids · doi:10.1007/s00726-018-2640-5 · Cited by 1,169 · see citing works
Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882 · see citing works
International Society of Sports Nutrition Position Stand: protein and exercise
Jäger, R., Kerksick, C. M., Campbell, B. I., Cribb, P. J., Wells, S. D., Skwiat, T. M., Purpura, M., Ziegenfuss, T. N., Ferrando, A. A., Arent, S. M., et al. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0177-8 · Cited by 873 · see citing works
Functional Amino Acids in Growth, Reproduction, and Health
Wu, G. (2010) · Advances in Nutrition · doi:10.3945/an.110.1008 · Cited by 791 · see citing works
International Society of Sports Nutrition position stand: protein and exercise
Campbell, B., Kreider, R. B., Ziegenfuss, T., La Bounty, P., Roberts, M., Burke, D., Landis, J., Lopez, H., & Antonio, J. (2007) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-4-8 · Cited by 716 · see citing works
International society of sports nutrition position stand: nutrient timing
Kerksick, C. M., Arent, S., Schoenfeld, B. J., Stout, J. R., Campbell, B., Wilborn, C. D., Taylor, L., Kalman, D., Smith-Ryan, A. E., Kreider, R. B., et al. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0189-4 · Cited by 622 · see citing works
Nitric oxide as an antioxidant
Kanner, J., Harel, S., & Rina, G. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90452-o · Cited by 429 · see citing works
Naghshi, S., Sadeghi, O., Willett, W. C., & Esmaillzadeh, A. (2020) · BMJ · doi:10.1136/bmj.m2412 · Cited by 371 · see citing works
Mitochondrial biogenesis and healthy aging
López-Lluch, G., Irusta, P. M., Navas, P., & de Cabo, R. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.014 · Cited by 364 · see citing works
Antioxidants, inflammation and cardiovascular disease
Mangge, H. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i6.462 · Cited by 339 · see citing works
Mondanelli, G., Bianchi, R., Pallotta, M. T., Orabona, C., Albini, E., Iacono, A., Belladonna, M. L., Vacca, C., Fallarino, F., Macchiarulo, A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.005 · Cited by 335 · see citing works
International society of sports nutrition position stand: diets and body composition
Aragon, A. A., Schoenfeld, B. J., Wildman, R., Kleiner, S., VanDusseldorp, T., Taylor, L., Earnest, C. P., Arciero, P. J., Wilborn, C., Kalman, D. S., et al. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0174-y · Cited by 301 · see citing works
Arginine and Endothelial Function
Gambardella, J., Khondkar, W., Morelli, M. B., Wang, X., Santulli, G., & Trimarco, V. (2020) · Biomedicines · doi:10.3390/biomedicines8080277 · Cited by 254 · see citing works
Arginine de novo and nitric oxide production in disease states
Luiking, Y. C., Have, G. A. M. T., Wolfe, R. R., & Deutz, N. E. P. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2012 · Cited by 243 · see citing works
Nitric oxide and major depression
Dhir, A., & Kulkarni, S. K. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.02.002 · Cited by 239 · see citing works
Role of indoleamine 2,3-dioxygenase in health and disease
Yeung, A. W. S., Terentis, A. C., King, N. J. C., & Thomas, S. R. (2015) · Clinical Science · doi:10.1042/cs20140392 · Cited by 235 · see citing works
l-Citrulline Supplementation: Impact on Cardiometabolic Health
Allerton, T. D., Proctor, D. N., Stephens, J. M., Dugas, T. R., Spielmann, G., & Irving, B. A. (2018) · Nutrients · doi:10.3390/nu10070921 · Cited by 235 · see citing works
Oral L-arginine improves endothelial function in healthy individuals older than 70 years
