The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
GelMA combined with sustained release of HUVECs derived exosomes for promoting cutaneous wound healing and facilitating skin regeneration
Abstract
It remains a clinical challenge for cutaneous wound healing and skin regeneration. Endothelial cells participate in the formation of blood vessels and play an important role in the whole process of wound healing. Recent studies suggested that exosomes contribute to the intercellular communication through paracrine pathways, and sustained release of exosomes from hydrogel-based materials provide a promising strategy for curing wound defects. In this study, we isolated exosomes derived from human umbilical vein endothelial cells (HUVECs) and found that HUVECs derived exosomes (HUVECs-Exos) could promote the proliferation and migration activities of keratinocytes and fibroblasts, which are two important effector cells for skin regeneration. Then we developed gelatin methacryloyl (GelMA) hydrogel as the wound dressing to incorporate HUVECs-Exos and applied it to the full-thickness cutaneous wounds. It demonstrated that GelMA scaffold could not only repair the wound defect, but also achieve sustained release of exosomes. The in vivo results showed accelerated re-epithelialization, promotion of collagen maturity and improvement of angiogenesis. Collectively, our findings suggested that HUVECs-Exos could accelerate wound healing and GelMA mediated controlled release of HUVECs-Exos might offer a new method for repairing cutaneous wound defects.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, exosomes derived from human umbilical vein endothelial cells (HUVECs) can promote collagen maturation and angiogenesis and regulate the keratinocytes and fibroblast growth, thereby accelerating skin wound healing [102].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [102]
Citations
Cites
2 retracted
Jianing, D., Wang, X., Chen, B., Zhang, J., & Xu, J. (2019) · BioMed Research International · doi:10.1155/2019/9742765 · Cited by 184
RetractedBarati, D., Shariati, S. R. P., Moeinzadeh, S., Melero‐Martin, J. M., Khademhosseini, A., & Jabbari, E. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.031 · Cited by 159
RetractedSinger, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.045 · Cited by 3,146 · cited 4×
“…sequences of arginine-glycine-aspartic acid (RGD), which is favorable for cells attachment and proliferation on scaffold (Liu and Chan-Park 2010; Hadjizadeh and Doillon 2010), it also contains matrix metalloproteinase (MMP) sequences that help cells migration and remodeling (Yue 2015; Steen 2002).”
BackgroundMethodInfluentialJohnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931
The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms
Velnar, T., Bailey, T. A., & Smrkolj, V. (2009) · Journal of International Medical Research · doi:10.1177/147323000903700531 · Cited by 2,446
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980
Biomaterials based on chitin and chitosan in wound dressing applications
Jayakumar, R., Prabaharan, M., Kumar, P. T. S., Nair, S. V., & Tamura, H. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.01.005 · Cited by 1,927
Epithelialization in Wound Healing: A Comprehensive Review
Pastar, I., Stojadinović, O., Yin, N. C., Ramirez, H. A., Nusbaum, A. G., Sawaya, A. P., Patel, S. B., Khalid, L., Isseroff, R. R., & Tomic‐Canic, M. (2014) · Advances in Wound Care · doi:10.1089/wound.2013.0473 · Cited by 1,604
Cited by
Sorted by citations
Items 101–139 of 139
Li, X., Wang, F., Wang, R., Cheng, Y., Liu, J., & Luo, W. (2025) · Biology · doi:10.3390/biology14080970 · Cited by 6
The Exosome and its Application in Skin Wound Healing: A Systematic Review on In vitro Studies
Heydari, M. B., Ghanbari‐Movahed, Z., Heydari, M., & Farzaei, M. H. (2025) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010323495241016085000 · Cited by 6
