Cited by 546Birth, Development, and HealthMaternal and Neonatal HealthcareHealth, Environment, Cognitive Aging

The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.

The Generation R Study: design and cohort update 2012

Jaddoe, Vincent W. V., van Duijn, Cornelia M., Franco, Oscar H., van der Heijden, Albert J., van IIzendoorn, Marinus H., de Jongste, Johan C., van der Lugt, Aad, Mackenbach, Johan P., Moll, Henriëtte A., Raat, Hein, Rivadeneira, Fernando, Steegers, Eric A. P., Tiemeier, Henning, Uitterlinden, Andre G., Verhulst, Frank C., Hofman, Albert·2012·European Journal of Epidemiology

DOI 10.1007/s10654-012-9735-1

Open this paper in CoChat — free account

Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. From the age of 5 years, regular detailed hands-on assessments are performed in a dedicated research center including advanced imaging facilities such as Magnetic Resonance Imaging. Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

Integrity signals

Registry

Crossref · 10.1007/s10654-012-9735-1

Cites

196 of 196 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
(1992) · PubMed · Cited by 33,716
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
The Strengths and Difficulties Questionnaire: A research note
Goodman, R. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01545.x · Cited by 14,908
Detection of Postnatal Depression: Development of the 10-item Edinburgh Postnatal Depression Scale
Cox, J. L., Holden, J. M., & Sagovsky, R. (1987) · British Journal of Psychiatry · doi:10.1192/bjp.150.6.782 · Cited by 14,183
The brief symptom inventory: an introductory report.
Derogatis, L. R., & Melisaratos, N. (1983) · Psychological Medicine · doi:10.1017/s0033291700048017 · Cited by 6,650
Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction: The American Heart Association’s Strategic Impact Goal Through 2020 and Beyond
Lloyd-Jones, D. M., Hong, Y., Labarthe, D., Mozaffarian, D., Appel, L. J., Van Horn, L., Greenlund, K., Daniels, S., Nichol, G., Tomaselli, G. F., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192703 · Cited by 4,750
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898
International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods
Asher, M., Keil, U., Anderson, H., Beasley, R., Crane, J., Martinez, F., Mitchell, E., Pearce, N., Sibbald, B., Stewart, A., et al. (1995) · European Respiratory Journal · doi:10.1183/09031936.95.08030483 · Cited by 3,724
THE McMASTER FAMILY ASSESSMENT DEVICE*
Epstein, N. B., Baldwin, L. M., & Bishop, D. S. (1983) · Journal of Marital and Family Therapy · doi:10.1111/j.1752-0606.1983.tb01497.x · Cited by 3,584
Childhood Functional Gastrointestinal Disorders: Child/Adolescent
Rasquin, A., Lorenzo, C. D., Forbes, D., Guiraldes, E., Hyams, J. S., Staiano, A., & Walker, L. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.063 · Cited by 1,785

Show all 195 references

Research works printed but not linked: 2

Statistics Netherlands. Allochtonen in Nederland 2004. Voorburg/Heerlen: Statistics Netherlands; 2004.
Veldhuis L, Struijk MK, Kroeze W, Oenema A, Renders CM, Bulk-Bunschoten AM, Hirasing RA, Raat H. ‘Be active, eat right’, evaluation of an overweight prevention protocol among 5-year-old children: design of a cluster randomised controlled trial. BMC Public Health. 2009;9:177. · DOI

