Combining text messaging and telephone counseling to increase varenicline adherence and smoking abstinence among cigarette smokers living with HIV: a randomized controlled study
Open accessAbstract
Smoking represents an important health risk for people living with HIV (PLHIV). Low adherence to smoking cessation pharmacotherapy may limit treatment effectiveness. In this study, 158 participants recruited from three HIV care centers in New York City were randomized to receive 12-weeks of varenicline (Chantix) either alone as standard care (SC) or in combination with text message (TM) support or TM plus cell phone-delivered adherence-focused motivational and behavioral therapy (ABT). Generalized linear mixed-effect models found a significant decline in varenicline adherence from week 1–12 across treatment groups. At 12-weeks, the probability of smoking abstinence was significantly higher in SC+TM+ABT than in SC. The study demonstrates the feasibility of delivering adherence-focused interventions to PLHIV who smoke. Findings suggest intensive behavioral support is an important component of an effective smoking cessation intervention for this population, and a focus on improving adherence self-efficacy may lead to more consistent adherence and higher smoking abstinence.
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Smoking cessation trials targeting people living with HIV who smoke have produced mixed findings.
“Subsequently, smoking cessation trials that target SLWH have yielded mixed findings.7–15”
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- Authors
- Tseng, T.-Y., Krebs, P., Schoenthaler, A., Wong, S., Sherman, S., Gonzalez, M., Urbina, A., Cleland, C. M., & Shelley, D.
- Affiliations
- New York University (US)
- St. Luke's-Roosevelt Hospital Center (US)
- Center for Drug Use and HIV Research (US)
- Corresponding author
- Shelley, Donna
- ORCID
- Venue
- AIDS and Behavior
- Published
- 2016-09-07
- Volume
- 21
- Issue
- 7
- Pages
- 1964-1974
- ISSN
- 1090-7165 (ISSN-L)
- 1573-3254
- PMC
- PMC5554578
- OpenAlex
- W2508283310
- Semantic Scholar
- 0193829e596790772dfacd8c9439645993fbfb5e
- Cited by
- 69
- References
- 68
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 12 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 12 · 2018: 6 · 2017: 7 · 2015: 1
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- AIDS and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R34 DA031636001A1)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- varenicline, smoking cessation, HIV, text messaging, telephone counseling, medication adherence, smoking abstinence, adherence self-efficacy
- MeSH terms
- Varenicline, Adult, Behavior Therapy, Counseling, Female, Humans, Male, Middle Aged, New York City, Research Design, Smoking, Telephone, HIV Infections, Smoking Cessation, Treatment Outcome, Nicotinic Agonists, Cell Phone, Medication Adherence, Text Messaging, Motivational Interviewing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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