Age-related deficit accumulation and the diseases of ageing

Frailty in Older Adults: Evidence for a Phenotype

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The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Brownian motion in a field of force and the diffusion model of chemical reactions

Kramers, H. A. (1940) · Physica · doi:10.1016/s0031-8914(40)90098-2 · Cited by 8,703 · see citing works

A standard procedure for creating a frailty index

Searle, S. D., Mitnitski, A., Gahbauer, E. A., Gill, T. M., & Rockwood, K. (2008) · BMC Geriatrics · doi:10.1186/1471-2318-8-24 · Cited by 3,568 · see citing works

Frailty in relation to the accumulation of deficits

Rockwood, K., & Mitnitski, A. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.7.722 · Cited by 3,076 · see citing works

Accumulation of Deficits as a Proxy Measure of Aging

Mitnitski, A. B., Mogilner, A. J., & Rockwood, K. (2001) · The Scientific World JOURNAL · doi:10.1100/tsw.2001.58 · Cited by 2,893 · see citing works

Geroscience: Linking Aging to Chronic Disease

Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works

The impact of heterogeneity in individual frailty on the dynamics of mortality

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Development and validation of an electronic frailty index using routine primary care electronic health record data

Clegg, A. P., Bates, C. J., Young, J. B., Ryan, R. P., Nichols, L., Teale, E. A., Mohammed, M. A., Parry, J., & Marshall, T. P. (2016) · Age and Ageing · doi:10.1093/ageing/afw039 · Cited by 1,308 · see citing works

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.052 · Cited by 1,261 · see citing works

Religious Orders Study and Rush Memory and Aging Project

Bennett, D. A., Buchman, A. S., Boyle, P. A., Barnes, L. L., Wilson, R. S., & Schneider, J. A. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179939 · Cited by 1,260 · see citing works

Frailty index as a predictor of mortality: a systematic review and meta-analysis

Kojima, G., Iliffe, S., & Walters, K. R. (2017) · Age and Ageing · doi:10.1093/ageing/afx162 · Cited by 958 · see citing works

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Franceschi, C., Garagnani, P., Morsiani, C., Conte, M., Santoro, A., Grignolio, A., Monti, D., Capri, M., & Salvioli, S. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00061 · Cited by 945 · see citing works

Sex differences in frailty: A systematic review and meta-analysis

Gordon, E. H., Peel, N. M., Samanta, M., Theou, O., Howlett, S. E., & Hubbard, R. E. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2016.12.021 · Cited by 683 · see citing works

Operationalization of Frailty Using Eight Commonly Used Scales and Comparison of Their Ability to Predict All‐Cause Mortality

Theou, O., Brothers, T. D., Mitnitski, A., & Rockwood, K. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12420 · Cited by 665 · see citing works

Deciphering death: a commentary on Gompertz (1825) ‘On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies’

Kirkwood, T. B. L. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0379 · Cited by 610 · see citing works

Frailty in elderly people: an evolving concept.

Rockwood, K. J., Fox, R. A., Stolee, P., Robertson, D., & Beattie, B. L. (1994) · PubMed Central · Cited by 598 · see citing works

Frailty models for survival data

Hougaard, P. (1995) · Lifetime Data Analysis · doi:10.1007/bf00985760 · Cited by 584 · see citing works

Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey

Rockwood, K. J., Song, X., & Mitnitski, A. (2011) · Canadian Medical Association Journal · doi:10.1503/cmaj.101271 · Cited by 573 · see citing works

Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality

Mitnitski, A., Song, X., Skoog, I., Broe, G., Cox, J. L., Grunfeld, E., & Rockwood, K. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00506.x · Cited by 547 · see citing works

A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans

Whitehead, J. C., Hildebrand, B. A., Sun, M., Rockwood, M. R. H., Rose, R. A., Rockwood, K. J., & Howlett, S. E. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt136 · Cited by 514 · see citing works

Long‐Term Risks of Death and Institutionalization of Elderly People in Relation to Deficit Accumulation at Age 70

Rockwood, K., Mitnitski, A., Song, X., Steen, B., & Skoog, I. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00738.x · Cited by 481 · see citing works

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study

Collerton, J., Martin-Ruiz, C., Davies, K., Hilkens, C. M., Isaacs, J., Kolenda, C., Parker, C., Dunn, M., Catt, M., Jagger, C., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.005 · Cited by 420 · see citing works

Social Vulnerability, Frailty and Mortality in Elderly People

Andrew, M. K., Mitnitski, A. B., & Rockwood, K. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002232 · Cited by 413 · see citing works

Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies

Boyle, P. A., Yu, L., Leurgans, S. E., Wilson, R. S., Brookmeyer, R., Schneider, J. A., & Bennett, D. A. (2019) · Annals of Neurology · doi:10.1002/ana.25380 · Cited by 318 · see citing works

Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the Rush Memory and Aging Project

Wallace, L. M. K., Theou, O., Godin, J., Andrew, M. K., Bennett, D. A., & Rockwood, K. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30371-5 · Cited by 310 · see citing works

Resilience as a multimodal dynamic process

Stainton, A., Chisholm, K., Kaiser, N., Rosen, M., Upthegrove, R., Ruhrmann, S., & Wood, S. J. (2019) · Early Intervention in Psychiatry · doi:10.1111/eip.12726 · Cited by 289 · see citing works

Age-related frailty and its association with biological markers of ageing

Mitnitski, A., Collerton, J. C., Martin-Ruiz, C. M., Jagger, C., von Zglinicki, T., Rockwood, K. J., & Kirkwood, T. B. L. (2015) · BMC Medicine · doi:10.1186/s12916-015-0400-x · Cited by 279 · see citing works

Standard laboratory tests to identify older adults at increased risk of death

Howlett, S. E., Rockwood, M. R. H., Mitnitski, A., & Rockwood, K. J. (2014) · BMC Medicine · doi:10.1186/s12916-014-0171-9 · Cited by 269 · see citing works

Medical research: Treat ageing

Fontana, L., Kennedy, B. K., Longo, V. D., Seals, D. R., & Melov, S. (2014) · Nature · doi:10.1038/511405a · Cited by 266 · see citing works

Limits to deficit accumulation in elderly people

Rockwood, K. J., & Mitnitski, A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.002 · Cited by 237 · see citing works

A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice

Rockwood, K. J., Blodgett, J. M., Theou, O., Sun, M., Feridooni, H. A., Mitnitski, A., Rose, R. A., Godin, J., Gregson, E., & Howlett, S. E. (2017) · Scientific Reports · doi:10.1038/srep43068 · Cited by 237 · see citing works

Disability and co-morbidity in relation to frailty: How much do they overlap?

Theou, O., Rockwood, M. R. H., Mitnitski, A., & Rockwood, K. J. (2012) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.03.001 · Cited by 232 · see citing works

Nontraditional risk factors combine to predict Alzheimer disease and dementia

Song, X., Mitnitski, A., & Rockwood, K. (2011) · Neurology · doi:10.1212/wnl.0b013e318225c6bc · Cited by 220 · see citing works

The geriatric management of frailty as paradigm of “The end of the disease era”

Cesari, M., Marzetti, E., Thiem, U., Pérez‐Zepeda, M. U., van Kan, G. A., Landi, F., Petrović, M., Cherubini, A., & Bernabei, R. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.03.005 · Cited by 211 · see citing works

Identifying Common Characteristics of Frailty Across Seven Scales

Theou, O., Brothers, T. D., Peña, F. G., Mitnitski, A., & Rockwood, K. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12773 · Cited by 209 · see citing works

NORMAL AGEING, IMPAIRED COGNITIVE FUNCTION, AND SENILE DEMENTIA OF THE ALZHEIMER'S TYPE: A CONTINUUM?

