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Psychiatric Comorbidity and Medication Use in Adults with Autism Spectrum Disorder
Open accessAbstract
The purpose of this study was to investigate comorbid psychiatric disorders and psychotropic medication use among adults with autism spectrum disorder (ASD) ascertained as children during a 1980's statewide Utah autism prevalence study (n = 129). Seventy-three individuals (56.6 %) met criteria for a current psychiatric disorder; 89 participants (69.0 %) met lifetime criteria for a psychiatric disorder. Caregivers reported a psychiatric diagnosis in 44 participants (34.1 %). Anxiety disorder had the highest current and lifetime prevalence (39.5 and 52.7 %, respectively). Participants with intellectual disability (n = 94, 72.8 %) were significantly less likely to have community-based diagnoses of anxiety (χ(2) = 5.37, p = 0.02) or depression (χ(2) = 13.18, p < 0.001) reported by caregivers. Seventy-six participants (58.9 %) were taking ≥1 psychotropic medication. Comorbid psychiatric disorders occur frequently in adults with ASD, though identifying these disorders poses a challenge in community settings. A greater understanding of the presentation of these conditions within this population will increase assessment validity and the potential for efficacious intervention.
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“The majority of autistic children, adolescents and adults have one or more associated mental health conditions (Buck et al., 2014; Simonoff et al., 2008), with co-occurring anxiety disorders among the most common concerns.”
From Self-guided mindfulness and cognitive behavioural practices reduce anxiety in autistic adults: A pilot 8-month waitlist-controlled trial of widely available online tools. (2020) · cites this paper as Buck et al., 2014
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“Although prevalence estimates vary across studies, the current consensus is that 40%–50% of autistic individuals meet formal criteria for a co-occurring anxiety disorder (Buck et al., 2014; Van Steensel et al., 2011)”
From Self-guided mindfulness and cognitive behavioural practices reduce anxiety in autistic adults: A pilot 8-month waitlist-controlled trial of widely available online tools. (2020) · cites this paper as Buck et al., 2014
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“Our results are, to a great extent, in line with the earlier studies on adults with ASD, which have shown that concomitant psychiatric symptoms and diagnoses are common”
From Older Adults with Autism Spectrum Disorders in Sweden: A Register Study of Diagnoses, Psychiatric Care Utilization and Psychotropic Medication of 601 Individuals (2018) · cites this paper as Buck et al. 2014
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“with co-occurring anxiety disorders among the most common concerns.”
From Self-guided mindfulness and cognitive behavioural practices reduce anxiety in autistic adults: A pilot 8-month waitlist-controlled trial of widely available online tools. (2020) · cites this paper as Buck et al., 2014
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Diagnostic and Statistical Manual of Mental Disorders, 5th ed.
Carter, M. J. (2014) · Therapeutic Recreation Journal · Cited by 15,154
Diagnostic and Statistical Manual of Mental Disorders, 3rd ed
Cooper, A. M., & Michels, R. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.1.128 · Cited by 7,419
Baio, J., Wiggins, L., Christensen, D. L., Maenner, M. J., Daniels, J., Warren, Z., Kurzius-Spencer, M., Zahorodny, W., Robinson, C., Rosenberg, et al. (2018) · MMWR. Surveillance Summaries · doi:10.15585/mmwr.ss6706a1 · Cited by 6,078
Diagnostic and Statistical Manual of Mental Disorders, 3rd ed
Kendell, R. E. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.12.1630 · Cited by 5,181
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318179964f · Cited by 3,399
Wechsler Adult Intelligence Scale--Fourth Edition
Wechsler, D. (2012) · PsycTESTS Dataset · doi:10.1037/t15169-000 · Cited by 2,232
Adult outcome for children with autism
Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00215.x · Cited by 1,813
Stanford-Binet Intelligence Scale
(2012) · Springer eBooks · doi:10.1007/springerreference_70151 · Cited by 1,671
Comorbid psychiatric disorders in children with autism: interview development and rates of disorders
Leyfer, O. T., Folstein, S. E., Bacalman, S., Davis, N. O., Dinh, E., Morgan, J., Tager-Flusberg, H., & Lainhart, J. E. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0123-0 · Cited by 1,637
Self-citationNaarden Braun, K. V., Lopez, M., White, T., et al. (2023) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/y3kk-5x30 · Cited by 1,381
Prevalence of Autism in a US Metropolitan Area
Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003) · JAMA · doi:10.1001/jama.289.1.49 · Cited by 1,248
Diagnostic and Statistical Manual of Mental Disorders
Preedy, V., & Watson, R. (2010) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5485 · Cited by 1,146
Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders
Hofvander, B., Delorme, R., Chaste, P., Nydén, A., Wentz, E., Ståhlberg, O., Herbrecht, E., Stopin, A., Anckarsäter, H., Gillberg, C., et al. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-35 · Cited by 812
Billstedt, E., Gillberg, C., & Gillberg, C. (2005) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-3302-5 · Cited by 783 · cited 3×
“…report a wide range of depression rates among adults with ASD, with higher rates consistently found in ASD samples without ID (Hofvander et al. 2009; Lugnegård et al. 2011), compared to those with a high co-occurrence of ID (Billstedt et al. 2005; Ghaziuddin et al. 2002; Morgan et al. 2003).”
