The Generation R Study: design and cohort update 2010

QIIME allows analysis of high-throughput community sequencing data

Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887

Untitled work

(1992) · PubMed · Cited by 33,716

The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection

Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033

UPARSE: highly accurate OTU sequences from microbial amplicon reads

Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,770

The Strengths and Difficulties Questionnaire: A research note

Goodman, R. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01545.x · Cited by 14,908

Detection of Postnatal Depression: Development of the 10-item Edinburgh Postnatal Depression Scale

Cox, J. L., Holden, J. M., & Sagovsky, R. (1987) · British Journal of Psychiatry · doi:10.1192/bjp.150.6.782 · Cited by 14,183

Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data

KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148

Untitled work

(1991) · Medical Entomology and Zoology · Cited by 8,071

Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities

Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,633

The brief symptom inventory: an introductory report.

Derogatis, L. R., & Melisaratos, N. (1983) · Psychological Medicine · doi:10.1017/s0033291700048017 · Cited by 6,650

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

Middeldorp, C. M., Hammerschlag, A. R., Ouwens, K. G., Groen‐Blokhuis, M. M., Pourcain, B. S., Greven, C. U., Pappa, I., Tiesler, C. M. T., Ang, W., Nolte, I. M., et al. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.05.025 · Cited by 129

It's the mother!: How assumptions about the causal primacy of maternal effects influence research on the developmental origins of health and disease

Sharp, G. C., Lawlor, D. A., & Richardson, S. S. (2018) · Social Science & Medicine · doi:10.1016/j.socscimed.2018.07.035 · Cited by 128

Vitamin D Deficiency in School-Age Children Is Associated with Sociodemographic and Lifestyle Factors

Voortman, T., van den Hooven, E. H., Heijboer, A. C., Albert Hofman, D., Jaddoe, V. W. V., & Franco, O. H. (2015) · Journal of Nutrition · doi:10.3945/jn.114.208280 · Cited by 128

Maternal Sensitivity and Internalizing Problems: Evidence from Two Longitudinal Studies in Early Childhood

Kok, R., Linting, M., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., & Tiemeier, H. W. (2013) · Child Psychiatry & Human Development · doi:10.1007/s10578-013-0369-7 · Cited by 150

Osteoporosis and Bone Mass Disorders: From Gene Pathways to Treatments

Rivadeneira, F., & Mäkitie, O. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.006 · Cited by 124

Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns

Kazmi, N., Sharp, G. C., Reese, S. E., Vehmeijer, F. O. L., Lahti, J. M. T., Page, C. M., Zhang, W., Rifas‐Shiman, S. L., Rezwan, F. I., Simpkin, A. J., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.12634 · Cited by 126

Pediatric population-based neuroimaging and the Generation R Study: the intersection of developmental neuroscience and epidemiology

White, T. J. H., Marroun, H. E., Nijs, I. M. T., Schmidt, M., van der Lugt, A., Wielopolki, P. A., Jaddoe, V. W. V., Albert Hofman, D., Krestin, G. P., Tiemeier, H. W., et al. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-013-9768-0 · Cited by 124

Intergenerational transmission: Theoretical and methodological issues and an introduction to four Dutch cohorts

Branje, S., Geeraerts, S. B., de Zeeuw, E. L., Oerlemans, A. M., Koopman‐Verhoeff, M. E., Schulz, S., Nelemans, S. A., Meeus, W., Hartman, C. A., Hillegers, M. H. J., et al. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100835 · Cited by 140

Prenatal exposure to selective serotonin reuptake inhibitors and social responsiveness symptoms of autism: Population-based study of young children

Marroun, H. E., White, T. J. H., van der Knaap, N. J. F., Homberg, J. R., Fernández, G., Schoemaker, N. K., Jaddoe, V. W. V., Hofman, A., Verhulst, F. C., Hudziak, J. J., et al. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.127746 · Cited by 117

Connectivity dynamics in typical development and its relationship to autistic traits and autism spectrum disorder

Rashid, B., Blanken, L. M. E., Muetzel, R. L., Miller, R., Damaraju, E., Arbabshirani, M. R., Erhardt, E. B., Verhulst, F. C., van der Lugt, A., Jaddoe, V. W. V., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24064 · Cited by 120

Small and large size for gestational age at birth, infant growth, and childhood overweight

