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Cited by 131Bipolar Disorder and TreatmentSchizophrenia research and treatmentPersonality Disorders and Psychopathology

A preliminary evaluation of the validity of at-risk criteria for bipolar disorders in help-seeking adolescents and young adults

Bechdolf, Andreas, Nelson, Barnaby, Cotton, Sue M., Chanen, Andrew, Thompson, Andrew, Kettle, Jonathan, Conus, Phillippe, Amminger, G. Paul +3 more·2010·Journal of Affective Disorders
DOI 10.1016/j.jad.2010.06.016
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Abstract

Introduction We have developed ultra-high risk criteria for bipolar affective disorder (bipolar at-risk - BAR) which include general criteria such as being in the peak age range of the onset of the disorder and a combination of specific criteria including sub-threshold mania, depressive symptoms, cyclothymic features and genetic risk. In the current study, the predictive validity of these criteria were tested in help-seeking adolescents and young adults.Method This medical file-audit study was conducted at ORYGEN Youth Health (OYH), a public mental health program for young people aged between 15 and 24years and living in metropolitan Melbourne, Australia. BAR criteria were applied to the intake assessments of all non-psychotic patients who were being treated in OYH on 31 January, 2008. All entries were then checked for conversion criteria. Hypomania/mania related additions or alterations to existing treatments or initiation of new treatment by the treating psychiatrist served as conversion criteria to mania.Results The BAR criteria were applied to 173 intake assessments. Of these, 22 patients (12.7%) met BAR criteria. The follow-up period of the sample was 265.5days on average (SD 214.7). There were significantly more cases in the BAR group (22.7%, n=5) than in the non-BAR group (0.7%, n=1) who met conversion criteria (p<.001).Conclusions These findings support the notion that people who develop a first episode of mania can be identified during the prodromal phase. The proposed criteria need further evaluation in prospective clinical trials.

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  • Indicated prevention in bipolar disorder was developed only fifteen years ago and is rapidly emerging, but its supporting evidence lags behind that for CHR-P.

    “Indicated prevention in bipolar disorder was developed, following the CHR-P template, only fifteen years ago 96,97 , and is rapidly emerging 98-101 . The supporting evidence lags behind that for CHR-P 99,102 .”

    From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [97]

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Authors
Bechdolf, A., Nelson, B., Cotton, S. M., Chanen, A., Thompson, A., Kettle, J., Conus, P., Amminger, G. P., Yung, A. R., Berk, M., & McGorry, P. D.
Affiliations
The University of Melbourne (AU)
Corresponding author
Bechdolf, Andreas
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2010-12
Volume
127
Issue
1-3
Pages
316-320
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2010.06.016
OpenAlex
W2006961746
Cited by
131
References
42
Citations by year
2026: 2 · 2025: 15 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 12 · 2020: 2 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 10 · 2014: 12 · 2013: 13 · 2012: 14
FWCI
6.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
bipolar disorder, predictive validity, young adults, prodromal symptoms, depressive symptoms, genetic risk, first-episode mania
MeSH terms
Adolescent, Adult, Bipolar Disorder, Community Mental Health Services, Female, Humans, Male, Mass Screening, Medical Audit, Patient Acceptance of Health Care, Personality Assessment, Psychometrics, Retrospective Studies, Risk Factors, Victoria, Reproducibility of Results, Genetic Predisposition to Disease, Early Diagnosis, Young Adult

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