Bode‐Böger, S. M., Muke, J., Surdacki, A., Brabant, G. E., Böger, R. H., & Frölich, J. C. (2003) · Vascular Medicine · doi:10.1191/1358863x03vm474oa · Cited by 198 · see citing works
Salminen, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101573 · Cited by 197 · see citing works
Micronutrient Supplementation to Reduce Cardiovascular Risk
An, P., Wan, S., Luo, Y., Luo, J., Zhang, X., Zhou, S., Xu, T., He, J., Mechanick, J. I., Wu, W.-C., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.09.048 · Cited by 189 · see citing works
Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta‐analysis
de MIRANDA, R. B., Weimer, P., & Rossi, R. C. (2021) · International Journal of Dermatology · doi:10.1111/ijd.15518 · Cited by 173 · see citing works
Ramos-López, O., Milagro, F. I., Allayee, H., Chmurzyńska, A., Choi, M. S., Curi, R., Caterina, R. D., Ferguson, L. R., Goñi, L., Kang, J. X., et al. (2017) · Lifestyle Genomics · doi:10.1159/000477729 · Cited by 172 · see citing works
Huang, T., Song, J. G., Gao, J. L., Cheng, J. R., Xie, H., Zhang, L., Wang, Y., Gao, Z., Wang, X., Wang, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31126-5 · Cited by 155 · see citing works
Fu, Y., Therkildsen, M., Aluko, R. E., & Lametsch, R. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1436038 · Cited by 152 · see citing works
Salminen, A. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02289-5 · Cited by 147 · see citing works
Melatonin, Aging, and Age-Related Diseases: Perspectives for Prevention, Intervention, and Therapy
Pöeggeler, B. (2005) · Endocrine · doi:10.1385/endo:27:2:201 · Cited by 137 · see citing works
Amino acids in the regulation of aging and aging-related diseases
Canfield, C.-A. E., & Bradshaw, P. C. (2019) · Translational Medicine of Aging · doi:10.1016/j.tma.2019.09.001 · Cited by 133 · see citing works
Global Improvement of Vascular Function and Redox State With Low-Dose Folic Acid
Shirodaria, C. C., Antoniades, C. A., Lee, J., Jackson, C. E., Robson, M. D., Francis, J. M., Moat, S. J., Ratnatunga, C., Pillai, R. G., Refsum, H., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.679084 · Cited by 131 · see citing works
L-Arginine Modulates Glucose and Lipid Metabolism in Obesity and Diabetes
Hu, S., Han, M., Rezaei, A., Li, D., Wu, G., & Ma, X. (2017) · Current Protein and Peptide Science · doi:10.2174/1389203717666160627074017 · Cited by 130 · see citing works
Khatri, M., Naughton, R. J., Clifford, T., Harper, L. D., & Corr, L. D. (2021) · Amino Acids · doi:10.1007/s00726-021-03072-x · Cited by 128 · see citing works
Liu, J., Klebach, M., de Visser, M., & Hofman, Z. (2019) · Nutrients · doi:10.3390/nu11112613 · Cited by 127 · see citing works
Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease
Pappolla, M. A., Perry, G. L., Fang, X., Zagorski, M. G., Sambamurti, K., & Pöeggeler, B. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105403 · Cited by 122 · see citing works
Self-citationAnti-aging effects of l-arginine
Gad, M. Z. (2010) · Journal of Advanced Research · doi:10.1016/j.jare.2010.05.001 · Cited by 121 · see citing works
An Overview of NO Signaling Pathways in Aging
Pourbagher-Shahri, A. M., Farkhondeh, T., Talebi, M., Kopustinskiene, D. M., Samarghandian, S., & Bernatoniene, J. (2021) · Molecules · doi:10.3390/molecules26154533 · Cited by 101 · see citing works
Lourenço, C. F., Ledo, A., Barbosa, R. M., & Laranjinha, J. A. N. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.026 · Cited by 99 · see citing works
Aging of the Nitric Oxide System: Are We as Old as Our NO?
