SWI and phase imaging reveal intracranial calcifications in the P301L mouse model of human tauopathy

Neurodegenerative Tauopathies

Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · see citing works

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

SantaCruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., et al. (2005) · Science · doi:10.1126/science.1113694 · Cited by 2,014 · see citing works

Susceptibility weighted imaging (SWI)

Haacke, E. M., Xu, Y., Cheng, Y. N., & Reichenbach, J. R. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20198 · Cited by 1,582 · see citing works

The role of magnetic susceptibility in magnetic resonance imaging: MRI magnetic compatibility of the first and second kinds

Schenck, J. F. (1996) · Medical Physics · doi:10.1118/1.597854 · Cited by 1,537 · see citing works

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526 · see citing works

Tau pathology and neurodegeneration

Spillantini, M. G., & Goedert, M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70090-5 · Cited by 1,133 · see citing works

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

Murray, M. E., Graff-Radford, N. R., Ross, O. A., Petersen, R. C., Duara, R., & Dickson, D. W. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70156-9 · Cited by 972 · see citing works

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)

Ramsden, M., Kotilinek, L., Forster, C., Paulson, J., McGowan, E., SantaCruz, K., Guimaraes, A., Yue, M., Lewis, J., Carlson, G., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3279-05.2005 · Cited by 702 · see citing works

Engineering and Algorithm Design for an Image Processing API: A Technical Report on ITK - the Insight Toolkit

Yoo, T. S., Ackerman, M., Lorensen, W. E., Schroeder, W., Chalana, V., Aylward, S., Metaxas, D., & Whitaker, R. (2002) · Studies in health technology and informatics · doi:10.3233/978-1-60750-929-5-586 · Cited by 621 · see citing works

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

Lasagna‐Reeves, C. A., Castillo‐Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R., & Kayed, R. (2012) · The FASEB Journal · doi:10.1096/fj.11-199851 · Cited by 527 · see citing works

Susceptibility-weighted imaging and quantitative susceptibility mapping in the brain

Liu, C., Li, W., Tong, K. A., Yeom, K. W., & Kuzminski, S. J. (2014) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24768 · Cited by 508 · see citing works

Tau filament formation in transgenic mice expressing P301L tau

Götz, J., Chen, F., Barmettler, R., & Nitsch, R. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006531200 · Cited by 495 · see citing works

An autoradiographic evaluation of AV-1451 Tau PET in dementia

Lowe, V. J., Curran, G., Fang, P., Liesinger, A. M., Josephs, K. A., Parisi, J. E., Kantarci, K., Boeve, B. F., Pandey, M. K., Bruinsma, T., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0315-6 · Cited by 474 · see citing works

Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts

Paloneva, J., Kestilä, M., Wu, J., Salminen, A., Böhling, T., Ruotsalainen, V., Hakola, P., Bakker, A. B. H., Phillips, J. H., Pekkarinen, P., et al. (2000) · Nature Genetics · doi:10.1038/77153 · Cited by 460 · see citing works

Neuropathological background of phenotypical variability in frontotemporal dementia

Josephs, K. A., Hodges, J. R., Snowden, J. S., Mackenzie, I. R., Neumann, M., Mann, D. M. A., & Dickson, D. W. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0839-6 · Cited by 453 · see citing works

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

Guerreiro, R. J., Lohmann, E., Brás, J. M., Gibbs, J. R., Rohrer, J. D., Gurunlian, N., Dursun, B., Bilgic, B., Hanagasi, H., Gurvit, H., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.579 · Cited by 374 · see citing works

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

Takeda, S., Wegmann, S., Cho, H., DeVos, S. L., Commins, C., Roe, A. D., Nicholls, S. B., Carlson, G. A., Pitstick, R., Nobuhara, C. K., et al. (2015) · Nature Communications · doi:10.1038/ncomms9490 · Cited by 371 · see citing works

Vascular pathology in the aged human brain

Grinberg, L. T., & Thal, D. R. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0652-7 · Cited by 345 · see citing works

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

Keller, A., Westenberger, A., Sobrido, M. J., García-Murias, M., Domingo, A., Sears, R. L., Lemos, R. R., Ordoñez-Ugalde, A., Nicolas, G., da Cunha, J. E. G., et al. (2013) · Nature Genetics · doi:10.1038/ng.2723 · Cited by 324 · see citing works

