Cited by 178Probiotics and Fermented FoodsAntibiotic Resistance in BacteriaBacterial Genetics and Biotechnology

A critical review of antibiotic resistance in probiotic bacteria

Li, Ting, Teng, Da, Mao, Ruoyu, Hao, Ya, Wang, Xiumin, Wang, Jianhua·2020·Food Research International

Abstract

Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit upon the host. At present, probiotics are gaining popularity worldwide and are widely used in food and medicine. Consumption of probiotics is increasing with further in-depth research on the relationship between intestinal flora and host health. Most people pay more attention to the function of probiotics but ignore their potential risks, such as infection and antibiotic resistance transfer to pathogenic microbes. Physiological functions, effects and mechanisms of action of probiotics were covered in this review, as well as the antibiotic resistance phenotypes, mechanisms and genes found in probiotics. Typical cases of antibiotic resistance of probiotics were also highlighted, as well as the potential risks (including pathogenicity, infectivity and excessive immune response) and corresponding strategies (dosage, formulation, and administration route). This timely study provides an avenue for further research, development and application of probiotics.

Integrity signals

Registry

Crossref · 10.1016/j.foodres.2020.109571

Cites

254 of 254 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

1 of the 255 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Li, T., Teng, D., Mao, R., Hao, Y., Wang, X., & Wang, J.
Affiliations
Chinese Academy of Agricultural Sciences (CN)
Corresponding author
  • Wang, Xiumin
  • Wang, Jianhua
Venue
Food Research International
Publisher
Elsevier BV
Published
2020-10
Volume
136
Pages
109571
ISSN
0963-9969 (ISSN-L)
OpenAlex
W3043165925
Cited by
172
References
255
Citations by year
2026: 29 · 2025: 36 · 2024: 37 · 2023: 23 · 2022: 32 · 2021: 13 · 2020: 2
FWCI
1.48
Type
journal article
Language
en
Open access
closed
Locations
  • Food Research International (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Chinese Academy of Agricultural Sciences
  • National Natural Science Foundation of China
  • Ministry of Science and Technology of the People's Republic of China
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
probiotics, antibiotic resistance, probiotic bacteria, antibiotic resistance genes, horizontal gene transfer, pathogenicity, immune response, route of administration, gut microbiota, health benefits
MeSH terms
Gastrointestinal Microbiome, Bacteria, Drug Resistance, Microbial, Probiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review