Taal, H. R., van der Heijden, A. J., Steegers, E. A. P., Albert Hofman, D., & Jaddoe, V. W. V. (2013) · Obesity · doi:10.1002/oby.20116 · Cited by 121

The Generation R Study: A Review of Design, Findings to Date, and a Study of the 5-HTTLPR by Environmental Interaction From Fetal Life Onward

Tiemeier, H. W., Velders, F. P., Székely, E., Roza, S. J., Dieleman, G. C., Jaddoe, V. W. V., Uitterlinden, A. G., White, T. J. H., Bakermans‐Kranenburg, M. J., Albert Hofman, D., et al. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.08.021 · Cited by 124

Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder

Uddin, L. Q. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.010 · Cited by 116

A novel common variant in DCST2 is associated with length in early life and height in adulthood

van der Valk, R. J. P., Kreiner‐Møller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Sääf, A. M., Bradfield, J. P., Geller, F., Hayes, M. G., Cousminer, D. L., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu510 · Cited by 121

Parental smoking during pregnancy, early growth, and risk of obesity in preschool children: the Generation R Study

Durmuş, B., Kruithof, C. J., Gillman, M. W., Willemsen, S. P., Albert Hofman, D., Raat, H., Eilers, P. H. C., Steegers, E. A. P., & Jaddoe, V. W. V. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.009225 · Cited by 121

Air Pollution, Blood Pressure, and the Risk of Hypertensive Complications During Pregnancy

van den Hooven, E. H., de Kluizenaar, Y., Pierik, F. H., Albert Hofman, D., van Ratingen, S. W., Zandveld, P. Y. J., Mackenbach, J. P., Steegers, E. A. P., Miedema, H., & Jaddoe, V. W. V. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.164087 · Cited by 119

Demographic, emotional and social determinants of cannabis use in early pregnancy: The Generation R study

Marroun, H. E., Tiemeier, H. W., Jaddoe, V. W. V., Albert Hofman, D., Mackenbach, J. P., Steegers, E. A. P., Verhulst, F. C., van den Brink, W., & Huizink, A. C. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.05.010 · Cited by 114

Low serum vitamin D is associated with axial length and risk of myopia in young children

Tideman, J. W. L., Polling, J. R., Voortman, T., Jaddoe, V. W. V., Uitterlinden, A. G., Albert Hofman, D., Vingerling, J. R., Franco, O. H., & Klaver, C. C. W. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0128-8 · Cited by 117

Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis

Neumann, A., Walton, E., Alemany, S., Cecil, C. A. M., González, J. R., Jima, D. D., Lahti, J. M. T., Tuominen, S., Barker, E. D., Binder, E. B., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01058-z · Cited by 121

Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study

Graaff, J. S., Roza, S. J., Steegers, E. A. P., Albert Hofman, D., Verhulst, F. C., Jaddoe, V. W. V., & Tiemeier, H. W. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.030791 · Cited by 114

Chronic Air Pollution Exposure during Pregnancy and Maternal and Fetal C-Reactive Protein Levels: The Generation R Study

van den Hooven, E. H., de Kluizenaar, Y., Pierik, F. H., Albert Hofman, D., van Ratingen, S. W., Zandveld, P. Y. J., Lindemans, J. W., Russcher, H., Steegers, E. A. P., Miedema, H., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104345 · Cited by 112

Early origins of chronic obstructive lung diseases across the life course

Duijts, L., Reiss, I. K. M., Brusselle, G., & de Jongste, J. C. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9981-5 · Cited by 113

Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study

Guxens, M., der Voort, A. M. M. S., Tiemeier, H. W., Albert Hofman, D., Sunyer, J., de Jongste, J. C., Jaddoe, V. W. V., & Duijts, L. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.044 · Cited by 119

Incidental Findings on Brain Imaging in the General Pediatric Population

Jansen, P. R., Dremmen, M. H. G., Berg, A. S. V. D., Dekkers, I. A., Blanken, L. M. E., Muetzel, R. L., Bolhuis, K., Mulder, R. H., Kocevska, D., Jansen, T. A., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmc1710724 · Cited by 111

Blood pressure tracking during pregnancy and the risk of gestational hypertensive disorders: The Generation R Study

Gaillard, R., Bakker, R., Willemsen, S. P., Albert Hofman, D., Steegers, E. A. P., & Jaddoe, V. W. V. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr275 · Cited by 111

Abnormal Cortical Growth in Schizophrenia Targets Normative Modules of Synchronized Development

