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The Generation R Study: design and cohort update 2010
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The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
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“The tools that we have for measuring brain functioning and connectivity are growing, but only recently sizeable multimodal normative brain developmental data have become available, with large prospective studies ongoing in Rotterdam (68), San Diego (69) and Philadelphia (70).”
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Self-citationAl‐Hassany, L., Wahab, R. J., Steegers, E. A. P., Jaddoe, V. W. V., & Gaillard, R. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.07.040 · Cited by 7
Self-citationThe experience of life events and body composition in middle childhood: a population-based study
Derks, I. P. M., Hannani, S., Vehmeijer, F. O. L., Tiemeier, H. W., & Jansen, P. W. (2021) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-021-01188-7 · Cited by 6
Self-citationSocioeconomic inequalities in placental vascular resistance: a prospective cohort study
Bouthoorn, S. H., van Lenthe, F. J., Gaillard, R., Albert Hofman, D., Steegers, E. A. P., Jaddoe, V. W. V., & Raat, H. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.02.001 · Cited by 6
Self-citationDeciduous molar hypomineralisation, its nature and nurture
Elfrink, M. E. C. (2012) · UvA-DARE (University of Amsterdam) · Cited by 6
Reducing behavior problems in children born after an unintended pregnancy: the generation R study
Enthoven, C. A., Labrecque, J. A., Koopman‐Verhoeff, M. E., den Berg, M. P. L., Hillegers, M. H. J., Marroun, H. E., & Jansen, P. W. (2024) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-024-02693-3 · Cited by 5
A genome-wide scan of non-coding RNAs and enhancers for refractive error and myopia
Tedja, M. S., Swierkowska, J., Enthoven, C. A., Meester‐Smoor, M. A., Hysi, P. G., Felix, J. F., Cowan, C. S., Cherry, T. J., van der Spek, P. J., Ghanbari, M., et al. (2025) · Human Genetics · doi:10.1007/s00439-024-02721-x · Cited by 7
Kevenaar, S. T., Zondervan-Zwijnenburg, M. A. J., Blok, E., Schmengler, H., Fakkel, M., de Zeeuw, E. L., van Bergen, E., Onland‐Moret, N. C., Peeters, M., Hillegers, M. H. J., et al. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100904 · Cited by 5
Eijgermans, D. G. M., Raat, H., Jansen, P. W., van de Looij‐Jansen, P. M., Hillegers, M. H. J., & Jansen, W. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01737-2 · Cited by 5
Luo, M., Meehan, A. J., Walton, E., Röder, S. W., Herberth, G., Zenclussen, A. C., Cosín‐Tomás, M., Sunyer, J., Mulder, R. H., Hidalgo, A. P. C., et al. (2021) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32862 · Cited by 5
Self-citationHaan, E., Sallis, H., Ystrøm, E., Njølstad, P. R., Andreassen, O. A., Reichborn‐Kjennerud, T., Munafo, M. R., Havdahl, A., & Zuccolo, L. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14692 · Cited by 5
Blaauwendraad, S. M., Stevens, D. R., van den Dries, M. A., Gaillard, R., Pronk, A., Spaan, S., Ferguson, K. K., & Jaddoe, V. W. V. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12267 · Cited by 5
Self-citationSharkawy, M. E., Felix, J. F., Grote, V., Voortman, T., Jaddoe, V. W. V., Koletzko, B. V., & Küpers, L. K. (2024) · Epigenetics · doi:10.1080/15592294.2023.2299045 · Cited by 6
Self-citationTaal, H. R., van den Hil, L. C. L., Albert Hofman, D., van der Heijden, A. J., & Jaddoe, V. W. V. (2012) · Early Human Development · doi:10.1016/j.earlhumdev.2012.02.014 · Cited by 5
Self-citationInfluence of genetic variants for birth weight on fetal growth and placental haemodynamics
Vermeulen, M. J., Gaillard, R., Miliku, K., Reiss, I. K. M., Steegers, E. A. P., Jaddoe, V. W. V., & Felix, J. F. (2019) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2019-317044 · Cited by 5
Self-citationKooijman, M. N., Jaddoe, V. W. V., Steegers, E. A. P., & Gaillard, R. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.12.011 · Cited by 5
Self-citationPaping, D. E., Vroegop, J. L., le Clercq, C. M. P., de Jong, R. J. B., & van der Schroeff, M. P. (2021) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.529 · Cited by 5
Hu, C., Duijts, L., van Meel, E. R., Looman, K. I. M., Jong, J. C. K., Pardo, L. M., Hijnen, D., Pasmans, S. G. M. A., de Jongste, J. C., Moll, H. A., et al. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.13869 · Cited by 5
