The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery
Open accessAbstract
Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely ‘NP-gel’) with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.
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Cites
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Cited by
Hydrogels and Their Applications in Targeted Drug Delivery
Narayanaswamy, R., & Torchilin, V. P. (2019) · Molecules · doi:10.3390/molecules24030603 · Cited by 664
Advanced Hydrogels as Wound Dressings
Tavakoli, S., & Klar, A. S. (2020) · Biomolecules · doi:10.3390/biom10081169 · Cited by 544
Nanoparticle-based local antimicrobial drug delivery
Gao, W., Chen, Y., Zhang, Y., Zhang, Q., & Zhang, L. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.015 · Cited by 396
Self-citationAdvanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment
Zhang, M., Hu, W., Cai, C., Wu, Y., Li, J., & Dong, S. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100223 · Cited by 394
Luo, Y., Li, J., Hu, Y., Gao, F., Pak-Heng Leung, G., Geng, F., Fu, C., & Zhang, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.05.011 · Cited by 72
Metadata
- Authors
- Gao, W., Zhang, Y., Zhang, Q., & Zhang, L.
- Venue
- Annals of Biomedical Engineering
- Published
- 2016-03-07
- Volume
- 44
- Issue
- 6
- Pages
- 2049-2061
- ISSN
- 0090-6964 (ISSN-L)
- 1573-9686
- OpenAlex
- W2296196708
- Cited by
- 346
- References
- 104
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Gao, W., Zhang, Y., Zhang, Q., & Zhang, L. (2016). Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery. Annals of Biomedical Engineering. https://doi.org/10.1007/s10439-016-1583-9
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