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The Generation R Study: design and cohort update 2010
Open accessAbstract
The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
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“The tools that we have for measuring brain functioning and connectivity are growing, but only recently sizeable multimodal normative brain developmental data have become available, with large prospective studies ongoing in Rotterdam (68), San Diego (69) and Philadelphia (70).”
From Pediatric psychopharmacology: Too much or too little? (2013) · cites this paper as [68]
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Self-citation
Metadata
- Authors
- Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A.
- Affiliations
- Erasmus MC (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Corresponding author
- Jaddoe, Vincent W. V.
- ORCID
- Venue
- European Journal of Epidemiology
- Published
- 2010-10-22
- Volume
- 25
- Issue
- 11
- Pages
- 823-841
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- PMC
- PMC2991548
- OpenAlex
- W2157465110
- Cited by
- 1,027
- References
- 521
- Citations by year
- 2026: 5 · 2025: 22 · 2024: 46 · 2023: 60 · 2022: 73 · 2021: 98 · 2020: 119 · 2019: 91 · 2018: 66 · 2017: 69 · 2016: 62 · 2015: 74 · 2014: 61 · 2013: 59 · 2012: 76
- FWCI
- 51.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- European Journal of Epidemiology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- HAL (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- ZonMw (907.00303, ZonMw 90700303, 916.10159)
- Erasmus Universiteit Rotterdam
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (90700303, 916.10159)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
- Keywords
- Generation R Study, prospective cohort, prenatal exposure, fetal development, child growth, developmental origins of health and disease, epigenetics, microbiome, body composition, eye development, hearing, oral health, facial growth, respiratory health, allergy, skin diseases, genome-wide association study, cohort studies
- MeSH terms
- Adult, Child, Child Behavior, Child Development, Child, Preschool, Cognition, Environmental Exposure, Female, Health Status Indicators, Humans, Infant, Infant, Newborn, Interviews as Topic, Male, Maternal-Child Health Centers, Netherlands, Physical Examination, Pregnancy, Prenatal Care, Prospective Studies, Surveys and Questionnaires, Cohort Studies, Epidemiologic Research Design, Genetic Diseases, Inborn, Genome-Wide Association Study, Young Adult
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