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Multifunctional Magnetic Nanoparticles for Targeted Drug Delivery Against Cancer: A Review of Mechanisms, Applications, Consequences, Limitations, and Tailoring Strategies

Riaz, Shumaila, Ali, Shaukat, Summer, Muhammad, Akhtar, Urva, Noor, Shehzeen, Haqqi, Rimsha, Farooq, Muhammad Adeel, Sardar, Iqra·2025·Annals of Biomedical Engineering
DOI 10.1007/s10439-025-03712-3
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Abstract

Magnetic nanoparticles (MNPs) have revolutionized cancer therapy by serving as effective drug transporters through active and passive targeting of tumor sites in conjugation with external alternating magnetic fields (AMFs), thus minimizing off-target effects. This precise targeting strategy guarantees a focused and controlled drug release at the tumor site, reducing the drawbacks of standard drug delivery systems and enhancing treatment effectiveness. Magnetic nanoparticles usually follow in magnetic hyperthermia (MHT) therapy, where AMFs raise the temperature at the tumor site, efficiently eliminating cancer cells and presenting a hopeful complement to conventional cancer treatments. In addition, side effects are reduced by launching a smart drug delivery system (SDDSs) in which treatment efficacy is enhanced by reducing the dosage frequency. Intrinsic properties of MNPs are measured when they serve as contrast agents in magnetic resonance imaging (MRI), providing a diagnostic aspect to their therapeutic capabilities and enabling medical professionals to monitor and record treatment outcomes with precision and higher accuracy. This comprehensive review highlights the multifaceted potential of MNPs in reshaping cancer treatment, emphasizing their role in targeted drug delivery, hyperthermia therapy, and imaging applications, and underscoring their transformative impact on the future of oncological care.

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Research works printed but not linked: 244

  1. Xia, C., X. Dong, H. Li, M. Cao, D. Sun, S. He, F. Yang, X. Yan, S. Zhang, and N. Li. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin. Med. J. 135(05):584–590, 2022. · DOI
  2. Pilleron, S., E. Soto-Perez-de-Celis, J. Vignat, J. Ferlay, I. Soerjomataram, F. Bray, and D. Sarfati. Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050. Int. J. Cancer. 148(3):601–608, 2021. · DOI
  3. Culp, M. B., I. Soerjomataram, J. A. Efstathiou, F. Bray, and A. Jemal. Recent global patterns in prostate cancer incidence and mortality rates. European urology. 77(1):38–52, 2020. · DOI · Paper page
  4. Totsuka, Y., M. Watanabe, and Y. Lin. New horizons of DNA adductome for exploring environmental causes of cancer. Cancer Sci. 112(1):7–15, 2021. · DOI
  5. Santucci, C., G. Carioli, P. Bertuccio, M. Malvezzi, U. Pastorino, P. Boffetta, E. Negri, C. Bosetti, and C. La Vecchia. Progress in cancer mortality, incidence, and survival: a global overview. Europ. J. Cancer Prevent. 29(5):367–381, 2020. · DOI
  6. Gholamzadeh, H., M. Ilkhani, A. Ameri, and N. Shakeri. Effect of reflexology on the side effects of chemotherapy in cancer patients: an integrative review. Evid. Based Care. 8(4):7–13, 2019.
  7. Dahaghin, A., Salimibani, M., Jahansa, P., Shiran, M. B., Bahreinizad, H., Haghpanahi, M., & Maleki, A. (2024). Evaluation of the accuracy from thermal imaging results in experimental tests when using 1 MHZ therapeutic ultrasound. Available at SSRN 4706342. · DOI
  8. Browning, R. J., P. J. T. Reardon, M. Parhizkar, R. B. Pedley, M. Edirisinghe, J. C. Knowles, and E. Stride. Drug delivery strategies for platinum-based chemotherapy. ACS Nano. 11(9):8560–8578, 2017. · DOI
  9. Li, X., W. Li, M. Wang, and Z. Liao. Magnetic nanoparticles for cancer theranostics: advances and prospects. J. Controll. Release. 335:437–448, 2021. · DOI
  10. Puyol, M., J. Seoane, E. Aguilar, L. B. Vozza, I. Orbe, K. H. Crawford, A. Fernández, F. Bray, S. E. Johnson, and S. Gopal. WORLD CANCER RESEARCH DAY: a call to action for a coordinated international research effort to prevent, diagnose, and treat cancerwcrd 2020: team up for cancer research to beat cancer sooner. Clin. Cancer Res. 27(4):963–966, 2021. · DOI
  11. Abed, A., M. Derakhshan, M. Karimi, M. Shirazinia, M. Mahjoubin-Tehran, M. Homayonfal, M. R. Hamblin, S. A. Mirzaei, H. Soleimanpour, and S. Dehghani. Platinum nanoparticles in biomedicine: preparation, anti-cancer activity, and drug delivery vehicles. Front. Pharmacol.13:797804, 2022. · DOI
  12. Castro, K. C., J. M. Costa, and M. G. N. Campos. Drug-loaded polymeric nanoparticles: a review. Int. J. Polym. Mater. Polym. Biomater. 71(1):1–13, 2022. · DOI
  13. Daeihamed, M., S. Dadashzadeh, A. Haeri, and M. Faghih Akhlaghi. Potential of liposomes for enhancement of oral drug absorption. Curr. Drug Deliv. 14(2):289–303, 2017.
  14. Mousavi, S. M., S. Soroshnia, S. A. Hashemi, A. Babapoor, Y. Ghasemi, A. Savardashtaki, and A. M. Amani. Graphene nano-ribbon based high potential and efficiency for DNA, cancer therapy and drug delivery applications. Drug Metabol. Rev. 51(1):91–104, 2019. · DOI
  15. Sana, S. S., R. P. Singh, M. Sharma, A. K. Srivastava, G. Manchanda, A. R. Rai, and Z.-J. Zhang. Biogenesis and application of nickel nanoparticles: a review. Curr. Pharmaceut. Biotechnol. 22(6):808–822, 2021. · DOI
  16. Jose, J., R. Kumar, S. Harilal, G. E. Mathew, D. G. T. Parambi, A. Prabhu, M. Uddin, L. Aleya, H. Kim, and B. Mathew. Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool. Environ. Sci. Pollut. Res. 27(16):19214–19225, 2020. · DOI
  17. Farzin, A., S. A. Etesami, J. Quint, A. Memic, and A. Tamayol. Magnetic nanoparticles in cancer therapy and diagnosis. Adv. Healthcare Mater. 9(9):1901058, 2020. · DOI
  18. Vallabani, N. V., S. Singh, and A. S. Karakoti. Magnetic nanoparticles: current trends and future aspects in diagnostics and nanomedicine. Curr. Drug Metabol. 20(6):457–472, 2019. · DOI
  19. Dan, M., Y. Bae, T. A. Pittman, and R. A. Yokel. Alternating magnetic field-induced hyperthermia increases iron oxide nanoparticle cell association/uptake and flux in blood–brain barrier models. Pharmaceut. Res. 32:1615–1625, 2015. · DOI
  20. Tietze, R., J. Zaloga, H. Unterweger, S. Lyer, R. P. Friedrich, C. Janko, M. Pöttler, S. Dürr, and C. Alexiou. Magnetic nanoparticle-based drug delivery for cancer therapy. Biochem. Biophys. Res. Commun. 468(3):463–470, 2015. · DOI · Paper page
  21. Sharma, K., and C. Chauhan. Role of magnetic nanoparticle (MNPs) in cancer treatment: a review. Mater. Today: Proceed. 81:919–925, 2023.