Alexander‐Bloch, A. F., Reiss, P. T., Rapoport, J. L., Mcadams, H., Giedd, J. N., Bullmore, E. T., & Gogtay, N. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.010 · Cited by 112

Prenatal marijuana exposure impacts executive functioning into young adulthood: An fMRI study

Smith, A., Mioduszewski, O., Hatchard, T., Byron-Alhassan, A., Fall, C., & Fried, P. A. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.05.010 · Cited by 114

Gestational vitamin D deficiency and autism spectrum disorder

Vinkhuyzen, A. A. E., Eyles, D. W., Burne, T. H. J., Blanken, L. M. E., Kruithof, C. J., Verhulst, F. C., White, T. J. H., Jaddoe, V. W. V., Tiemeier, H. W., & McGrath, J. J. (2017) · BJPsych Open · doi:10.1192/bjpo.bp.116.004077 · Cited by 113

Socio-demographic and lifestyle determinants of ‘Western-like’ and ‘Health conscious’ dietary patterns in toddlers

Jong, J. C. K., de Vries, J. H. M., Bleeker, S. E., Jaddoe, V. W. V., Albert Hofman, D., Raat, H., & Moll, H. A. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000682 · Cited by 107

DNA methylation profiles at birth and child ADHD symptoms.

van Mil, N. V., Steegers-Theunissen, R., Bouwland-Both, M., Verbiest, M., Rijlaarsdam, J., Hofman, A., Steegers, E., Heijmans, B., Jaddoe, V., Verhulst, F., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.10.017 · Cited by 113

Multicentre reference values for cardiac magnetic resonance imaging derived ventricular size and function for children aged 0–18 years

van der Ven, J. P. G., Sadighy, Z., Buechel, E. R. V., Sarikouch, S., Robbers‐Visser, D., Kellenberger, C. J., Kaiser, T., Beerbaum, P., Boersma, E. H., & Helbing, W. A. (2019) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jez164 · Cited by 106

Is maternal lipid profile in early pregnancy associated with pregnancy complications and blood pressure in pregnancy and long term postpartum?

Adank, M. C., Benschop, L. H., Peterbroers, K. R., Gregoor, A. M. S., Kors, A. W., Mulder, M. T., Schalekamp–Timmermans, S., van Lennep, J. E. R., & Steegers, E. A. P. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.03.025 · Cited by 106

Cohort Profile: The European Longitudinal Study of Pregnancy and Childhood (ELSPAC) in the Czech Republic

Piler, P., Kandrnal, V., Kukla, L., Andrýsková, L., Švancara, J., Jarkovský, J., Dušek, L., Pikhart, H., Bobák, M., & Klánová, J. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw091 · Cited by 104

Infant Attachment, Parenting Stress, and Child Emotional and Behavioral Problems at Age 3 Years

Tharner, A., Luijk, M. P. C. M., van IJzendoorn, M. H., Bakermans‐Kranenburg, M. J., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., & Tiemeier, H. W. (2012) · Parenting · doi:10.1080/15295192.2012.709150 · Cited by 103

Functional connectivity between parietal and frontal brain regions and intelligence in young children: The Generation R study

Langeslag, S. J. E., Schmidt, M., Ghassabian, A., Jaddoe, V. W. V., Albert Hofman, D., van der Lugt, A., Verhulst, F. C., Tiemeier, H. W., & White, T. J. H. (2012) · Human Brain Mapping · doi:10.1002/hbm.22143 · Cited by 105

An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication

Rijlaarsdam, J., Pappa, I., Walton, E., Bakermans-Kranenburg, M. J., Mileva-Seitz, V. R., Rippe, R. C. A., Roza, S. J., Jaddoe, V. W. V., Verhulst, F. C., Felix, J. F., et al. (2016) · Epigenetics · doi:10.1080/15592294.2016.1145329 · Cited by 97

Consequences of Perinatal Cannabis Exposure

Scheyer, A. F., Melis, M., Trezza, V., & Manzoni, O. J. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.08.010 · Cited by 106

Maternal Early-Pregnancy Thyroid Function Is Associated With Subsequent Hypertensive Disorders of Pregnancy: The Generation R Study

Medici, M., Korevaar, T. I. M., Schalekamp–Timmermans, S., Gaillard, R., de Rijke, Y. B., Visser, W. E., Visser, W. E., Keizer‐Schrama, S. M. P. F. D. M., Albert Hofman, D., Hooijkaas, H., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1505 · Cited by 103