Brayne, C., & Calloway, P. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92081-8 · Cited by 209 · see citing works

Fifteen years of progress in understanding frailty and health in aging

Rockwood, K. J., & Howlett, S. E. (2018) · BMC Medicine · doi:10.1186/s12916-018-1223-3 · Cited by 201 · see citing works

A Procedure for Creating a Frailty Index Based on Deficit Accumulation in Aging Mice

Parks, R. J., Fares, E., MacDonald, J. K., Ernst, M. C., Sinal, C. J., Rockwood, K. J., & Howlett, S. E. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr193 · Cited by 194 · see citing works

Sleep Disturbance is Associated with Incident Dementia and Mortality

Sterniczuk, R., Theou, O., Rusak, B., & Rockwood, K. J. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990134 · Cited by 185 · see citing works

Heterogeneity of Human Aging and Its Assessment

Mitnitski, A., Howlett, S. E., & Rockwood, K. J. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw089 · Cited by 184 · see citing works

Assessing biological aging: the origin of deficit accumulation

Mitnitski, A., Song, X., & Rockwood, K. J. (2013) · Biogerontology · doi:10.1007/s10522-013-9446-3 · Cited by 182 · see citing works

Social vulnerability from a social ecology perspective: a cohort study of older adults from the National Population Health Survey of Canada

Andrew, M. K., & Keefe, J. M. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-90 · Cited by 182 · see citing works

Resilience and HIV: a review of the definition and study of resilience

Dulin, A., Dale, S. K., Earnshaw, V. A., Fava, J. L., Mugavero, M. J., Napravnik, S., Hogan, J. W., Carey, M. P., & Howe, C. J. (2018) · AIDS Care · doi:10.1080/09540121.2018.1515470 · Cited by 167 · see citing works

Changes with age in the distribution of a frailty index

Rockwood, K. J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.05.003 · Cited by 155 · see citing works

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

Kirkwood, T. B. L., Feder, M., Finch, C. E., Franceschi, C., Globerson, A., Klingenberg, C. P., LaMarco, K., Omholt, S., & Westendorp, R. G. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.008 · Cited by 144 · see citing works

Age dependency of risk factors for cognitive decline

Legdeur, N., Heymans, M. W., Comijs, H. C., Huisman, M. A., Maier, A. B., & Visser, P. J. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0876-2 · Cited by 144 · see citing works

The rate of aging: the rate of deficit accumulation does not change over the adult life span

Mitnitski, A., & Rockwood, K. J. (2015) · Biogerontology · doi:10.1007/s10522-015-9583-y · Cited by 143 · see citing works

Frailty: a tale of two concepts

Walston, J. D., & Bandeen‐Roche, K. (2015) · BMC Medicine · doi:10.1186/s12916-015-0420-6 · Cited by 142 · see citing works

How cardiomyocyte excitation, calcium release and contraction become altered with age

Feridooni, H. A., Dibb, K. M., & Howlett, S. E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.12.004 · Cited by 142 · see citing works

A frailty index based on laboratory deficits in community-dwelling men predicted their risk of adverse health outcomes

Blodgett, J. M., Theou, O., Howlett, S. E., Wu, F. C. W., & Rockwood, K. J. (2016) · Age and Ageing · doi:10.1093/ageing/afw054 · Cited by 138 · see citing works

Frailty in People Aging With Human Immunodeficiency Virus (HIV) Infection

Brothers, T. D., Kirkland, S., Guaraldi, G., Falutz, J., Theou, O., Johnston, B. L., & Rockwood, K. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu258 · Cited by 136 · see citing works

Aging, frailty and complex networks

Mitnitski, A., Rutenberg, A. D., Farrell, S. R. M., & Rockwood, K. J. (2017) · Biogerontology · doi:10.1007/s10522-017-9684-x · Cited by 129 · see citing works

Frailty trajectories to identify end of life: a longitudinal population-based study

Stow, D., Matthews, F. E., & Hanratty, B. (2018) · BMC Medicine · doi:10.1186/s12916-018-1148-x · Cited by 122 · see citing works

Impairments in mobility and balance in relation to frailty

Davis, D. H. J., Rockwood, M. R. H., Mitnitski, A. B., & Rockwood, K. J. (2010) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2010.06.013 · Cited by 120 · see citing works

Canadian Study of Health and Aging Clinical Frailty Scale: Does It Predict Adverse Outcomes among Geriatric Trauma Patients?

Cheung, A., Haas, B., Ringer, T. J., McFarlan, A., & Wong, C. L. (2017) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2017.08.008 · Cited by 119 · see citing works

Conceptual Models of Frailty: Accumulation of Deficits

Rockwood, K. J. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.03.020 · Cited by 118 · see citing works

Frailty is an independent predictor of incident dementia: Evidence from the English Longitudinal Study of Ageing

Rogers, N. T., Steptoe, A., & Cadar, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-16104-y · Cited by 118 · see citing works

Is there room for resilience? A scoping review and critique of substance use literature and its utilization of the concept of resilience

Rudzinski, K., McDonough, P., Gartner, R., & Strıke, C. (2017) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/s13011-017-0125-2 · Cited by 114 · see citing works

Assessing the social dimension of frailty in old age: A systematic review

Bessa, B., Ribeiro, Ó. M., & Coelho, T. (2018) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2018.06.005 · Cited by 113 · see citing works

A Frailty Index Based on Common Laboratory Tests in Comparison With a Clinical Frailty Index for Older Adults in Long-Term Care Facilities

Rockwood, K. J., McMillan, M., Mitnitski, A., & Howlett, S. E. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.03.027 · Cited by 110 · see citing works

Age-related deficit accumulation and the risk of late-life dementia

Song, X., Mitnitski, A., & Rockwood, K. J. (2014) · Alzheimer s Research & Therapy · doi:10.1186/s13195-014-0054-5 · Cited by 110 · see citing works

The impact of social vulnerability on the survival of the fittest older adults

Andrew, M. K., Mitnitski, A., Kirkland, S., & Rockwood, K. J. (2012) · Age and Ageing · doi:10.1093/ageing/afr176 · Cited by 108 · see citing works

A limit to frailty in very old, community-dwelling people: a secondary analysis of the Chinese longitudinal health and longevity study

Bennett, S. L., Song, X., Mitnitski, A., & Rockwood, K. J. (2012) · Age and Ageing · doi:10.1093/ageing/afs180 · Cited by 106 · see citing works

Going from bad to worse: A stochastic model of transitions in deficit accumulation, in relation to mortality

Mitnitski, A., Bao, L., & Rockwood, K. J. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.007 · Cited by 106 · see citing works

Unifying aging and frailty through complex dynamical networks

Rutenberg, A. D., Mitnitski, A., Farrell, S. G., & Rockwood, K. J. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.08.027 · Cited by 97 · see citing works

The impacts of age and frailty on heart rate and sinoatrial node function

Moghtadaei, M., Jansen, H. J., Mackasey, M., Rafferty, S. A., Bogachev, O., Sapp, J. L., Howlett, S. E., & Rose, R. A. (2016) · The Journal of Physiology · doi:10.1113/jp272979 · Cited by 95 · see citing works

Frailty as a risk predictor in cardiac surgery: Beyond the eyeball test

Yanagawa, B., Graham, M. M., Afilalo, J., Hassan, A., & Arora, R. C. (2018) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2018.01.103 · Cited by 93 · see citing works

Tracking changes in frailty throughout later life: results from a 17-year longitudinal study in the Netherlands

Hoogendijk, E. O., Rockwood, K. J., Theou, O., Armstrong, J. J., Onwuteaka-Philipsen, B. D., Deeg, D. J. H., & Huisman, M. A. (2018) · Age and Ageing · doi:10.1093/ageing/afy081 · Cited by 91 · see citing works

Reliability of a Frailty Index Based on the Clinical Assessment of Health Deficits in Male C57BL/6J Mice

Feridooni, H. A., Sun, M., Rockwood, K. J., & Howlett, S. E. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu161 · Cited by 88 · see citing works

Convergent validity of the electronic frailty index

Brundle, C., Heaven, A., Brown, L., Teale, E. A., Young, J. B., West, R. M., & Clegg, A. P. (2018) · Age and Ageing · doi:10.1093/ageing/afy162 · Cited by 88 · see citing works

New horizons in frailty: ageing and the deficit-scaling problem

Howlett, S. E., & Rockwood, K. J. (2013) · Age and Ageing · doi:10.1093/ageing/aft059 · Cited by 85 · see citing works

How golden is the gold standard of neuropathology in dementia?