  22. Khan, M. S., R. A. Shah, S. Mei, A. Shabnam, and S. A. Shah. Active and passive control of nanoparticles in squeezing flow under the influence of magnetic field of variable intensity. Adv. Mech. Eng. 14(1):16878140221075200, 2022. · DOI
  23. Puri, R., V. Arora, A. Kabra, H. Dureja, and S. Hamaal. Magnetosomes: A tool for targeted drug delivery in the management of cancer. J. Nanomater. 2022. https://doi.org/10.1155/2022/6414585. · DOI
  24. Pan, Y., X. Du, F. Zhao, and B. Xu. Magnetic nanoparticles for the manipulation of proteins and cells. Chem. Soc. Rev. 41(7):2912–2942, 2012. · DOI
  25. Comanescu, C. Recent advances in surface functionalization of magnetic nanoparticles. Coatings. 13(10):1772, 2023. · DOI · Paper page
  26. Teng, Y., Y. Du, J. Shi, and P. W. Pong. Magnetic iron oxide nanoparticle-hollow mesoporous silica spheres: fabrication and potential application in drug delivery. Curr. Appl. Phys. 20(2):320–325, 2020. · DOI
  27. Kianfar, E. Magnetic nanoparticles in targeted drug delivery: a review. J. Supercond. Novel Magn. 34(7):1709–1735, 2021. · DOI
  28. Albarqi, H. A., L. H. Wong, C. Schumann, F. Y. Sabei, T. Korzun, X. Li, M. N. Hansen, P. Dhagat, A. S. Moses, and O. Taratula. Biocompatible nanoclusters with high heating efficiency for systemically delivered magnetic hyperthermia. ACS Nano. 13(6):6383–6395, 2019. · DOI
  29. Gas, P., and J. Wyszkowska. Influence of multi-tine electrode configuration in realistic hepatic RF ablative heating. Archiv. Electrical Eng. 68(3):521–533, 2019.
  30. Rocha-Santos, T. A. Sensors and biosensors based on magnetic nanoparticles. TrAC Trends Anal. Chem. 62:28–36, 2014. · DOI
  31. Kim, J.-E., J.-Y. Shin, and M.-H. Cho. Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects. Archiv. Toxicol. 86:685–700, 2012. · DOI
  32. Aslam, H., S. Shukrullah, M. Y. Naz, H. Fatima, H. Hussain, S. Ullah, and M. A. Assiri. Current and future perspectives of multifunctional magnetic nanoparticles based controlled drug delivery systems. J. Drug Deliv. Sci. Technol.67:102946, 2022. · DOI
  33. Bodnaruk, A., V. Kalita, M. Kulyk, S. Ryabchenko, A. Tovstolytkin, S. Solopan, and A. Belous. Critical behavior of ensembles of superparamagnetic nanoparticles with dispersions of magnetic parameters. J. Phys.: Condens. Matter.31(37):375801, 2019.
  34. Bruschi, M. L., and L. de Toledo. Pharmaceutical applications of iron-oxide magnetic nanoparticles. Magnetochemistry. 5(3):50, 2019. · DOI
  35. Mohammed, L., H. G. Gomaa, D. Ragab, and J. Zhu. Magnetic nanoparticles for environmental and biomedical applications: a review. Particuology. 30:1–14, 2017. · DOI · Paper page
  36. Katz, E. Synthesis, properties and applications of magnetic nanoparticles and nanowires—a brief introduction. Magnetochemistry. 5(4):61, 2019. · DOI
  37. Antone, A. J., Z. Sun, and Y. Bao. Preparation and application of iron oxide nanoclusters. Magnetochemistry. 5(3):45, 2019. · DOI
  38. Liu, X., Y. Tian, and L. Jiang. Manipulating dispersions of magnetic nanoparticles. Nano Lett. 21(7):2699–2708, 2021. · DOI
  39. Arsalani, S., E. J. Guidelli, M. A. Silveira, C. E. Salmon, J. F. Araujo, A. C. Bruno, and O. Baffa. Magnetic Fe3O4 nanoparticles coated by natural rubber latex as MRI contrast agent. J. Magn. Magn. Mater. 475:458–464, 2019. · DOI
  40. Etli̇ Akar, E. E. A. Magnetic nanoparticles for diagnosis and treatment. Medicine. 11(2):934–941, 2022.
  41. Stueber, D. D., J. Villanova, I. Aponte, Z. Xiao, and V. L. Colvin. Magnetic nanoparticles in biology and medicine: past, present, and future trends. Pharmaceutics. 13(7):943, 2021. · DOI
  42. Yoshida, S., Duong, C., Oestergaard, M., Fazio, M., Chen, C., Peralta, R., Guo, S., Seth, P. P., Li, Y., & Beckett, L. (2020). MXD3 antisense oligonucleotide with superparamagnetic iron oxide nanoparticles: A new targeted approach for neuroblastoma. Nanomed.: Nanotechnol. Biol. Med. 24:102127. · DOI
  43. Hedayatnasab, Z., F. Abnisa, and W. M. A. W. Daud. Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application. Mater. Design. 123:174–196, 2017. · DOI
  44. Majidi, S., F. Zeinali Sehrig, S. M. Farkhani, M. Soleymani Goloujeh, and A. Akbarzadeh. Current methods for synthesis of magnetic nanoparticles. Artif. Cells Nanomed. Biotechnol. 44(2):722–734, 2016. · DOI
  45. Vijayasri, G., Bhaskar, R. C., & Rajesh, J. (2022). An essential advancement of magnetic nanoparticles. In Fundamentals and Industrial Applications of Magnetic Nanoparticles (pp. 41-63). Elsevier. · DOI
  46. Yeap, S. P., J. Lim, B. S. Ooi, and A. L. Ahmad. Agglomeration, colloidal stability, and magnetic separation of magnetic nanoparticles: collective influences on environmental engineering applications. J. Nanopart. Res. 19(11):1–15, 2017. · DOI