Sverdlov, A. L., Ngo, D. T. M., Chan, W. P. A., Chirkov, Y. Y., & Horowitz, J. D. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000973 · Cited by 97 · see citing works
Zarić, B. L., Radovanović, J., Gluvic, Z. M., Stewart, A. J., Essack, M., Motwalli, O., Gojobori, T., & Isenović, E. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.551758 · Cited by 92 · see citing works
Immunoregulatory Interplay Between Arginine and Tryptophan Metabolism in Health and Disease
Mondanelli, G., Iacono, A., Allegrucci, M., Puccetti, P., & Grohmann, U. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01565 · Cited by 86 · see citing works
Central kynurenine pathway shift with age in women
de Bie, J., Guest, J., Guillemin, G. J., & Grant, R. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13496 · Cited by 83 · see citing works
Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis
Pappolla, M. A., Matsubara, E., Vidal, R., Pacheco‐Quinto, J., Pöeggeler, B., Zagorski, M. G., & Sambamurti, K. (2018) · Current Alzheimer Research · doi:10.2174/1567205015666180411092551 · Cited by 83 · see citing works
Self-citationCollagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge
Martinez-Puig, D., Costa-Larrión, E., Rubio-Rodríguez, N., & Gálvez‐Martín, P. (2023) · Nutrients · doi:10.3390/nu15061332 · Cited by 81 · see citing works
Arginine metabolism regulates the pathogenesis of inflammatory bowel disease
Li, J., Guo, Y., Zhou, H., Yue, T., Wang, F., Sun, F., & Wang, W. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac070 · Cited by 77 · see citing works
Emerging Roles of Endothelial Nitric Oxide in Preservation of Cognitive Health
Katusic, Z. S., d’Uscio, L. V., & He, T. (2023) · Stroke · doi:10.1161/strokeaha.122.041444 · Cited by 73 · see citing works
Assar, M. E., Angulo, J., Santos‐Ruiz, M., de Adana, J. C. R., Martínez, M. L. P., Sánchez‐Ferrer, A., Hernández, A., & Rodríguez‐Mañas, L. (2016) · The Journal of Physiology · doi:10.1113/jp271836 · Cited by 69 · see citing works
Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice
Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B., & Matsubara, E. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.012 · Cited by 69 · see citing works
Self-citationAcquarone, E., Argyrousi, E. K., van den Berg, M., Gulisano, W., Fà, M., Staniszewski, A., Calcagno, E., Zuccarello, E., D'adamio, L., Deng, S.-X., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0326-4 · Cited by 67 · see citing works
Role of specific dietary amino acids in clinical conditions
Jonker, R., Engelen, M., & Deutz, N. (2012) · British Journal of Nutrition · doi:10.1017/s0007114512002358 · Cited by 65 · see citing works
Shiraseb, F., Asbaghi, O., Bagheri, R., Wong, A., Figueroa, A., & Mirzaei, K. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab155 · Cited by 63 · see citing works
A Novel Endogenous Indole Protects Rodent Mitochondria and Extends Rotifer Lifespan
Pöeggeler, B., Sambamurti, K., Siedlak, S. L., Perry, G. L., Smith, M. A., & Pappolla, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010206 · Cited by 60 · see citing works
Self-citationTargeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management
Janković, A., Korać, A., Buzadžić, B., Stančić, A., Otašević, V., Ferdinándy, P., Daiber, A., & Korać, B. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13498 · Cited by 60 · see citing works
Oxenkrug, G. F. (2011) · Europe PMC (PubMed Central) · Cited by 58 · see citing works
Nitric oxide/cGMP/CREB pathway and amyloid-beta crosstalk: From physiology to Alzheimer’s disease
Tropea, M. R., Gulisano, W., Vacanti, V., Arancio, O., Puzzo, D., & Palmeri, A. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.022 · Cited by 55 · see citing works
Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes
