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The Generation R Study: design and cohort update 2012
Abstract
The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. From the age of 5 years, regular detailed hands-on assessments are performed in a dedicated research center including advanced imaging facilities such as Magnetic Resonance Imaging. Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
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“In a very large sample including 774 6–10 year-old children from the Generation R Study (122), higher levels of autistic traits and ASD diagnosis were associated with longer dwell times in a functional connectivity state characterized by global disconnection (123).”
From Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder (2021) · cites this paper as [122]
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DNA Methylation: A Mediator Between Parenting Stress and Adverse Child Development?
Mulder, R. H., Rijlaarsdam, J., & van IJzendoorn, M. H. (2017) · Springer eBooks · doi:10.1007/978-3-319-55376-4_7 · Cited by 15
de Jesus, S. M. C. B. P., den Dekker, H. T., de Jongste, J. C., Reiss, I. K. M., Steegers, E. A. P., Jaddoe, V. W. V., & Duijts, L. (2017) · Pediatric Pulmonology · doi:10.1002/ppul.23733 · Cited by 15
Langen, C. D., Muetzel, R. L., Blanken, L. M. E., van der Lugt, A., Tiemeier, H. W., Verhulst, F. C., Niessen, W. J., & White, T. J. H. (2018) · Brain and Behavior · doi:10.1002/brb3.1031 · Cited by 18
van den Heuvel, M. M., Oei, E. H. G., Renkens, J. J. M., Bierma‐Zeinstra, S., & van Middelkoop, M. (2020) · The Spine Journal · doi:10.1016/j.spinee.2020.10.003 · Cited by 14
Sociodemographic factors and social media use in 9-year-old children: the Generation R Study
You, Y., Yang‐Huang, J., Raat, H., & van Grieken, A. (2021) · BMC Public Health · doi:10.1186/s12889-021-12061-4 · Cited by 14
Casas, M., den Dekker, H. T., Kruithof, C. J., Reiss, I. K. M., Vrijheid, M., de Jongste, J. C., Jaddoe, V. W. V., & Duijts, L. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12645 · Cited by 14
In utero origin of sex-related differences in future cardiovascular disease
Schalekamp–Timmermans, S., Cornette, J. M. J., Albert Hofman, D., Helbing, W. A., Jaddoe, V. W. V., Steegers, E. A. P., & Verburg, B. O. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0108-4 · Cited by 15
Piler, P., Kandrnal, V., & Bláha, L. (2017) · Public Health · doi:10.1016/j.puhe.2016.12.037 · Cited by 14
Hu, C., Nijsten, T. E. C., Pasmans, S. G. M. A., de Jongste, J. C., Jansen, P. W., & Duijts, L. (2019) · British Journal of Dermatology · doi:10.1111/bjd.18705 · Cited by 14
Steegers, C. P. M., Dieleman, G. C., Moskalenko, V. D., Santos, S., Hillegers, M. H. J., White, T. J. H., & Jansen, P. W. (2021) · International Journal of Eating Disorders · doi:10.1002/eat.23633 · Cited by 13
Tracking of structural and functional cardiac measures from infancy into school-age
Toemen, L., Gaillard, R., van Osch-Gevers, L. M., Helbing, W. A., Albert Hofman, D., & Jaddoe, V. W. V. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317715512 · Cited by 14
Childhood thyroid function, body composition and cardiovascular function
Barjaktarovic, M., Korevaar, T. I. M., Gaillard, R., de Rijke, Y. B., Visser, T. J., Jaddoe, V. W. V., & Peeters, R. P. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0369 · Cited by 14
FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression
Bryushkova, L., Zai, C., Chen, S., Pappa, I., Mileva, V., Tiemeier, H., Bakermans-Kranenburg, M., Kennedy, J. L., & Beitchman, J. H. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2015.09.052 · Cited by 13
Bello–Álvarez, L. M., Fernandez-Felix, B. M., Allotey, J., Thangaratinam, S., & Zamora, J. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70401 · Cited by 19
Cadman, T., Avraam, D., Carson, J., Elhakeem, A., Grote, V., Guerlich, K., Guxens, M., Howe, L. D., Huang, R., Harris, J. R., et al. (2024) · BMC Public Health · doi:10.1186/s12889-024-20291-5 · Cited by 14
Voerman, E., Jaddoe, V. W. V., Franco, O. H., Steegers, E. A. P., & Gaillard, R. (2016) · Diabetologia · doi:10.1007/s00125-016-4135-9 · Cited by 13
Neuroanatomical correlates of donating behavior in middle childhood
Wildeboer, A., Thijssen, S., Muetzel, R. L., Bakermans‐Kranenburg, M. J., Tiemeier, H. W., White, T. J. H., & van IJzendoorn, M. H. (2017) · Social Neuroscience · doi:10.1080/17470919.2017.1361864 · Cited by 14