The Allen Brain Atlas: 5 years and beyond

Jones, A. R., Overly, C. C., & Sunkin, S. M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2722 · Cited by 322 · see citing works

Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export

Legati, A., Giovannini, D., Nicolas, G., López-Sánchez, U., Quintáns, B., de Oliveira, J. R. M., Sears, R., Ramos, E. M., Spiteri, E., Sobrido, M., et al. (2015) · Nature Genetics · doi:10.1038/ng.3289 · Cited by 315 · see citing works

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Bemiller, S. M., McCray, T. J., Allan, K., Formica, S. V., Xu, G., Wilson, G., Kokiko-Cochran, O. N., Crish, S. D., Lasagna-Reeves, C. A., Ransohoff, R. M., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0216-6 · Cited by 299 · see citing works

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

Fu, H., Rodriguez, G. A., Herman, M., Emrani, S., Nahmani, E., Barrett, G., Figueroa, H. Y., Goldberg, E., Hussaini, S. A., & Duff, K. E. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.023 · Cited by 264 · see citing works

Identification of calcification with MRI using susceptibility‐weighted imaging: A case study

Wu, Z., Mittal, S., Kish, K. K., Yu, Y., Hu, J., & Haacke, E. M. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21617 · Cited by 259 · see citing works

The genetic causes of basal ganglia calcification, dementia, and bone cysts: <i>DAP12</i> and <i>TREM2</i>

Klünemann, H. H., Ridha, B. H., Magy, L., Wherrett, J. R., Hemelsoet, D. M., Keen, R. W., De Bleecker, J. L., Rossor, M. N., Marienhagen, J., Klein, H. E., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000160304.00003.ca · Cited by 254 · see citing works

Four-repeat tauopathies

Rösler, T. W., Marvian, A. T., Brendel, M., Nykänen, N.-P., Höllerhage, M., Schwarz, S. C., Hopfner, F., Koeglsperger, T., Respondek, G., Schweyer, K., et al. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101644 · Cited by 219 · see citing works

Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies

Ono, M., Sahara, N., Kumata, K., Ji, B., Ni, R., Koga, S., Dickson, D. W., Trojanowski, J. Q., Lee, V. M. ‐., Yoshida, M., et al. (2016) · Brain · doi:10.1093/brain/aww339 · Cited by 202 · see citing works

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

Brelstaff, J., Tolkovsky, A. M., Ghetti, B., Goedert, M., & Spillantini, M. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.072 · Cited by 195 · see citing works

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

Blair, L. J., Frauen, H. D., Zhang, B., Nordhues, B. A., Bijan, S., Lin, Y.-C., Zamudio, F., Hernandez, L. D., Sabbagh, J. J., Selenica, M.-L. B., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0186-2 · Cited by 193 · see citing works

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

Gamache, J., Benzow, K. A., Forster, C. L., Kemper, L. J., Hlynialuk, C. J. W., Furrow, E., Ashe, K. H., & Koob, M. D. (2019) · Nature Communications · doi:10.1038/s41467-019-10428-1 · Cited by 171 · see citing works

Susceptibility weighted imaging at ultra high magnetic field strengths: Theoretical considerations and experimental results

Deistung, A., Rauscher, A., Sedlacik, J., Stadler, J., Witoszynskyj, S., & Reichenbach, J. R. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21754 · Cited by 169 · see citing works

Neuropathological Correlates of Psychotic Phenomena in Confirmed Alzheimer's Disease

Förstl, H., Burns, A. S., Levy, R., & Cairns, N. J. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.165.1.53 · Cited by 161 · see citing works

A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

Guerreiro, R., Bilgic, B., Guven, G., Brás, J., Rohrer, J., Lohmann, E., Hanagasi, H., Gurvit, H., & Emre, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.005 · Cited by 158 · see citing works

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

Giraldo, M., Lopera, F., Siniard, A. L., Corneveaux, J. J., Schrauwen, I., Carvajal, J., Muñoz, C., Ramirez-Restrepo, M., Gaiteri, C., Myers, A. J., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.016 · Cited by 147 · see citing works

Recessive Mutations in the Gene Encoding the Tight Junction Protein Occludin Cause Band-like Calcification with Simplified Gyration and Polymicrogyria

O'Driscoll, M. C., Daly, S. B., Urquhart, J. E., Black, G. C. M., Pilz, D. T., Brockmann, K., McEntagart, M., Abdel-Salam, G., Zaki, M., Wolf, N. I., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.07.012 · Cited by 145 · see citing works

Experimental evidence for the age dependence of tau protein spread in the brain

Wegmann, S., Bennett, R. E., Delorme, L., Robbins, A. B., Hu, M., MacKenzie, D., Kirk, M. J., Schiantarelli, J., Tunio, N., Amaral, A. C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw6404 · Cited by 144 · see citing works

X-ray imaging physics for nuclear medicine technologists. Part 2: X-ray interactions and image formation.

