Cited by 546Birth, Development, and HealthMaternal and Neonatal HealthcareHealth, Environment, Cognitive Aging

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The Generation R Study: design and cohort update 2012

Jaddoe, Vincent W. V., van Duijn, Cornelia M., Franco, Oscar H., van der Heijden, Albert J., van IIzendoorn, Marinus H., de Jongste, Johan C., van der Lugt, Aad, Mackenbach, Johan P., Moll, Henriëtte A., Raat, Hein, Rivadeneira, Fernando, Steegers, Eric A. P., Tiemeier, Henning, Uitterlinden, Andre G., Verhulst, Frank C., Hofman, Albert·2012·European Journal of Epidemiology

DOI 10.1007/s10654-012-9735-1

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Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. From the age of 5 years, regular detailed hands-on assessments are performed in a dedicated research center including advanced imaging facilities such as Magnetic Resonance Imaging. Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

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Authors: Jaddoe, V. W. V., van Duijn, C. M., Franco, O. H., van der Heijden, A. J., van IIzendoorn, M. H., de Jongste, J. C., van der Lugt, A., Mackenbach, J. P., Moll, H. A., Raat, H., Rivadeneira, F., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A.
Affiliations: Erasmus MC (NL)
Corresponding author: Jaddoe, Vincent W. V.
ORCID: Jaddoe, Vincent W. V.
Franco, Oscar H.
Rivadeneira, Fernando
Tiemeier, Henning
Venue: European Journal of Epidemiology
Publisher: Springer Science and Business Media LLC
Published: 2012-09
Volume: 27
Issue: 9
Pages: 739-756
ISSN: 0393-2990 (ISSN-L)
1573-7284
DOI: 10.1007/s10654-012-9735-1
OpenAlex: W2280586107
Cited by: 546
References: 195
Citations by year: 2026: 5 · 2025: 19 · 2024: 13 · 2023: 13 · 2022: 24 · 2021: 21 · 2020: 36 · 2019: 35 · 2018: 27 · 2017: 57 · 2016: 85 · 2015: 85 · 2014: 77 · 2013: 45 · 2012: 2
FWCI: 58.61
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders: ZonMw (907.00303, 916.10159)
Erasmus Universiteit Rotterdam
Erasmus Medisch Centrum
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (90700303, 916.10159)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords: Generation R Study, prospective cohort, fetal development, child growth, maternal health, physical development, cognitive development, behavioral development, respiratory health, allergy, childhood diseases, child health care, epigenetics, genome-wide association study, environmental exposure, prenatal exposure, birth cohort
MeSH terms: Adult, Child, Child Behavior, Child Development, Cognition, Data Collection, Environment, Family Characteristics, Female, Growth Disorders, Humans, Infant, Male, Maternal Health Services, Netherlands, Physical Examination, Pregnancy, Surveys and Questionnaires, Research Design, Cohort Studies, Epidemiologic Research Design, Fetal Development, Genome-Wide Association Study

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