The effects of vitamin C on respiratory, allergic and immunological diseases: An experimental and clinical-based review
Open accessAbstract
Vitamin C is used in modern medicine supplements for treatment of various disorders associated with oxidative stress, inflammation and immune dysregulation. In this review article, experimental and clinical results regarding the effects of vitamin C on respiratory immunologic, and allergic diseases are reviewed. Various databases and appropriate keywords are used to search the effect of vitamin C on respiratory diseases until the end of May 2022. Books, theses and articles were included. These studies assessed the effects of vitamin C on respiratory disorders including asthma, chronic obstructive pulmonary disease (COPD), lung infection and lung cancer. Vitamin C showed relaxant effect on tracheal smooth muscle via various mechanisms. The preventive effects of vitamin C were mediated by antioxidant, immunomodulatory and anti-inflammatory mechanisms in the experimental animal models of different respiratory diseases. Some clinical studies also indicated the effect of vitamin C on lung cancer and lung infections. Therefore, vitamin C could be used a preventive and/or relieving therapy in respiratory diseases.
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Vitamin C supplementation for more than 6 months can impact respiratory function.
“As an example, vitamin C supplementation for more than 6 months can impact respiratory function, which could be measured with surveys and standard measures of immunity and health [48].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [48]
The Introduction and the COPD table report that vitamin C supplementation can affect lung function. The Clinical results table lists supplementation lasting up to six months, not more than six months, and the cited passages do not establish the proposed use of surveys and standard measures of immunity and health to assess respiratory function. No page numbers are provided in our copy. (LLM, conf=0.85)
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- Authors
- Ghalibaf, M. H. E., Kianian, F., Beigoli, S., Behrouz, S., Marefati, N., Boskabady, M., & Boskabady, M. H.
- Affiliations
- Mashhad University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Baqiyatallah University of Medical Sciences (IR)
- Corresponding author
- Boskabady, Mohammad Hossein
- Venue
- Inflammopharmacology
- Published
- 2023-02-27
- Volume
- 31
- Issue
- 2
- Pages
- 653-672
- ISSN
- 0925-4692 (ISSN-L)
- 1568-5608
- PMC
- PMC9970132
- OpenAlex
- W4322418706
- Cited by
- 60
- References
- 119
- Citations by year
- 2026: 10 · 2025: 29 · 2024: 17 · 2023: 3
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Inflammopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- vitamin C, respiratory diseases, allergic diseases, asthma, chronic obstructive pulmonary disease, pulmonary infection, lung cancer, oxidative stress, inflammation, immune dysregulation, antioxidant activity, immunomodulation, tracheal smooth muscle relaxation, vitamin C supplementation
- MeSH terms
- Animals, Ascorbic Acid, Asthma, Lung Neoplasms, Pneumonia, Respiratory Tract Diseases, Vitamins, Pulmonary Disease, Chronic Obstructive
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