Scheltens, P., & Rockwood, K. J. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.04.011 · Cited by 84 · see citing works

A Murine Frailty Index Based on Clinical and Laboratory Measurements: Links Between Frailty and Pro-inflammatory Cytokines Differ in a Sex-Specific Manner

Kane, A. E., Keller, K. M., Heinze-Milne, S., Grandy, S. A., & Howlett, S. E. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly117 · Cited by 80 · see citing works

Frailty and Social Vulnerability

Andrew, M. K. (2015) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000381236 · Cited by 79 · see citing works

Scoping review of frailty in vascular surgery

Drudi, L. M., Ades, M., Landry, T., Gill, H. L., Grenon, S. M., Steinmetz, O. K., & Afilalo, J. (2018) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2018.10.053 · Cited by 79 · see citing works

The association between frailty, the metabolic syndrome, and mortality over the lifespan

Kane, A. E., Gregson, E., Theou, O., Rockwood, K. J., & Howlett, S. E. (2017) · GeroScience · doi:10.1007/s11357-017-9967-9 · Cited by 74 · see citing works

Atrial structure, function and arrhythmogenesis in aged and frail mice

Jansen, H. J., Moghtadaei, M., Mackasey, M., Rafferty, S. A., Bogachev, O., Sapp, J. L., Howlett, S. E., & Rose, R. A. (2017) · Scientific Reports · doi:10.1038/srep44336 · Cited by 73 · see citing works

Dynamics of Frailty and Cognition After Age 50: Why It Matters that Cognitive Decline is Mostly Seen in Old Age

Godin, J., Armstrong, J. J., Rockwood, K. J., & Andrew, M. K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161280 · Cited by 69 · see citing works

Trajectories of changes over twelve years in the health status of Canadians from late middle age

Mitnitski, A., Song, X., & Rockwood, K. J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.06.015 · Cited by 68 · see citing works

Accumulation of Non-Traditional Risk Factors for Coronary Heart Disease Is Associated with Incident Coronary Heart Disease Hospitalization and Death

Wallace, L. M. K., Theou, O., Kirkland, S., Rockwood, M. R. H., Davidson, K. W., Shimbo, D., & Rockwood, K. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090475 · Cited by 67 · see citing works

Operationalizing a frailty index using routine blood and urine tests

Ritt, M., Jäger, J., Ritt, J., Sieber, C. C., & Gaßmann, K. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s131987 · Cited by 64 · see citing works

Association between routine laboratory tests and long-term mortality among acutely admitted older medical patients: a cohort study

Klausen, H. H., Petersen, J., Bandholm, T., Juul‐Larsen, H. G., Tavenier, J., Eugen‐Olsen, J., & Andersen, O. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0434-3 · Cited by 63 · see citing works

A FRAILTY INDEX BASED ON COMMON LABORATORY TESTS IN COMPARISON WITH A CLINICAL FRAILTY INDEX FOR OLDER ADULTS IN LONG TERM CARE FACILITIES.

(2015) · The Gerontologist · doi:10.1093/geront/gnv564.09 · Cited by 62 · see citing works

Evaluating frailty scores to predict mortality in older adults using data from population based electronic health records: case control study

Stow, D., Matthews, F. E., Barclay, S. I. G., Iliffe, S., Clegg, A. P., Biase, S. D., Robinson, L., & Hanratty, B. (2018) · Age and Ageing · doi:10.1093/ageing/afy022 · Cited by 61 · see citing works

Effect of age on cardiac excitation–contraction coupling

Fares, E., & Howlett, S. E. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05276.x · Cited by 56 · see citing works

The impact of age and frailty on ventricular structure and function in C57BL/6J mice

Feridooni, H. A., Kane, A. E., Ayaz, O., Boroumandi, A., Polidovitch, N., Tsushima, R. G., Rose, R. A., & Howlett, S. E. (2017) · The Journal of Physiology · doi:10.1113/jp274134 · Cited by 56 · see citing works

Sex Differences in the Limit to Deficit Accumulation in Late Middle-Aged and Older Chinese People: Results From the Beijing Longitudinal Study of Aging

Shi, J. C., Yang, Z., Song, X., Yu, P., Fang, X., Tang, Z., Peng, D., Mitnitski, A., & Rockwood, K. J. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt143 · Cited by 55 · see citing works

Frailty in the Honolulu-Asia Aging Study: Deficit Accumulation in a Male Cohort Followed to 90% Mortality

Armstrong, J. J., Mitnitski, A., Launer, L. J., White, L. R., & Rockwood, K. J. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu089 · Cited by 53 · see citing works

Network model of human aging: Frailty limits and information measures

Farrell, S. G., Mitnitski, A., Rockwood, K. J., & Rutenberg, A. D. (2016) · Physical review. E · doi:10.1103/physreve.94.052409 · Cited by 48 · see citing works

Conceptual Models of Frailty: The Sarcopenia Phenotype

Afilalo, J. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.05.017 · Cited by 46 · see citing works

Application of an electronic Frailty Index in Australian primary care: data quality and feasibility assessment

Ambagtsheer, R. C., Beilby, J., Dabravolskaj, J., Abbasi, M., Archibald, M. M., & Dent, E. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-1023-9 · Cited by 44 · see citing works

Genealogical data and the biodemography of human longevity

Gavrilov, L. A., Gavrilova, N. S., Olshansky, S. J., & Carnes, B. A. (2002) · Biodemography and Social Biology · doi:10.1080/19485565.2002.9989056 · Cited by 43 · see citing works

Cumulative impact of health deficits, social vulnerabilities, and protective factors on cognitive dynamics in late life: A multistate modeling approach

Armstrong, J. J., Mitnitski, A., Andrew, M. K., Launer, L. J., White, L. R., & Rockwood, K. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0120-7 · Cited by 42 · see citing works

Frailty and usage of health care systems: Results from the South Australian Monitoring and Surveillance System (SAMSS)

Dent, E., Grande, E. D., Price, K., & Taylor, A. W. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.07.003 · Cited by 42 · see citing works

Predictive validity of two frailty tools for mortality in Chinese nursing home residents: frailty index based on common laboratory tests (FI-Lab) versus FRAIL-NH

Yang, M. J., Zhuo, Y., Hu, X., & Xie, L. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-1041-7 · Cited by 42 · see citing works

Predicting 3‐Year Survival in Older People with Intellectual Disabilities Using a Frailty Index

Schoufour, J. D., Mitnitski, A., Rockwood, K. J., Evenhuis, H. M., & Echteld, M. A. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13239 · Cited by 41 · see citing works

Using an accumulation of deficits approach to measure frailty in a population of home care users with intellectual and developmental disabilities: an analytical descriptive study

McKenzie, K., Ouellette-Kuntz, H. M. J., & Martin, L. (2015) · BMC Geriatrics · doi:10.1186/s12877-015-0170-5 · Cited by 41 · see citing works

Social and Societal Implications of Frailty, Including Impact on Canadian Healthcare Systems

Andrew, M. K., Dupuis‐Blanchard, S., Maxwell, C. J., Giguere, A. M. C., Keefe, J. M., Rockwood, K. J., & John, P. S. (2018) · The Journal of Frailty & Aging · doi:10.14283/jfa.2018.30 · Cited by 41 · see citing works