Seibert, J. A., & Boone, J. M. (2005) · PubMed · Cited by 129 · see citing works

Increased intrathecal inflammatory activity in frontotemporal dementia: pathophysiological implications

Sjogren, M. (2004) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp.2003.019422 · Cited by 125 · see citing works

Intracranial calcification on gradient-echo phase image: depiction of diamagnetic susceptibility.

Yamada, N., Imakita, S., Sakuma, T., & Takamiya, M. (1996) · Radiology · doi:10.1148/radiology.198.1.8539373 · Cited by 121 · see citing works

Mutations inTREM2lead to pure early-onset dementia without bone cysts

Chouery, É., Delague, V., Bergougnoux, A., Koussa, S., Serre, J., & Mégarbané, A. (2008) · Human Mutation · doi:10.1002/humu.20836 · Cited by 120 · see citing works

Analysis of Tau Phosphorylation and Truncation in a Mouse Model of Human Tauopathy

Delobel, P., Lavenir, I., Fraser, G. M., Ingram, E., Holzer, M., Ghetti, B. F., Spillantini, M. G., Crowther, R. A., & Goedert, M. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070627 · Cited by 120 · see citing works

A Homozygous Mutation in the Tight-Junction Protein JAM3 Causes Hemorrhagic Destruction of the Brain, Subependymal Calcification, and Congenital Cataracts

Mochida, G. H., Ganesh, V. S., Felie, J. M., Gleason, D., Hill, R. S., Clapham, K. R., Rakiec, D. P., Tan, W., Akawi, N. A., Al‐Saffar, M., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.10.026 · Cited by 111 · see citing works

Using magnetic field simulation to study susceptibility-related phase contrast in gradient echo MRI

Schäfer, A., Wharton, S., Gowland, P. A., & Bowtell, R. W. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.093 · Cited by 110 · see citing works

Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice

Pennanen, L., Wolfer, D. P., Nitsch, R. M., & Götz, J. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00165.x · Cited by 102 · see citing works

Diffuse neurofibrillary tangles with calcification: a new presenile dementia.

Kosaka, K. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.5.594 · Cited by 100 · see citing works

Pineal calcification in Alzheimer's disease: An in vivo study using computed tomography

Mahlberg, R., Walther, S., Kalus, P., Böhner, G., Hädel, S., Reischies, F. M., Kühl, K.-P., Hellweg, R., & Kunz, D. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.003 · Cited by 93 · see citing works

Neuropsychological Alterations in Patients With Computed Tomography--Detected Basal Ganglia Calcification

López‐Villegas, D., Kulisevsky, J., Deus, J., Junqué, C., Pujol, J., Guardia, E., & Grau, J. M. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550030061023 · Cited by 91 · see citing works

Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice

Pennanen, L., Welzl, H., D’Adamo, P., Nitsch, R. M., & Götz, J. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.020 · Cited by 89 · see citing works

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification

Vanlandewijck, M., Lebouvier, T., Mäe, M. A., Nahar, K., Hornemann, S., Kenkel, D., Cunha, S. I., Lennartsson, J., Boss, A., Heldin, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143407 · Cited by 89 · see citing works

SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway‐Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification

Wallingford, M. C., Chia, J. J., Leaf, E. M., Borgeia, S., Chavkin, N. W., Sawangmake, C., Marro, K. I., Cox, T. C., Speer, M. Y., & Giachelli, C. M. (2016) · Brain Pathology · doi:10.1111/bpa.12362 · Cited by 88 · see citing works

Age and gender related prevalence of intracranial calcifications in CT imaging; data from 12,000 healthy subjects

Yalçın, A., Ceylan, M., Bayraktutan, O. F., Sonkaya, A. R., & Yüce, İ. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.07.008 · Cited by 85 · see citing works

