Dopamine and serotonin levels following prenatal viral infection in mouse—implications for psychiatric disorders such as schizophrenia and autism
Open accessAbstract
Prenatal viral infection has been associated with neurodevelopmental disorders such as schizophrenia and autism. It has previously been demonstrated that viral infection causes deleterious effects on brain structure and function in mouse offspring following late first trimester (E9) and middle-late second trimester (E18) administration of influenza virus. Neurochemical analysis following infection on E18 using this model has revealed significantly altered levels of serotonin, 5-hydroxyindoleacetic acid, and taurine, but not dopamine. In order to monitor these different patterns of monoamine expression in exposed offspring in more detail and to see if there are changes in the dopamine system at another time point, pregnant C57BL6J mice were infected with a sublethal dose of human influenza virus or sham-infected using vehicle solution on E16. Male offspring of the infected mice were collected at P0, P14, and P56, their brains removed and cerebellum dissected and flash frozen. Dopamine and serotonin levels were then measured using HPLC-ED technique. When compared to controls, there was a significant decrease in serotonin levels in the cerebella of offspring of virally exposed mice at P14. No differences in levels of dopamine were observed in exposed and control mice, although there was a significant decrease in dopamine at P14 and P56 when compared to P0. The present study shows that the serotonergic system is disrupted following prenatal viral infection, potentially modelling disruptions that occur in patients with schizophrenia and autism.
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Prenatal flu exposure decreased 5-HT and 5-HIAA levels in cerebellum.
“prenatal flu exposure decreased 5-HT and 5-HIAA levels in the cerebellum (Fatemi et al., 2008; Winter et al., 2008).”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as Winter et al., 2008
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- Authors
- Winter, C., Reutiman, T. J., Folsom, T. D., Sohr, R., Wolf, R. J., Juckel, G., & Fatemi, S. H.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- University of Minnesota (US)
- Ruhr University Bochum (DE)
- Corresponding author
- Juckel, Georg
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 18
- Issue
- 10
- Pages
- 712-716
- ISSN
- 0924-977X (ISSN-L)
- PMC
- PMC2714699
- OpenAlex
- W2134700369
- Cited by
- 92
- References
- 37
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 10 · 2014: 4 · 2013: 7 · 2012: 13
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD046589)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prenatal viral infection, influenza virus, dopamine, serotonin, serotonergic system, cerebellum, schizophrenia, autism spectrum disorder, neurodevelopmental disorders, monoamines, 5-hydroxyindoleacetic acid, taurine, mouse model
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Animals, Newborn, Cerebellum, Dopamine, Embryo, Mammalian, Female, Male, Mice, Inbred C57BL, Influenza A virus, Pregnancy, Prenatal Exposure Delayed Effects, Serotonin, Time Factors, Central Nervous System Viral Diseases, Mice
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