Shannon, O. M., Clifford, T., Seals, D. R., Craighead, D. H., & Rossman, M. J. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.06.002 · Cited by 51 · see citing works
Meier, T., Senftleben, K., Deumelandt, P., Christen, O., Riedel, K., & Langer, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135990 · Cited by 48 · see citing works
Murray, K. O., Mahoney, S. A., Venkatasubramanian, R., Seals, D., & Clayton, Z. S. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112105 · Cited by 48 · see citing works
Protein and amino acid supplementation in older humans
Fukagawa, N. K. (2013) · Amino Acids · doi:10.1007/s00726-013-1480-6 · Cited by 43 · see citing works
Menzel, D., Haller, H. G., Wilhelm, M. G., & Robenek, H. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1342-6 · Cited by 43 · see citing works
Bechtold, D. A. (2008) · Journal of Genetics · doi:10.1007/s12041-008-0067-6 · Cited by 42 · see citing works
Kresnajati, S., Lin, Y.-Y., Mündel, T., Bernard, J. R., Lin, H.-F., & Liao, Y. (2022) · Cells · doi:10.3390/cells11223544 · Cited by 42 · see citing works
Fujii, J., & Osaki, T. (2023) · Molecules · doi:10.3390/molecules28020814 · Cited by 42 · see citing works
Seljeflot, I., Nilsson, B. B., Westheim, A. S., Bratseth, V., & Arnesen, H. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.09.003 · Cited by 40 · see citing works
Nitrone Derivatives as Therapeutics: From Chemical Modification to Specific-targeting
Rosselin, M., Pöeggeler, B., & Durand, G. (2017) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026617666170303115324 · Cited by 40 · see citing works
Novel metabolic roles of L-arginine in body energy metabolism and possible clinical applications
Hristina, K., Langerholc, T., & Trapečar, M. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0015-5 · Cited by 37 · see citing works
Effect of oral administration of L-arginine on senile dementia
Ohtsuka, Y., & Nakaya, J. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00396-4 · Cited by 37 · see citing works
Ristić-Medić, D., Peruničić-Peković, G., Rašić-Milutinović, Z., Takić, M. M., Popović, T., Arsić, A., & Glibetić, M. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/563576 · Cited by 36 · see citing works
Asymmetric dimethylarginine predicts survival in the elderly
Pizzarelli, F., Maas, R., Dattolo, P. C. G., Tripepi, G. L., Michelassi, S., D’Arrigo, G., Mieth, M., Bandinelli, S., Ferrucci, L., & Zoccali, C. (2013) · AGE · doi:10.1007/s11357-013-9523-1 · Cited by 35 · see citing works
Sakaguchi, Y., Kaimori, J., & Isaka, Y. (2023) · Nutrients · doi:10.3390/nu15041002 · Cited by 35 · see citing works
Lépine, G., Fouillet, H., Rémond, D., Huneau, J., Mariotti, F., & Polakof, S. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab073 · Cited by 32 · see citing works
Neacsu, M., Vaughan, N. J., Multari, S., Haljas, E., Scobbie, L., Duncan, G., Cantlay, L. L., Fyfe, C., Anderson, S. E., Horgan, G. W., et al. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02711-z · Cited by 32 · see citing works
Rocha, B. S. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.778467 · Cited by 30 · see citing works
Mazloom, Z., Dashtabi, A., Fararouei, M., & Hejazi, N. (2015) · Research in Cardiovascular Medicine · doi:10.5812/cardiovascmed.29419 · Cited by 30 · see citing works
Dahlberg, C. J., Ou, J. J., Babish, J. G., Lamb, J. J., Eliason, S., Brabazon, H., Gao, W., Kaadige, M. R., & Tripp, M. L. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0704 · Cited by 25 · see citing works
McDonald, J. D., Mah, E., Chitchumroonchokchai, C., Dey, P., Labyk, A. N., Villamena, F. A., Volek, J. S., & Bruno, R. S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.018 · Cited by 22 · see citing works
Reule, C. A., Goyvaerts, B., & Schoen, C. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1603-9 · Cited by 22 · see citing works