  47. Öztürk Er, E., D. B. G. Büyükpınar, and S. Bakırdere. Magnetic nanoparticles based solid phase extraction methods for the determination of trace elements. Crit. Rev. Anal. Chem. 52(2):231, 2022. · DOI
  48. Cristea, C., M. Tertis, and R. Galatus. Magnetic nanoparticles for antibiotics detection. Nanomaterials. 7(6):119, 2017. · DOI
  49. Xu, J.-K., F.-F. Zhang, J.-J. Sun, J. Sheng, F. Wang, and M. Sun. Bio and nanomaterials based on Fe3O4. Molecules. 19(12):21506–21528, 2014. · DOI
  50. Hosu, O., M. Tertis, and C. Cristea. Implication of magnetic nanoparticles in cancer detection, screening and treatment. Magnetochemistry. 5(4):55, 2019. · DOI
  51. Liu, C., B. Zou, A. J. Rondinone, and Z. J. Zhang. Reverse micelle synthesis and characterization of superparamagnetic MnFe2O4 spinel ferrite nanocrystallites. J. Phys. Chem. B. 104(6):1141–1145, 2000. · DOI
  52. Chen, Z., C. Wu, Z. Zhang, W. Wu, X. Wang, and Z. Yu. Synthesis, functionalization, and nanomedical applications of functional magnetic nanoparticles. Chin. Chem. Lett. 29(11):1601–1608, 2018. · DOI
  53. Zhang, X.-F., Z.-G. Liu, W. Shen, and S. Gurunathan. Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches. Int. J. Mole. Sci. 17(9):1534, 2016. · DOI
  54. Abd Elrahman, A. A., and F. R. Mansour. Targeted magnetic iron oxide nanoparticles: preparation, functionalization and biomedical application. J. Drug Deliv. Sci. Technol. 52:702–712, 2019. · DOI
  55. Manescu, V., G. Paltanea, I. Antoniac, and M. Vasilescu. Magnetic nanoparticles used in oncology. Materials. 14(20):5948, 2021. · DOI
  56. Wang, D., B. Fei, L. V. Halig, X. Qin, Z. Hu, H. Xu, Y. A. Wang, Z. Chen, S. Kim, and D. M. Shin. Targeted iron-oxide nanoparticle for photodynamic therapy and imaging of head and neck cancer. ACS nano. 8(7):6620–6632, 2014. · DOI
  57. Ahmad, F., N. Ashraf, T. Ashraf, R.-B. Zhou, and D.-C. Yin. Biological synthesis of metallic nanoparticles (MNPs) by plants and microbes: their cellular uptake, biocompatibility, and biomedical applications. Appl. Microbiol. Biotechnol. 103(7):2913–2935, 2019. · DOI
  58. Ali, S., S. Hussain, R. Khan, S. Mumtaz, N. Ashraf, S. Andleeb, H. A. Shakir, H. M. Tahir, M. K. A. Khan, and M. Ulhaq. Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits. Environ. Sci. Pollut. Res. 26(4):3909–3920, 2019. · DOI
  59. Karade, V., T. Dongale, S. C. Sahoo, P. Kollu, A. Chougale, P. Patil, and P. Patil. Effect of reaction time on structural and magnetic properties of green-synthesized magnetic nanoparticles. J. Phys. Chem. Solids. 120:161–166, 2018. · DOI
  60. Mosayebi, J., M. Kiyasatfar, and S. Laurent. Synthesis, functionalization, and design of magnetic nanoparticles for theranostic applications. Adv. Healthc Mater. 6:1700306, 2017. · DOI
  61. Norfolk, L., A. E. Rawlings, J. P. Bramble, K. Ward, N. Francis, R. Waller, A. Bailey, and S. S. Staniland. Macrofluidic coaxial flow platforms to produce tunable magnetite nanoparticles: a study of the effect of reaction conditions and biomineralisation protein mms6. Nanomaterials. 9(12):1729, 2019. · DOI
  62. Rajan, A., and N. K. Sahu. Review on magnetic nanoparticle-mediated hyperthermia for cancer therapy. J. Nanopart. Res. 22(11):1–25, 2020. · DOI
  63. Chenthamara, D., S. Subramaniam, S. G. Ramakrishnan, S. Krishnaswamy, M. M. Essa, F.-H. Lin, and M. W. Qoronfleh. Therapeutic efficacy of nanoparticles and routes of administration. Biomater. Res. 23(1):20, 2019. · DOI
  64. Chao, X., Z. Zhang, L. Guo, J. Zhu, M. Peng, A. J. Vermorken, W. J. Van de Ven, C. Chen, and Y. Cui. A novel magnetic nanoparticle drug carrier for enhanced cancer chemotherapy. PLoS ONE. 2012. https://doi.org/10.1371/journal.pone.0040388. · DOI
  65. Chertok, B., A. E. David, and V. C. Yang. Brain tumor targeting of magnetic nanoparticles for potential drug delivery: effect of administration route and magnetic field topography. J. Controll. Release. 155(3):393–399, 2011. · DOI
  66. Saadat, M., M. K. Manshadi, M. Mohammadi, M. J. Zare, M. Zarei, R. Kamali, and A. Sanati-Nezhad. Magnetic particle targeting for diagnosis and therapy of lung cancers. J. Controll. Release. 328:776–791, 2020. · DOI
  67. Dürr, S., C. Janko, S. Lyer, P. Tripal, M. Schwarz, J. Zaloga, R. Tietze, and C. Alexiou. Magnetic nanoparticles for cancer therapy. Nanotechnol. Rev. 2(4):395–409, 2013. · DOI
  68. Wang, L., J. Dong, W. Ouyang, X. Wang, and J. Tang. Anticancer effect and feasibility study of hyperthermia treatment of pancreatic cancer using magnetic nanoparticles. Oncol. Rep. 27(3):719–726, 2012.