Self-citationWormer, J. R., Shankar, A., van Hensbroek, M. B., Hindori‐Mohangoo, A. D., Covert, H. H., Lichtveld, M. Y., & Zijlmans, W. C. W. R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182010739 · Cited by 5
You, Y., van Grieken, A., Estévez‐López, F., Yang‐Huang, J., & Raat, H. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2021.785054 · Cited by 5
Eijgermans, D. G. M., Boelens, M., Groeniger, J. O., van der Zanden, W. H. M., Jansen, P. W., Raat, H., & Jansen, W. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-057376 · Cited by 5
Body fat, pericardial fat, liver fat and arterial health at age 10 years
Monasso, G. S., Santos, S., Silva, C. C. V., Geurtsen, M. L., Oei, E. H. G., Gaillard, R., Felix, J. F., & Jaddoe, V. W. V. (2022) · Pediatric Obesity · doi:10.1111/ijpo.12926 · Cited by 5
Self-citationPatro-Gołąb, B., Voerman, E., van der Lugt, A., Santos, S., & Jaddoe, V. W. V. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0287-7 · Cited by 5
Self-citationEthnic background and children’s television viewing trajectories: The Generation R Study
Yang‐Huang, J., van Grieken, A., Wang, L., Jaddoe, V. W. V., Jansen, W., & Raat, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209375 · Cited by 5
Self-citationPENGEMBANGAN APLIKASI UNTUK PEMANTAUAN DAN EVALUASI PENDIDIKAN ANAK USIA DINI
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Childhood Adiposity Associated With Expanded Effector Memory CD8+ and Vδ2+Vγ9+ T Cells
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Self-citationDevelopmental cannabinoid exposure: New perspectives on outcomes and mechanisms
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Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure
Silva, C. C. V., Santos, S., Muetzel, R. L., Vernooij, M. W., van Rijn, B. B., Jaddoe, V. W. V., & Marroun, H. E. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026133 · Cited by 4
Self-citationHuizing, A., Welten, M., van der Pal, S. M., Schönbeck, Y., van Empelen, P., Gaillard, R., Jaddoe, V. W. V., & van Buuren, S. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-05661-1 · Cited by 4
Self-citationAttanasi, M., Mian, A., Karramass, T., & Duijts, L. (2025) · Pediatric Pulmonology · doi:10.1002/ppul.71227 · Cited by 4
Evidence on the effect of in-utero cannabis exposure in neonates
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Wiertsema, C. J., Wahab, R. J., Mulders, A. G. M. G. J., & Gaillard, R. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02670-5 · Cited by 4
Metadata
- Authors
- Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A.
- Affiliations
- Erasmus MC (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Corresponding author
- Jaddoe, Vincent W. V.
- ORCID
- Venue
- European Journal of Epidemiology
- Published
- 2010-10-22
- Volume
- 25
- Issue
- 11
- Pages
- 823-841
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- PMC
- PMC2991548
- OpenAlex
- W2157465110
- Cited by
- 1,027
- References
- 521
- Citations by year
- 2026: 5 · 2025: 22 · 2024: 46 · 2023: 60 · 2022: 73 · 2021: 98 · 2020: 119 · 2019: 91 · 2018: 66 · 2017: 69 · 2016: 62 · 2015: 74 · 2014: 61 · 2013: 59 · 2012: 76
- FWCI
- 51.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- European Journal of Epidemiology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- HAL (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- ZonMw (907.00303, ZonMw 90700303, 916.10159)
- Erasmus Universiteit Rotterdam
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (90700303, 916.10159)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
- Keywords
- Generation R Study, prospective cohort, prenatal exposure, fetal development, child growth, developmental origins of health and disease, epigenetics, microbiome, body composition, eye development, hearing, oral health, facial growth, respiratory health, allergy, skin diseases, genome-wide association study, cohort studies
- MeSH terms
- Adult, Child, Child Behavior, Child Development, Child, Preschool, Cognition, Environmental Exposure, Female, Health Status Indicators, Humans, Infant, Infant, Newborn, Interviews as Topic, Male, Maternal-Child Health Centers, Netherlands, Physical Examination, Pregnancy, Prenatal Care, Prospective Studies, Surveys and Questionnaires, Cohort Studies, Epidemiologic Research Design, Genetic Diseases, Inborn, Genome-Wide Association Study, Young Adult
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