Zhu, X., Cai, L., Liu, J., Zhu, W., Cui, C., Ouyang, D., & Ye, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123409 · Cited by 19 · see citing works
Nitric Oxide as a Determinant of Human Longevity and Health Span
Pöeggeler, B., Singh, S. K., Sambamurti, K., & Pappolla, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914533 · Cited by 19 · see citing works
Self-citationPromoting healthy cardiovascular aging: emerging topics
Clayton, Z. S., Craighead, D. H., Darvish, S., Coppock, M. E., Ludwig, K., Brunt, V. E., Seals, D., & Rossman, M. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.27 · Cited by 19 · see citing works
Homoarginine in health and disease
Tsikas, D. (2022) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000889 · Cited by 17 · see citing works
Boit, M. D., Tommasi, S., Elliot, D. J., Zinellu, A., Sotgia, S., Sibson, R., Meakin, J. R., Aspden, R. M., Carru, C., Mangoni, A. A., et al. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0964-6 · Cited by 16 · see citing works
Tryptophan in Nutrition and Health
Pöeggeler, B., Singh, S. K., & Pappolla, M. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105455 · Cited by 15 · see citing works
Self-citationRajendra, A., Bondonno, N. P., Rainey‐Smith, S. R., Gardener, S. L., Hodgson, J. M., & Bondonno, C. P. (2022) · Food & Function · doi:10.1039/d2fo02427f · Cited by 14 · see citing works
Mazloom, Z., Dashtabi, A., Fararouei, M., & Hejazi, N. (2016) · Research in Cardiovascular Medicine · doi:10.4103/2251-9572.218698 · Cited by 14 · see citing works
Site-Specific Antioxidative Therapy for Prevention of Atherosclerosis and Cardiovascular Disease
Otani, H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/796891 · Cited by 13 · see citing works
The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity.
Engin, A., & Engin, A. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-48382-5_22 · Cited by 13 · see citing works
da Silva, I. D. C. G., Marchioni, D. M. L., Carioca, A. A. F., Bueno, V., & Colleoni, G. W. B. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00244-x · Cited by 12 · see citing works
Khosroshahi, M. Z., Asbaghi, O., Moradi, S., Kelishadi, M. R., Kaviani, M., Mardani, M., & Jalili, C. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104022 · Cited by 11 · see citing works
Zhang, S., Deng, Y., Zhang, A., Yan, L., Zhang, Z., Wei, J., & Zhang, Q. (2022) · Metabolites · doi:10.3390/metabo12090841 · Cited by 10 · see citing works
Editorial: Pharmacology of L-Arginine and L-Arginine-Rich Food
Pöeggeler, B., Robenek, H., & Pappolla, M. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.743788 · Cited by 5 · see citing works
Self-citationThe Lymphatic System in Neurological Disease and Alzheimer's Disease. A Brief Editorial
Pappolla, M. A., Carare, R. O., Poeggeler, B., Wısnıewskı, T., & Sambamurti, K. (2022) · Current Alzheimer Research · doi:10.2174/1567205020666221028111517 · Cited by 2 · see citing works
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Self-citationZhou, J., Liu, H., Hu, L., Kagami, H., & Wang, S. (2024) · Medicine Plus · doi:10.1016/j.medp.2023.100003 · Cited by 17 · see citing works
Li, X., Zheng, K., Chen, H., & Li, W. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46100677 · Cited by 16 · see citing works
Bernhardt, A., Jamil, A., Morshed, M. T., Ponnath, P., Gille, V., Stephan, N., Sauer, H., & Wartenberg, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-70382-x · Cited by 10 · see citing works
Ferroptosis: The Initiation Process of Lipid Peroxidation in Muscle Food
Kanner, J., Shpaizer, A., & Tirosh, O. (2025) · Antioxidants · doi:10.3390/antiox14101157 · Cited by 9 · see citing works
Institute of Biology, P. U. I. S., Tkaczenko, H., Lukash, O., Kamiński, P., & Kurhaluk, N. (2024) · Cellular Physiology and Biochemistry · doi:10.33594/000000716 · Cited by 7 · see citing works