Sorted by citations

The Generation R Study: design and cohort update 2017
Kooijman, M. N., Kruithof, C. J., van Duijn, C. M., Duijts, L., Franco, O. H., van IJzendoorn, M. H., de Jongste, J. C., Klaver, C. C. W., van der Lugt, A., Mackenbach, J. P., et al. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0224-9 · Cited by 1,235
The Generation R Study: design and cohort update 2010
Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9516-7 · Cited by 1,027
Enhancing studies of the connectome in autism using the autism brain imaging data exchange II
Martino, A. D., O’Connor, D. A., Chen, B., Alaerts, K., Anderson, J. S., Assaf, M., Balsters, J. H., Baxter, L. C., Beggiato, A., Bernaerts, S., et al. (2017) · Scientific Data · doi:10.1038/sdata.2017.10 · Cited by 713
Fundamental constructs in food parenting practices: a content map to guide future research
Vaughn, A., Ward, D. S., Fisher, J. O., Faith, M. S., Hughes, S. O., Kremers, S., Musher‐Eizenman, D. R., O’Connor, T. M., Patrick, H., & Power, T. G. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuv061 · Cited by 731
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
Bønnelykke, K., Abou‐Sleiman, P. M., Nielsen, K. R., Kreiner‐Møller, E., Mercader, J. M., Belgrave, D. C. M., den Dekker, H. T., Husby, A., Sevelsted, A., Tellez, G. F., et al. (2013) · Nature Genetics · doi:10.1038/ng.2830 · Cited by 582
Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study
Korevaar, T. I. M., Muetzel, R. L., Medici, M., Chaker, L., Jaddoe, V. W. V., de Rijke, Y. B., Steegers, E. A. P., Visser, T. J., White, T. J. H., Tiemeier, H. W., et al. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00327-7 · Cited by 571
Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy
Gaillard, R., Durmuş, B., Albert Hofman, D., Mackenbach, J. P., Steegers, E. A. P., & Jaddoe, V. W. V. (2013) · Obesity · doi:10.1002/oby.20088 · Cited by 519
First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study
Jaddoe, V. W. V., de Jonge, L. L., Hofman, A., Franco, O. H., Steegers, E. A. P., & Gaillard, R. (2014) · BMJ · doi:10.1136/bmj.g14 · Cited by 445
The Tohoku Medical Megabank Project: Design and Mission
Kuriyama, S., Yaegashi, N., Nagami, F., Arai, T., Kawaguchi, Y., Osumi, N., Sakaida, M., Suzuki, Y., Nakayama, K., Hashizume, H., et al. (2016) · Journal of Epidemiology · doi:10.2188/jea.je20150268 · Cited by 356
Unraveling the Miswired Connectome: A Developmental Perspective
Martino, A. D., Fair, D. A., Kelly, C. A. M., Satterthwaite, T. D., Castellanos, F. X., Thomason, M. E., Craddock, R. C., Luna, B., LEVENTHAL, B. L., Zuo, X., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.050 · Cited by 357
Axial length growth and the risk of developing myopia in European children
Tideman, J. W. L., Polling, J. R., Vingerling, J. R., Jaddoe, V. W. V., Williams, C., Guggenheim, J. A., & Klaver, C. C. W. (2017) · Acta Ophthalmologica · doi:10.1111/aos.13603 · Cited by 351
Etiology in psychiatry: embracing the reality of poly‐gene‐environmental causation of mental illness
Uher, R., & Zwicker, A. (2017) · World Psychiatry · doi:10.1002/wps.20436 · Cited by 331
The Rotterdam Study: 2014 objectives and design update
Albert Hofman, D., Murad, S. D., van Duijn, C. M., Franco, O. H., Goedegebure, A., Ikram, M. A., Klaver, C. C. W., Nijsten, T. E. C., Peeters, R. P., Stricker, B. H. C., et al. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-013-9866-z · Cited by 335
Trajectories of picky eating during childhood: A general population study
Cano, S. C., Tiemeier, H. W., van Hoeken, D., Tharner, A., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., & Hoek, H. W. (2015) · International Journal of Eating Disorders · doi:10.1002/eat.22384 · Cited by 293
Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., et al. (2016) · JAMA · doi:10.1001/jama.2016.1975 · Cited by 284
Pregnancy and Birth Cohort Resources in Europe: a Large Opportunity for Aetiological Child Health Research
Larsen, P. S., Kamper‐Jørgensen, M., Adamson, A., Barros, H., Bonde, J. ., Brescianini, S., Brophy, S. T., Casas, M., Devereux, G. S., Eggesbø, M. Å., et al. (2013) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12060 · Cited by 276
Air Pollution Exposure During Fetal Life, Brain Morphology, and Cognitive Function in School-Age Children
Guxens, M., Lubczynska, M. J., Muetzel, R. L., Dalmau-Bueno, A., Jaddoe, V. W. V., Hoek, G., van der Lugt, A., Verhulst, F. C., White, T. J. H., Brunekreef, B., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.016 · Cited by 291
Childhood Cardiometabolic Outcomes of Maternal Obesity During Pregnancy
Gaillard, R., Steegers, E. A. P., Duijts, L., Felix, J. F., Albert Hofman, D., Franco, O. H., & Jaddoe, V. W. V. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02671 · Cited by 269
Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns
