Biodegradation and biotransformation of organofluorine compounds
Abstract
The carbon-fluorine bond is one of the strongest in nature, and the increasing use of organofluorine compounds in agriculture, human and veterinary medicine, and industry has raised concerns about their fate in the environment. Microorganisms can degrade organofluorine compounds, either via specific enzymatic hydrolysis of the C-F bond, or through transformation by catabolic enzymes with broad substrate specificities. Here our current understanding of organofluorine catabolism in microorganisms is summarised.
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FAcD has been isolated from Pseudomonas sp. strain A., P. fluorescens, Deftia acidovorans, Burkholderia sp. FA1, Rhodopseudomonas palustris CGA009, Synergistetes strain MFA1 and Moraxella.
“FAcDhas been isolated fromPseudomo- nas sp. strain A., P. fluorescens, Deftia acidovorans, Burkholderia sp. FA1, Rhodopseudomonas palustris CGA009, Synergistetes strain MFA1 and Moraxella (Goldman, 1965; Leong et al., 2016, 2017; Murphy, 2010; Seong et al., 2019).”
From A review of microbial degradation of per- and polyfluoroalkyl substances (PFAS): Biotransformation routes and enzymes (2023) · cites this paper as Murphy, 2010
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- Authors
- Murphy, C. D.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Murphy, Cormac D.
- ORCID
- Murphy, Cormac D.
- Venue
- Biotechnology Letters
- Published
- 2009-11-27
- Volume
- 32
- Issue
- 3
- Pages
- 351-359
- ISSN
- 0141-5492 (ISSN-L)
- 1573-6776
- OpenAlex
- W2005841943
- Cited by
- 93
- References
- 69
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 8 · 2012: 4
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biotechnology Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Pollution › Microbial bioremediation and biosurfactants
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Keywords
- organofluorine compounds, biodegradation, biotransformation, carbon-fluorine bond, microbial catabolism, catabolic enzymes, environmental fate, fluorinated pesticides, fluorinated drugs
- MeSH terms
- Biodegradation, Environmental, Biotransformation, Enzymes, Fluorine, Humans, Magnetic Resonance Spectroscopy, Organic Chemicals
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