Frailty Index and Cognitive Decline in Alzheimer's Disease: Data from the Impact of Cholinergic Treatment US e Study

Kelaiditi, E., Canevelli, M., Andrieu, S., del Campo, N., Soto, M. E., Vellas, B. J., Cesari, M., & the Impact of Cholinergic Treatment Use Study/DSA Group (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13956 · Cited by 40 · see citing works

Frailty as a risk predictor in cardiac surgery: Beyond the eyeball test

Yanagawa, B., Graham, M. M., Afilalo, J., Hassan, A., & Arora, R. C. (2018) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2018.08.054 · Cited by 40 · see citing works

Dynamical network model for age-related health deficits and mortality

Taneja, S., Mitnitski, A., Rockwood, K. J., & Rutenberg, A. D. (2016) · Physical review. E · doi:10.1103/physreve.93.022309 · Cited by 38 · see citing works

Lower Extremity Function Is Independently Associated With Hospitalization Burden in Heart Failure With Preserved Ejection Fraction

Hornsby, W., Sareini, M.-A., Golbus, J. R., Willer, C. J., McNamara, J. L., Konerman, M. C., & Hummel, S. L. (2018) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2018.09.002 · Cited by 38 · see citing works

Lessons From Mixed Dementia

Rockwood, K. J. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004407 · Cited by 37 · see citing works

Ageing: Develop models of frailty

Howlett, S. E., & Rockwood, K. J. (2014) · Nature · doi:10.1038/512253d · Cited by 36 · see citing works

The Impact of Frailty on the Risk of Conversion from Mild Cognitive Impairment to Alzheimer’s Disease: Evidences from a 5-Year Observational Study

Trebbastoni, A., Canevelli, M., D’Antonio, F., Imbriano, L., Podda, L., Rendace, L., Campanelli, A., Celano, V., Bruno, G., & de Lena, C. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00178 · Cited by 35 · see citing works

ACTN3 genotype and physical function and frailty in an elderly Chinese population: the Rugao Longevity and Ageing Study

Ma, T., Lu, D., Zhu, Y., Chu, X., Wang, Y., Shi, G., Wang, Z., Li, Y., Jiang, X., & Wang, X. (2018) · Age and Ageing · doi:10.1093/ageing/afy007 · Cited by 34 · see citing works

Frailty Phenotype and Deficit Accumulation Frailty Index in Predicting Recovery After Transcatheter and Surgical Aortic Valve Replacement

Shi, S., Afilalo, J., Lipsitz, L. A., Popma, J. J., Khabbaz, K. R., Laham, R. J., Guibone, K., Grodstein, F., Lux, E., & Kim, D. H. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly196 · Cited by 34 · see citing works

Understanding risk in the oldest old: Frailty and the metabolic syndrome in a Chinese community sample aged 90+ years

Hao, Q., Song, X., Yang, M. J., Dong, B., & Rockwood, K. J. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0680-7 · Cited by 34 · see citing works

The potential use of physical resilience to predict healthy aging

Schorr, A., Carter, C. S., & Ladiges, W. (2017) · Pathobiology of Aging & Age-related Diseases · doi:10.1080/20010001.2017.1403844 · Cited by 32 · see citing works

Frailty in relation to the risk of Alzheimer's disease, dementia, and death in older Chinese adults: A seven-year prospective study

Wang, C., Ji, X., Wu, X., Tang, Z., Zhang, X., Guan, S., Liu, H., & Fang, X. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0798-7 · Cited by 31 · see citing works

Promoting the Assessment of Frailty in the Clinical Approach to Cognitive Disorders

Canevelli, M., Cesari, M., Remiddi, F., Trebbastoni, A., Quarata, F., Vico, C., de Lena, C., & Bruno, G. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00036 · Cited by 31 · see citing works

Rodent models of frailty and their application in preclinical research

Banga, S., Heinze-Milne, S., & Howlett, S. E. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.01.008 · Cited by 31 · see citing works

Prediction of mortality in Chinese very old people through the frailty index based on routine laboratory data

Hao, Q., Sun, X., Yang, M. J., Dong, B., Dong, B., & Wei, Y. (2019) · Scientific Reports · doi:10.1038/s41598-018-36569-9 · Cited by 29 · see citing works

A Cumulative Deficit Laboratory Test–based Frailty Index: Personal and Neighborhood Associations

King, K. E., Fillenbaum, G. G., & Cohen, H. J. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14983 · Cited by 27 · see citing works

Understanding frailty to predict and prevent dementia

Panza, F., Lozupone, M., & Logroscino, G. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30446-0 · Cited by 27 · see citing works

Understanding risk in the oldest old: Frailty and the metabolic syndrome in a chinese community sample aged 90+ years

Hao, Q., Song, X., Yang, M. J., Dong, B., & Rockwood, K. J. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0553-5 · Cited by 25 · see citing works

Probing the network structure of health deficits in human aging

Farrell, S. G., Mitnitski, A., Theou, O., Rockwood, K. J., & Rutenberg, A. D. (2018) · Physical review. E · doi:10.1103/physreve.98.032302 · Cited by 21 · see citing works

Resilience and frailty: Further steps, best taken together

Rockwood, K. J., & Mitnitski, A. (2015) · European Geriatric Medicine · doi:10.1016/j.eurger.2015.06.001 · Cited by 19 · see citing works

Modelling physical resilience in ageing mice

Schosserer, M., Banks, G. T., Doğan, S., Dungel, P., Fernandes, A. M. A., Marolt, D., Matheu, A., Osuchowski, M. F., Potter, P. K., Sanfeliu, C., et al. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.10.001 · Cited by 19 · see citing works

CAN AN INTERVENTION WITH TESTOSTERONE AND NUTRITIONAL SUPPLEMENT IMPROVE THE FRAILTY LEVEL OF UNDER-NOURISHED OLDER PEOPLE?

Theou, O., WIJEYARATNE, L., PIANTADOSI, C., LANGE, K., Naganathan, V., Hunter, P., Cameron, I. D., Rockwood, K. J., Visvanathan, R., & Chapman, I. (2016) · The Journal of Frailty & Aging · doi:10.14283/jfa.2016.108 · Cited by 16 · see citing works

Construct validation of a Frailty Index, an HIV Index and a Protective Index from a clinical HIV database

Franconi, I., Theou, O., Wallace, L. M. K., Malagoli, A., Mussini, C., Rockwood, K. J., & Guaraldi, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201394 · Cited by 13 · see citing works

Dementia Research: Populations, Progress, Problems, and Predictions

Hunter, S., Smailagic, N., & Brayne, C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179927 · Cited by 6 · see citing works

Lower-Extremity Function as a Marker of Frailty and Outcomes of Heart Failure With Preserved Ejection Fraction in Older Adults

Kim, D. H., & Shi, S. (2018) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2018.11.002 · Cited by 1 · see citing works

Using the Clinical Frailty Scale in Allocating Scarce Health Care Resources

Rockwood, K. J., & Theou, O. (2020) · Canadian Geriatrics Journal · doi:10.5770/cgj.23.463 · Cited by 913 · see citing works

The degree of frailty as a translational measure of health in aging

Howlett, S. E., Rutenberg, A. D., & Rockwood, K. J. (2021) · Nature Aging · doi:10.1038/s43587-021-00099-3 · Cited by 343 · see citing works

Common risk factors for major noncommunicable disease, a systematic overview of reviews and commentary: the implied potential for targeted risk reduction

Peters, R., Ee, N., Peters, J., Beckett, N., Booth, A., Rockwood, K., & Anstey, K. J. (2019) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622319880392 · Cited by 213 · see citing works

The role of illness acuity on the association between frailty and mortality in emergency department patients referred to internal medicine

