Cited by 1,027Birth, Development, and HealthHealth, Environment, Cognitive AgingMaternal and Neonatal Healthcare

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The Generation R Study: design and cohort update 2010

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Jaddoe, Vincent W. V., van Duijn, Cock M., van der Heijden, Albert J., Mackenbach, Johan P., Moll, Henriëtte A., Steegers, Eric A. P., Tiemeier, Henning, Uitterlinden, Andre G., Verhulst, Frank C., Hofman, Albert·2010·European Journal of Epidemiology

DOI 10.1007/s10654-010-9516-7PMC PMC2991548

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Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

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Fig. 1 Enrolment and measurements until the age of 4 yearsCC BY-NC · PubMed Central

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Authors: Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A.
Affiliations: Erasmus MC (NL)
Erasmus MC - Sophia Children’s Hospital (NL)
Corresponding author: Jaddoe, Vincent W. V.
ORCID: Jaddoe, Vincent W. V.
Mackenbach, Johan P.
Moll, Henriëtte A.
Steegers, Eric A. P.
Tiemeier, Henning
Verhulst, Frank C.
Venue: European Journal of Epidemiology
Publisher: Springer Science and Business Media LLC
Published: 2010-10-22
Volume: 25
Issue: 11
Pages: 823-841
ISSN: 0393-2990 (ISSN-L)
1573-7284
DOI: 10.1007/s10654-010-9516-7
PMC: PMC2991548
OpenAlex: W2157465110
Cited by: 1,027
References: 521
Citations by year: 2026: 5 · 2025: 22 · 2024: 46 · 2023: 60 · 2022: 73 · 2021: 98 · 2020: 119 · 2019: 91 · 2018: 66 · 2017: 69 · 2016: 62 · 2015: 74 · 2014: 61 · 2013: 59 · 2012: 76
FWCI: 51.31
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: European Journal of Epidemiology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
HAL (submittedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders: ZonMw (907.00303, ZonMw 90700303, 916.10159)
Erasmus Universiteit Rotterdam
Erasmus Medisch Centrum
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (90700303, 916.10159)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
Keywords: Generation R Study, prospective cohort, prenatal exposure, fetal development, child growth, developmental origins of health and disease, epigenetics, microbiome, body composition, eye development, hearing, oral health, facial growth, respiratory health, allergy, skin diseases, genome-wide association study, cohort studies
MeSH terms: Adult, Child, Child Behavior, Child Development, Child, Preschool, Cognition, Environmental Exposure, Female, Health Status Indicators, Humans, Infant, Infant, Newborn, Interviews as Topic, Male, Maternal-Child Health Centers, Netherlands, Physical Examination, Pregnancy, Prenatal Care, Prospective Studies, Surveys and Questionnaires, Cohort Studies, Epidemiologic Research Design, Genetic Diseases, Inborn, Genome-Wide Association Study, Young Adult

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