  69. Rego, G. N., M. P. Nucci, J. B. Mamani, F. A. Oliveira, L. C. Marti, I. S. Filgueiras, J. M. Ferreira, C. C. Real, D. P. Faria, and P. L. Espinha. Therapeutic efficiency of multiple applications of magnetic hyperthermia technique in glioblastoma using aminosilane coated iron oxide nanoparticles: in vitro and in vivo study. Int. J. Mole. Sci. 21(3):958, 2020. · DOI
  70. Wu, Y.-N., Chen, D.-H., Shi, X.-Y., Lian, C.-C., Wang, T.-Y., Yeh, C.-S., Ratinac, K. R., Thordarson, P., Braet, F., & Shieh, D.-B. (2011). Cancer-cell-specific cytotoxicity of non-oxidized iron elements in iron core-gold shell NPs. Nanomed.: Nanotechnol. Biol. Med., 7(4):420-427. · DOI
  71. Ardelean, I. L., D. Ficai, M. Sonmez, O. Oprea, G. Nechifor, E. Andronescu, A. Ficai, and M. A. Titu. Hybrid magnetic nanostructures for cancer diagnosis and therapy. Anti-Cancer Agents Med. Chem. 19(1):6–16, 2019. · DOI
  72. Kandasamy, G., and D. Maity. Recent advances in superparamagnetic iron oxide nanoparticles (SPIONs) for in vitro and in vivo cancer nanotheranostics. Int. J. Pharmaceut. 496(2):191–218, 2015. · DOI
  73. Gul, S., S. B. Khan, I. U. Rehman, M. A. Khan, and M. Khan. A comprehensive review of magnetic nanomaterials modern day Front. Mater. 6:179, 2019. · DOI
  74. Zhou, J., W. Liu, X. Zhao, Y. Xian, W. Wu, X. Zhang, N. Zhao, F. J. Xu, and C. Wang. Natural melanin/alginate hydrogels achieve cardiac repair through ROS scavenging and macrophage polarization. Adv. Sci. 8(20):2100505, 2021. · DOI
  75. Avval, Z. M., L. Malekpour, F. Raeisi, A. Babapoor, S. M. Mousavi, S. A. Hashemi, and M. Salari. Introduction of magnetic and supermagnetic nanoparticles in new approach of targeting drug delivery and cancer therapy application. Drug Metabol. Rev. 52(1):157–184, 2020. · DOI
  76. Mukherjee, S., L. Liang, and O. Veiseh. Recent advancements of magnetic nanomaterials in cancer therapy. Pharmaceutics. 12(2):147, 2020. · DOI
  77. Kudr, J., Y. Haddad, L. Richtera, Z. Heger, M. Cernak, V. Adam, and O. Zitka. Magnetic nanoparticles: from design and synthesis to real world applications. Nanomaterials. 7(9):243, 2017. · DOI
  78. Kyriazi, M.-E., D. Giust, A. H. El-Sagheer, P. M. Lackie, O. L. Muskens, T. Brown, and A. G. Kanaras. Multiplexed mRNA sensing and combinatorial-targeted drug delivery using DNA-gold nanoparticle dimers. Acs Nano. 12(4):3333–3340, 2018. · DOI
  79. Thomsen, L. B., M. S. Thomsen, and T. Moos. Targeted drug delivery to the brain using magnetic nanoparticles. Therapeut. Deliv. 6(10):1145–1155, 2015. · DOI
  80. Noqta, O. A., A. A. Aziz, I. A. Usman, and M. Bououdina. Recent advances in iron oxide nanoparticles (IONPs): synthesis and surface modification for biomedical applications. J. Supercond. Novel Magn. 32(4):779–795, 2019. · DOI
  81. Jouyandeh, M., J. A. Ali, V. Akbari, M. Aghazadeh, S. M. R. Paran, G. Naderi, M. R. Saeb, Z. Ranjbar, and M. R. Ganjali. Curing epoxy with polyvinylpyrrolidone (PVP) surface-functionalized MnxFe3-xO4 magnetic nanoparticles. Progress Organic Coatings.136:105247, 2019. · DOI
  82. Ziarani, G. M., M. Malmir, N. Lashgari, and A. Badiei .The role of hollow magnetic nanoparticles in drug delivery. RSC Adv. 9(43):25094–25106, 2019. · DOI
  83. Malik, M. A., M. Y. Wani, and M. A. Hashim. Microemulsion method: A novel route to synthesize organic and inorganic nanomaterials: 1st Nano Updat. Arab. J. Chem. 5(4):397–417, 2012. · DOI
  84. Cheng, Z., A. L. K. Tan, Y. Tao, D. Shan, K. E. Ting, and X. J. Yin. Synthesis and characterization of iron oxide nanoparticles and applications in the removal of heavy metals from industrial wastewater. Int. J. Photoenergy. 2012. https://doi.org/10.1155/2012/608298. · DOI
  85. Kievit, F. M., Z. R. Stephen, K. Wang, C. J. Dayringer, J. G. Sham, R. G. Ellenbogen, J. R. Silber, and M. Zhang. Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiatio. Mole. Oncol. 9(6):1071–1080, 2015. · DOI
  86. Bates, D., S. Abraham, M. Campbell, I. Zehbe, and L. Curiel. Development and characterization of an antibody-labeled super-paramagnetic iron oxide contrast agent targeting prostate cancer cells for magnetic resonance imaging. PloS one.9(5):e97220, 2014. · DOI
  87. Kim, D., M. K. Yu, T. S. Lee, J. J. Park, Y. Y. Jeong, and S. Jon. Amphiphilic polymer-coated hybrid nanoparticles as CT/MRI dual contrast agents. Nanotechnology.22(15):155101, 2011. · DOI
  88. Turcheniuk, K., A. V. Tarasevych, A. P. Kukhar, R. Boukherroub, and S. Szunerits. Recent advances in surface chemistry strategies for the fabrication of functional iron oxide based magnetic nanoparticles. Nanoscale. 5(22):10729–10752, 2013. · DOI
  89. Cerezo-Navarrete, C., P. Lara, and L. M. Martínez-Prieto. Organometallic nanoparticles ligated by NHCs: synthesis, surface chemistry and ligand effects. Catalysts. 10(10):1144, 2020. · DOI
  90. Aulia, G., E. Budianto, and M. Khalil, M. (2020). Fabrication and colloidal stability of surface-modified magnetite nanoparticles at high salinity. In AIP Conference Proceedings (Vol. 2242, No. 1). AIP Publishing. · DOI
  91. Simmons, M. D., N. Jones, D. J. Evans, C. Wiles, P. Watts, S. Salamon, M. E. Castillo, H. Wende, D. C. Lupascu, M. G. Francesconi. Doping of inorganic materials in microreactors–preparation of Zn doped Fe3O4 nanoparticles. Lab Chip. 15(15):3154–3162, 2015. · DOI
  92. Etminan, A., M. Salimibani, A. Dahaghin, M. Haghpanahi, and A. Maleki. FEM thermal assessment of a 3-D irregular tumor with capillaries in magnetic nanoparticle hyperthermia via dissimilar injection points. Comput. Biol. Med.157:106771, 2023. · DOI
  93. Zhu, C., S. Liang, E. Song, Y. Zhou, W. Wang, F. Shan, and L. Sun. In-situ liquid cell transmission electron microscopy investigation on oriented attachment of gold nanoparticles. Nat. Commun. 9(1):421, 2018. · DOI
  94. Sadchaiyaphum, I., P. Phapugrangkul, P. Chaiyasat, and A. Chaiyasata. High encapsulation efficiency of magnetite nanoparticles in hydrophobic polymer microcapsules using microsuspension conventional radical polymerization. Orient. J. Chem. 35(2), 2019. · DOI
  95. Gholami-Shabani, M., M. Shams-Ghahfarokhi, Z. Gholami-Shabani, A. Akbarzadeh, G. Riazi, S. Ajdari, and M. Razzaghi-Abyaneh. Enzymatic synthesis of gold nanoparticles using sulfite reductase purified from Escherichia coli: a green eco-friendly approach. Process Biochem. 50(7):1076–1085, 2015. · DOI