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

Wang, H., Li, Y., Ryder, J. W., Hole, J. T., Ebert, P. J., Airey, D. C., Qian, H.-R., Logsdon, B., Fisher, A., Ahmed, Z., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0296-y · Cited by 83 · see citing works

Detection of Cerebral Microbleeds with Quantitative Susceptibility Mapping in the Arcabeta Mouse Model of Cerebral Amyloidosis

Klohs, J., Deistung, A., Schweser, F., Grandjean, J., Dominietto, M., Waschkies, C., Nitsch, R. M., Knuesel, I., Reichenbach, J. R., & Rudin, M. (2011) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2011.118 · Cited by 83 · see citing works

Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response

Zarb, Y., Weber‐Stadlbauer, U., Kirschenbaum, D. S., Kindler, D., Richetto, J., Keller, D. X., Rademakers, R., Dickson, D. W., Pasch, A., Byzova, T. V., et al. (2019) · Brain · doi:10.1093/brain/awz032 · Cited by 76 · see citing works

Severe vascular disturbance in a case of familial brain calcinosis

Judith Miklossy, A., Mackenzie, I. R., Dorovini‐Zis, K., Calne, D. B., Wszołek, Z. K., Klegeris, A., & McGeer, P. L. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1007-7 · Cited by 74 · see citing works

Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models

Ni, R., Ji, B., Ono, M., Sahara, N., Zhang, M.-R., Aoki, I., Nordberg, A., Suhara, T., & Higuchi, M. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.201632 · Cited by 72 · see citing works

Neurological disorders in 166 patients with basal ganglia calcification: a statistical evaluation

F�rstl, H., Krumm, B., Eden, S., & Kohlmeyer, K. (1992) · Journal of Neurology · doi:10.1007/bf00839209 · Cited by 70 · see citing works

In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510

Ishikawa, A., Tokunaga, M., Maeda, J., Minamihisamatsu, T., Shimojo, M., Takuwa, H., Ono, M., Ni, R., Hirano, S., Kuwabara, S., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170509 · Cited by 69 · see citing works

Accumulation of amyloid precursor protein in damaged neuronal processes and microglia following intracerebral administration of aluminum salts

Shigematsu, K., & McGeer, P. L. (1992) · Brain Research · doi:10.1016/0006-8993(92)91272-g · Cited by 66 · see citing works

Detection of Intratumoral Calcification in Oligodendrogliomas by Susceptibility-Weighted MR Imaging

Zulfiqar, M., Dumrongpisutikul, N., Intrapiromkul, J., & Yousem, D. M. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2862 · Cited by 64 · see citing works

Primary familial brain calcifications: genetic and clinical update

Westenberger, A., Balck, A., & Klein, C. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000712 · Cited by 60 · see citing works

Vascular fibrosis and calcification in the hippocampus in aging, Alzheimer disease, and Down syndrome

Węgiel, J., Kuchna, I., Wısnıewskı, T., de Leon, M. J., Reisberg, ‌., Pirttilä, T., Kivimäki, T., & Lehtimäki, T. J. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0471-y · Cited by 57 · see citing works

Genetics and molecular biology of brain calcification

Deng, H., Zheng, W. L., & Jankovic, J. J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.004 · Cited by 54 · see citing works

Calcification of the basal ganglia in Down's syndrome and Alzheimer's disease

Mann, D. M. A. (1988) · Acta Neuropathologica · doi:10.1007/bf00689598 · Cited by 47 · see citing works

Microglia control small vessel calcification via TREM2

Zarb, Y., Sridhar, S., Nassiri, S., Utz, S. G., Schaffenrath, J., Maheshwari, U., Rushing, E. J., Nilsson, K. P. R., Delorenzi, M., Colonna, M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abc4898 · Cited by 44 · see citing works

<i>APP</i> Mutations in Cerebral Amyloid Angiopathy with or without Cortical Calcifications: Report of Three Families and a Literature Review

Sellal, F., Wallon, D., Martinez-Almoyna, L., Marelli, C., Dhar, A., Oesterlé, H., Rovelet-Lecrux, A., Rousseau, S., Kourkoulis, C. E., Rosand, J., et al. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160709 · Cited by 43 · see citing works

Immunohistochemical examination on intracranial calcification in neurodegenerative diseases

Fujita, D., Terada, S., Ishizu, H., Yokota, O., Nakashima, H., Ishihara, T., & Kuroda, S. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0640-7 · Cited by 42 · see citing works

Osteopontin as a two-sided mediator in acute neuroinflammation in rat models.