Pulok, M. H., Theou, O., van der Valk, A. M., & Rockwood, K. J. (2020) · Age and Ageing · doi:10.1093/ageing/afaa089 · Cited by 172 · see citing works

Frailty, lifestyle, genetics and dementia risk

Ward, D. D., Ranson, J. M., Wallace, L. M. K., Llewellyn, D. J., & Rockwood, K. J. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-327396 · Cited by 170 · see citing works

Frailty and Physical Fitness in Elderly People: A Systematic Review and Meta-analysis

Navarrete-Villanueva, D., Gómez-Cabello, A., Marín-Puyalto, J., Moreno, L., Vicente-Rodríguez, G., & Casajús, J. (2020) · Sports Medicine · doi:10.1007/s40279-020-01361-1 · Cited by 134 · see citing works

Sex differences in frailty: Comparisons between humans and preclinical models

Kane, A. E., & Howlett, S. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111546 · Cited by 138 · see citing works

Clinical outcomes in patients with atrial fibrillation and frailty: insights from the ENGAGE AF-TIMI 48 trial

Wilkinson, C., Wu, J., Searle, S. D., Todd, O. M., Hall, M., Kunadian, V., Clegg, A. P., Rockwood, K. J., & Gale, C. P. (2020) · BMC Medicine · doi:10.1186/s12916-020-01870-w · Cited by 116 · see citing works

Bed rest and accelerated aging in relation to the musculoskeletal and cardiovascular systems and frailty biomarkers: A review

Kehler, D. S., Theou, O., & Rockwood, K. J. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110643 · Cited by 88 · see citing works

Frailty among middle-aged and older Canadians: population norms for the frailty index using the Canadian Longitudinal Study on Aging

Pérez‐Zepeda, M. U., Godin, J., Armstrong, J. J., Andrew, M. K., Mitnitski, A., Kirkland, S., Rockwood, K. J., & Theou, O. (2020) · Age and Ageing · doi:10.1093/ageing/afaa144 · Cited by 76 · see citing works

Routine Frailty Screening in Critical Illness

Darvall, J. N., Bellomo, R., Paul, E. M., Bailey, M., Young, P. J., Reid, A., Rockwood, K. J., & Pilcher, D. V. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.05.049 · Cited by 70 · see citing works

Atrial fibrillation and oral anticoagulation in older people with frailty: a nationwide primary care electronic health records cohort study

Wilkinson, C., Clegg, A. P., Todd, O. M., Rockwood, K. J., Yadegarfar, M. E., Gale, C. P., & Hall, M. (2020) · Age and Ageing · doi:10.1093/ageing/afaa265 · Cited by 67 · see citing works

Deficit Accumulation Frailty Trajectories of Older Breast Cancer Survivors and Non-Cancer Controls: The Thinking and Living With Cancer Study

Mandelblatt, J. S., Zhou, X., Small, B. J., Ahn, J., Zhai, W., Ahles, T. A., Extermann, M., Graham, D. M. A., Jacobsen, P. B., Jim, H., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab003 · Cited by 57 · see citing works

Frailty and Risk of Dementia in Mild Cognitive Impairment Subtypes

Ward, D. D., Wallace, L. M. K., & Rockwood, K. J. (2021) · Annals of Neurology · doi:10.1002/ana.26064 · Cited by 56 · see citing works

Biomarkers and phenotypic expression in Alzheimer’s disease: exploring the contribution of frailty in the Alzheimer’s Disease Neuroimaging Initiative

Initiative, A. D. N., Canevelli, M., Arisi, I., Bacigalupo, I., Arighi, A., Galimberti, D., Vanacore, N., D’Onofrio, M., Cesari, M., & Bruno, G. (2020) · GeroScience · doi:10.1007/s11357-020-00293-y · Cited by 53 · see citing works

Applying a Life Course Biological Age Framework to Improving the Care of Individuals With Adult Cancers

Mandelblatt, J. S., Ahles, T. A., Lippman, M. E., Isaacs, C. J., Adams-Campbell, L. L., Saykin, A. J., Cohen, H. J., & Carroll, J. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.1160 · Cited by 53 · see citing works

Cumulative health deficits, APOE genotype, and risk for later-life mild cognitive impairment and dementia

Ward, D. D., Wallace, L. M. K., & Rockwood, K. J. (2020) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-324081 · Cited by 53 · see citing works

Prognostic significance of frailty in older patients with hip fracture: a systematic review and meta-analysis

Yan, B., Sun, W., Wang, W., Wu, J., Wang, G., & Dou, Q. (2022) · International Orthopaedics · doi:10.1007/s00264-022-05605-9 · Cited by 50 · see citing works

Associations of Adverse Childhood Experiences with Frailty in Older Adults: A Cross-Sectional Analysis of Data from the Canadian Longitudinal Study on Aging

Mian, O., Anderson, L. N., Belsky, D. W., González, A., Ma, J., Sloboda, D. M., Bowdish, D. M. E., & Verschoor, C. P. (2021) · Gerontology · doi:10.1159/000520327 · Cited by 47 · see citing works

Acceleration of health deficit accumulation in late-life: evidence of terminal decline in frailty index three years before death in the US Health and Retirement Study

Stolz, E., Mayerl, H., Hoogendijk, E. O., Armstrong, J. J., Roller‐Wirnsberger, R., & Freidl, W. (2021) · Annals of Epidemiology · doi:10.1016/j.annepidem.2021.03.008 · Cited by 39 · see citing works

The Relationship Between Frailty and Emotional Health in Older Patients with Advanced Cancer

Gilmore, N. J., Kehoe, L., Bauer, J., Xu, H., Hall, B., Wells, M., Lei, L., Culakova, E., Flannery, M. A., Grossman, V. A., et al. (2021) · The Oncologist · doi:10.1002/onco.13975 · Cited by 39 · see citing works

Longitudinal Association between Late-Life Depression (LLD) and Frailty: Findings from a Prospective Cohort Study (MiMiCS-FRAIL)

Borges, M. K., Romanini, C. V., Lima, N. A., Petrella, M., da Costa, D. L., An, V. N., Aguirre, B. N., Galdeano, J. R., Fernandes, I. C., Cecato, J. F., et al. (2021) · The journal of nutrition health & aging · doi:10.1007/s12603-021-1639-x · Cited by 38 · see citing works

Frailty and cytokines in preclinical models: Comparisons with humans

Heinze-Milne, S., Banga, S., & Howlett, S. E. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111706 · Cited by 38 · see citing works

Frailty indices based on self-report, blood-based biomarkers and examination-based data in the Canadian Longitudinal Study on Aging

Blodgett, J. M., Pérez‐Zepeda, M. U., Godin, J., Kehler, D. S., Andrew, M. K., Kirkland, S., Rockwood, K. J., & Theou, O. (2022) · Age and Ageing · doi:10.1093/ageing/afac075 · Cited by 37 · see citing works

Network analysis of frailty and aging: Empirical data from the Mexican Health and Aging Study

García‐Peña, C., Ramírez‐Aldana, R., Parra‐Rodríguez, L., Gómez-Verján, J. C., Pérez‐Zepeda, M. U., & Gutiérrez‐Robledo, L. M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110747 · Cited by 35 · see citing works

Frailty—A promising concept to evaluate disease vulnerability

Ribeiro, A. R., Howlett, S. E., & Fernandes, A. M. A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111217 · Cited by 35 · see citing works

Short Physical Performance Battery as a Crosswalk Between Frailty Phenotype and Deficit Accumulation Frailty Index

Jung, H., Baek, J. Y., Jang, I., Guralnik, J. M., Rockwood, K. J., Lee, E., & Kim, D. H. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab087 · Cited by 35 · see citing works

Course of frailty stratified by physical and mental multimorbidity patterns: a 5-year follow-up of 92,640 participants of the LifeLines cohort study

Voshaar, R. C. O., Jeuring, H. W., Borges, M. K., van den Brink, R. H. S., Marijnissen, R. M., Hoogendijk, E. O., Munster, B. C. V., & Aprahamian, I. (2021) · BMC Medicine · doi:10.1186/s12916-021-01904-x · Cited by 34 · see citing works

A 6‐year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder

Voshaar, R. C. O., Dimitriadis, M., VANDENBRINK, R., Aprahamian, I., Borges, M. K., Marijnissen, R. M., Hoogendijk, E. O., Rhebergen, D., & Jeuring, H. W. (2021) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5588 · Cited by 34 · see citing works

How “old age” was withdrawn as a diagnosis from ICD-11

Rabheru, K., Byles, J., & Kalache, A. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00102-7 · Cited by 34 · see citing works

Prevalence and factors associated with frailty and pre-frailty in the older adults in China: a national cross-sectional study

Zeng, X., Meng, L., Li, Y., Jia, N., Shi, J. C., Zhang, C., Hu, X., Hu, J.-B., Li, J., Wu, D., et al. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1110648 · Cited by 33 · see citing works

Exploring cellular senescence in the musculoskeletal system: Any insights for biomarkers discovery?