  96. Laurent, S., A. A. Saei, S. Behzadi, A. Panahifar, and M. Mahmoudi. Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges. Expert Opin. Drug Deliv. 11(9):1449–1470, 2014. · DOI
  97. Shariatinia, Z. Big family of nano-and microscale drug delivery systems ranging from inorganic materials to polymeric and stimuli-responsive carriers as well as drugconjugates. J. Drug Deliv. Sci. Technol. 66:102790, 2021. · DOI
  98. Sheikh Arabi, M., and S. Z. Hoseini. Fe3O4/HA nanocarriers of curcumin to evaluate the anti-cancer effect in MCF-7. J. Clin. Basic Res. 7(1):25–29, 2023. · DOI
  99. Kalaydina, R.-V., Bajwa, K., Qorri, B., Decarlo, A., & Szewczuk, M. R. (2018). Recent advances in “smart” delivery systems for extended drug release in cancer therapy. Int. J. Nanomed., 4727-4745. · DOI
  100. Brigger, I., C. Dubernet, and P. Couvreur. Nanoparticles in cancer therapy and diagnosis. Adv. Drug Deliv. Rev. 64:24–36, 2012. · DOI
  101. Beach, M. A., U. Nayanathara, Y. Gao, C. Zhang, Y. Xiong, Y. Wang, and G. K. Such. Polymeric nanoparticles for drug delivery. Chem. Rev. 2024. https://doi.org/10.1021/acs.chemrev.3c00705 · DOI
  102. Wolfschwenger, M., A. Jaufenthaler, F. Hanser, J. Gamper, T. S. Hofer, and D. Baumgarten. Molecular dynamics modelling of interacting magnetic nanoparticles for investigating equilibrium and dynamic ensemble properties. Appl. Math. Modell.136:115624, 2024. · DOI
  103. Patitsa, M., K. Karathanou, Z. Kanaki, L. Tzioga, N. Pippa, C. Demetzos, D. A. Verganelakis, Z. Cournia, and A. Klinakis. Magnetic nanoparticles coated with polyarabic acid demonstrate enhanced drug delivery and imaging properties for cancer theranostic applications. Sci. Rep. 7(1):775, 2017. · DOI
  104. Jeevanandam, J., Chan, Y. S., Pan, S., & Danquah, M. K. (2019). Metal oxide nanocomposites: Cytotoxicity and Targeted Drug Delivery Applications. Hybrid nanocomposites: Fundamentals, synthesis and applications, 111-147. · DOI
  105. Eleftheriadis, G. K., Kontogiannidou, E., Karavasili, C., & Fatouros, D. G. (2022). Strategies for MR formulation development: mesoporous silica. Oral Drug Delivery Modified Release Formul, 161-179. · DOI
  106. Tarkistani, M. A. M., V. Komalla, and V. Kayser. Recent advances in the use of iron–gold hybrid nanoparticles for biomedical applications. Nanomaterials. 11(5):1227, 2021. · DOI
  107. Liu, Q., Z. Tan, D. Zheng, and X. Qiu. pH-responsive magnetic Fe3O4/carboxymethyl chitosan/aminated lignosulfonate nanoparticles with uniform size for targeted drug loading. Int. J. Biol. Macromole. 225:1182–1192, 2023. · DOI
  108. Su, Y., L. Chen, F. Yang, and P. C. Cheung. Beta-d-glucan-based drug delivery system and its potential application in targeting tumor associated macrophages. Carbohydrate Polym.253:117258, 2021. · DOI
  109. Flores-Rojas, G. G., F. López-Saucedo, R. Vera-Graziano, E. Mendizabal, and E. Bucio. Magnetic nanoparticles for medical applications: Updated review. Macromol. 2(3):374–390, 2022. · DOI
  110. Mortezaee, K., A. Narmani, M. Salehi, H. Bagheri, B. Farhood, H. Haghi-Aminjan, and M. Najafi. Synergic effects of nanoparticles-mediated hyperthermia in radiotherapy/chemotherapy of cancer. Life Sci.269:119020, 2021. · DOI
  111. Huang, Y., K. Mao, B. Zhang, and Y. Zhao. Superparamagnetic iron oxide nanoparticles conjugated with folic acid for dual target-specific drug delivery and MRI in cancer theranostics. Mater. Sci Eng.: C. 70:763–771, 2017. · DOI
  112. Yang, Y., Q. Guo, J. Peng, J. Su, X. Lu, Y. Zhao, and Z. Qian. Doxorubicin-conjugated heparin-coated superparamagnetic iron oxide nanoparticles for combined anticancer drug delivery and magnetic resonance imaging. J. Biomed. Nanotechnol. 12(11):1963–1974, 2016. · DOI
  113. Gavilán, H., S. K. Avugadda, T. Fernández-Cabada, N. Soni, M. Cassani, B. T. Mai, R. Chantrell, and T. Pellegrino. Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer. Chem. Soc. Rev. 50(20):11614–11667, 2021. · DOI
  114. Gavilán, H., K. Simeonidis, E. Myrovali, E. Mazarío, O. Chubykalo-Fesenko, R. Chantrell, L. Balcells, M. Angelakeris, M. P. Morales, and D. Serantes. How size, shape and assembly of magnetic nanoparticles give rise to different hyperthermia scenarios. Nanoscale. 13(37):15631–15646, 2021. · DOI
  115. Sebak, A. A., B. M. El-Shenawy, S. El-Safy, and M. El-Shazly. From passive targeting to personalized nanomedicine: multidimensional insights on nanoparticles’ interaction with the tumor microenvironment. Curr. Pharmaceut. Biotechnol. 22(11):1444–1465, 2021. · DOI
  116. Fang, J., H. Nakamura, and H. Maeda. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv. Drug Deliv. Rev. 63(3):136–151, 2011. · DOI
  117. Maeda, H. Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. J. Controll. Release. 164(2):138–144, 2012. · DOI
  118. Tang, L., J. Li, Q. Zhao, T. Pan, H. Zhong, and W. Wang. Advanced and innovative nano-systems for anticancer targeted drug delivery. Pharmaceutics. 13(8):1151, 2021. · DOI
  119. Natfji, A. A., D. Ravishankar, H. M. Osborn, and F. Greco. Parameters affecting the enhanced permeability and retention effect: the need for patient selection. J. Pharmaceut. Sci. 106(11):3179–3187, 2017. · DOI
  120. Anarjan, F. S. Active targeting drug delivery nanocarriers: ligands. Nano-Struct. Nano-Objects.19:100370, 2019. · DOI · Paper page
  121. Kim, J. W., and J. R. Cochran. Targeting ligand–receptor interactions for development of cancer therapeutics. Curr. Opinion Chem. Biol. 38:62–69, 2017. · DOI
  122. Rahim, M. A., N. Jan, S. Khan, H. Shah, A. Madni, A. Khan, A. Jabar, S. Khan, A. Elhissi, and Z. Hussain. Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting. Cancers. 13(4):670, 2021. · DOI
  123. Xue, B., V. Kozlovskaya, M. A. Sherwani, S. Ratnayaka, S. Habib, T. Anderson, M. Manuvakhova, L. Klampfer, N. Yusuf, and E. Kharlampieva. Peptide-functionalized hydrogel cubes for active tumor cell targeting. Biomacromolecules. 19(10):4084–4097, 2018. · DOI
  124. Hua, S., M. B. De Matos, J. M. Metselaar, and G. Storm. Current trends and challenges in the clinical translation of nanoparticulate nanomedicines: pathways for translational development and commercialization. Front. Pharmacol. 9:790, 2018. · DOI
  125. Ventola, C. L. Progress in nanomedicine: approved and investigational nanodrugs. Pharm. Therapeut. 42(12):742, 2017.