Joubert, B. R., den Dekker, H. T., Felix, J. F., Bohlin, J., Ligthart, S., Beckett, E., Tiemeier, H. W., van Meurs, J. B. J., Uitterlinden, A. G., Albert Hofman, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms10577 · Cited by 268
Maternal Mild Thyroid Hormone Insufficiency in Early Pregnancy and Attention-Deficit/Hyperactivity Disorder Symptoms in Children
Modesto, T., Tiemeier, H. W., Peeters, R. P., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., & Ghassabian, A. (2015) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2015.0498 · Cited by 248
Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development
Guxens, M., García‐Esteban, R., Giorgis-Allemand, L., Forns, J., Badaloní, C., Ballester, F., Beelen, R. M. J., Cesaroni, G., Chatzi, L., Agostini, M. D., et al. (2014) · Epidemiology · doi:10.1097/ede.0000000000000133 · Cited by 236
The Generation R Study: Biobank update 2015
Kruithof, C. J., Kooijman, M. N., van Duijn, C. M., Franco, O. H., de Jongste, J. C., Klaver, C. C. W., Mackenbach, J. P., Moll, H. A., Raat, H., Rings, E. H. H. M., et al. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9980-6 · Cited by 225
Toward an operative diagnosis of fussy/picky eating: a latent profile approach in a population-based cohort
Tharner, A., Jansen, P. W., Jong, J. C. K., Moll, H. A., van der Ende, J., Jaddoe, V. W. V., Albert Hofman, D., Tiemeier, H. W., & Franco, O. H. (2014) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-11-14 · Cited by 208
DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring
Küpers, L. K., Xu, X., Jankipersadsing, S. A., Vaez, A., Gemert, S. L. B., Scholtens, S., Nolte, I. M., Richmond, R. C., Relton, C. L., Felix, J. F., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv048 · Cited by 194
Gestational vitamin D deficiency and autism-related traits: the Generation R Study
Vinkhuyzen, A. A. E., Eyles, D. W., Burne, T. H. J., Blanken, L. M. E., Kruithof, C. J., Verhulst, F. C., Jaddoe, V. W. V., Tiemeier, H. W., & McGrath, J. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.213 · Cited by 196
Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data
Gervin, K., Salas, L. A., Bakulski, K. M., van Zelm, M. C., Koestler, D. C., Wiencke, J. K., Duijts, L., Moll, H. A., Kelsey, K. T., Kobor, M. S., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0717-y · Cited by 196
The Generation R Study.
van der Voort, Gaillard, R., Albert Hofman, D., de Jongste, J. C., & Duijts, L. (2013) · Cited by 181
Marijuana Use in Pregnancy and While Breastfeeding
Metz, T. D., & Borgelt, L. M. (2018) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002878 · Cited by 181
Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes
Miliku, K., Vinkhuyzen, A. A. E., Blanken, L. M. E., McGrath, J. J., Eyles, D. W., Burne, T. H. J., Albert Hofman, D., Tiemeier, H. W., Steegers, E. A. P., Gaillard, R., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.123752 · Cited by 191
Prenatal cannabis exposure and infant outcomes: Overview of studies
Huizink, A. C. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.014 · Cited by 178
Splitting hair for cortisol? Associations of socio-economic status, ethnicity, hair color, gender and other child characteristics with hair cortisol and cortisone
Rippe, R. C. A., Noppe, G., Windhorst, D. A., Tiemeier, H. W., van Rossum, E. F. C., Jaddoe, V. W. V., Verhulst, F. C., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., & van den Akker, E. L. T. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.12.016 · Cited by 173
Maternal weight gain in different periods of pregnancy and childhood cardio-metabolic outcomes. The Generation R Study
Gaillard, R., Steegers, E. A. P., Franco, O. H., Hofman, A., & Jaddoe, V. W. V. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.175 · Cited by 173
The Stability of Problem Behavior Across the Preschool Years: An Empirical Approach in the General Population
Basten, M., Tiemeier, H. W., Althoff, R. R., van de Schoot, R., Jaddoe, V. W. V., Albert Hofman, D., Hudziak, J. J., Verhulst, F. C., & van der Ende, J. (2015) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-015-9993-y · Cited by 179
Paediatric population neuroimaging and the Generation R Study: the second wave
White, T. J. H., Muetzel, R. L., Marroun, H. E., Blanken, L. M. E., Jansen, P. R., Bolhuis, K., Kocevska, D., Mous, S. E., Mulder, R. H., Jaddoe, V. W. V., et al. (2017) · European Journal of Epidemiology · doi:10.1007/s10654-017-0319-y · Cited by 178
Feeding practices and child weight: is the association bidirectional in preschool children?
Jansen, P. W., Tharner, A., van der Ende, J., Wake, M. A., Raat, H., Albert Hofman, D., Verhulst, F. C., van IJzendoorn, M. H., Jaddoe, V. W. V., & Tiemeier, H. W. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.088922 · Cited by 171
Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment
Kemp, J. P., Medina‐Gómez, C., Estrada, K., Pourcain, B. S., Heppe, D. H. M., Warrington, N. M., Oei, L., Ring, S. M., Kruithof, C. J., Timpson, N. J., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004423 · Cited by 159
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Alves, A. C., Silva, N. M. G. D., Karhunen, V., Sovio, U., Das, S., Taal, H. R., Warrington, N. M., Lewin, A., Kaakinen, M., Cousminer, D. L., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw3095 · Cited by 158
Ethnic differences in maternal thyroid parameters during pregnancy: the Generation R study
Korevaar, T. I. M., Medici, M., de Rijke, Y. B., Visser, W., de Muinck Keizer-Schrama, S. M. P. F., Jaddoe, V. W. V., Hofman, A., Ross, H. A., Visser, W. E., Hooijkaas, H., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2005 · Cited by 150
Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project
Guxens, M., Ghassabian, A., Gong, T., Garcia-Esteban, R., Porta, D., Giorgis-Allemand, L., Almqvist, C., Aranbarri, A., Beelen, R., Badaloni, C., et al. (2016) · Environmental Health Perspectives · doi:10.1289/ehp.1408483 · Cited by 144
Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother–Child Cohort (Crete, Greece)
Vafeiadi, M., Georgiou, V., Chalkiadaki, G., Rantakokko, P., Kiviranta, H., Karachaliou, M., Fthenou, E., Venihaki, M., Sarri, K. O., Vassilaki, M. E., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409062 · Cited by 145
Executive functions in early childhood: The role of maternal and paternal parenting practices
Lucassen, N., Kok, R., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., den Berg, M. P. L., & Tiemeier, H. W. (2015) · British Journal of Developmental Psychology · doi:10.1111/bjdp.12112 · Cited by 160
Reference ranges and determinants of total hCG levels during pregnancy: the Generation R Study
Korevaar, T. I. M., Steegers, E. A. P., de Rijke, Y. B., Schalekamp–Timmermans, S., Visser, W. E., Albert Hofman, D., Jaddoe, V. W. V., Tiemeier, H. W., Visser, T. J., Medici, M., et al. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-0039-0 · Cited by 140
Downstream Effects of Maternal Hypothyroxinemia in Early Pregnancy: Nonverbal IQ and Brain Morphology in School-Age Children
Ghassabian, A., Marroun, H. E., Peeters, R. P., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., Tiemeier, H. W., & White, T. J. H. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4281 · Cited by 144
Sex-specific differences in fetal and infant growth patterns: a prospective population-based cohort study
Broere-Brown, Z. A., Baan, E. J., Schalekamp–Timmermans, S., Verburg, B. O., Jaddoe, V. W. V., & Steegers, E. A. P. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0119-1 · Cited by 139
Neuronal substrates and functional consequences of prenatal cannabis exposure
Calvigioni, D., Hurd, Y. L., Harkany, T., & Keimpema, E. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0550-y · Cited by 143
Experience during adolescence shapes brain development: From synapses and networks to normal and pathological behavior
Dow-Edwards, D. L., MacMaster, F. P., Peterson, B. S., Niesink, R. J. M., Andersen, S. L., & Braams, B. R. (2019) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2019.106834 · Cited by 160
Breastfeeding and the risk of respiratory tract infections after infancy: The Generation R Study
Tromp, I. I. M., Jong, J. C. K., Raat, H., Jaddoe, V. W. V., Franco, O. H., Albert Hofman, D., de Jongste, J. C., & Moll, H. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172763 · Cited by 133
Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children
Neumann, A., Pappa, I., Lahey, B. B., Verhulst, F. C., Medina-Gomez, C., Jaddoe, V. W., Bakermans-Kranenburg, M. J., Moffitt, T. E., van IJzendoorn, M. H., & Tiemeier, H. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.09.498 · Cited by 121
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
Wild, P. S., Felix, J. F., Schillert, A., Teumer, A., Chen, M.-H., Leening, M. J. G., Völker, U., Großmann, V., Brody, J. A., Irvin, M. R., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci84840 · Cited by 129
Self-citation
Tailored anti-TNF therapy during pregnancy in patients with IBD: maternal and fetal safety
de Lima, A., Zelinková, Z., van der Ent, C., Steegers, E. A. P., & van der Woude, C. J. (2015) · Gut · doi:10.1136/gutjnl-2015-309321 · Cited by 129
Vitamin D Deficiency in School-Age Children Is Associated with Sociodemographic and Lifestyle Factors
Voortman, T., van den Hooven, E. H., Heijboer, A. C., Albert Hofman, D., Jaddoe, V. W. V., & Franco, O. H. (2015) · Journal of Nutrition · doi:10.3945/jn.114.208280 · Cited by 128
Osteoporosis and Bone Mass Disorders: From Gene Pathways to Treatments
Rivadeneira, F., & Mäkitie, O. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.006 · Cited by 124
