Estimation of the Potential Antitumor Activity of Microencapsulated Lactobacillus acidophilus Yogurt Formulation in the Attenuation of Tumorigenesis in Apc(Min/+) Mice

Urbanska, Aleksandra Malgorzata; Bhathena, Jasmine; Martoni, Christopher; Prakash, Satya

doi:10.1007/s10620-008-0363-2

Cited by 80Probiotics and Fermented FoodsCancer Research and TreatmentsGut microbiota and health

Estimation of the Potential Antitumor Activity of Microencapsulated Lactobacillus acidophilus Yogurt Formulation in the Attenuation of Tumorigenesis in Apc(Min/+) Mice

Urbanska, Aleksandra Malgorzata, Bhathena, Jasmine, Martoni, Christopher, Prakash, Satya·2009·Digestive Diseases and Sciences

DOI 10.1007/s10620-008-0363-2

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Abstract

There is a strong correlation between orally administered probiotics and suppression of the low-grade inflammation that can lead to restoration of normal local immune functions. We studied the potential immunomodulatory and antitumorigenic properties of microencapsulated probiotic bacterial cells in a yogurt formulation in Min mice carrying a germline APC mutation. Daily oral administration of microencapsulated Lactobacillus acidophilus bacterial cells in the yogurt formulation mice resulted in significant suppression of colon tumor incidence, tumor multiplicity, and reduced tumor size. Results show that oral administration of microencapsulated L. acidophilus contributed to the stabilization of animal body weight and decreased the release of bile acids. Histopathological analyses revealed fewer adenomas in treated versus untreated animals. Furthermore, treated animals exhibited fewer gastrointestinal intra-epithelial neoplasias with a lower grade of dysplasia in detected tumors. Results suggest that oral administration of microencapsulated probiotic L. acidophilus exerts anti-tumorous activity, which consequently leads to reduced tumor outcome.

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Animal studies suggest that fermented milk might augment probiotic functionality when compared to water or saline carriers.
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A novel microencapsulated probiotic yogurt formulation for oral delivery in the suppression of intestinal tumorigenesis in «Apc»Min mice
Urbanska, A. M. (2009) · doi:10.82308/6885
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Orally delivered microencapsulated probiotic formulation favorably impacts polyp formation in APC (Min/+) model of intestinal carcinogenesis
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Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation
Urbanska, A. M., Paul, A., Bhahena, J., & Prakash, S. (2010) · International Journal of Inflammation · doi:10.4061/2010/894972 · Cited by 26 · see citing works
Self-citation
Research Article Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of
Probiotic, M., Formulation, Y., Urbanska, A. M., Paul, A., Bhahena, J., & Prakash, S. (2013)
Self-citation
Design and validation of an orally administrated active L. fermentum-L. acidophilus probiotic formulation using colorectal cancer Apc Min/+ mouse model
Kahouli, I., Malhotra, M., Westfall, S., Alaoui‐Jamali, M. A., & Prakash, S. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7885-x · Cited by 79 · see citing works
Self-citation

Authors: Urbanska, A. M., Bhathena, J., Martoni, C., & Prakash, S.
Affiliations: McGill University (CA)
Corresponding author: Prakash, Satya
ORCID: Martoni, Christopher
Prakash, Satya
Venue: Digestive Diseases and Sciences
Publisher: Springer Science and Business Media LLC
Published: 2008-07-17
Volume: 54
Issue: 2
Pages: 264-273
ISSN: 0163-2116 (ISSN-L)
1573-2568
DOI: 10.1007/s10620-008-0363-2
OpenAlex: W2066812881
Cited by: 80
References: 55
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 5 · 2012: 5
FWCI: 6.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Digestive Diseases and Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: Lactobacillus acidophilus, probiotics, microencapsulation, yogurt formulation, ApcMin/+ mice, colon cancer, tumor suppression, immunomodulation, bile acids, intestinal dysplasia, adenoma, low-grade inflammation
MeSH terms: Adenoma, Animals, Bile Acids and Salts, Body Weight, Colon, Drug Compounding, Feces, Lactobacillus acidophilus, Male, Mice, Inbred C57BL, Occult Blood, Yogurt, Colorectal Neoplasms, Interleukin-6, Genes, APC, Probiotics, Mice

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Estimation of the Potential Antitumor Activity of Microencapsulated Lactobacillus acidophilus Yogurt Formulation in the Attenuation of Tumorigenesis in Apc(Min/+) Mice

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