  126. Caster, J. M., A. N. Patel, T. Zhang, and A. Wang. Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials. Wiley Interdiscipl. Rev.: Nanomed. Nanobiotechnol.9(1):e1416, 2017.
  127. Bor, G., I. D. Mat Azmi, and A. Yaghmur. Nanomedicines for cancer therapy: Current status, challenges and future prospects. Therapeutic Deliv. 10(2):113–132, 2019. · DOI
  128. Erdoğar, N., & Bilensoy, E. (2018). Cyclodextrin-based nanosystems in targeted cancer therapy. Cyclodextrin Appl Med, Food, Environ Liquid Cryst, 59-80. · DOI
  129. Taghipour, Y. D., A. Zarebkohan, R. Salehi, F. Rahimi, V. P. Torchilin, M. R. Hamblin, and A. Seifalian. An update on dual targeting strategy for cancer treatment. J. Controll. Release. 349:67–96, 2022. · DOI
  130. Kydd, J., R. Jadia, P. Velpurisiva, A. Gad, S. Paliwal, and P. Rai. Targeting strategies for the combination treatment of cancer using drug delivery systems. Pharmaceutics. 9(4):46, 2017. · DOI
  131. Colombo, M., S. Carregal-Romero, M. F. Casula, L. Gutiérrez, M. P. Morales, I. B. Böhm, J. T. Heverhagen, D. Prosperi, and W. J. Parak. Biological applications of magnetic nanoparticles. Chem. Soc. Rev. 41(11):4306–4334, 2012. · DOI
  132. Mirza, S., Ahmad, M. S., Shah, M. I. A., & Ateeq, M. (2020). Magnetic Nanoparticles: Drug Delivery and Bioimaging Applications. In Metal Nanoparticles for Drug Delivery and Diagnostic Applications (pp. 189-213). Elsevier. · DOI
  133. Attia, M. F., N. Anton, J. Wallyn, Z. Omran, and T. F. Vandamme. An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites. J. Pharm. Pharmacol. 71(8):1185–1198, 2019. · DOI
  134. Dutta, B., K. Barick, and P. Hassan. Recent advances in active targeting of nanomaterials for anticancer drug delivery. Adv. Colloid Interface Sci.296:102509, 2021. · DOI
  135. Cai, L., T. Michelakos, C. R. Ferrone, L. Zhang, V. Deshpande, Q. Shen, A. DeLeo, T. Yamada, G. Zhang, and S. Ferrone. Expression status of folate receptor alpha is a predictor of survival in pancreatic ductal adenocarcinoma. Oncotarget. 8(23):37646, 2017. · DOI
  136. Fung, K. Y., G. D. Fairn, and W. L. Lee. Transcellular vesicular transport in epithelial and endothelial cells: challenges and opportunities. Traffic. 19(1):5–18, 2018. · DOI
  137. Guo, J., M. Schlich, J. F. Cryan, and C. M. O’Driscoll. Targeted drug delivery via folate receptors for the treatment of brain cancer: can the promise deliver? J. Pharmaceut. Sci. 106(12):3413–3420, 2017. · DOI
  138. Xia, W., and P. S. Low. Folate-targeted therapies for cancer. J. Med. Chem. 53(19):6811–6824, 2010. · DOI · Paper page
  139. Levin, A. A. Targeting therapeutic oligonucleotides. New England .J Med. 376(1):86–88, 2017. · DOI
  140. Nikdouz, A., N. Namarvari, R. G. Shayan, and A. Hosseini. Comprehensive comparison of theranostic nanoparticles in breast cancer. Am. J. Clin. Experim. Immunol. 11(1):1, 2022.
  141. Kang, T., M. Jiang, D. Jiang, X. Feng, J. Yao, Q. Song, H. Chen, X. Gao, and J. Chen. Enhancing glioblastoma-specific penetration by functionalization of nanoparticles with an iron-mimic peptide targeting transferrin/transferrin receptor complex. Mole. Pharmaceut. 12(8):2947–2961, 2015. · DOI
  142. Fatima, A., Nasim, N., Haider, M. F., Rahman, M. A., Mall, J., Saifi, M. S., & Akhtar, J. (2024). A comprehensive review on nanocarriers as a targeted delivery system for the treatment of breast cancer. Intelligent Pharmacy. · DOI
  143. Yewale, C., D. Baradia, I. Vhora, S. Patil, and A. Misra. Epidermal growth factor receptor targeting in cancer: a review of trends and strategies. Biomaterials. 34(34):8690–8707, 2013. · DOI · Paper page
  144. Ivanenko, K., V. Prassolov, and E. Khabusheva. Transcription factor sp1 in the expression of genes encoding components of mapk, JAK/STAT, and PI3K/Akt signaling pathways. Mole. Biol. 56(5):756–769, 2022. · DOI
  145. da Silva Santos, E., K. A. B. Nogueira, L. C. C. Fernandes, J. R. P. Martins, A. V. F. Reis, J. B. V. Neto, I. J. da Silva Júnior, C. Pessoa, R. Petrilli, and J. O. Eloy. EGFR targeting for cancer therapy: pharmacology and immunoconjugates with drugs and nanoparticles. Int. J. Pharmaceutics. 592:120082, 2021. · DOI
  146. Rusdin, A., N. Wathoni, K. Motoyama, I. M. Joni, and R. Lesmana. Nanoparticles targeted drug delivery system via epidermal growth factor receptor. J. Pharm. 1(3):77–91, 2019.