Fetal and Infant Growth and Asthma Symptoms in Preschool Children: The Generation R Study

der Voort, A. M. M. S., Jaddoe, V. W. V., Raat, H., Moll, H. A., Albert Hofman, D., de Jongste, J. C., & Duijts, L. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201107-1266oc · Cited by 101

Air pollution exposure during pregnancy and childhood and brain morphology in preadolescents

Lubczynska, M. J., Muetzel, R. L., Marroun, H. E., Hoek, G., Kooter, I. M., Thomson, E. M., Hillegers, M. H. J., Vernooij, M. W., White, T. J. H., Tiemeier, H. W., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110446 · Cited by 100

Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition

Gervin, K., Page, C. M., Aass, H. C. D., Jansen, M. A. E., Fjeldstad, H. E., Kulle, B., Duijts, L., van Meurs, J. B. J., van Zelm, M. C., Jaddoe, V. W. V., et al. (2016) · Epigenetics · doi:10.1080/15592294.2016.1214782 · Cited by 99

Economic Disadvantage and Young Children’s Emotional and Behavioral Problems: Mechanisms of Risk

Rijlaarsdam, J., Stevens, G. W. J. M., van der Ende, J., Albert Hofman, D., Jaddoe, V. W. V., Mackenbach, J. P., Verhulst, F. C., & Tiemeier, H. W. (2012) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-012-9655-2 · Cited by 117

Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy

Ghassabian, A., Pierotti, L., Basterrechea, M., Chatzi, L., Estarlich, M., Fernández‐Somoano, A., Fleisch, A. F., Gold, D. R., Júlvez, J., Karakosta, P., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.12902 · Cited by 96

High Circulating Folate and Vitamin B-12 Concentrations in Women During Pregnancy Are Associated with Increased Prevalence of Atopic Dermatitis in Their Offspring

Jong, J. C. K., Timmermans, S., Jaddoe, V. W. V., Albert Hofman, D., Tiemeier, H. W., Steegers, E. A. P., de Jongste, J. C., & Moll, H. A. (2012) · Journal of Nutrition · doi:10.3945/jn.111.154948 · Cited by 97

Interaction between lifestyle and genetic susceptibility in myopia: the Generation R study

Enthoven, C. A., Tideman, J. W. L., Polling, J. R., Tedja, M. S., Raat, H., Iglesias, A. I., Verhoeven, V. J. M., & Klaver, C. C. W. (2019) · European Journal of Epidemiology · doi:10.1007/s10654-019-00512-7 · Cited by 99

Parental depression and child well-being: young children's self-reports helped addressing biases in parent reports

Ringoot, A. P., Tiemeier, H. W., Jaddoe, V. W. V., So, P., Albert Hofman, D., Verhulst, F. C., & Jansen, P. W. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.03.009 · Cited by 95

Fetal and Infant Growth Patterns Associated With Total and Abdominal Fat Distribution in School-Age Children

Gishti, O., Gaillard, R., Manniesing, R., Berkeveld, M. A., van der Beek, E. M., Heppe, D. H. M., Steegers, E. A. P., Albert Hofman, D., Duijts, L., Durmuş, B., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4345 · Cited by 95

Parenting Style, the Home Environment, and Screen Time of 5-Year-Old Children; The ‘Be Active, Eat Right’ Study

Veldhuis, L., van Grieken, A., Renders, C. M., Hirasing, R. A., & Raat, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088486 · Cited by 96

Dynamics and Determinants of Staphylococcus aureus Carriage in Infancy: the Generation R Study

Lebon, A., Labout, J. A. M., Verbrugh, H. A., Jaddoe, V. W. V., Albert Hofman, D., van Wamel, W. J. B., Moll, H. A., & van Belkum, A. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00641-08 · Cited by 96

Associations between Nausea, Vomiting, Fatigue and Health-Related Quality of Life of Women in Early Pregnancy: The Generation R Study

Bai, G., Korfage, I. J., Groen, E. H., Jaddoe, V. W. V., Mautner, E., & Raat, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166133 · Cited by 94

Maternal plasma PUFA concentrations during pregnancy and childhood adiposity: the Generation R Study

Vidakovic, A. J., Gishti, O., Voortman, T., Felix, J. F., Williams, M. A., Albert Hofman, D., Demmelmair, H., Koletzko, B. V., Tiemeier, H. W., Jaddoe, V. W. V., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.112847 · Cited by 96

Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3: GWAS of Height-Adjusted BMI

Stergiakouli, E., Gaillard, R., Tavaré, J. M., Balthasar, N., Loos, R. J., Taal, H. R., Evans, D. M., Rivadeneira, F., St Pourcain, B., Uitterlinden, A. G., et al. (2014) · Obesity · doi:10.1002/oby.20840 · Cited by 90

Testing the direction of effects between child body composition and restrictive feeding practices: results from a population-based cohort

Derks, I. P. M., Tiemeier, H. W., Sijbrands, E. J. G., Nicholson, J. M., Voortman, T., Verhulst, F. C., Jaddoe, V. W. V., & Jansen, P. W. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156448 · Cited by 92

An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration

van den Heuvel, O. A., Boedhoe, P. S. W., Bertolín, S., Bruin, W. B., Francks, C., Ivanov, I., Jahanshad, N., Kong, X., Kwon, J. S., O’Neill, J., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.24972 · Cited by 91

Sonographic assessment of abdominal fat distribution in infancy

Holzhauer, S., Zwijsen, R. M. L., Jaddoe, V. W. V., Boehm, G., Moll, H. A., Mulder, P. G. H., Kleyburg-Linkers, V. A., Albert Hofman, D., & Witteman, J. C. M. (2009) · European Journal of Epidemiology · doi:10.1007/s10654-009-9368-1 · Cited by 91

Levels of Antibodies Against Tissue Transglutaminase During Pregnancy Are Associated With Reduced Fetal Weight and Birth Weight

Jong, J. C. K., Jaddoe, V. W. V., Uitterlinden, A. G., Steegers, E. A. P., Willemsen, S. P., Albert Hofman, D., Hooijkaas, H., & Moll, H. A. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.003 · Cited by 91

Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia

Tao, R., Li, C., Jaffe, A. E., Shin, J. H., Deep‐Soboslay, A., Yamin, R., Weinberger, D. R., Hyde, T. M., & Kleinman, J. E. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0832-8 · Cited by 90

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

Qi, Q., Downer, M. K., Kilpeläinen, T. O., Taal, H. R., Barton, S. J., Ντάλλα, Ι., Standl, M., Perica, V. B., Huikari, V., Jong, J. C. K., et al. (2015) · Diabetes · doi:10.2337/db14-1629 · Cited by 93

Maternal and Birth Characteristics Are Determinants of Offspring Thyroid Function

Korevaar, T. I. M., Chaker, L., Jaddoe, V. W. V., Visser, T. J., Medici, M., & Peeters, R. P. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3559 · Cited by 91

Low Urinary Iodine Excretion during Early Pregnancy Is Associated with Alterations in Executive Functioning in Children3

Mil, N. H. G., Tiemeier, H. W., Bongers‐Schokking, J. J., Ghassabian, A., Albert Hofman, D., Hooijkaas, H., Jaddoe, V. W. V., Keizer-Schrama, S. M. D. M., Steegers, E. A. P., Visser, T. J., et al. (2012) · Journal of Nutrition · doi:10.3945/jn.112.161950 · Cited by 90

Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype

Rijlaarsdam, J., van IJzendoorn, M. H., Verhulst, F. C., Jaddoe, V. W. V., Felix, J. F., Tiemeier, H. W., & Bakermans‐Kranenburg, M. J. (2016) · Autism Research · doi:10.1002/aur.1681 · Cited by 98

Immune system development varies according to age, location, and anemia in African children

Hill, D. L., Carr, E. J., Rutishauser, T., Moncunill, G., Campo, J. J., Innocentin, S., Mpina, M., Nhabomba, A., Tumbo, A., Jairoce, C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw9522 · Cited by 89

Developmental Considerations in Obsessive Compulsive Disorder: Comparing Pediatric and Adult-Onset Cases

Geller, D. A., Homayoun, S., & Johnson, G. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.678538 · Cited by 89

Duration and exclusiveness of breastfeeding and childhood asthma-related symptoms

der Voort, A. M. M. S., Jaddoe, V. W. V., van der Valk, R. J. P., Willemsen, S. P., Hofman, A., Moll, H. A., de Jongste, J. C., & Duijts, L. (2011) · European Respiratory Journal · doi:10.1183/09031936.00178110 · Cited by 89

Recreational Cannabis Legalization in the US and Maternal Use during the Preconception, Prenatal, and Postpartum Periods

