Cited by 232Gut microbiota and healthAutism Spectrum Disorder ResearchGastrointestinal motility and disorders

Gut microbiota and autism: key concepts and findings

Ding, Helen T., Taur, Ying, Walkup, John T.·2017·Journal of Autism and Developmental Disorders

Abstract

There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms.

Integrity signals

Registry

Crossref · 10.1007/s10803-016-2960-9

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Many studies have reported dysbiosis of the gut microbiota in individuals with ASD.

    “Additionally, many studies have reported dysbiosis of the gut microbiota in individuals with ASD (26–28).”
  • A variety of mechanisms has been proposed in ASD associated with the function of gut microbiota, including immune activation/dysfunction, bacterial-derived toxin, metabolites aberrations, and dysregulated metabolism of free amino acids.

    “So far, a variety of mechanism has been proposed in ASD associated with the function of gut microbiota, including immune activation/dysfunction, bacterial-derived toxin (e.g., LPS, phenols, p-cresol, 4-EPS), metabolites aberrations in fermentation process or products, such as propionic acid (PPA) and other SCFAs, and the dysregulated metabolism of free amino acids61.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ding, H. T., Taur, Y., & Walkup, J. T.
Affiliations
  • NewYork–Presbyterian Hospital (US)
  • Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Ding, Helen T.
Venue
Journal of Autism and Developmental Disorders
Published
2016-11-24
Volume
47
Issue
2
Pages
480-489
ISSN
  • 0162-3257 (ISSN-L)
  • 1573-3432
OpenAlex
W2552521103
Cited by
232
References
68
Citations by year
2026: 7 · 2025: 14 · 2024: 23 · 2023: 19 · 2022: 29 · 2021: 35 · 2020: 33 · 2019: 36 · 2018: 22 · 2017: 13
FWCI
12.30
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Autism and Developmental Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, autism spectrum disorder, intestinal bacteria, Clostridium, Sutterella, microbial toxins, gut fermentation, immune abnormalities, metabolic abnormalities, animal models of autism, pathogenesis
MeSH terms
Autism Spectrum Disorder, Gastrointestinal Microbiome, Animals, Autistic Disorder, Child, Humans, Clostridium histolyticum, Hathewaya histolytica, Gastrointestinal Absorption

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review