  147. Kim, D. I., H. Lee, S. H. Kwon, Y. J. Sung, W. K. Song, and S. Park. Bilayer hydrogel sheet-type intraocular microrobot for drug delivery and magnetic nanoparticles retrieval. Adv. Healthcare Mater. 9(13):2000118, 2020. · DOI
  148. Amini-Fazl, M. S., R. Mohammadi, and K. Kheiri. 5-fluorouracil loaded chitosan/polyacrylic acid/Fe3O4 magnetic nanocomposite hydrogel as a potential anticancer drug delivery system. Int. J. Biol. Macromole. 132:506–513, 2019. · DOI
  149. Naderi, Z., J. Azizian, E. Moniri, and N. Farhadyar. Synthesis and characterization of carboxymethyl cellulose/β-cyclodextrin/chitosan hydrogels and investigating the effect of magnetic nanoparticles (Fe3O4) on a novel carrier for a controlled release of methotrexate as drug delivery. J. Inorg. Organometall. Polym. Mater. 30(4):1339–1351, 2020. · DOI
  150. Yue, X., and Z. Dai. Liposomal nanotechnology for cancer theranostics. Curr. Med. Chem. 25(12):1397–1408, 2018. · DOI
  151. Toro-Cordova, A., M. Flores-Cruz, J. Santoyo-Salazar, E. Carrillo-Nava, R. Jurado, P. A. Figueroa-Rodriguez, P. Lopez-Sanchez, L. A. Medina, and P. Garcia-Lopez. Liposomes loaded with cisplatin and magnetic nanoparticles: physicochemical characterization, pharmacokinetics, and in-vitro efficacy. Molecules. 23(9):2272, 2018. · DOI
  152. Hollingsworth, S. A., and R. O. Dror. Molecular dynamics simulation for all. Neuron. 99(6):1129–1143, 2018. · DOI
  153. Zawawi, M. H., Saleha, A., Salwa, A., Hassan, N. H., Zahari, N. M., Ramli, M. Z., & Muda, Z. C. (2018, November). A Review: Fundamentals of Computational Fluid Dynamics (CFD). In AIP Conference Proceedings (Vol. 2030, No. 1). AIP Publishing. · DOI
  154. Papich, M. G. Pharmacokinetic–pharmacodynamic (PK–PD) modeling and the rational selection of dosage regimes for the prudent use of antimicrobial drugs. Veterin. Microbiol. 171(3–4):480–486, 2014. · DOI
  155. Mikayilov, E., N. Zeynalov, D. Taghiyev, and S. Taghiyev. Role of computational modeling in the design and development of nanotechnology-based drug delivery systems. Chem. Biochem. Eng. Quarterly. 38(2):97–110, 2024. · DOI
  156. Chaturvedi, V. K., A. Singh, V. K. Singh, and M. P. Singh. Cancer nanotechnology: a new revolution for cancer diagnosis and therapy. Curr. Drug Metabol. 20(6):416–429, 2019. · DOI
  157. Zehner, B., F. Schmidt, W. Korth, M. Cokoja, and A. Jess. Determination of the critical micelle concentration of imidazolium ionic liquids in aqueous hydrogen peroxide. Langmuir. 35(49):16297–16303, 2019. · DOI
  158. Sabra, S. A., S. A. Sheweita, M. Haroun, D. Ragab, M. A. Eldemellawy, Y. Xia, D. Goodale, A. L. Allan, A. O. Elzoghby, and S. Rohani. Magnetically guided self-assembled protein micelles for enhanced delivery of dasatinib to human triple-negative breast cancer cells. J. Pharmaceut. Sci. 108(5):1713–1725, 2019. · DOI
  159. Li, Z., N. Song, and Y.-W. Yang. Stimuli-responsive drug-delivery systems based on supramolecular nanovalves. Matter. 1(2):345–368, 2019. · DOI
  160. Govindan, B., M. A. Sabri, A. Hai, F. Banat, and M. A. Haija. A review of advanced multifunctional magnetic nanostructures for cancer diagnosis and therapy integrated into an artificial intelligence approach. Pharmaceutics. 15(3):868, 2023. · DOI
  161. Ghaffar, A., Yameen, B., Latif, M., & Malik, M. I. (2020). pH-Sensitive Drug Delivery Systems. In Metal Nanoparticles for Drug Delivery and Diagnostic Applications (pp. 259-278). Elsevier. · DOI
  162. Vermaas, J. V., M. F. Crowley, and G. T. Beckham. Molecular lignin solubility and structure in organic solvents. ACS Sustain. Chem. Eng. 8(48):17839–17850, 2020. · DOI
  163. Cai, H., X. Dai, X. Wang, P. Tan, L. Gu, Q. Luo, X. Zheng, Z. Li, H. Zhu, and H. Zhang. A nanostrategy for efficient imaging-guided antitumor therapy through a stimuli-responsive branched polymeric prodrug. Adv. Sci. 7(6):1903243, 2020. · DOI
  164. Theodosis-Nobelos, P., D. Charalambous, C. Triantis, and M. Rikkou-Kalourkoti. Drug conjugates using different dynamic covalent bonds and their application in cancer therapy. Curr. Drug Deliv. 17(7):542–557, 2020. · DOI
  165. Amrutkar, M., and I. P. Gladhaug. Pancreatic cancer chemoresistance to gemcitabine. Cancers. 9(11):157, 2017. · DOI
  166. Vermeulen, L. M., T. Brans, S. K. Samal, P. Dubruel, J. Demeester, S. C. De Smedt, K. Remaut, and K. Braeckmans. Endosomal size and membrane leakiness influence proton sponge-based rupture of endosomal vesicles. ACS nano. 12(3):2332–2345, 2018. · DOI
  167. Mertz, D., O. Sandre, and S. Begin-Colin. Drug releasing nanoplatforms activated by alternating magnetic fields. Biochim et Biophysica Acta (BBA)-General Subjects. 1861(6):1617–1641, 2017. · DOI · Paper page
  168. Comanescu, C. Magnetic nanoparticles: current advances in nanomedicine, drug delivery and MRI. Chemistry. 4(3):872–930, 2022. · DOI
  169. Bushra, R., M. Ahmad, K. Alam, F. Seidi, S. Shakeel, J. Song, and H. Xiao. Recent advances in magnetic nanoparticles: key applications, environmental insights, and future strategies. Sustain. Mater. Technol. 40:e00985, 2024.
  170. Desai, N. Challenges in development of nanoparticle-based therapeutics. AAPS J. 14(2):282–295, 2012. · DOI · Paper page
  171. Cortesi, M., C. Liverani, L. Mercatali, T. Ibrahim, and E. Giordano. Computational models to explore the complexity of the epithelial to mesenchymal transition in cancer. Wiley Interdiscipl. Rev.: Syst. Biol. Med.12(6):e1488, 2020.
  172. Vulović, A., T. Šušteršič, S. Cvijić, S. Ibrić, and N. Filipović. Coupled in silico platform: computational fluid dynamics (CFD) and physiologically-based pharmacokinetic (PBPK) modelling. Europ. J. Pharmaceut. Sci. 113:171–184, 2018. · DOI
  173. Lin, Y., K. Zhang, R. Zhang, Z. She, R. Tan, Y. Fan, and X. Li. Magnetic nanoparticles applied in targeted therapy and magnetic resonance imaging: crucial preparation parameters, indispensable pre-treatments, updated research advancements and future perspectives. J. Mater. Chem. B. 8(28):5973–5991, 2020. · DOI
  174. Anik, M. I., M. K. Hossain, I. Hossain, A. Mahfuz, M. T. Rahman, and I. Ahmed. Recent progress of magnetic nanoparticles in biomedical applications: a review. Nano Select. 2(6):1146–1186, 2021. · DOI · Paper page
  175. Davidson, J. C., N. R. Anderson, and K. L. Livesey. Field-dependent magnetic relaxation times of magnetic nanoparticle systems: analytic approximations supported by numerical simulations. Phys. Rev. B.110(14):144447, 2024. · DOI
  176. Torres, T. E., E. Lima Jr., M. P. Calatayud, B. Sanz, A. Ibarra, R. Fernández-Pacheco, and G. F. Goya. The relevance of brownian relaxation as power absorption mechanism in Magnetic Hyperthermia. Sci. Rep. 9(1):3992, 2019. · DOI
  177. Zhao, Z., I. Torres-Díaz, C. Vélez, D. Arnold, and C. Rinaldi. Brownian dynamics simulations of magnetic nanoparticles captured in strong magnetic field gradients. J. Phys. Chem. C. 121(1):801–810, 2017. · DOI
  178. Li, J., Z. Yue, M. Tang, W. Wang, Y. Sun, T. Sun, and C. Chen. Strategies to reverse hypoxic tumor microenvironment for enhanced sonodynamic therapy. Adv. Healthcare Mater. 13(1):2302028, 2024. · DOI
  179. Baronzio, G., G. Parmar, M. Ballerini, A. Szasz, M. Baronzio, and V. Cassutti. A brief overview of hyperthermia in cancer treatment. J. Integr. Oncol. 3(115):2, 2014.