Gerosa, L., Malvandi, A. M., Malavolta, M., Provinciali, M., & Lombardi, G. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101943 · Cited by 32 · see citing works

Frailty Index as a clinical measure of biological age in psychiatry

Bersani, F. S., Canevelli, M., Cesari, M., Maggioni, E., Pasquini, M., Wolkowitz, O. M., Ferracuti, S., Biondi, M., & Bruno, G. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.015 · Cited by 32 · see citing works

Operationalization of a frailty index in patients with multiple sclerosis: A cross-sectional investigation

Belvisi, D., Canevelli, M., Baione, V., Buscarinu, M. C., Pellicciari, G., Fantozzi, R., Creta, A., Cecchi, G., Cola, G., Nicoletti, C. G., et al. (2021) · Multiple Sclerosis Journal · doi:10.1177/1352458520987541 · Cited by 32 · see citing works

Age related weight loss in female 5xFAD mice from 3 to 12 months of age

Gendron, W. A. C., Fertan, E., Pelletier, S., Roddick, K. M., O’Leary, T. P., Anini, Y., & Brown, R. E. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113214 · Cited by 31 · see citing works

Older adults’ experiences of loneliness over the lifecourse: An exploratory study using the BBC loneliness experiment

Victor, C. R., Rippon, I., Barreto, M., Hammond, C., & Qualter, P. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104740 · Cited by 30 · see citing works

Is Frailty Index a better predictor than pre-stroke modified Rankin Scale for neurocognitive outcomes 3-months post-stroke?

Munthe‐Kaas, R., Aam, S., Saltvedt, I. T., Wyller, T. B., Pendlebury, S. T., Lydersen, S., Hagberg, G., Schellhorn, T., Rostoft, S., & Ihle‐Hansen, H. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-02840-y · Cited by 30 · see citing works

Identifying Frail Patients by Using Electronic Health Records in Primary Care: Current Status and Future Directions

Luo, J., Liao, X., Zou, C., Zhao, Q., Yao, Y., Fang, X., & Spicer, J. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.901068 · Cited by 29 · see citing works

New horizons in understanding oral health and swallowing function within the context of frailty

Robison, R., Garand, K. L., Affoo, R. H., Yeh, C., Chin, N. A., McArthur, C., Pulia, M. S., & Rogus‐Pulia, N. M. (2023) · Age and Ageing · doi:10.1093/ageing/afac276 · Cited by 29 · see citing works

Considering Frailty in SARS-CoV-2 Vaccine Development: How Geriatricians Can Assist

Andrew, M. K., Schmader, K. E., Rockwood, K. J., Clarke, B., & McElhaney, J. E. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s295522 · Cited by 28 · see citing works

The Molecular Role of Polyamines in Age-Related Diseases: An Update

Jiménez-Gutiérrez, G. E., Jiménez, F. V. B., Muñoz, L. G., Tapia-Guerrero, Y. S., Murillo-Melo, N. M., Cristóbal-Luna, J. M., Leyva‐García, N., Cordero‐Martínez, J., & Magaña, J. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216469 · Cited by 28 · see citing works

The Influence of Lifestyle Behaviors on the Incidence of Frailty

Borda, M. G., Pérez‐Zepeda, M. U., Samper‐Ternent, R., Gómez, R. C., Ávila‐Funes, J. A., & Cano, C. A. (2020) · The Journal of Frailty & Aging · doi:10.14283/jfa.2019.37 · Cited by 27 · see citing works

The association between continuing work after retirement and the incidence of frailty: evidence from the China health and retirement longitudinal study

Sun, L., Deng, G., Lu, X., Xie, X., Kang, L., Sun, T., & Dai, X. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100398 · Cited by 27 · see citing works

Age, Sex and Overall Health, Measured As Frailty, Modify Myofilament Proteins in Hearts From Naturally Aging Mice

Kane, A. E., Bisset, E. S., Keller, K. M., Ghimire, A., Pyle, W. G., & Howlett, S. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-66903-z · Cited by 26 · see citing works

Sex Moderates the Association between Frailty and Mild Behavioral Impairment

Guan, D. X., Rockwood, K. J., Smith, E. E., & Ismail, Z. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.61 · Cited by 26 · see citing works

Prediction of Hospitalizations in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index

Legge, A. C., Kirkland, S., Rockwood, K. J., Andreou, P., Bae, S., Gordon, C., Romero‐Díaz, J., Sánchez‐Guerrero, J., Wallace, D. J., Bernatsky, S., et al. (2020) · Arthritis Care & Research · doi:10.1002/acr.24504 · Cited by 25 · see citing works

Frailty in the oldest old: is the current level or the rate of change more predictive of mortality?

Stolz, E., Mayerl, H., & Hoogendijk, E. O. (2022) · Age and Ageing · doi:10.1093/ageing/afac020 · Cited by 25 · see citing works

Insights Into the Older Adults' World: Concepts of Aging, Care, and Using Assistive Technology in Late Adulthood

Wilkowska, W., Offermann, J., Laurentius, T., Bollheimer, L. C., & Ziefle, M. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.653931 · Cited by 24 · see citing works

Early-Life War Exposure and Later-Life Frailty Among Older Adults in Vietnam: Does War Hasten Aging?

Zimmer, Z., Korinek, K., Young, Y., Teerawichitchainan, B., & Toàn, T. K. (2021) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbab190 · Cited by 25 · see citing works

A study on the prevalence and related factors of frailty and pre-frailty in the older population with diabetes in China: A national cross-sectional study

Zeng, X., Jia, N., Meng, L., Shi, J. C., Li, Y., Hu, X., Hu, J.-B., Xu, H., Li, J., Li, H., et al. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.996190 · Cited by 24 · see citing works

Muscle Steatosis and Fibrosis in Older Adults, From the AJR Special Series on Imaging of Fibrosis

Lenchik, L., Mazzoli, V., Cawthon, P. M., Hepple, R. T., & Boutin, R. D. (2023) · American Journal of Roentgenology · doi:10.2214/ajr.23.29742 · Cited by 23 · see citing works

The Association of a Frailty Index and Incident Delirium in Older Hospitalized Patients: An Observational Cohort Study

Sillner, A. Y., McConeghy, R., Madrigal, C. B., Culley, D. J., Arora, R. C., & Rudolph, J. L. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s249284 · Cited by 23 · see citing works

Education, wealth, and duration of life expected in various degrees of frailty

Zimmer, Z., Saito, Y., Theou, O., Haviva, C., & Rockwood, K. J. (2021) · European Journal of Ageing · doi:10.1007/s10433-020-00587-2 · Cited by 22 · see citing works

Associations among frailty and quality of life in older patients with cancer treated with chemotherapy