Connectivity dynamics in typical development and its relationship to autistic traits and autism spectrum disorder
Rashid, B., Blanken, L. M. E., Muetzel, R. L., Miller, R., Damaraju, E., Arbabshirani, M. R., Erhardt, E. B., Verhulst, F. C., van der Lugt, A., Jaddoe, V. W. V., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24064 · Cited by 120
Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder
Uddin, L. Q. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.010 · Cited by 116
A novel common variant in DCST2 is associated with length in early life and height in adulthood
van der Valk, R. J. P., Kreiner‐Møller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Sääf, A. M., Bradfield, J. P., Geller, F., Hayes, M. G., Cousminer, D. L., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu510 · Cited by 121
Low serum vitamin D is associated with axial length and risk of myopia in young children
Tideman, J. W. L., Polling, J. R., Voortman, T., Jaddoe, V. W. V., Uitterlinden, A. G., Albert Hofman, D., Vingerling, J. R., Franco, O. H., & Klaver, C. C. W. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0128-8 · Cited by 117
Environmental Risk Factors Can Reduce Axial Length Elongation and Myopia Incidence in 6- to 9-Year-Old Children
Tideman, J. W. L., Polling, J. R., Jaddoe, V. W. V., Vingerling, J. R., & Klaver, C. C. W. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2018.06.029 · Cited by 114
Low-educated women have an increased risk of gestational diabetes mellitus: the Generation R Study
Bouthoorn, S. H., Silva, L. M., Murray, S. E., Steegers, E. A. P., Jaddoe, V. W. V., Moll, H., Hofman, A., Mackenbach, J. P., & Raat, H. (2015) · Acta Diabetologica · doi:10.1007/s00592-014-0668-x · Cited by 110
Self-citation
Maternal Childhood Maltreatment and Offspring Emotional and Behavioral Problems
Rijlaarsdam, J., Stevens, G. W. J. M., Jansen, P. W., Ringoot, A. P., Jaddoe, V. W. V., Albert Hofman, D., Ayer, L. A., Verhulst, F. C., Hudziak, J. J., & Tiemeier, H. W. (2014) · Child Maltreatment · doi:10.1177/1077559514527639 · Cited by 113
Prenatal marijuana exposure impacts executive functioning into young adulthood: An fMRI study
Smith, A., Mioduszewski, O., Hatchard, T., Byron-Alhassan, A., Fall, C., & Fried, P. A. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.05.010 · Cited by 114
Gestational vitamin D deficiency and autism spectrum disorder
Vinkhuyzen, A. A. E., Eyles, D. W., Burne, T. H. J., Blanken, L. M. E., Kruithof, C. J., Verhulst, F. C., White, T. J. H., Jaddoe, V. W. V., Tiemeier, H. W., & McGrath, J. J. (2017) · BJPsych Open · doi:10.1192/bjpo.bp.116.004077 · Cited by 113
Cannabis use during pregnancy and its relationship with fetal developmental outcomes and psychiatric disorders. A systematic review
Roncero, C., Valriberas-Herrero, I., Gava, M. M., Villegas, J. L., Aguilar, L., & Grau‐López, L. (2020) · Reproductive Health · doi:10.1186/s12978-020-0880-9 · Cited by 114
Effects of Race on Perinatal Outcomes in High- and Upper-Middle-Income Countries: Individual Participant Data (IPD) Meta-Analysis of 2,198,655 Pregnancies
Sheikh, J., Allotey, J., Kew, T., Fernandez-Felix, B. M., Zamora, J., Khalil, A. A., Thangaratinam, S., Abdollahain, M., Savitri, A. I., Salvesen, K. Å., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01191-6 · Cited by 128
Dealing with missing covariates in epidemiologic studies: a comparison between multiple imputation and a full Bayesian approach
Erler, N. S., Rizopoulos, D., van Rosmalen, J., Jaddoe, V. W. V., Franco, O. H., & Lesaffre, E. M. E. H. (2016) · Statistics in Medicine · doi:10.1002/sim.6944 · Cited by 103
DNA methylation profiles at birth and child ADHD symptoms.
van Mil, N. V., Steegers-Theunissen, R., Bouwland-Both, M., Verbiest, M., Rijlaarsdam, J., Hofman, A., Steegers, E., Heijmans, B., Jaddoe, V., Verhulst, F., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.10.017 · Cited by 113
BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children
Gishti, O., Gaillard, R., Durmuş, B., Abrahamse, M., van der Beek, E. M., Albert Hofman, D., Franco, O. H., de Jonge, L. L., & Jaddoe, V. W. V. (2015) · Pediatric Research · doi:10.1038/pr.2015.29 · Cited by 106
Prenatal folate, homocysteine and vitamin B 12 levels and child brain volumes, cognitive development and psychological functioning: the Generation R Study
Ars, C. L., Nijs, I. M. T., Marroun, H. E., Muetzel, R. L., Schmidt, M., Graaff, J. S., van der Lugt, A., Jaddoe, V. W. V., Albert Hofman, D., Steegers, E. A. P., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114515002081 · Cited by 110
Cohort Profile: The European Longitudinal Study of Pregnancy and Childhood (ELSPAC) in the Czech Republic
Piler, P., Kandrnal, V., Kukla, L., Andrýsková, L., Švancara, J., Jarkovský, J., Dušek, L., Pikhart, H., Bobák, M., & Klánová, J. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw091 · Cited by 104