Yang, L., & Lv, Y. (2026) · Journal of Tissue Engineering · doi:10.1177/20417314251410000 · Cited by 7
GelMA - PVAMA hydrogel loaded with MYDGF accelerates wound healing by promoting angiogenesis
Huang, S., Kou, H., Zheng, Z., Lu, M., Wu, L., & Zheng, H. (2024) · International Journal of Polymeric Materials · doi:10.1080/00914037.2024.2302606 · Cited by 5
Tian, M., Wu, J., Du, Q., Han, J., Yang, M., Li, X., Li, M., Ding, X., & Song, Y. (2025) · Journal of Diabetes Research · doi:10.1155/jdr/4656485 · Cited by 6
Photocrosslinkable and biodegradable hydrogels for the controlled delivery of exosomesPreprint
Ayala‐Mar, S., Jeon, O., Chacón-Ponce, P., González‐Valdez, J., & Alsberg, E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.01.646472 · Cited by 8
Engineered Exosomes Complexed with Botulinum Toxin Type A for Enhanced Anti-Aging Effects on Skin
Wang, Y., Wang, K., Ben, X., Tian, M., Liu, X., Li, Z., Ni, P., Liu, Q., Ma, Z., Yi, X., et al. (2025) · Biology · doi:10.3390/biology14081040 · Cited by 4
Self-citationExosome-Based Therapies in Dermatology
Aryal, S. (2025) · Aesthetic Plastic Surgery · doi:10.1007/s00266-025-05073-7 · Cited by 4
Jiang, B., Shi, A., Xu, Y., Zhang, Y., Chen, Y., Jiang, X., Liu, H., & Zhang, L. (2022) · Materials Today Communications · doi:10.1016/j.mtcomm.2022.105152 · Cited by 3
Wang, J., Song, S., Zhang, S., Tian, X., Ma, B., Liu, D., & Duan, P. (2024) · Materials Today Communications · doi:10.1016/j.mtcomm.2024.109219 · Cited by 3
Ellistasari, E. Y., Kariosentono, H., Purwanto, B., Wasita, B., Riswiyant, R. C. A., Pamungkasari, E. P., & Soetrisno, S. (2022) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2022.9969 · Cited by 2
Li, G., & Lei, M. (2026) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.70045 · Cited by 2
Plant-Derived Exosomes in Aesthetic Medicine
Chen, R., Wei, S., Dan, X., Li, S. S., Chen, H., Pu, Y., Liu, X., Li, T., Lei, L., Li, Y., et al. (2026) · Biomaterials Research · doi:10.34133/bmr.0397 · Cited by 3
Self-citationImmune dysregulation in chronic diabetic wounds: therapeutic opportunities for healing reprogramming
Yu, W., Li, Q., Wang, J., Fu, J., Hao, Y., Wang, Z., Xu, H., Zhang, M., Zhao, G., & Ma, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1889465 · Cited by 2
Self-citationDesigner Engineered Exosomes: a New Regenerative Medicine Platform for Skin Wound Healing
Zahedi, P., Ghaderi, G., Shekarriz, H., Rahimi, P., Panahian, A., Salmani, M., Movahed, N. Y., Parsaei, H., & Jafari, D. (2025) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00385-1 · Cited by 2
Lithium‐loaded GelMA‐Phosphate glass fibre constructs: Implications for astrocyte response
Keskin‐Erdogan, Z., Mandakhbayar, N., Jin, G., Li, Y., Chau, D. Y. S., Day, R. M., Kim, H., & Knowles, J. C. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37686 · Cited by 2
Self-citationMoghan, M., Naidu, P., Zulkifly, N. B., Selan, Y. N., Setyawan, E. M. N., Winarsih, S., & Kusindarta, D. L. (2023) · Open Veterinary Journal · doi:10.5455/ovj.2023.v13.i12.9 · Cited by 1
Liu, H., Jiang, W., Han, L., & Lu, X. (2025) · Macromolecular Bioscience · doi:10.1002/mabi.202400546 · Cited by 1
Nie, L., Wei, Q., Ding, X., Yan, L., Li, J., Guo, W., Huang, D., Okoro, O. V., Sun, Y., Jiang, G., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149474 · Cited by 1
Guo, Y., Miao, Y., Hu, Z., & Qu, Q. (2026) · Journal of Molecular Histology · doi:10.1007/s10735-026-10771-w · Cited by 1
Peng, J., Zhang, J., Li, Q., Liu, W., Zou, W., Zhu, L., Zhou, Q., Liu, D., Jia, M., & Li, H. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103276 · Cited by 1
Self-citationLi, M., Yu, M., Liu, L., & Tian, W. (2022) · PubMed Central · doi:10.12182/20220360507 · Cited by 2