Crowder, S. L., Hoogland, A. I., Small, B. J., Carpenter, K. M., Fischer, S. M., Li, D., Kinney, A. Y., Welniak, T. L., Brownstein, N. C., Reich, R. R., et al. (2022) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2022.08.010 · Cited by 22 · see citing works

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Foessl, I., Bassett, J. H. D., Bjørnerem, Å., Busse, B., Calado, Â., Chavassieux, P., Christou, M., Douni, E. K., Fiedler, I. A. K., Fonseca, J. E., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.720728 · Cited by 22 · see citing works

Frailty in Parkinson's disease and its association with early dementia: A longitudinal study

Borda, M. G., Pérez‐Zepeda, M. U., Jaramillo-Jiménez, A., Chaudhuri, К. R., Tovar, D., Wallace, L. M. K., Batzu, L., Rockwood, K. J., Tysnes, O., Aarsland, D., et al. (2022) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2022.05.004 · Cited by 22 · see citing works

Frailty in geriatric psychiatry inpatients: a retrospective cohort study

Aprahamian, I., Landowski, A., Ahn, F. O., Neves, B. A., Rocha, J. T., Strauss, J., Borges, M. K., Morley, J. E., & Voshaar, R. C. O. (2020) · International Psychogeriatrics · doi:10.1017/s1041610220003403 · Cited by 21 · see citing works

Comparative lifespan and healthspan of nonhuman primate species common to biomedical research

Huber, H. F., Ainsworth, H. C., Quillen, E. E., Salmon, A., Ross, C. N., Azhar, A. D., Bales, K. L., Basso, M. A., Coleman, K., Colman, R. J., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01421-8 · Cited by 23 · see citing works

The bidirectional association between frailty index and cardiovascular disease: A Mendelian randomization study

Xu, Q., Jia, Y., Wang, Y., Yang, P., Sun, L., Liu, Y., Chang, X., He, Y., Guo, D., Shi, M., et al. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.10.018 · Cited by 20 · see citing works

Aging-Related Changes in the Ultrastructure of Hepatocytes and Cardiomyocytes of Elderly Mice Are Enhanced in ApoE-Deficient Animals

Łysek-Gładysińska, M., Wieczorek, A., Jóźwik, A., Walaszczyk, A., Jelonek, K., Szczukiewicz-Markowska, G., Horbańczuk, O. K., Pietrowska, M., Widłak, P., & Gabryś, D. (2021) · Cells · doi:10.3390/cells10030502 · Cited by 19 · see citing works

External validation of the Systemic Lupus International Collaborating Clinics Frailty Index as a predictor of adverse health outcomes in systemic lupus erythematosus

Legge, A. C., Malone, A., & Hanly, J. G. (2021) · Lara D. Veeken · doi:10.1093/rheumatology/keab546 · Cited by 19 · see citing works

Delirium is significantly associated with hospital frailty risk score derived from administrative data

Lim, Z., Ling, N. M. W., Ho, V., Vidhya, N., Chen, M. Z., Wong, B., Ng, S. E., Murphy, D. P., & Merchant, R. A. (2023) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5872 · Cited by 19 · see citing works

Premature aging as an accumulation of deficits in young adult survivors of pediatric cancer

Williams, A. M., Mandelblatt, J. S., Wang, M., Armstrong, G. T., Bhakta, N. H., Brinkman, T. M., Chemaitilly, W., Ehrhardt, M. J., Mulrooney, D. A., Small, B. J., et al. (2022) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djac209 · Cited by 18 · see citing works

Frailty is associated with the clinical expression of neuropsychological deficits in older adults

Canevelli, M., Wallace, L. M. K., Bruno, G., Cesari, M., Rockwood, K. J., & Ward, D. D. (2023) · European Journal of Neurology · doi:10.1111/ene.16072 · Cited by 17 · see citing works

The Role of Frailty in Predicting 3 and 6 Months Functional Decline in Hospitalized Older Adults: Findings from a Secondary Analysis

Tavares, J., Sá‐Couto, P., Reis, J. D., Boltz, M. P., & Capezuti, E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18137126 · Cited by 17 · see citing works

Deficit Accumulation Index and Biological Markers of Aging in Survivors of Childhood Cancer

Williams, A. M., Mandelblatt, J. S., Wang, M., Dong, Q., Armstrong, G. T., Bhakta, N. H., Brinkman, T. M., Ehrhardt, M. J., Mulrooney, D. A., Gilmore, N. J., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.44015 · Cited by 17 · see citing works

A study on the prevalence and related factors of frailty and pre-frailty in the older population with hypertension in China: A national cross-sectional study

Zeng, X., Jia, N., Meng, L., Shi, J. C., Li, Y., Hu, J.-B., Hu, X., Li, H., Xu, H., Li, J., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1057361 · Cited by 16 · see citing works

Rationing care in COVID-19: if we must do it, can we do better?

Rockwood, K. J. (2020) · Age and Ageing · doi:10.1093/ageing/afaa202 · Cited by 16 · see citing works

Evaluating the association of frailty with communication about aging‐related concerns between older patients with advanced cancer and their oncologists

Gilmore, N. J., Xu, H., Kehoe, L., Kleckner, A. S., Moorthi, K., Lei, L., Mohamed, M., Loh, K. P., Culakova, E., Flannery, M. A., et al. (2021) · Cancer · doi:10.1002/cncr.34010 · Cited by 17 · see citing works

Frailty in Caregivers and Its Relationship with Psychological Stress and Resilience: A Cross-Sectional Study Based on the Deficit Accumulation Model

Canevelli, M., Bersani, F. S., Sciancalepore, F., Salzillo, M., Cesari, M., Tarsitani, L., Pasquini, M., Ferracuti, S., Biondi, M., & Bruno, G. (2021) · The Journal of Frailty & Aging · doi:10.14283/jfa.2021.29 · Cited by 15 · see citing works

Toxicity risk score and clinical decline after adjuvant chemotherapy in older breast cancer survivors

Ji, J., Sun, C., Cohen, H. J., Muss, H. B., Bae, M., & Sedrak, M. S. (2023) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djad029 · Cited by 15 · see citing works

Investigating Neuroimaging Correlates of Early Frailty in Patients With Behavioral Variant Frontotemporal Dementia: A MRI and FDG-PET Study

Amanzio, M., Palermo, S., Stanziano, M., D’Agata, F., Galati, A., Gentile, S., Castellano, G., Bartoli, M., Cipriani, G. E., Rubino, E., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.637796 · Cited by 15 · see citing works

Frailty among older patients receiving home care services

Krogseth, M., Rostoft, S., Benth, J. Š., Selbæk, G., & Wyller, T. B. (2021) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.20.0688 · Cited by 15 · see citing works

Inflammation, a Common Mechanism in Frailty and COVID-19, and Stem Cells as a Therapeutic Approach

Becerra, J., & Durán, I. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.21-0074 · Cited by 13 · see citing works

Protective Effects of APOE ε2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study

Dyk, K. V., Zhou, X., Small, B. J., Ahn, J., Zhai, W., Ahles, T. A., Graham, D. M. A., Jacobsen, P. B., Jim, H., McDonald, B. C., et al. (2021) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkab013 · Cited by 14 · see citing works

Aging in Adult Survivors of Childhood Cancer: Implications for Future Care

Schuitema, I., Alexander, T. C., Hudson, M. M., Krull, K. R., & Edelstein, K. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.02534 · Cited by 13 · see citing works

Epidemiological status and associated factors of frailty and pre-frailty in older adults with asthma in China: A national cross-sectional study

Zeng, X., Meng, L., Jia, N., Shi, J. C., Zhang, C., Li, Y., Hu, X., Hu, J.-B., Li, J., Wu, D., et al. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1136135 · Cited by 13 · see citing works

