CoChat
Sign Up
Cited by 293Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesChild and Animal Learning Development

The onset of autism: patterns of symptom emergence in the first years of life

Open access
Ozonoff, Sally, Heung, Kelly, Byrd, Robert, Hansen, Robin, Hertz‐Picciotto, Irva·2008·Autism Research
DOI 10.1002/aur.53PMC PMC2857525
Open this paper in CoChat — free account

Abstract

Previous conceptualizations of autism have suggested that symptoms are evident either early in the first year of life or later in the second year, after a loss of previously acquired skills. New research suggests, however, that these two patterns do not capture all the different ways autism can emerge. For example, some children show a developmental plateau marked by failure to progress, while other children display mixed features, with both early delays and later losses evident. This article reviews the literature on autism onset, discusses problems with the traditional ways in which onset has been conceptualized, and provides recommendations for future research. We suggest that onset is better thought of as a dimensional process rather than dichotomous categories.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/aur.53

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Neurobiological evidence suggests that individuals with both ASD and language impairment show similar patterns of structural brain abnormalities in core language areas as those with SLI without ASD, whereas individuals with ASD without language impairment do not show this pattern.

    “Neurobiological evidence suggests that individuals with both ASD and language impairment show similar patterns of structural brain abnormalities in the core language areas of the brain (for example, Wernicke’s and Broca’s areas) as those individuals with SLI without ASD, whereas individuals with ASD without language impairment do not show this pattern [56].”

    From DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes (2013) · cites this paper as [56]

    Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured

  • Previous longitudinal studies of high-risk infant siblings have suggested that ASD onset may be more complex and less homogeneous than previously understood, both with respect to timing and the consolidation of symptoms into a clear diagnostic profile.

    “Previous longitudinal studies of high-risk infant siblings [23, 34, 52] have suggested that ASD onset may be more complex and less homogeneous than previously understood [1, 33, 35], both with respect to timing and the consolidation of symptoms into a clear diagnostic profile [51].”

    From Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life (2015) · cites this paper as [33]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 67 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Heung K Is autistic regression too narrowly defined? Doctoral dissertation 2008 University of California, Davis. University Microfilms International

Cited by

Sorted by citations

Related

Authors
Ozonoff, S., Heung, K., Byrd, R., Hansen, R., & Hertz‐Picciotto, I.
Affiliations
University of California, Davis (US)
Corresponding author
Ozonoff, Sally
ORCID
Venue
Autism Research
Publisher
Wiley
Published
2008-12
Volume
1
Issue
6
Pages
320-328
ISSN
  • 1939-3792 (ISSN-L)
  • 1939-3806
DOI
10.1002/aur.53
PMC
PMC2857525
OpenAlex
W1969908029
Cited by
293
References
67
Citations by year
2026: 2 · 2025: 6 · 2024: 13 · 2023: 32 · 2022: 29 · 2021: 33 · 2020: 20 · 2019: 25 · 2018: 22 · 2017: 21 · 2016: 15 · 2015: 15 · 2014: 8 · 2013: 13 · 2012: 14
FWCI
3.96
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 29 d)
Locations
  • Autism Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH068398)
  • National Institute of Environmental Health Sciences (R01ES015359)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
Keywords
early childhood development, regression analysis, first year of life
MeSH terms
Autistic Disorder, Humans, Infant, Severity of Illness Index, Age of Onset, Early Diagnosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review