Shin, T. (2012) · Acta Histochemica · doi:10.1016/j.acthis.2012.08.004 · Cited by 39 · see citing works

Basal ganglia calcification and psychotic symptoms in the very old

Östling, S., Andreasson, L. A., & Skoog, I. G. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.997 · Cited by 33 · see citing works

Astrocyte–microglial association and matrix composition are common events in the natural history of primary familial brain calcification

Nahar, K., Lebouvier, T., Mäe, M. A., Konzer, A., Bergquist, J., Zarb, Y., Johansson, B. R., Betsholtz, C., & Vanlandewijck, M. (2019) · Brain Pathology · doi:10.1111/bpa.12787 · Cited by 33 · see citing works

Familial calcification of the basal ganglia: a case report and review of the literature

Flint, J., & Goldstein, L. H. (1992) · Psychological Medicine · doi:10.1017/s0033291700038046 · Cited by 31 · see citing works

fMRI Reveals Mitigation of Cerebrovascular Dysfunction by Bradykinin Receptors 1 and 2 Inhibitor Noscapine in a Mouse Model of Cerebral Amyloidosis

Ni, R., Kindler, D., Waag, R., Rouault, M., Ravikumar, P., Nitsch, R. M., Rudin, M., Camici, G. G., Liberale, L., Kulic, L., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00027 · Cited by 31 · see citing works

Quantitative assessment of microvasculopathy in arcAβ mice with USPIO-enhanced gradient echo MRI

Klohs, J., Deistung, A., Ielacqua, G. D., Seuwen, A., Kindler, D., Schweser, F., Vaas, M., Kipar, A., Reichenbach, J. R., & Rudin, M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15621500 · Cited by 30 · see citing works

Cerebral Amyloid Angiopathy With Vascular Iron Accumulation and Calcification

Bulk, M., Moursel, L. G., van der Graaf, L. M., van Veluw, S. J., Greenberg, S. M., van Duinen, S. G., van Buchem, M. A., van Rooden, S., & van der Weerd, L. (2018) · Stroke · doi:10.1161/strokeaha.118.021872 · Cited by 27 · see citing works

Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach

Fontaine, S. N., Ingram, A., Cloyd, R., Meier, S. E., Miller, E., Lyons, D. N., Nation, G. K., Mechas, E., Weiss, B. E., Lanzillotta, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.04.007 · Cited by 24 · see citing works

Vascular and Tissue Changes of Magnetic Susceptibility in the Mouse Brain After Transient Cerebral Ischemia

Vaas, M., Deistung, A., Reichenbach, J. R., Keller, A., Kipar, A., & Klohs, J. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0591-x · Cited by 23 · see citing works

Hippocampal Calcification on Computed Tomography in Relation to Cognitive Decline in Memory Clinic Patients: A Case-Control Study

Kockelkoren, R., Vis, J. B. D., Mali, W. P. T. M., Hendrikse, J., de Jong, P. A., Rozemüller, A. J. M., & Koek, H. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167444 · Cited by 21 · see citing works

Neuropsychological and 18FDG-PET studies in a family with idiopathic basal ganglia calcifications

Ber, I. L., Marié, R., Chabot, B., Lalevée, C., & Defer, G. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.03.017 · Cited by 19 · see citing works

Distribution of basal ganglia lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of five autopsy cases

Tsuchiya, K., Nakayama, H., Iritani, S., Arai, T., Niizato, K., Haga, C., Matsushita, M., & Ikeda, K. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0501-9 · Cited by 19 · see citing works

Diffuse neurofibrillary tangles with calcification (Kosaka–Shibayama disease) in Japan

Ukai, K., & Kosaka, K. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12334 · Cited by 16 · see citing works

Histological validation of calcifications in the human hippocampus as seen on computed tomography

Peters, M. E. M., Kockelkoren, R., de Brouwer, E. J. M., Koek, H. L., Bleys, R. L. A. W., Mali, W. P. T. M., Hendrikse, J., Rozemüller, A. J. M., & de Jong, P. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197073 · Cited by 15 · see citing works

Changes of diffuse neurofibrillary tangles with calcification (DNTC) in a woman without evidence of dementia.