Insensitive parenting may accelerate the development of the amygdala–medial prefrontal cortex circuit
Thijssen, S., Muetzel, R. L., Bakermans‐Kranenburg, M. J., Jaddoe, V. W. V., Tiemeier, H. W., Verhulst, F. C., White, T. J. H., & van IJzendoorn, M. H. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000141 · Cited by 97
An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication
Rijlaarsdam, J., Pappa, I., Walton, E., Bakermans-Kranenburg, M. J., Mileva-Seitz, V. R., Rippe, R. C. A., Roza, S. J., Jaddoe, V. W. V., Verhulst, F. C., Felix, J. F., et al. (2016) · Epigenetics · doi:10.1080/15592294.2016.1145329 · Cited by 97
Self-citation
Maternal Early-Pregnancy Thyroid Function Is Associated With Subsequent Hypertensive Disorders of Pregnancy: The Generation R Study
Medici, M., Korevaar, T. I. M., Schalekamp–Timmermans, S., Gaillard, R., de Rijke, Y. B., Visser, W. E., Visser, W. E., Keizer‐Schrama, S. M. P. F. D. M., Albert Hofman, D., Hooijkaas, H., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1505 · Cited by 103
Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition
Gervin, K., Page, C. M., Aass, H. C. D., Jansen, M. A. E., Fjeldstad, H. E., Kulle, B., Duijts, L., van Meurs, J. B. J., van Zelm, M. C., Jaddoe, V. W. V., et al. (2016) · Epigenetics · doi:10.1080/15592294.2016.1214782 · Cited by 99
Parental depression and child well-being: young children's self-reports helped addressing biases in parent reports
Ringoot, A. P., Tiemeier, H. W., Jaddoe, V. W. V., So, P., Albert Hofman, D., Verhulst, F. C., & Jansen, P. W. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.03.009 · Cited by 95
Fetal and Infant Growth Patterns Associated With Total and Abdominal Fat Distribution in School-Age Children
Gishti, O., Gaillard, R., Manniesing, R., Berkeveld, M. A., van der Beek, E. M., Heppe, D. H. M., Steegers, E. A. P., Albert Hofman, D., Duijts, L., Durmuş, B., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4345 · Cited by 95
Early life antibiotic use and the risk of asthma and asthma exacerbations in children
Ahmadizar, F., Vijverberg, S. J. H., Arets, H. G. M., de Boer, A., Turner, S., Devereux, G. S., Arabkhazaeli, A., Soares, P., Mukhopadhyay, S., Garssen, J., et al. (2017) · Pediatric Allergy and Immunology · doi:10.1111/pai.12725 · Cited by 94
Parenting Style, the Home Environment, and Screen Time of 5-Year-Old Children; The ‘Be Active, Eat Right’ Study
Veldhuis, L., van Grieken, A., Renders, C. M., Hirasing, R. A., & Raat, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088486 · Cited by 96
Associations between Nausea, Vomiting, Fatigue and Health-Related Quality of Life of Women in Early Pregnancy: The Generation R Study
Bai, G., Korfage, I. J., Groen, E. H., Jaddoe, V. W. V., Mautner, E., & Raat, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166133 · Cited by 94
Maternal plasma PUFA concentrations during pregnancy and childhood adiposity: the Generation R Study
Vidakovic, A. J., Gishti, O., Voortman, T., Felix, J. F., Williams, M. A., Albert Hofman, D., Demmelmair, H., Koletzko, B. V., Tiemeier, H. W., Jaddoe, V. W. V., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.112847 · Cited by 96
Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3: GWAS of Height-Adjusted BMI
Stergiakouli, E., Gaillard, R., Tavaré, J. M., Balthasar, N., Loos, R. J., Taal, H. R., Evans, D. M., Rivadeneira, F., St Pourcain, B., Uitterlinden, A. G., et al. (2014) · Obesity · doi:10.1002/oby.20840 · Cited by 90
Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents
Qi, Q., Downer, M. K., Kilpeläinen, T. O., Taal, H. R., Barton, S. J., Ντάλλα, Ι., Standl, M., Perica, V. B., Huikari, V., Jong, J. C. K., et al. (2015) · Diabetes · doi:10.2337/db14-1629 · Cited by 93
Prenatal stress exposure, oxytocin receptor gene (OXTR) methylation, and child autistic traits: The moderating role of OXTR rs53576 genotype
Rijlaarsdam, J., van IJzendoorn, M. H., Verhulst, F. C., Jaddoe, V. W. V., Felix, J. F., Tiemeier, H. W., & Bakermans‐Kranenburg, M. J. (2016) · Autism Research · doi:10.1002/aur.1681 · Cited by 98
Recreational Cannabis Legalization in the US and Maternal Use during the Preconception, Prenatal, and Postpartum Periods
Skelton, K. R., Hecht, A. A., & Benjamin‐Neelon, S. E. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17030909 · Cited by 93
Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area
Ghassabian, A., Graaff, J. S., Peeters, R. P., Ross, H. A., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., White, T. J. H., & Tiemeier, H. W. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005520 · Cited by 89
Prenatal parental tobacco smoking, gene specific DNA methylation, and newborns size: the Generation R study
