Assessment and etiology of attention deficit hyperactivity disorder and oppositional defiant disorder in boys and girls
Open accessAbstract
Attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) are more common in boys than girls. In this paper, we investigated whether the prevalence differences are attributable to measurement bias. In addition, we examined sex differences in the genetic and environmental influences on variation in these behaviors. Teachers completed the Conners Teacher Rating Scale-Revised:Short version (CTRS-R:S) in a sample of 800 male and 851 female 7-year-old Dutch twins. No sex differences in the factor structure of the CTRS-R:S were found, implying the absence of measurement bias. The heritabilities for both ADHD and ODD were high and were the same in boys and girls. However, partly different genes are expressed in boys and girls.
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Most studies hold that the majority of the variance of ADHD, CD, and ODD is explained by unique and non-shared genetic and environmental effects.
“Most studies hold that the majority of the variance of ADHD, CD and ODD is explained by unique and non-shared genetic and environmental e ff ects”
From ADHD, CD, and ODD: Systematic review of genetic and environmental risk factors (2018) · cites this paper as Derks, Dolan, Hudziak, Neale, & Boomsma, 2007
The Results (Genetic analyses; page unavailable) attribute variation in the ADHD and oppositional-behavior scales to additive genetic and unique environmental effects, with genetic effects explaining 56–71%. The paper does not establish the claim for conduct disorder (CD) or show that “most studies” reach this conclusion; its reported analysis concerns teacher-rated behavior in seven-year-old Dutch twins. (LLM, conf=0.87)
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Cites
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de Zeeuw, E. L., van Beijsterveldt, C. E. M., Lubke, G. H., Glasner, T. J., & Boomsma, D. I. (2015) · Behavior Genetics · doi:10.1007/s10519-015-9712-z · Cited by 17 · see citing works
Self-citation
- Authors
- Derks, E. M., Dolan, C. V., Hudziak, J. J., Neale, M. C., & Boomsma, D. I.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- University of Vermont (US)
- Virginia Commonwealth University (US)
- Corresponding author
- Derks, Eske M.
- Venue
- Behavior Genetics
- Published
- 2007-04-19
- Volume
- 37
- Issue
- 4
- Pages
- 559-566
- ISSN
- 0001-8244 (ISSN-L)
- 1573-3297
- PMC
- PMC1914288
- OpenAlex
- W2170410897
- Cited by
- 51
- References
- 2
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 6 · 2014: 2 · 2013: 3 · 2012: 6
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Behavior Genetics (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (904–57–94, 575-25-012, 65322, 575-25-006)
- National Institutes of Health
- National Institute of Mental Health (R01MH065322, MH 65322, R56MH058799, R01MH058799, MH-58799)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, oppositional defiant disorder, sex differences, measurement bias, heritability, genetic factors, environmental influences, twins, factor structure
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Mental Disorders, Child, Diseases in Twins, Female, Gene Expression Regulation, Humans, Male, Netherlands, Registries, Sex Characteristics, Attention Deficit and Disruptive Behavior Disorders
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