Cited by 60Vitamin C and Antioxidants ResearchAsthma and respiratory diseasesAntioxidant Activity and Oxidative Stress

The effects of vitamin C on respiratory, allergic and immunological diseases: An experimental and clinical-based review

Open access
Ghalibaf, Mohammad Hossein Eshaghi, Kianian, Farzaneh, Beigoli, Sima, Behrouz, Sepideh, Marefati, Narges, Boskabady, Marzie, Boskabady, Mohammad Hossein·2023·Inflammopharmacology

Abstract

Vitamin C is used in modern medicine supplements for treatment of various disorders associated with oxidative stress, inflammation and immune dysregulation. In this review article, experimental and clinical results regarding the effects of vitamin C on respiratory immunologic, and allergic diseases are reviewed. Various databases and appropriate keywords are used to search the effect of vitamin C on respiratory diseases until the end of May 2022. Books, theses and articles were included. These studies assessed the effects of vitamin C on respiratory disorders including asthma, chronic obstructive pulmonary disease (COPD), lung infection and lung cancer. Vitamin C showed relaxant effect on tracheal smooth muscle via various mechanisms. The preventive effects of vitamin C were mediated by antioxidant, immunomodulatory and anti-inflammatory mechanisms in the experimental animal models of different respiratory diseases. Some clinical studies also indicated the effect of vitamin C on lung cancer and lung infections. Therefore, vitamin C could be used a preventive and/or relieving therapy in respiratory diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s10787-023-01169-1

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Vitamin C supplementation for more than 6 months can impact respiratory function.

    “As an example, vitamin C supplementation for more than 6 months can impact respiratory function, which could be measured with surveys and standard measures of immunity and health [48].”

    From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [48]

    The Introduction and the COPD table report that vitamin C supplementation can affect lung function. The Clinical results table lists supplementation lasting up to six months, not more than six months, and the cited passages do not establish the proposed use of surveys and standard measures of immunity and health to assess respiratory function. No page numbers are provided in our copy. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

2 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ghalibaf, M. H. E., Kianian, F., Beigoli, S., Behrouz, S., Marefati, N., Boskabady, M., & Boskabady, M. H.
Affiliations
  • Mashhad University of Medical Sciences (IR)
  • Tehran University of Medical Sciences (IR)
  • Baqiyatallah University of Medical Sciences (IR)
Corresponding author
Boskabady, Mohammad Hossein
Venue
Inflammopharmacology
Published
2023-02-27
Volume
31
Issue
2
Pages
653-672
ISSN
  • 0925-4692 (ISSN-L)
  • 1568-5608
OpenAlex
W4322418706
Cited by
60
References
119
Citations by year
2026: 10 · 2025: 29 · 2024: 17 · 2023: 3
FWCI
2.13
Type
journal article
Language
en
Open access
Locations
  • Inflammopharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
vitamin C, respiratory diseases, allergic diseases, asthma, chronic obstructive pulmonary disease, pulmonary infection, lung cancer, oxidative stress, inflammation, immune dysregulation, antioxidant activity, immunomodulation, tracheal smooth muscle relaxation, vitamin C supplementation
MeSH terms
Animals, Ascorbic Acid, Asthma, Lung Neoplasms, Pneumonia, Respiratory Tract Diseases, Vitamins, Pulmonary Disease, Chronic Obstructive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review