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The Generation R Study Biobank: a resource for epidemiological studies in children and their parents
Open accessAbstract
The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. In total, 9,778 mothers were enrolled in the study. Prenatal and postnatal data collection is conducted by physical examinations, questionnaires, interviews, ultrasound examinations and biological samples. Major efforts have been conducted for collecting biological specimens including DNA, blood for phenotypes and urine samples. In this paper, the collection, processing and storage of these biological specimens are described. Together with detailed phenotype measurements, these biological specimens form a unique resource for epidemiological studies focused on environmental exposures, genetic determinants and their interactions in relation to growth, health and development from fetal life onwards.
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Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
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Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
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(2007) · New England Journal of Medicine · doi:10.1056/nejmoa073493 · Cited by 1,746
Cited by
The Generation R Study: design and cohort update 2010
Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9516-7 · Cited by 1,027
Self-citationProlonged and Exclusive Breastfeeding Reduces the Risk of Infectious Diseases in Infancy
Duijts, L., Jaddoe, V. W. V., Hofman, A., & Moll, H. A. (2010) · Pediatrics · doi:10.1542/peds.2008-3256 · Cited by 682
Self-citationThe Generation R Study: Design and cohort update 2012
Jaddoe, V. W. V., van Duijn, C. M., Franco, O. H., van der Heijden, A. J., van IIzendoorn, M. H., de Jongste, J. C., van der Lugt, A., Mackenbach, J. P., Moll, H. A., Raat, H., et al. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9735-1 · Cited by 546
Ye, X., Pierik, F. H., Hauser, R., Duty, S., Angerer, J., Park, M. M., Burdorf, A., Hofman, A., Jaddoe, V. W. V., Mackenbach, J. P., et al. (2008) · Environmental Research · doi:10.1016/j.envres.2008.07.014 · Cited by 307
Self-citationCousminer, D. L., Berry, D. J., Timpson, N. J., Ang, W., Thiering, E., Byrne, E. M., Taal, H. R., Huikari, V., Bradfield, J. P., Kerkhof, M., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt104 · Cited by 209
Self-citationThe Odense Child Cohort: Aims, Design, and Cohort Profile
Kyhl, H. B., Jensen, T. K., Barington, T., Buhl, S., Norberg, L. A., Jørgensen, J. S., Jensen, D. F. G., Christesen, H. T., Lamont, R. F., & Husby, S. (2015) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12183 · Cited by 166
Bakker, R., Steegers, E. A., Obradov, A., Raat, H., Hofman, A., & Jaddoe, V. W. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28792 · Cited by 144
Luijk, M. P. C. M., Saridjan, N., Tharner, A., van IJzendoorn, M. H., Bakermans‐Kranenburg, M. J., Jaddoe, V. W. V., Hofman, A., Verhulst, F. C., & Tiemeier, H. (2010) · Developmental Psychobiology · doi:10.1002/dev.20446 · Cited by 135
Self-citationPaternal depressive symptoms during pregnancy are related to excessive infant crying
van den Berg, M. P., van der Ende, J., Crijnen, A. A. M., Jaddoe, V. W. V., Moll, H. A., Mackenbach, J. P., Hofman, A., Hengeveld, M. W., Tiemeier, H., & Verhulst, F. C. (2009) · Pediatrics · doi:10.1542/peds.2008-3100 · Cited by 127
Self-citationLow-educated women have an increased risk of gestational diabetes mellitus: the Generation R Study
Bouthoorn, S. H., Silva, L. M., Murray, S. E., Steegers, E. A. P., Jaddoe, V. W. V., Moll, H., Hofman, A., Mackenbach, J. P., & Raat, H. (2015) · Acta Diabetologica · doi:10.1007/s00592-014-0668-x · Cited by 110
Self-citationStergiakouli, E., Gaillard, R., Tavaré, J. M., Balthasar, N., Loos, R. J., Taal, H. R., Evans, D. M., Rivadeneira, F., St Pourcain, B., Uitterlinden, A. G., et al. (2014) · Obesity · doi:10.1002/oby.20840 · Cited by 90
Self-citationFetal Exposure to Maternal and Paternal Smoking and the Risks of Wheezing in Preschool Children
Duijts, L., Jaddoe, V. W. V., van der Valk, R. J. P., Henderson, J. A., Hofman, A., Raat, H., Steegers, E. A. P., Moll, H. A., & de Jongste, J. C. (2012) · Chest · doi:10.1378/chest.11-0112 · Cited by 73
Self-citationTobacco Smoke Exposure, Airway Resistance, and Asthma in School-age Children
den Dekker, H. T., Voort, A. M. M. S.-V. D., de Jongste, J. C., Reiss, I. K., Hofman, A., Jaddoe, V. W. V., & Duijts, L. (2015) · CHEST · doi:10.1378/chest.14-1520 · Cited by 65
Self-citationMaternal Folate Levels during Pregnancy and Offspring Brain Development in Late Childhood
Zou, R., El Marroun, H., Cecil, C., Jaddoe, V. W. V., Hillegers, M., Tiemeier, H., & White, T. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.11.025 · Cited by 44
Self-citationHerba, C. M., Roza, S. J., Govaert, P., van Rossum, J., Hofman, A., Jaddoe, V., Verhulst, F. C., & Tiemeier, H. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.07.003 · Cited by 24
Self-citationSuleri, A., Blok, E., Durkut, M., Rommel, A.-S., Witte, L. D., Jaddoe, V., Bergink, V., & White, T. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.03.018 · Cited by 18
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Metadata
- Authors
- Jaddoe, V. W. V., Bakker, R., van Duijn, C. M., van der Heijden, A. J., Lindemans, J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A.
- Venue
- European Journal of Epidemiology
- Published
- 2007-12
- Volume
- 22
- Issue
- 12
- Pages
- 917-923
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- OpenAlex
- W2020723040
- Cited by
- 250
- References
- 3
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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