The impact of gestational hypothyroxinemia on the cognitive and motor development of offspring
Chen, Y., & Xue, F. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1529749 · Cited by 13
Musculoskeletal pain in 6-year-old children: the Generation R Study
van den Heuvel, M. M., Jansen, P. W., Bindels, P., Bierma‐Zeinstra, S., & van Middelkoop, M. (2020) · Pain · doi:10.1097/j.pain.0000000000001797 · Cited by 13
DRD4 VNTRs, observed stranger fear in preschoolers and later ADHD symptoms
Pappa, I., Mileva‐Seitz, V. R., Székely, E., Verhulst, F. C., Bakermans‐Kranenburg, M. J., Jaddoe, V. W. V., Albert Hofman, D., Tiemeier, H. W., & van IJzendoorn, M. H. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.09.004 · Cited by 13
Early origins of ethnic disparities in cardiovascular risk factors
Gishti, O., Gaillard, R., Felix, J. F., Bouthoorn, S. H., Steegers, E. A. P., Raat, H., Albert Hofman, D., Duijts, L., Franco, O. H., & Jaddoe, V. W. V. (2015) · Preventive Medicine · doi:10.1016/j.ypmed.2015.03.027 · Cited by 13
Hendriks, A. M., Ip, H. F., Nivard, M. G., Finkenauer, C., Beijsterveldt, C. E. M. V., Bartels, M., & Boomsma, D. I. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13218 · Cited by 13
First-trimester maternal protein intake and childhood kidney outcomes: the Generation R Study
Miliku, K., Voortman, T., van den Hooven, E. H., Albert Hofman, D., Franco, O. H., & Jaddoe, V. W. V. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.102228 · Cited by 13
Serdarević, F., van Batenburg‐Eddes, T., Mous, S. E., White, T. J. H., Albert Hofman, D., Jaddoe, V. W. V., Verhulst, F. C., Ghassabian, A., & Tiemeier, H. W. (2015) · Developmental Science · doi:10.1111/desc.12326 · Cited by 12
25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study
Tromp, I. I. M., Franco, O. H., van den Hooven, E. H., Heijboer, A. C., Jaddoe, V. W. V., Duijts, L., de Jongste, J. C., Moll, H. A., & Jong, J. C. K. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.11.019 · Cited by 12
Third trimester fetal hemodynamics and cardiovascular outcomes in childhood
Kooijman, M. N., de Jonge, L. L., Steegers, E. A. P., van Osch-Gevers, L. M., Verburg, B. O., Albert Hofman, D., Helbing, W. A., & Jaddoe, V. W. V. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000174 · Cited by 12
Macronutrient Intakes in Infancy Are Associated with Sleep Duration in Toddlerhood
Kocevska, D., Voortman, T., Dashti, H. S., van den Hooven, E. H., Ghassabian, A., Rijlaarsdam, J., Schneider, N., Feskens, E. J. M., Jaddoe, V. W. V., Tiemeier, H. W., et al. (2016) · Journal of Nutrition · doi:10.3945/jn.115.225847 · Cited by 12
Metadata
- Authors
- Jaddoe, V. W. V., van Duijn, C. M., Franco, O. H., van der Heijden, A. J., van IIzendoorn, M. H., de Jongste, J. C., van der Lugt, A., Mackenbach, J. P., Moll, H. A., Raat, H., Rivadeneira, F., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Jaddoe, Vincent W. V.
- Venue
- European Journal of Epidemiology
- Published
- 2012-09
- Volume
- 27
- Issue
- 9
- Pages
- 739-756
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- OpenAlex
- W2280586107
- Cited by
- 546
- References
- 195
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 13 · 2023: 13 · 2022: 24 · 2021: 21 · 2020: 36 · 2019: 35 · 2018: 27 · 2017: 57 · 2016: 85 · 2015: 85 · 2014: 77 · 2013: 45 · 2012: 2
- FWCI
- 58.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- ZonMw (907.00303, 916.10159)
- Erasmus Universiteit Rotterdam
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (90700303, 916.10159)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- Generation R Study, prospective cohort, fetal development, child growth, maternal health, physical development, cognitive development, behavioral development, respiratory health, allergy, childhood diseases, child health care, epigenetics, genome-wide association study, environmental exposure, prenatal exposure, birth cohort
- MeSH terms
- Adult, Child, Child Behavior, Child Development, Cognition, Data Collection, Environment, Family Characteristics, Female, Growth Disorders, Humans, Infant, Male, Maternal Health Services, Netherlands, Physical Examination, Pregnancy, Surveys and Questionnaires, Research Design, Cohort Studies, Epidemiologic Research Design, Fetal Development, Genome-Wide Association Study
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