Application of Free Skin Flap Transplantation in Skin Malignant Tumor Resection
Zhou, Y., Xu, W., Hou, J., Hou, C., & Zhang, J. (2022) · Journal of Oncology · doi:10.1155/2022/7510330 · Cited by 1
RetractedBeihaghia, M., Sahebi, R., Beihaghi, M. R., Tehrani, H., Dowom, S. A., neissiani, R. K., & Janati, Z. (2023) · Preprints.org · doi:10.20944/preprints202312.0021.v1
Research Progress of Exosome in Gastric Cancer
陈, 鑫. (2022) · Advances in Clinical Medicine · doi:10.12677/acm.2022.12101338
Dou, Y., Hong, Z., Li, H., Xing, H., Zhu, C., & Xuan, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-3951081/v1
Regenerative Medicine in Clinical and Aesthetic Dermatology
Verling, S. D., Mashoudy, K. D., Gompels, M. T., & Goldenberg, G. (2024) · Springer eBooks · doi:10.1007/978-3-031-48503-9_10
Liu, X., Xiong, J., Li, X., Pan, H., & Osama, H. (2024) · Archives of Dermatological Research · doi:10.1007/s00403-024-02992-4
Karimzadeh, Z., Balanezhad, S. Z., Baharara, J., Shahrokhabadi, K. N., & Khorshid, P. (2025) · Current Stem Cell Research & Therapy · doi:10.2174/011574888x385954250819085742
Jiang, Y., Hao, M., Jiang, F., Li, J., Yang, K., Li, C., Ma, L., Liu, S., Kou, X., Shi, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24499344
Dou, Y., Hong, Z., Li, H., Xing, H., Zhu, C., & Xuan, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26231233
Li, S., Sun, J., Yang, J., Yang, Y., Ding, H., Yu, B., Ma, K., & Chen, M. (2023) · Figshare · doi:10.6084/m9.figshare.22611896
Liu, W., Wang, R., Zhao, F., Fang, Z., Ma, J. Y., Mai, Z., He, Y. Q., Sheng, J. Z., Shi, Y., Zhao, Z., et al. (2026) · Research · doi:10.34133/research.1329
Dehydrated silk fibroin matrices as versatile delivery systems for extracellular vesicles
Sarisoy, A., Xu, Y., Rütten, S., Buhl, E. M., Maire, C. L., Fuest, S., Smeets, R., Ricklefs, F. L., & Apel, C. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1873981
Noh, M., Heo, T.-H., Kang, M.-K., & Jeong, G. (2026) · Polymers · doi:10.3390/polym18141781
Datta, D., Nison, M., Colaco, V., Prabhu, M. R., Bandi, S. P., Dhas, N. L., Hebbar, S., Pai, V., & Singh, S. K. (2026) · Progress in Additive Manufacturing · doi:10.1007/s40964-026-01928-w
Huang, S., Meng, Z., Wang, Y., Wu, Y., Ni, Z., Li, X., Chen, Y., Hu, S., & Huang, H. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158829
Self-citationLim, J., Lin, C.-Y., Bupphathong, S., Sung, P.-C., Kuo, T.-Y., Zhang, C.-W., & Lin, C.-H. (2026) · ACS Applied Polymer Materials · doi:10.1021/acsapm.6c03468
Chen, L., Li, M., Jiang, C., Hu, H., & Zhang, T. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.117373
Metadata
- Authors
- Zhao, D., Yu, Z., Li, Y., Wang, Y., Li, Q., & Han, D.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Li, Qingfeng
- Han, Dong
- Venue
- Journal of Molecular Histology
- Published
- 2020-05-09
- Volume
- 51
- Issue
- 3
- Pages
- 251-263
- ISSN
- 1567-2379 (ISSN-L)
- 1567-2387
- OpenAlex
- W3023186039
- Cited by
- 139
- References
- 67
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 27 · 2023: 27 · 2022: 31 · 2021: 16 · 2020: 2
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Histology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81620108019, 81571944)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- exosomes, human umbilical vein endothelial cells, gelatin methacryloyl hydrogel, skin wound healing, skin regeneration, wound dressings, keratinocyte proliferation and migration, fibroblast proliferation and migration, re-epithelialization, collagen maturation, angiogenesis, paracrine signaling
- MeSH terms
- Animals, Cell Movement, Collagen, Fibroblasts, Humans, Male, Regeneration, Skin, Wound Healing, Keratinocytes, Rats, Sprague-Dawley, Neovascularization, Physiologic, Hydrogels, Cell Proliferation, Exosomes, Human Umbilical Vein Endothelial Cells, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