Bouwland-Both, M. I., Mil, N. H. G., Tolhoek, C. P., Stolk, L., Eilers, P. H. C., Verbiest, M. M. P. J., Heijmans, B. T., Uitterlinden, A. G., Albert Hofman, D., van IJzendoorn, M. H., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0115-z · Cited by 88
Maternal Parity, Fetal and Childhood Growth, and Cardiometabolic Risk Factors
Gaillard, R., Rurangirwa, A. A., Williams, M. A., Albert Hofman, D., Mackenbach, J. P., Franco, O. H., Steegers, E. A. P., & Jaddoe, V. W. V. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03492 · Cited by 92
Fetal sex specific differences in human placentation: A prospective cohort study
Brown, Z. A., Schalekamp–Timmermans, S., Tiemeier, H. W., Hofman, A., Jaddoe, V. W. V., & Steegers, E. (2014) · Placenta · doi:10.1016/j.placenta.2014.03.014 · Cited by 90
Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: The Generation R Study
Vinkhuyzen, A. A. E., Eyles, D. W., Burne, T. H. J., Blanken, L. M. E., Kruithof, C. J., Verhulst, F. C., Jaddoe, V. W. V., Tiemeier, H. W., & McGrath, J. J. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.09.018 · Cited by 85
Risk factors and consequences of maternal anaemia and elevated haemoglobin levels during pregnancy: a population-based prospective cohort study.
Gaillard, R., Eilers, P., Yassine, S., Hofman, A., Steegers, E., & Jaddoe, V. (2014) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12112 · Cited by 76
The Dysregulation Profile in Young Children: Empirically Defined Classes in the Generation R Study
Basten, M., Althoff, R. R., Tiemeier, H. W., Jaddoe, V. W. V., Albert Hofman, D., Hudziak, J. J., Verhulst, F. C., & van der Ende, J. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.007 · Cited by 85
Correlates of Physical Activity in 2-Year-Old Toddlers: The Generation R Study
Wijtzes, A. I., Kooijman, M. N., Jong, J. C. K., de Vries, S. I., Henrichs, J., Jansen, W., Jaddoe, V. W. V., Albert Hofman, D., Moll, H. A., & Raat, H. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.02.029 · Cited by 84
Cortical Morphology in 6- to 10-Year Old Children With Autistic Traits: A Population-Based Neuroimaging Study
Blanken, L. M. E., Mous, S. E., Ghassabian, A., Muetzel, R. L., Schoemaker, N. K., El Marroun, H., van der Lugt, A., Jaddoe, V. W. V., Hofman, A., Verhulst, F. C., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14040482 · Cited by 84
Social inequalities in young children’s sports participation and outdoor play
Wijtzes, A. I., Jansen, W., Bouthoorn, S. H., Pot, N., Albert Hofman, D., Jaddoe, V. W. V., & Raat, H. (2014) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-014-0155-3 · Cited by 96
Placental Vascular Dysfunction, Fetal and Childhood Growth, and Cardiovascular Development
Gaillard, R., Steegers, E. A. P., Tiemeier, H. W., Albert Hofman, D., & Jaddoe, V. W. V. (2013) · Circulation · doi:10.1161/circulationaha.113.003881 · Cited by 83
Maternal first-trimester diet and childhood bone mass: the Generation R Study
Heppe, D. H. M., Medina‐Gómez, C., Albert Hofman, D., Franco, O. H., Rivadeneira, F., & Jaddoe, V. W. V. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.051052 · Cited by 80
Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study
Richmond, R. C., Timpson, N. J., Felix, J. F., Palmer, T., Gaillard, R., McMahon, G., Smith, G. D., Jaddoe, V. W. V., & Lawlor, D. A. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002221 · Cited by 83
Tracking of fetal growth characteristics during different trimesters and the risks of adverse birth outcomes
Gaillard, R., Steegers, E. A. P., de Jongste, J. C., Albert Hofman, D., & Jaddoe, V. W. V. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu036 · Cited by 87
White matter integrity and cognitive performance in school-age children: A population-based neuroimaging study
Muetzel, R. L., Mous, S. E., van der Ende, J., Blanken, L. M. E., van der Lugt, A., Jaddoe, V. W. V., Verhulst, F. C., Tiemeier, H. W., & White, T. J. H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.014 · Cited by 82
Stimulation of Thyroid Function by Human Chorionic Gonadotropin During Pregnancy: A Risk Factor for Thyroid Disease and a Mechanism for Known Risk Factors
Korevaar, T. I. M., de Rijke, Y. B., Chaker, L., Medici, M., Jaddoe, V. W. V., Steegers, E. A. P., Visser, T. J., & Peeters, R. P. (2017) · Thyroid · doi:10.1089/thy.2016.0527 · Cited by 78
Prenatal Cannabinoid Exposure: Emerging Evidence of Physiological and Neuropsychiatric Abnormalities
Nashed, M. G., Hardy, D. B., & Laviolette, S. R. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.624275 · Cited by 74
The Development of a Diet Quality Score for Preschool Children and Its Validation and Determinants in the Generation R Study
Voortman, T., Jong, J. C. K., Geelen, A., Villamor, E., Moll, H. A., de Jongste, J. C., Raat, H., Albert Hofman, D., Jaddoe, V. W. V., Franco, O. H., et al. (2014) · Journal of Nutrition · doi:10.3945/jn.114.199349 · Cited by 75