  180. Zhou, K., X. Zhou, J. Liu, and Z. Huang. Application of magnetic nanoparticles in petroleum industry: a review. J. Petrol. Sci. Eng.188:106943, 2020. · DOI
  181. Jordan, A., R. Scholz, P. Wust, H. Fähling, J. Krause, W. Wlodarczyk, and R. Felix. Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo. Int. J. Hyperthermia. 13(6):587–605, 1997. · DOI
  182. Attaluri, A., R. Ma, Y. Qiu, W. Li, and L. Zhu. Nanoparticle distribution and temperature elevations in prostatic tumours in mice during magnetic nanoparticle hyperthermia. Int. J. Hyperthermia. 27(5):491–502, 2011. · DOI
  183. Pucci, C., A. Degl’Innocenti, M. B. Gümüş, and G. Ciofani. Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era. Biomater. Sci. 10(9):2103–2121, 2022. · DOI
  184. Darvishi, V., M. Navidbakhsh, and S. Amanpour. Heat and mass transfer in the hyperthermia cancer treatment by magnetic nanoparticles. Heat Mass Transf. 58(6):1029–1039, 2022. · DOI
  185. Dahaghin, A., S. Emadiyanrazavi, M. Salimibani, H. Bahreinizad, M. Haghpanahi, R. Eivazzadeh-Keihan, and A. Maleki. A numerical investigation into the magnetic nanoparticles hyperthermia cancer treatment injection strategies. Biocybern. Biomed. Eng. 41(2):516–526, 2021. · DOI
  186. Thorat, N. D., R. A. Bohara, V. Malgras, S. A. Tofail, T. Ahamad, S. M. Alshehri, and Y. Yamauchi. Multimodal superparamagnetic nanoparticles with unusually enhanced specific absorption rate for synergetic cancer therapeutics and magnetic resonance imaging. ACS Appl. Mater. Interfaces. 8(23):14656–14664, 2016. · DOI
  187. Munir, A., Z. Zhu, J. Wang, and H. S. Zhou. FEM analysis of magnetic agitation for tagging biomolecules with magnetic nanoparticles in a microfluidic system. Sens. Actuat. B: Chem. 197:1–12, 2014. · DOI
  188. Naimullah, B. S. S., Lias, K., Buniyamin, N., Hassan, M. M., Basri, H. M., & Ispawi, D. I. (2021, July). SAR Evaluation Towards Breast Cancer in Hyperthermia Treatment. In 2021 IEEE Symposium on Industrial Electronics & Applications (ISIEA) (pp. 1-5). IEEE. · DOI
  189. Shabestari Khiabani, S., M. Farshbaf, A. Akbarzadeh, and S. Davaran. Magnetic nanoparticles: preparation methods, applications in cancer diagnosis and cancer therapy. Artif. Cells Nanomed. Biotechnol. 45(1):6–17, 2017. · DOI
  190. Huynh, K.-H., X.-H. Pham, J. Kim, S. H. Lee, H. Chang, W.-Y. Rho, and B.-H. Jun. Synthesis, properties, and biological applications of metallic alloy nanoparticles. Int. J. Mole. Sci. 21(14):5174, 2020. · DOI
  191. Chen, L., C. Chen, P. Wang, and T. Song. Mechanisms of cellular effects directly induced by magnetic nanoparticles under magnetic fields. J. Nanomater. 2017. https://doi.org/10.1155/2017/1564634. · DOI
  192. Skandalakis, G. P., D. R. Rivera, C. D. Rizea, A. Bouras, J. G. Jesu Raj, D. Bozec, and C. G. Hadjipanayis. Hyperthermia treatment advances for brain tumors. Int. J. Hyperthermia. 37(2):3–19, 2020. · DOI
  193. Habibi, M. R., M. Ghassemi, and M. H. Hamedi. Analysis of high gradient magnetic field effects on distribution of nanoparticles injected into pulsatile blood stream. J. Magn. Magn. Mater. 324(8):1473–1482, 2012. · DOI
  194. Tang, Y., J. Zou, R. C. Flesch, and T. Jin. Backflow modeling in nanofluid infusion and analysis of its effects on heat induced damage during magnetic hyperthermia. Appl. Math. Modell. 114:583–600, 2023. · DOI
  195. Cao, J., D. Huang, and N. A. Peppas. Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites. Adv. Drug Deliv. Rev. 167:170–188, 2020. · DOI
  196. Hedayati, M., O. Thomas, B. Abubaker-Sharif, H. Zhou, C. Cornejo, Y. Zhang, and R. Ivkov. The effect of cell cluster size on intracellular nanoparticle-mediated hyperthermia: is it possible to treat microscopic tumors? Nanomedicine. 8(1):29–41, 2013. · DOI
  197. Andrä, W., C. G. d’Ambly, R. Hergt, I. Hilger, and W. A. Kaiser. Temperature distribution as function of time around a small spherical heat source of local magnetic hyperthermia. J. Magn. Magn. Mater. 194(1–3):197–203, 1999. · DOI
  198. Rytov, R. A., V. A. Bautin, and N. A. Usov. Towards optimal thermal distribution in magnetic hyperthermia. Sci. Rep. 12(1):3023, 2022. · DOI
  199. Crezee, J., Franken, N., & Oei, A. (2021). Hyperthermia-based anti-cancer treatments. cancers 2021, 13, 1240. in: s note: MDPI stays neutral with regard to jurisdictional claims in published · DOI
  200. Alavijeh, A. A., M. Barati, M. Barati, and H. A. Dehkordi. The potential of magnetic nanoparticles for diagnosis and treatment of cancer based on body magnetic field and organ-on-the-chip. Adv. Pharmaceut. Bullet. 9(3):360, 2019. · DOI

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Metadata

Authors
Riaz, S., Ali, S., Summer, M., Akhtar, U., Noor, S., Haqqi, R., Farooq, M. A., & Sardar, I.
Venue
Annals of Biomedical Engineering
Publisher
Springer Science and Business Media LLC
Published
2025-03-26
Volume
53
Issue
6
Pages
1291-1327
ISSN
  • 0090-6964
  • 1573-9686
DOI
10.1007/s10439-025-03712-3
Cited by
38
References
4
Language
en
Licence

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