COVID-19 related mortality in older adults: analysis of the first wave in Colombia and Mexico

Pérez‐Zepeda, M. U., Campos-Fajardo, S., & Cano, C. A. (2021) · Revista Panamericana de Salud Pública · doi:10.26633/rpsp.2021.109 · Cited by 13 · see citing works

Frailty in Long-Term Prostate Cancer Survivors and Its Association With Quality of Life and Emotional Health

Meissner, V. H., Imhof, K., Jahnen, M., Lunger, L., Dinkel, A., Schiele, S., Ankerst, D. P., Gschwend, J. E., & Herkommer, K. (2024) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2024.7066 · Cited by 12 · see citing works

DNA Damage in Circulating Hematopoietic Progenitor Stem Cells as Promising Biological Sensor of Frailty

Grasselli, C., Bombelli, S., Eriani, S., Domenici, G., Galluccio, R., Tropeano, C., Marco, S. D., Bolognesi, M. M., Torsello, B., Bianchi, C., et al. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac034 · Cited by 12 · see citing works

Association between major discrimination and deficit accumulation in African American cancer survivors: The Detroit Research on Cancer Survivors Study

Mandelblatt, J. S., Ruterbusch, J. J., Thompson, H. S., Zhou, X., Bethea, T. N., Adams-Campbell, L. L., Purrington, K. S., & Schwartz, A. G. (2023) · Cancer · doi:10.1002/cncr.34673 · Cited by 12 · see citing works

Frailty as a comprehensive health measure beyond seizure control in patients with epilepsy: A cross‐sectional study

Irelli, E. C., Borioni, M. S., Morano, A., Mazzeo, A., Moro, P., Orlando, B., Salamone, E. M., Giordano, L., Petrungaro, A., Blasi, M. T., et al. (2024) · Epilepsia · doi:10.1111/epi.17964 · Cited by 12 · see citing works

Preclinical Studies on the Effects of Frailty in the Aging Heart

Rose, R. A., & Howlett, S. E. (2024) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2024.03.003 · Cited by 11 · see citing works

Risk stratification for frailty, impairment and assessment of sleep disorders in community-dwelling older adults

Ribeiro, B. C., Silva, A. D. A. C. E., de Souza, L. B. R., Moraes, J. B. D. A., Carneiro, S. R., & Neves, L. M. T. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112370 · Cited by 10 · see citing works

Frailty Predicts Dementia and Death in Older Adults Living in Long-Term Care

Song, X., Greeley, B., Low, H., & McDermid, R. C. (2024) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2024.03.118 · Cited by 10 · see citing works

Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels

Tveit, K., Hermann, M., Waade, R. B., Nilsen, R. M., Wallerstedt, S. M., & Molden, E. (2020) · Drugs & Aging · doi:10.1007/s40266-020-00784-9 · Cited by 10 · see citing works

Frailty in older people living in Africa: A systematic review of prevalence and associated factors

Kasa, A. S., Lee, S., & Chang, H. (2024) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2024.100078 · Cited by 9 · see citing works

Impact of Pre-Stroke Frailty on Outcome Three Years after Acute Stroke: The Nor-COAST Study

Munthe‐Kaas, R., Lydersen, S., Quinn, T., Aam, S., Pendlebury, S. T., & Ihle‐Hansen, H. (2024) · Cerebrovascular Diseases · doi:10.1159/000541565 · Cited by 9 · see citing works

Blood biomarkers of frailty and cognition: A scoping review

Hodgins, M. L., Maxwell, S. P., Howlett, S. E., & Rockwood, K. J. (2026) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2026.01.003 · Cited by 10 · see citing works

A simple test‐based frailty index to predict survival among cancer patients with an unplanned hospitalization: An observational cohort study

Hembree, T. N., Theou, O., Thirlwell, S., Reich, R. R., Cao, B., Sehovic, M., Syed, M., Verma, N., Nguyen, T., Keerty, D., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.4107 · Cited by 9 · see citing works

Data-driven health deficit assessment improves a frailty index’s prediction of current cognitive status and future conversion to dementia: results from ADNI

Engvig, A., Maglanoc, L. A., Doan, N. T., Westlye, L. T., & Initiative, A. D. N. (2022) · GeroScience · doi:10.1007/s11357-022-00669-2 · Cited by 10 · see citing works

The Importance of Complementary Collaboration of Researchers, Veterinarians, and Husbandry Staff in the Successful Training of Marmoset Behavioral Assays

Murai, T., & Rizzo, S. J. S. (2020) · ILAR Journal · doi:10.1093/ilar/ilaa024 · Cited by 8 · see citing works

Human Metapneumovirus Epidemiology Among Middle-aged and Older Adults Hospitalized With Acute Respiratory Infection

Pott, H., LeBlanc, J. J., ElSherif, M. S., Hatchette, T. F., Andrew, M. K., & McNeil, S. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf083 · Cited by 7 · see citing works

Sex-specific effects of frailty on cardiac structure and function: insights from preclinical models

Bisset, E. S., & Howlett, S. E. (2024) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2024-0009 · Cited by 7 · see citing works

The association between olfactory subdomains and frailty: A prospective case‒control study investigation

Cheng, M. Z., Vohra, V., Wang, H., Katuri, A., Langdon, J. M., Xue, Q., & Rowan, N. R. (2024) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23398 · Cited by 7 · see citing works

Preclinical models of frailty: Focus on interventions and their translational impact: A review

Mishra, M., & Howlett, S. E. (2020) · Nutrition and Healthy Aging · doi:10.3233/nha-200103 · Cited by 7 · see citing works

Professional home care providers' conceptualisations of frailty in the context of home care: A focus group study

Voie, K. S., Blix, B. H., Helgesen, A. K., Larsen, T. A., & Mæhre, K. S. (2022) · International Journal of Older People Nursing · doi:10.1111/opn.12511 · Cited by 7 · see citing works

Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing

Tirkkonen, A., Mak, J. K. L., Eriksson, J. G., Halonen, P., Jylhävä, J., Hägg, S., Enroth, L., Raitanen, J. A., Hovatta, I., Jääskeläinen, T., et al. (2025) · Age and Ageing · doi:10.1093/ageing/afaf075 · Cited by 6 · see citing works

Risk prediction model of frailty and its associated factors in older adults: a cross-sectional study in Anhui Province, China

Xu, Q., Liu, H., Tao, X., Zhou, Z. E., Mei, G., Zhang, M., & Zou, S. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1611914 · Cited by 6 · see citing works

The Parallel Mediation Effects of Depression, Well-Being, and Social Activity on Physical Performance and Frailty in Community-Dwelling Middle-Aged and Older People

Tallutondok, E. B., Hsieh, C., & Li, P.-S. (2022) · Current Gerontology and Geriatrics Research · doi:10.1155/2022/7979006 · Cited by 6 · see citing works

Conceptual Models of Frailty: Accumulation of Deficits

Rockwood, K. J. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.03.020 · Cited by 118 · see citing works

Ageing

Heemels, M.-T. (2010) · Nature · doi:10.1038/464503a · Cited by 12 · see citing works

A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice

Rockwood, K. J., Blodgett, J. M., Theou, O., Sun, M., Feridooni, H. A., Mitnitski, A., Rose, R. A., Godin, J., Gregson, E., & Howlett, S. E. (2017) · Scientific Reports · doi:10.1038/srep43068 · Cited by 237 · see citing works

The Accumulation of Deficits with Age and Possible Invariants of Aging

Mitnitski, A. B., Mogilner, A. J., MacKnight, C., & Rockwood, K. J. (2002) · The Scientific World JOURNAL · doi:10.1100/tsw.2002.861 · Cited by 175 · see citing works

USING A FRAILTY INDEX BASED ON DEFICIT ACCUMULATION

Rockwood, K. J. (2017) · Innovation in Aging · doi:10.1093/geroni/igx004.4834