Cited by 283Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Dysfunction of NMDA receptors in Alzheimer’s disease

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Zhang, Yan, Li, Peiyao, Feng, Jianbo, Wu, Minghua·2016·Neurological Sciences

DOI 10.1007/s10072-016-2546-5PMC PMC4917574

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Abstract

N-methyl-D-aspartate receptors (NMDARs) play a pivotal role in the synaptic transmission and synaptic plasticity thought to underlie learning and memory. NMDARs activation has been recently implicated in Alzheimer's disease (AD) related to synaptic dysfunction. Synaptic NMDARs are neuroprotective, whereas overactivation of NMDARs located outside of the synapse cause loss of mitochondrial membrane potential and cell death. NMDARs dysfunction in the glutamatergic tripartite synapse, comprising presynaptic and postsynaptic neurons and glial cells, is directly involved in AD. This review discusses that both beta-amyloid (Aβ) and tau perturb synaptic functioning of the tripartite synapse, including alterations in glutamate release, astrocytic uptake, and receptor signaling. Particular emphasis is given to the role of NMDARs as a possible convergence point for Aβ and tau toxicity and possible reversible stages of the AD through preventive and/or disease-modifying therapeutic strategies.

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“1998; Huang 2012; Zhang 2016).”

Authors: Zhang, Y., Li, P., Feng, J., & Wu, M.
Affiliations: Central South University (CN)
Corresponding author: Wu, Minghua
ORCID: Zhang, Yan
Li, Peiyao
Feng, Jianbo
Wu, Minghua
Venue: Neurological Sciences
Publisher: Springer Science and Business Media LLC
Published: 2016-03-12
Volume: 37
Issue: 7
Pages: 1039-1047
ISSN: 1590-1874 (ISSN-L)
1590-3478
DOI: 10.1007/s10072-016-2546-5
PMC: PMC4917574
OpenAlex: W2293608890
Cited by: 282
References: 72
Citations by year: 2026: 15 · 2025: 30 · 2024: 36 · 2023: 29 · 2022: 29 · 2021: 27 · 2020: 39 · 2019: 23 · 2018: 35 · 2017: 15 · 2016: 3
FWCI: 2.97
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Neurological Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: NMDA receptor, Alzheimer's disease, synaptic dysfunction, tripartite synapse, amyloid-beta, tau protein, glutamate release, astrocytes, synaptic plasticity, mitochondrial membrane potential, neuroprotection, disease-modifying therapy
MeSH terms: Alzheimer Disease, Humans, Synapses, Receptors, N-Methyl-D-Aspartate, Amyloid beta-Peptides, tau Proteins

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Dysfunction of NMDA receptors in Alzheimer’s disease

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