Skelton, K. R., Hecht, A. A., & Benjamin‐Neelon, S. E. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17030909 · Cited by 93

Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area

Ghassabian, A., Graaff, J. S., Peeters, R. P., Ross, H. A., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., White, T. J. H., & Tiemeier, H. W. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005520 · Cited by 89

Prenatal parental tobacco smoking, gene specific DNA methylation, and newborns size: the Generation R study

Bouwland-Both, M. I., Mil, N. H. G., Tolhoek, C. P., Stolk, L., Eilers, P. H. C., Verbiest, M. M. P. J., Heijmans, B. T., Uitterlinden, A. G., Albert Hofman, D., van IJzendoorn, M. H., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0115-z · Cited by 88

Fetal sex specific differences in human placentation: A prospective cohort study

Brown, Z. A., Schalekamp–Timmermans, S., Tiemeier, H. W., Hofman, A., Jaddoe, V. W. V., & Steegers, E. (2014) · Placenta · doi:10.1016/j.placenta.2014.03.014 · Cited by 90

Eating behavior and body composition across childhood: a prospective cohort study

Derks, I. P. M., Sijbrands, E. J. G., Wake, M. A., Qureshi, F., van der Ende, J., Hillegers, M. H. J., Jaddoe, V. W. V., Tiemeier, H. W., & Jansen, P. W. (2018) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-018-0725-x · Cited by 87

Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts

Sharp, G. C., Arathimos, R., Reese, S. E., Page, C. M., Felix, J. F., Küpers, L. K., Rifas‐Shiman, S. L., Liu, C., The Cohorts for Heart and Aging Research in Genomic Epidemiology plus (CHARGE +) methylation alcohol working group, Burrows, K., et al. (2017) · Epigenomics · doi:10.2217/epi-2017-0095 · Cited by 86

The Dysregulation Profile in Young Children: Empirically Defined Classes in the Generation R Study

Basten, M., Althoff, R. R., Tiemeier, H. W., Jaddoe, V. W. V., Albert Hofman, D., Hudziak, J. J., Verhulst, F. C., & van der Ende, J. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.007 · Cited by 85

Occupational exposure to chemicals and fetal growth: the Generation R Study

Snijder, C. A., Roeleveld, N., Velde, E. R. T., Steegers, E. A. P., Raat, H., Albert Hofman, D., Jaddoe, V. W. V., & Burdorf, A. (2012) · Human Reproduction · doi:10.1093/humrep/der437 · Cited by 84

Correlates of Physical Activity in 2-Year-Old Toddlers: The Generation R Study

Wijtzes, A. I., Kooijman, M. N., Jong, J. C. K., de Vries, S. I., Henrichs, J., Jansen, W., Jaddoe, V. W. V., Albert Hofman, D., Moll, H. A., & Raat, H. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.02.029 · Cited by 84

Cortical Morphology in 6- to 10-Year Old Children With Autistic Traits: A Population-Based Neuroimaging Study

Blanken, L. M. E., Mous, S. E., Ghassabian, A., Muetzel, R. L., Schoemaker, N. K., El Marroun, H., van der Lugt, A., Jaddoe, V. W. V., Hofman, A., Verhulst, F. C., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14040482 · Cited by 84

Social inequalities in young children’s sports participation and outdoor play

Wijtzes, A. I., Jansen, W., Bouthoorn, S. H., Pot, N., Albert Hofman, D., Jaddoe, V. W. V., & Raat, H. (2014) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-014-0155-3 · Cited by 96

Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

Contreras, Z. A., Chen, Z., Roumeliotaki, T., Annesi‐Maesano, I., Baïz, N., Berg, A. V., Bergström, A., Crozier, S., Duijts, L., Ekström, S., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.00504-2018 · Cited by 84

Placental Vascular Dysfunction, Fetal and Childhood Growth, and Cardiovascular Development

Gaillard, R., Steegers, E. A. P., Tiemeier, H. W., Albert Hofman, D., & Jaddoe, V. W. V. (2013) · Circulation · doi:10.1161/circulationaha.113.003881 · Cited by 83

Maternal lipid profile in early pregnancy is associated with foetal growth and the risk of a child born large-for-gestational age: a population-based prospective cohort study

Adank, M. C., Benschop, L. H., Kors, A. W., Peterbroers, K. R., Gregoor, A. M. S., Mulder, M. T., Schalekamp–Timmermans, S., van Lennep, J. E. R., & Steegers, E. A. P. (2020) · BMC Medicine · doi:10.1186/s12916-020-01730-7 · Cited by 87

