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Cited by 164Cancer survivorship and careLymphatic System and DiseasesBreast Cancer Treatment Studies

Safety and efficacy of progressive resistance training in breast cancer: a systematic review and meta-analysis

Cheema, Birinder S., Kilbreath, Sharon L., Fahey, Paul P., Delaney, Geoffrey P., Atlantis, Evan·2014·Breast Cancer Research and Treatment
DOI 10.1007/s10549-014-3162-9
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Abstract

The purpose of this study was to assess the safety and efficacy of progressive resistance training (PRT) in breast cancer. Randomized controlled trials (RCTs) published to November 2013 that reported on the effects of PRT (>6 weeks) on breast cancer-related lymphedema (BCRL) (incidence/exacerbation, arm volume, and symptom severity), physical functioning (upper and lower body muscular strength), and health-related quality of life (HRQoL) in breast cancer patients were included. Of 446 citations retrieved, 15 RCTs in 1,652 patients were included and yielded five studies on BCRL incidence/exacerbation (N = 647), four studies on arm volume (N = 384) and BCRL symptom severity (N = 479), 11 studies on upper body muscular strength (N = 1,252), nine studies on lower body muscular strength (N = 1,079), and seven studies on HRQoL (N = 823). PRT reduced the risk of BCRL versus control conditions [OR = 0.53 (95% CI 0.31-0.90); I2 = 0%] and did not worsen arm volume or symptom severity (both SMD = -0.07). PRT significantly improved upper [SMD = 0.57 (95% CI 0.37-0.76); I2 = 58.4%] and lower body muscular strength [SMD = 0.48 (95% CI 0.30-0.67); I2 = 46.7%] but not HRQoL [SMD = 0.17 (95% CI -0.03 to 0.38); I2 = 47.0%]. The effect of PRT on HRQoL became significant in our sensitivity analysis when two studies conducted during adjuvant chemotherapy [SMD = 0.30 (95% CI 0.04-0.55), I2 = 37.0%] were excluded. These data indicate that PRT improves physical functioning and reduces the risk of BCRL. Clinical practice guidelines should be updated to inform clinicians on the benefits of PRT in this cohort.

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  • Research supports that cancer survivors can respond positively to exercise training by improving cardiorespiratory fitness, muscular strength and endurance, and body composition.

    “Research to date supports the potential of cancer survivors to respond positively to an exercise training stimulus by improving individual components of physical fitness, including cardiorespiratory fitness (i.e., VO2peak)(86), muscular strength and endurance(87, 88), body composition(89).”

    From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [88]

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Authors
Cheema, B. S., Kilbreath, S. L., Fahey, P. P., Delaney, G. P., & Atlantis, E.
Affiliations
  • Western Sydney University (AU)
  • The University of Sydney (AU)
  • The University of Adelaide (AU)
Corresponding author
Cheema, Birinder S.
ORCID
Venue
Breast Cancer Research and Treatment
Publisher
Springer Science and Business Media LLC
Published
2014-10-17
Volume
148
Issue
2
Pages
249-268
ISSN
  • 0167-6806 (ISSN-L)
  • 1573-7217
DOI
10.1007/s10549-014-3162-9
OpenAlex
W2078213544
Cited by
164
References
71
Citations by year
2026: 7 · 2025: 11 · 2024: 20 · 2023: 7 · 2022: 16 · 2021: 16 · 2020: 12 · 2019: 23 · 2018: 13 · 2017: 21 · 2016: 13 · 2015: 5
FWCI
1.47
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Breast Cancer Research and Treatment (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders
U.S. National Library of Medicine
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
progressive resistance training, breast cancer, breast cancer-related lymphedema, arm volume, muscle strength, physical function, health-related quality of life, exercise safety, adjuvant chemotherapy, exercise recommendations
MeSH terms
Breast Neoplasms, Exercise Therapy, Female, Humans, Quality of Life, Safety, Randomized Controlled Trials as Topic, Resistance Training

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