Prevalence and Onset of Regression within Autism Spectrum Disorders: A Meta-analytic Review
Abstract
Rates and onset of regression were meta-analyzed from 85 articles representing 29,035 participants with autism spectrum disorders (ASD). Overall prevalence rate for regression was 32.1, 95 % CI [29.5, 34.8] occurring at mean of 1.78 years, 95 % CI [1.67, 1.89]. Regression prevalence rates differed according to four types of regression: language regression, 24.9 %; language/social regression, 38.1 %; mixed regression, 32.5 %; and unspecified regression, 39.1 %. Regression prevalence also differed according to sampling method: population-based prevalence was 21.8 %, clinic-based prevalence was 33.6 %, and parent survey-based prevalence was 40.8 %. Risk of regression was equal for males and females, but higher for individuals diagnosed with autism versus another ASD. Later age of regression onset was predicted by older age of child.
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Cognitive profiles based on the relative discrepancy between verbal and non-verbal skills in ASD have been identified.
“cognitive profiles based on the relative discrepancy between verbal and non-verbal skills in ASD have been identified [50,51].”
From DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes (2013) · cites this paper as [51]
A recent meta-analysis suggested a mean prevalence of parent-reported regression of 32%.
“A recent meta-analysis suggested a mean prevalence of parentreported regression of 32% (Barger et al. 2013), but rates vary depending on how stringent a definition is employed (Hansen et al. 2008, Stefanatos 2008).”
From Recent Advances in Autism Research as Reflected in DSM-5 Criteria for Autism Spectrum Disorder (2015) · cites this paper as Barger et al. 2013
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1 retracted
Wakefield, A., Murch, S., Anthony, A., Linnell, J., Casson, D., Malik, M., Berelowitz, M., Dhillon, A., Thomson, M., Harvey, P., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11096-0 · Cited by 3,006 · see citing works
RetractedCicchetti, D. V. (1994) · Psychological Assessment · doi:10.1037/1040-3590.6.4.284 · Cited by 9,349 · see citing works
The onset of autism: patterns of symptom emergence in the first years of life
Ozonoff, S., Heung, K., Byrd, R., Hansen, R., & Hertz‐Picciotto, I. (2008) · Autism Research · doi:10.1002/aur.53 · Cited by 293 · see citing works
Regression in Autism: Prevalence and Associated Factors in the CHARGE Study
Hansen, R. L., Ozonoff, S., Krakowiak, P., Angkustsiri, K., Jones, C., Deprey, L. J., Le, D.-N., Croen, L. A., & Hertz-Picciotto, I. (2008) · Ambulatory Pediatrics · doi:10.1016/j.ambp.2007.08.006 · Cited by 164 · see citing works
Jones, L. A., & Campbell, J. M. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0823-3 · Cited by 76 · see citing works
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Lai, M.-C., Lombardo, M. V., & Baron-Cohen, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61539-1 · Cited by 2,371 · see citing works
Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development
Bernier, R., Golzio, C., Xiong, B., Stessman, H. A., Coe, B. P., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Vulto-van Silfhout, A. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.017 · Cited by 798 · see citing works
DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes
Grzadzinski, R., Huerta, M., & Lord, C. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-12 · Cited by 378 · see citing works
Gut microbiota and autism: key concepts and findings
Ding, H. T., Taur, Y., & Walkup, J. T. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2960-9 · Cited by 232 · see citing works
Recent Advances in Autism Research as Reflected in DSM-5 Criteria for Autism Spectrum Disorder
Lord, C., & Bishop, S. L. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032814-112745 · Cited by 224 · see citing works
Jack, A., & A. Pelphrey, K. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12687 · Cited by 159 · see citing works
Ozonoff, S., & Iosif, A.-M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.012 · Cited by 146 · see citing works
Boterberg, S., Charman, T., Marschik, P. B., Bölte, S., & Roeyers, H. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.013 · Cited by 77 · see citing works
Pearson, N., Charman, T., Happé, F., Bolton, P. F., & McEwen, F. S. (2018) · Autism Research · doi:10.1002/aur.2035 · Cited by 75 · see citing works
Epilepsy and autism severity: a study of 6,975 children
Ewen, J. B., Marvin, A. R., Law, K., & Lipkin, P. H. (2019) · Autism Research · doi:10.1002/aur.2132 · Cited by 56 · see citing works
- Authors
- Barger, B. D., Campbell, J. M., & McDonough, J. D.
- Affiliations
- University of Georgia (US)
- University of Kentucky (US)
- Corresponding author
- Campbell, Jonathan M.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2012-08-02
- Volume
- 43
- Issue
- 4
- Pages
- 817-828
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2005515221
- Cited by
- 243
- References
- 5
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 20 · 2023: 39 · 2022: 21 · 2021: 31 · 2020: 20 · 2019: 18 · 2018: 14 · 2017: 17 · 2016: 11 · 2015: 8 · 2014: 12 · 2013: 6
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, regression analysis, language regression, social regression, prevalence, risk factors, sex differences, diagnostic subtypes
- MeSH terms
- Age Factors, Autistic Disorder, Child, Child Development Disorders, Pervasive, Humans, Regression, Psychology, Time Factors, Prevalence, Age of Onset
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