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study

Richmond, R. C., Timpson, N. J., Felix, J. F., Palmer, T., Gaillard, R., McMahon, G., Smith, G. D., Jaddoe, V. W. V., & Lawlor, D. A. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002221 · Cited by 83

General psychopathology, internalising and externalising in children and functional outcomes in late adolescence

Sallis, H., Székely, E., Neumann, A., Jolicoeur‐Martineau, A., van IJzendoorn, M. H., Hillegers, M. H. J., Greenwood, C. M. T., Meaney, M. J., Steiner, M. S., Tiemeier, H. W., et al. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13067 · Cited by 92

Physically demanding work, fetal growth and the risk of adverse birth outcomes. The Generation R Study

Snijder, C. A., Brand, T., Jaddoe, V. W. V., Albert Hofman, D., Mackenbach, J. P., Steegers, E. A. P., & Burdorf, A. (2012) · Occupational and Environmental Medicine · doi:10.1136/oemed-2011-100615 · Cited by 79

White matter integrity and cognitive performance in school-age children: A population-based neuroimaging study

Muetzel, R. L., Mous, S. E., van der Ende, J., Blanken, L. M. E., van der Lugt, A., Jaddoe, V. W. V., Verhulst, F. C., Tiemeier, H. W., & White, T. J. H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.014 · Cited by 82

Maternal phthalate urine concentrations, fetal growth and adverse birth outcomes. A population-based prospective cohort study

Santos, S., Sol, C. M., van Zwol‐Janssens, C., Philips, E. M., Asimakopoulos, A. G., Martínez, M. P. S., Kannan, K., Jaddoe, V. W. V., & Trasande, L. (2021) · Environment International · doi:10.1016/j.envint.2021.106443 · Cited by 77

Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts

Jorcano, A., Lubczynska, M. J., Pierotti, L., Altuğ, H., Ballester, F., Cesaroni, G., Marroun, H. E., Fernández‐Somoano, A., Freire, C., Hanke, W., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.104927 · Cited by 77

Toward Precision Medicine in ADHD

Buitelaar, J. K., Bölte, S., Brandeis, D., Caye, A., Christmann, N., Cortese, S., Coghill, D., Faraone, S. V., Franke, B., Gleitz, M., et al. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.900981 · Cited by 83

Pre- and Postnatal Determinants of Deciduous Molar Hypomineralisation in 6-Year-Old Children. The Generation R Study

Elfrink, M. E. C., Moll, H. A., Jong, J. C. K., Jaddoe, V. W. V., Albert Hofman, D., ten Cate, J. M., & Veerkamp, J. S. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091057 · Cited by 77

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight

Tyrrell, J., Huikari, V., Christie, J. T., Cavadino, A., Bakker, R., Brion, M., Geller, F., Paternoster, L., Myhre, R., Potter, C., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds372 · Cited by 75

Frequent Bullying Involvement and Brain Morphology in Children

Muetzel, R. L., Mulder, R. H., Lamballais, S., Hidalgo, A. P. C., Jansen, P. W., Güroğlu, B., Vernooij, M. W., Hillegers, M. H. J., White, T. J. H., Marroun, H. E., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00696 · Cited by 76

FTO at rs9939609, Food Responsiveness, Emotional Control and Symptoms of ADHD in Preschool Children

Velders, F. P., Wit, J. E. D., Jansen, P. W., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., & Tiemeier, H. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049131 · Cited by 76

Breast-feeding and growth in children until the age of 3 years: the Generation R Study

Durmuş, B., van Rossem, L., Duijts, L., Arends, L. R., Raat, H., Moll, H. A., Albert Hofman, D., Steegers, E. A. P., & Jaddoe, V. W. V. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114510005374 · Cited by 75

Fetal Exposure to Maternal and Paternal Smoking and the Risks of Wheezing in Preschool Children

Duijts, L., Jaddoe, V. W. V., van der Valk, R. J. P., Henderson, J. A., Hofman, A., Raat, H., Steegers, E. A. P., Moll, H. A., & de Jongste, J. C. (2012) · Chest · doi:10.1378/chest.11-0112 · Cited by 73

Exploring the Relation of Harsh Parental Discipline with Child Emotional and Behavioral Problems by Using Multiple Informants. The Generation R Study

