Estimating HIV prevalence and risk behaviors of transgender persons in the United States: a systematic review
Open accessAbstract
Transgender populations in the United States have been impacted by the HIV/AIDS epidemic. This systematic review estimates the prevalence of HIV infection and risk behaviors of transgender persons. Comprehensive searches of the US-based HIV behavioral prevention literature identified 29 studies focusing on male-to-female (MTF) transgender women; five of these studies also reported data on female-to-male (FTM) transgender men. Using meta-analytic approaches, prevalence rates were estimated by synthesizing weighted means. Meta-analytic findings indicated that 27.7% (95% confidence interval [CI], 24.8-30.6%) of MTFs tested positive for HIV infection (four studies), while 11.8% (95% CI, 10.5-13.2%) of MTFs self-reported being HIV-seropositive (18 studies). Higher HIV infection rates were found among African-American MTFs regardless of assessment method (56.3% test result; 30.8% self-report). Large percentages of MTFs (range, 27-48%) reported engaging in risky behaviors (e.g., unprotected receptive anal intercourse, multiple casual partners, sex work). Prevalence rates of HIV and risk behaviors were low among FTMs. Contextual factors potentially related to increased HIV risk include mental health concerns, physical abuse, social isolation, economic marginalization, and unmet transgender-specific healthcare needs. Additional research is needed to explain the causes of HIV risk behavior of transgender persons. These findings should be considered when developing and adapting prevention interventions for transgender populations.
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Social isolation was associated with HIV infection as a contextual risk factor in transsexuals, possibly mediated through feelings of discomfort or being unsafe in public.
“one of which found that social isolation was associated with HIV infection as a contextual risk factor in transsexuals, possibly mediated through feelings of discomfort or being unsafe in public 34 .”
From An overview of systematic reviews on the public health consequences of social isolation and loneliness (2017) · cites this paper as [34]
The overview found an association (+) between social isolation and sexual health behaviours, supported by one review or multiple lower quality reviews.
“| Sexual health behaviours (Black et al 2000, Herbst et al 2008, Seto & Lalumiere 2010*) | + | + | |”
From An overview of systematic reviews on the public health consequences of social isolation and loneliness (2017) · cites this paper as Herbst et al 2008
The overview found an association (+) between loneliness and sexual health behaviours, supported by one review or multiple lower quality reviews.
“| Sexual health behaviours (Black et al 2000, Herbst et al 2008, Seto & Lalumiere 2010*) | + | + | |”
From An overview of systematic reviews on the public health consequences of social isolation and loneliness (2017) · cites this paper as Herbst et al 2008
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Pitasi, M. A., Kerani, R. P., Kohn, R., Murphy, R. D., Pathela, P., Schumacher, C. M., Tabidze, I., & Llata, E. (2019) · Sexually Transmitted Diseases · doi:10.1097/olq.0000000000000917 · Cited by 61 · see citing works
Dowshen, N., Lee, S., Franklin, J., Castillo, M., & Barg, F. (2017) · Transgender Health · doi:10.1089/trgh.2016.0046 · Cited by 57 · see citing works
Stigma and HIV risk among<i>Metis</i>in Nepal
Wilson, E., Pant, S. B., Comfort, M., & Ekstrand, M. (2011) · Culture, Health & Sexuality · doi:10.1080/13691058.2010.524247 · Cited by 47 · see citing works
Through a Different Lens: Occupational Health of Sex-Working Young Trans Women
Fisher, M. R., Turner, C., McFarland, W., Breslow, A. S., Wilson, E. C., & Arayasirikul, S. (2023) · Transgender Health · doi:10.1089/trgh.2021.0109 · Cited by 24 · see citing works
- Authors
- for the HIV/AIDS Prevention Research Synthesis Team, Herbst, J. H., Jacobs, E. D., Finlayson, T. J., McKleroy, V. S., Neumann, M. S., & Crepaz, N.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Herbst, Jeffrey H.
- Venue
- AIDS and Behavior
- Published
- 2007-08-13
- Volume
- 12
- Issue
- 1
- Pages
- 1-17
- ISSN
- 1090-7165 (ISSN-L)
- 1573-3254
- OpenAlex
- W2093647119
- Cited by
- 933
- References
- 79
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 29 · 2023: 31 · 2022: 52 · 2021: 73 · 2020: 86 · 2019: 107 · 2018: 82 · 2017: 75 · 2016: 81 · 2015: 67 · 2014: 53 · 2013: 34 · 2012: 32
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- AIDS and Behavior (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Centers for Disease Control and Prevention
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Keywords
- HIV prevalence, transgender people, HIV risk behavior, unprotected receptive anal intercourse, sex work, HIV prevention, social isolation, economic exclusion, mental health, physical abuse, unmet health needs
- MeSH terms
- Adult, Female, Humans, Male, Risk-Taking, Sexual Behavior, Sexual Partners, Transsexualism, Meta-Analysis as Topic, HIV Infections, Prevalence
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