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Cited by 35Bipolar Disorder and TreatmentSchizophrenia research and treatmentPersonality Disorders and Psychopathology

Early interventions for youths at high risk for bipolar disorder: a developmental approach

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Benarous, Xavier, Consoli, Angèle, Milhiet, Vanessa, Cohen, David·2016·European Child & Adolescent Psychiatry
DOI 10.1007/s00787-015-0773-6
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Abstract

In recent decades, ongoing research programmes on primary prevention and early identification of bipolar disorder (BD) have been developed. The aim of this article is to review the principal forms of evidence that support preventive interventions for BD in children and adolescents and the main challenges associated with these programmes. We performed a literature review of the main computerised databases (MEDLINE, PUBMED) and a manual search of the literature relevant to prospective and retrospective studies of prodromal symptoms, premorbid stages, risk factors, and early intervention programmes for BD. Genetic and environmental risk factors of BD were identified. Most of the algorithms used to measure the risk of developing BD and the early interventions programmes focused on the familial risk. The prodromal signs varied greatly and were age dependent. During adolescence, depressive episodes associated with genetic or environmental risk factors predicted the onset of hypomanic/manic episodes over subsequent years. In prepubertal children, the lack of specificity of clinical markers and difficulties in mood assessment were seen as impeding preventive interventions at these ages. Despite encouraging results, biomarkers have not thus far been sufficiently validated in youth samples to serve as screening tools for prevention. Additional longitudinal studies in youths at high risk of developing BD should include repeated measures of putative biomarkers. Staging models have been developed as an integrative approach to specify the individual level of risk based on clinical (e.g. prodromal symptoms and familial history of BD) and non-clinical (e.g. biomarkers and neuroimaging) data. However, there is still a lack of empirically validated studies that measure the benefits of using these models to design preventive intervention programmes.

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  • Indicated prevention in bipolar disorder was developed only fifteen years ago and is rapidly emerging, but its supporting evidence lags behind that for CHR-P.

    “Indicated prevention in bipolar disorder was developed, following the CHR-P template, only fifteen years ago 96,97 , and is rapidly emerging 98-101 . The supporting evidence lags behind that for CHR-P 99,102 .”

    From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [101]

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Authors
Benarous, X., Consoli, A., Milhiet, V., & Cohen, D.
Affiliations
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Inserm (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Benarous, Xavier
ORCID
Venue
European Child & Adolescent Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2015-09-22
Volume
25
Issue
3
Pages
217-233
ISSN
  • 1018-8827 (ISSN-L)
  • 1435-165X
DOI
10.1007/s00787-015-0773-6
OpenAlex
W1729155468
Cited by
35
References
129
Citations by year
2026: 3 · 2025: 2 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 3
FWCI
0.41
Type
journal article
Language
en
Open access
Licence
Locations
  • European Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Funders
No grant
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
bipolar disorder, early intervention, primary prevention, prodromal symptoms, familial risk, genetic risk factors, environmental risk factors, adolescents, children, depressive episodes, biomarkers, screening, staging model, developmental approach
MeSH terms
Adolescent, Psychology, Adolescent, Bipolar Disorder, Child, Psychology, Child, Humans, Male, Prospective Studies, Retrospective Studies, Early Diagnosis, Early Medical Intervention, Prodromal Symptoms

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