Mackenbach, J. D., Ringoot, A. P., van der Ende, J., Verhulst, F. C., Jaddoe, V. W. V., Albert Hofman, D., Jansen, P. W., & Tiemeier, H. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104793 · Cited by 74

Protein intake in early childhood and body composition at the age of 6 years: The Generation R Study

Voortman, T., Braun, K. V. E., Jong, J. C. K., Jaddoe, V. W. V., Franco, O. H., & van den Hooven, E. H. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.29 · Cited by 74

How do you Recruit and Retain a Prebirth Cohort? Lessons Learnt from Growing Up in New Zealand

Morton, S., Grant, C. C., Carr, P. A., Robinson, E. M., Kinloch, J. M., Fleming, C. J., Kingi, T. K., Perese, L., & Liang, R. (2012) · Evaluation & the Health Professions · doi:10.1177/0163278712462717 · Cited by 73

Maternal smoking during pregnancy and kidney volume in the offspring: the Generation R Study

Taal, H. R., Geelhoed, J. J. M., Steegers, E. A. P., Albert Hofman, D., Moll, H. A., Lequin, M. H., van der Heijden, A. J., & Jaddoe, V. W. V. (2011) · Pediatric Nephrology · doi:10.1007/s00467-011-1848-3 · Cited by 74

A population-based prospective cohort study examining the influence of early-life respiratory tract infections on school-age lung function and asthma

van Meel, E. R., den Dekker, H. T., Elbert, N. J., Jansen, P. W., Moll, H. A., Reiss, I. K. M., de Jongste, J. C., Jaddoe, V. W. V., & Duijts, L. (2017) · Thorax · doi:10.1136/thoraxjnl-2017-210149 · Cited by 73

Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands

van den Dries, M. A., Pronk, A., Guxens, M., Spaan, S., Voortman, T., Jaddoe, V. W. V., Jusko, T. A., Longnecker, M. P., & Tiemeier, H. W. (2018) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2018.01.013 · Cited by 74

Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood

Cárdenas, A., Faleschini, S., Hidalgo, A. P. C., Rifas‐Shiman, S. L., Baccarelli, A., DeMeo, D. L., Litonjua, A. A., Neumann, A., Felix, J. F., Jaddoe, V. W. V., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0653-x · Cited by 74

Diet quality in childhood: the Generation R Study

van der Velde, L. A., Nguyen, A. N., Schoufour, J. D., Geelen, A., Jaddoe, V. W. V., Franco, O. H., & Voortman, T. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1651-z · Cited by 72

Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium

Chen, L., Aubert, A. M., Shivappa, N., Bernard, J. Y., Mensink‐Bout, S. M., Geraghty, A. A., Mehegan, J., Suderman, M. J., Polańska, K., Hanke, W., et al. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003491 · Cited by 80

The Generation R Study: design and cohort update 2017

Kooijman, M. N., Kruithof, C. J., van Duijn, C. M., Duijts, L., Franco, O. H., van IJzendoorn, M. H., de Jongste, J. C., Klaver, C. C. W., van der Lugt, A., Mackenbach, J. P., et al. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0224-9 · Cited by 1,238

The Generation R Study: Design and cohort update 2012

Jaddoe, V. W. V., van Duijn, C. M., Franco, O. H., van der Heijden, A. J., van IIzendoorn, M. H., de Jongste, J. C., van der Lugt, A., Mackenbach, J. P., Moll, H. A., Raat, H., et al. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9735-1 · Cited by 546

The Generation R Study: Design and cohort profile

Jaddoe, V. W. V., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H. W., Verhulst, F. C., Witteman, J. C. M., & Albert Hofman, D. (2006) · European Journal of Epidemiology · doi:10.1007/s10654-006-9022-0 · Cited by 400

The Generation R Study: design and cohort update until the age of 4 years

Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H. W., Uitterlinden, A. G., Verhulst, F. C., & Albert Hofman, D. (2008) · European Journal of Epidemiology · doi:10.1007/s10654-008-9309-4 · Cited by 180

DEVELOPMENTAL EPIDEMIOLOGY The Generation R Study Biobank: a resource for epidemiological studies in children and their parents

Tiemeier, H. W., Andre, Æ., Uitterlinden, G., Frank, Æ., Verhulst, C., Albert Hofman, D., Jaddoe, V. W. V., Bakker, R., Hofman, A., Lindemans, J., et al. (2013)