The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
GelMA combined with sustained release of HUVECs derived exosomes for promoting cutaneous wound healing and facilitating skin regeneration
Abstract
It remains a clinical challenge for cutaneous wound healing and skin regeneration. Endothelial cells participate in the formation of blood vessels and play an important role in the whole process of wound healing. Recent studies suggested that exosomes contribute to the intercellular communication through paracrine pathways, and sustained release of exosomes from hydrogel-based materials provide a promising strategy for curing wound defects. In this study, we isolated exosomes derived from human umbilical vein endothelial cells (HUVECs) and found that HUVECs derived exosomes (HUVECs-Exos) could promote the proliferation and migration activities of keratinocytes and fibroblasts, which are two important effector cells for skin regeneration. Then we developed gelatin methacryloyl (GelMA) hydrogel as the wound dressing to incorporate HUVECs-Exos and applied it to the full-thickness cutaneous wounds. It demonstrated that GelMA scaffold could not only repair the wound defect, but also achieve sustained release of exosomes. The in vivo results showed accelerated re-epithelialization, promotion of collagen maturity and improvement of angiogenesis. Collectively, our findings suggested that HUVECs-Exos could accelerate wound healing and GelMA mediated controlled release of HUVECs-Exos might offer a new method for repairing cutaneous wound defects.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, exosomes derived from human umbilical vein endothelial cells (HUVECs) can promote collagen maturation and angiogenesis and regulate the keratinocytes and fibroblast growth, thereby accelerating skin wound healing [102].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [102]
Citations
Cites
2 retracted
Jianing, D., Wang, X., Chen, B., Zhang, J., & Xu, J. (2019) · BioMed Research International · doi:10.1155/2019/9742765 · Cited by 184
RetractedBarati, D., Shariati, S. R. P., Moeinzadeh, S., Melero‐Martin, J. M., Khademhosseini, A., & Jabbari, E. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.031 · Cited by 159
RetractedSinger, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.045 · Cited by 3,146 · cited 4×
“…sequences of arginine-glycine-aspartic acid (RGD), which is favorable for cells attachment and proliferation on scaffold (Liu and Chan-Park 2010; Hadjizadeh and Doillon 2010), it also contains matrix metalloproteinase (MMP) sequences that help cells migration and remodeling (Yue 2015; Steen 2002).”
BackgroundMethodInfluentialJohnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931
The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms
Velnar, T., Bailey, T. A., & Smrkolj, V. (2009) · Journal of International Medical Research · doi:10.1177/147323000903700531 · Cited by 2,446
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980
Biomaterials based on chitin and chitosan in wound dressing applications
Jayakumar, R., Prabaharan, M., Kumar, P. T. S., Nair, S. V., & Tamura, H. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.01.005 · Cited by 1,927
Epithelialization in Wound Healing: A Comprehensive Review
Pastar, I., Stojadinović, O., Yin, N. C., Ramirez, H. A., Nusbaum, A. G., Sawaya, A. P., Patel, S. B., Khalid, L., Isseroff, R. R., & Tomic‐Canic, M. (2014) · Advances in Wound Care · doi:10.1089/wound.2013.0473 · Cited by 1,604
Cited by
Sorted by citations
Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323
Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing
Kharaziha, M., Baidya, A., & Annabi, N. (2021) · Advanced Materials · doi:10.1002/adma.202100176 · Cited by 742
Extracellular vesicle-loaded hydrogels for tissue repair and regeneration
Ju, Y., Hu, Y., Pu, Y., Xie, X., & Fang, B. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100522 · Cited by 471
Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
Kurian, A. G., Singh, R. K., Patel, K. D., Lee, J., & Kim, H. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.027 · Cited by 462
Wang, Y., Cao, Z., Wei, Q., Ma, K., Hu, W., Huang, Q., Su, J., Li, H., Zhang, C., & Fu, X. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.05.018 · Cited by 225
Self-citation
Metadata
- Authors
- Zhao, D., Yu, Z., Li, Y., Wang, Y., Li, Q., & Han, D.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Li, Qingfeng
- Han, Dong
- Venue
- Journal of Molecular Histology
- Published
- 2020-05-09
- Volume
- 51
- Issue
- 3
- Pages
- 251-263
- ISSN
- 1567-2379 (ISSN-L)
- 1567-2387
- OpenAlex
- W3023186039
- Cited by
- 139
- References
- 67
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 27 · 2023: 27 · 2022: 31 · 2021: 16 · 2020: 2
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Histology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81620108019, 81571944)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- exosomes, human umbilical vein endothelial cells, gelatin methacryloyl hydrogel, skin wound healing, skin regeneration, wound dressings, keratinocyte proliferation and migration, fibroblast proliferation and migration, re-epithelialization, collagen maturation, angiogenesis, paracrine signaling
- MeSH terms
- Animals, Cell Movement, Collagen, Fibroblasts, Humans, Male, Regeneration, Skin, Wound Healing, Keratinocytes, Rats, Sprague-Dawley, Neovascularization, Physiologic, Hydrogels, Cell Proliferation, Exosomes, Human Umbilical Vein Endothelial Cells, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