Langlois, N. E. I., Grieve, J. H. K., & Best, P. V. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.59.1.103 · Cited by 15 · see citing works

Diagnostic accuracy of susceptibility-weighted magnetic resonance imaging for the evaluation of pineal gland calcification

Adams, L. C., Böker, S. M., Bender, Y. Y., Diederichs, G., Fallenberg, E. M., Wagner, M., Hamm, B., & Makowski, M. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172764 · Cited by 14 · see citing works

Assessment of Physiologic Intracranial Calcification in Healthy Adults Using18F-NaF PET/CT

Al-Zaghal, A., Seraj, S. M., Werner, T. J., Gerke, O., Høilund‐Carlsen, P. F., & Alavi, A. A. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.213678 · Cited by 13 · see citing works

Microglia protect against age-associated brain pathologies

Munro, D. A. D., Bestard-Cuche, N., McQuaid, C., Chagnot, A., Shabestari, S. K., Chadarevian, J. P., Maheshwari, U., Szymkowiak, S., Morris, K., Mohammad, M., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.05.018 · Cited by 82 · see citing works

Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways

Lai, C., Chen, Z., Ding, Y., Qian, C., Su, S., Liu, H., Ni, R., & Tang, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.782434 · Cited by 47 · see citing works

Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography

Vagenknecht, P., Luzgin, A., Ono, M., Ji, B., Higuchi, M., Noaín, D., Maschio, C., Sobek, J., Chen, Z., Konietzko, U., et al. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-022-05708-w · Cited by 42 · see citing works

Aquaporin 4 is differentially increased and dislocated in association with tau and amyloid-beta

Kecheliev, V., Boss, L., Maheshwari, U., Konietzko, U., Keller, A., Razansky, D., Nitsch, R. M., Klohs, J., & Ni, R. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121593 · Cited by 34 · see citing works

Diffusion tensor imaging reveals whole-brain microstructural changes in the P301L mouse model of tauopathy.

Massalimova, A., Ni, R., Nitsch, R. M., Reisert, M., von Elverfeldt, D., & Klohs, J. (2020) · Neurodegenerative Diseases · doi:10.1159/000515754 · Cited by 28 · see citing works

Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy

Ni, R., Chen, Z., Gerez, J., Shi, G., Zhou, Q., Riek, R., Nilsson, K. P. R., Razansky, D., & Klohs, J. (2020) · Biomedical Optics Express · doi:10.1364/boe.395803 · Cited by 22 · see citing works

Positron Emission Tomography in Animal Models of Tauopathies

Cao, L., Kong, Y., Ji, B., Ren, Y., Guan, Y., & Ni, R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.761913 · Cited by 14 · see citing works

In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease.

Kim, E., Di Censo, D., Baraldo, M., Simmons, C., Rosa, I., Randall, K., Ballard, C., Dickie, B. R., Williams, S. C. R., Killick, R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91899-5 · Cited by 15 · see citing works

Deep learning facilitates fully automated brain image registration of optoacoustic tomography and magnetic resonance imaging

Hu, Y., Lafci, B., Luzgin, A., Wang, H., Klohs, J., Deán‐Ben, X. L., Ni, R., Razansky, D., & Ren, W. (2022) · Biomedical Optics Express · doi:10.1364/boe.458182 · Cited by 14 · see citing works

Visualizing alpha‐synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo

Straumann, N., Combes, B. F., Deán‐Ben, X. L., Sternke‐Hoffmann, R., Gerez, J., Dias, I., Chen, Z., Watts, B., Rostami, I., Shi, K., et al. (2024) · Brain Pathology · doi:10.1111/bpa.13288 · Cited by 12 · see citing works

Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy

Kindler, D., Maschio, C. A., Ni, R., Zerbi, V., Razansky, D., & Klohs, J. (2021) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x211062274 · Cited by 9 · see citing works

Magnetic Resonance Imaging in Tauopathy Animal Models

Ni, R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.791679 · Cited by 8 · see citing works

Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy

Kindler, D., Maschio, C., Ni, R., Zerbi, V., Razansky, D., & Klohs, J. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.3929/ethz-b-000520246 · Cited by 10 · see citing works

Multimodal Contrast Agents for Optoacoustic Brain Imaging in Small Animals

Shi, X., Ji, B., Kong, Y., Guan, Y., & Ni, R. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.746815 · Cited by 8 · see citing works

Spiral volumetric optoacoustic tomography of reduced oxygen saturation in the spinal cord of M83 mouse model of Parkinson’s disease