Authors: Jaddoe, V. W. V., van Duijn, C. M., Franco, O. H., van der Heijden, A. J., van IIzendoorn, M. H., de Jongste, J. C., van der Lugt, A., Mackenbach, J. P., Moll, H. A., Raat, H., Rivadeneira, F., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A.
Affiliations: Erasmus MC (NL)
Corresponding author: Jaddoe, Vincent W. V.
ORCID: Jaddoe, Vincent W. V.
Franco, Oscar H.
Rivadeneira, Fernando
Tiemeier, Henning
Venue: European Journal of Epidemiology
Publisher: Springer Science and Business Media LLC
Published: 2012-09
Volume: 27
Issue: 9
Pages: 739-756
ISSN: 0393-2990 (ISSN-L)
1573-7284
DOI: 10.1007/s10654-012-9735-1
OpenAlex: W2280586107
Cited by: 546
References: 195
Citations by year: 2026: 5 · 2025: 19 · 2024: 13 · 2023: 13 · 2022: 24 · 2021: 21 · 2020: 36 · 2019: 35 · 2018: 27 · 2017: 57 · 2016: 85 · 2015: 85 · 2014: 77 · 2013: 45 · 2012: 2
FWCI: 58.61
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders: ZonMw (907.00303, 916.10159)
Erasmus Universiteit Rotterdam
Erasmus Medisch Centrum
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (90700303, 916.10159)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords: Generation R Study, prospective cohort, fetal development, child growth, maternal health, physical development, cognitive development, behavioral development, respiratory health, allergy, childhood diseases, child health care, epigenetics, genome-wide association study, environmental exposure, prenatal exposure, birth cohort
MeSH terms: Adult, Child, Child Behavior, Child Development, Cognition, Data Collection, Environment, Family Characteristics, Female, Growth Disorders, Humans, Infant, Male, Maternal Health Services, Netherlands, Physical Examination, Pregnancy, Surveys and Questionnaires, Research Design, Cohort Studies, Epidemiologic Research Design, Fetal Development, Genome-Wide Association Study

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Generation R Study: design and cohort update 2012

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks