No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort
Abstract
Hand-grip strength is strongly correlated with measures of muscle mass and can be taken to predict morbidity and mortality. The aim of this study was to investigate the relationship between hand-grip strength and other markers associated with immune ageing, such as Cytomegalovirus (CMV) infection, leukocyte telomere length and serum levels of inflammatory and anti-inflammatory markers in the elderly. We have assessed grip strength with the Smedley Dynamometer in younger (22-37 years) and older (60-85 years) men and women in a sample of people living in Berlin (the BASE-II study). Serum cytokine levels were determined by flow-cytometry, CMV serostatus via ELISA and leukocyte telomere length by quantitative PCR. IL-1β levels tended to be negatively associated with grip strength, but we did not find a significant association with IL-6 levels. CMV-seropositivity was not associated with higher levels of IL-1β, IL-6 or TNF, nor with weaker grip strength in men or women at any age. A putative general measure of organismal ageing, overall leukocyte telomere length, was also found not to be associated with lower grip strength in the elderly. Hand-grip strength remains an important biomarker independent of CMV infection or shorter telomere lengths, and poorly reflected in peripheral pro-inflammatory cytokine levels, all of which have been associated in some studies with frailty and mortality.
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Evidence that the association between CMV infection and CVD and mortality is mediated by inflammageing is scant.
“However, evidence that the association between CMV infection and CVD and mortality is mediated by inflammageing is scant at best109,130.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [130]
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- Authors
- Goldeck, D., Pawelec, G., Norman, K., Steinhagen-Thiessen, E., Oettinger, L., Haehnel, K., & Demuth, I.
- Affiliations
- University of Tübingen (DE)
- Nottingham Trent University (GB)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Pawelec, Graham
- Venue
- Biogerontology
- Published
- 2015-04-24
- Volume
- 17
- Issue
- 1
- Pages
- 189-198
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W2089819175
- Cited by
- 30
- References
- 47
- Citations by year
- 2023: 4 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF) (16SV5536K)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- grip strength, CMV serostatus, serum cytokines, IL-1β, interleukin-6, TNF-α, leukocyte telomere length, immunosenescence, muscle strength, frailty, older adults
- MeSH terms
- Immunosenescence, Aged, Aging, Cytomegalovirus Infections, Female, Germany, Humans, Male, Middle Aged, Sensitivity and Specificity, Statistics as Topic, Reproducibility of Results, Cohort Studies, Cytokines, Hand Strength, Young Adult
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