Combes, B. F., Kalva, S. K., Benveniste, P., Tournant, A., Law, M. H., Newton, J., Krüger, M., Weber, R., Dias, I., Noaín, D., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06938-w · Cited by 9 · see citing works

Intracranial calcifications associated with factors related and unrelated to atherosclerosis in older people: A community dwelling cohort study

Matsuoka, T., Oya, N., Imai, A., Sun, W., Kitabayashi, Y., Akazawa, K., Yamada, K., Ikeda, K., Matoba, S., & Narumoto, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30011 · Cited by 6 · see citing works

Structural MRI Reveals Cervical Spinal Cord Atrophy in the P301L Mouse Model of Tauopathy: Gender and Transgene-Dosing Effects

Sartoretti, T., Ganley, R., Ni, R., Freund, P., Zeilhofer, H., & Klohs, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.825996 · Cited by 4 · see citing works

Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease

Schober, R., Hilbrich, I., Jäger, C., & Holzer, M. (2021) · Neuropathology · doi:10.1111/neup.12742 · Cited by 5 · see citing works

The appearance of magnetic susceptibility objects in SWI phase depends on object size: Comparison with QSM and CT

Xie, H., Zhuang, H., Guo, Y., Sharma, R., Zhang, Q., Li, J., Lu, S., Xu, L., Chan, Q., Yoneda, T., et al. (2021) · Clinical Imaging · doi:10.1016/j.clinimag.2021.11.005 · Cited by 5 · see citing works

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson’s disease in vivoPreprint

Straumann, N., Combes, B. F., Deán‐Ben, X. L., Sternke‐Hoffmann, R., Gerez, J., Dias, I., Chen, Z., Watts, B., Rostami, I., Shi, K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.28.546962 · Cited by 3 · see citing works

Spinal cord perfusion impairments in the M83 mouse model of Parkinson’s diseasePreprint

Combes, B. F., Kalva, S. K., Benveniste, P., Tournant, A., Law, M. H., Newton, J., Krüger, M., Weber, R., Dias, I., Noaín, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.27.591432 · Cited by 2 · see citing works

Neuronal alkaline phosphatase promotes the spread of Tau-induced pathology, and its blockade prevents neurodegeneration and memory loss

Soria-Tobar, L., Corredera, D. O., Román-Valero, L., Hernández, F., Millán, P. J. L., Alvarez‐Castelao, B., Sebastián‐Serrano, Á., Aivar, P., & Dı́az-Hernández, M. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00869 · Cited by 1 · see citing works

Aquaporin 4 is differentially increased and depolarized in association with tau and amyloid-betaPreprint

Kecheliev, V., Boss, L., Maheshwari, U., Konietzko, U., Keller, A., Razansky, D., Nitsch, R. M., Klohs, J., & Ni, R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.26.489273 · Cited by 1 · see citing works

Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models

Ni, R., & Rominger, A. (2025) · Open Research (University of Surrey) · doi:10.1002/viw.20250071

Transcranial detection of tauopathy in vivo in P301L mice with high‐resolution large‐field multifocal illumination fluorescence microscopy

Ni, R., Chen, Z., Gerez, J., Shi, G., Zhou, Q., Riek, R., Nilsson, K. P. R., Razansky, D., & Klohs, J. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.047238

Identification of calcification with MRI using susceptibility‐weighted imaging: A case study

Wu, Z., Mittal, S., Kish, K. K., Yu, Y., Hu, J., & Haacke, E. M. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21617 · Cited by 259 · see citing works

In vivoimaging reveals reduced activity of neuronal circuits in a mouse tauopathy model

Marinković, P., Blumenstock, S., Goltstein, P. M., Korzhova, V., Peters, F., Knebl, A., & Herms, J. W. (2019) · Brain · doi:10.1093/brain/awz035 · Cited by 63 · see citing works

In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510

Ai, I., Tokunaga, M., Jun, M., Takeharu, M., Masafumi, S., Hiroyuki, T., Maiko, O., Ni, R., Shigeki, H., Satoshi, K., et al. (2018) · QST-Repository (National Institutes for Quantum and Radiological Science and Technology)

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)

Ramsden, M., Kotilinek, L., Forster, C., Paulson, J., McGowan, E., SantaCruz, K., Guimaraes, A., Yue, M., Lewis, J., Carlson, G., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3279-05.2005 · Cited by 702 · see citing works