Microvascular Health as a Key Determinant of Organismal Aging
Cenciarini, M., Uccelli, A., Mangili, F., Grunewald, M., & Bersini, S. (2025) · Advanced Science · doi:10.1002/advs.202508659 · Cited by 7 · see citing works
Aron, A., Landrum, E., Schneider, A. D., Via, M., Evans, L., & Rawson, E. S. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.07.008 · Cited by 6 · see citing works
Sleep deprivation and the development of oxidative stress in animal models
Bukareva, O., Pavlova, O. N., Сергеевна, Г. Д., Zakharov, A. V., & Shirolapov, I. V. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2025125031124 · Cited by 4 · see citing works
Malic enzyme 1 reverses cardiomyocyte senescence in a nitric oxide-dependent manner
Wu, W., Lei, R., Xu, H., Lü, L., Song, C., Wu, D., Li, M., Chen, L., Yu, Y., & Fang, X. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.07.048 · Cited by 3 · see citing works
Sleep Deprivation and the Development of Oxidative Stress in Animal Models
Bukareva, O., Pavlova, O. N., Сергеевна, Г. Д., Zakharov, A. V., & Shirolapov, I. V. (2025) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01864-2 · Cited by 3 · see citing works
Kurhaluk, N., Kołodziejska, R., Buyun, L., Kamiński, P., & Tkaczenko, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083461 · Cited by 3 · see citing works
Tang, H., Zhai, Y., Wang, G., Shi, J., Li, Y., Wang, Z., Guan, Y., Zhang, K., Wang, W., Li, Q., et al. (2026) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2026005 · Cited by 2 · see citing works
Special Issue “The 25th Anniversary of NO”
Mancardi, D., & Samaja, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136058 · Cited by 1 · see citing works
KL-6 assisted subtyping of ARDS: from subtype-specific metabolomics to LPCAT1 as a pathogenic target
Wang, X., Xue, M., Su, L., Luo, X. F., Li, Y., Fan, S., Hu, Q., Liao, H., Jiang, C., Chen, J., et al. (2026) · Respiratory Research · doi:10.1186/s12931-026-03650-1 · Cited by 1 · see citing works
Aging of the vascular system: proposal of preventive intervention with known natural substances
Fazio, S., Fazio, V., & Affuso, F. (2025) · Exploration of Cardiology · doi:10.37349/ec.2025.101268
Comorbidity of type 2 diabetes and Alzheimer's disease
Pöeggeler, B. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-32848-0.00029-7
Athar, S. S., Ghavamzadeh, S., Zayer, B., Yekta, Z., & Hasaniani, L. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-026-01987-4
Ferrari, R. R., Garofalo, M., Gerlando, R. D., Pellegrini, E., Dragoni, F., Rizzo, B., Rossi, M., Calatozzolo, C., Guaita, A., Davin, A., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02581-5
Alagh, K., Zalzal, R. N., Kumar, A., Xiong, Y., Xia, Z., & Kamra, K. (2026) · Antioxidants · doi:10.3390/antiox15111390
- Authors
- Poeggeler, B., Singh, K. S., Sambamurti, K., & Pappolla, M. A.
- Affiliations
- Medical University of South Carolina (US)
- The University of Texas Medical Branch at Galveston (US)
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2023-09-06
- Volume
- 24
- Issue
- 19
- Pages
- 14533-14533
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC10572643
- OpenAlex
- W4387059256
- Cited by
- 20
- References
- 90
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 5 · 2023: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- nitric oxide, superoxide, L-arginine, nitric oxide synthase, asymmetric dimethylarginine, antioxidant supplementation, vitamin C, oxidative stress, healthy aging, longevity, healthspan, NO bioavailability, age-related degeneration
- MeSH terms
- Antioxidants, Arginine, Humans, Longevity, Nitric Oxide, Nitric Oxide Synthase
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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