BackgroundRice, C. E. (2009) · PsycEXTRA Dataset · doi:10.1037/e562722010-001 · Cited by 762
Young Adult Outcome of Autism Spectrum Disorders
Eaves, L. C., & Ho, H. H. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0441-x · Cited by 683
Depression in Persons with Autism: Implications for Research and Clinical Care
Ghaziuddin, M., Ghaziuddin, N., & Greden, J. (2002) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1016330802348 · Cited by 579
Moss, S., Prosser, H., Costello, H., Simpson, N., Patel, P., Rowe, S., Turner, S., & Hatton, C. (1998) · Journal of Intellectual Disability Research · doi:10.1046/j.1365-2788.1998.00116.x · Cited by 571
Presentation of depression in autism and Asperger syndrome: A review
Stewart, M. E., Barnard, L., Pearson, J., Hasan, R., & O’Brien, G. (2006) · Autism · doi:10.1177/1362361306062013 · Cited by 515
High Rates of Psychiatric Co-Morbidity in PDD-NOS
de Bruin, E. I., Ferdinand, R. F., Meester, S., de Nijs, P. F. A., & Verheij, F. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0215-x · Cited by 509
Brereton, A. V., Tonge, B. J., & Einfeld, S. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0125-y · Cited by 507
Mack, A. H. (2011) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/j.ypsy.2010.11.009 · Cited by 500
Journal of Clinical Neuropsychology
Costa, L. D., Rourke, B. P., Adams, K. M., Bakker, D. J., Benton, A. L., Broughton, R., Brown, G. G., & Bryden, M. (1981) · Cited by 492
Psychiatric comorbidity in young adults with a clinical diagnosis of Asperger syndrome
Lugnegård, T., Hallerbäck, M. U., & Gillberg, C. (2011) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2011.03.025 · Cited by 483 · cited 8×
“referred samples of adults with ASD, predominantly in the absence of co-occurring ID (Hofvander et al. 2009; Joshi et al. 2013; Lugnegård et al. 2011; Stahlberg et al. 2004).”
BackgroundInfluentialJoshi, G., Petty, C., Wozniak, J., Henin, A., Fried, R., Galdo, M., Kotarski, M., Walls, S., & Biederman, J. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-0996-9 · Cited by 464
Comorbidity of Asperger syndrome: a preliminary report
Ghaziuddin, M., Weidmer‐Mikhail, E., & Ghaziuddin, N. (1998) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1998.tb01647.x · Cited by 428
Mattila, M., Hurtig, T. M., Haapsamo, H., Jussila, K. K., Kuusikko‐Gauffin, S., Kielinen, M., Linna, S., Ebeling, H. E., Bloigu, R., Joskitt, L., et al. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-0958-2 · Cited by 427
Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., Kotte, A., Stevens, J., Furtak, S. L., Bourgeois, M., et al. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1679-5 · Cited by 419
(2009) · PubMed · Cited by 409
Stanford‐Binet Intelligence Scales
Kamphaus, R. W., & Juechter, J. I. (2010) · Wiley eBooks · doi:10.1002/9780470479216.corpsy0941 · Cited by 385
Levels of anxiety and sources of stress in adults with autism
Gillott, A., & Standen, P. J. (2007) · Journal of Intellectual Disabilities · doi:10.1177/1744629507083585 · Cited by 359
The UCLA-University of Utah epidemiologic survey of autism: prevalence
(1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.2.194 · Cited by 273
Self-citationStahlberg, O., Soderstrom, H., Rastam, M., & Gillberg, C. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0115-1 · Cited by 273
Sterling, L., Dawson, G., Estes, A., & Greenson, J. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0477-y · Cited by 263
Psychiatric problems in individuals with autism, their parents and siblings
Lainhart, J. E. (1999) · International Review of Psychiatry · doi:10.1080/09540269974177 · Cited by 255
Fletcher, R. J., Loschen, E. L., & Stavrakaki, C. (2017) · Cited by 253
Esbensen, A. J., Greenberg, J. S., Seltzer, M. M., & Aman, M. G. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0750-3 · Cited by 238
Obsessions and compulsions in Asperger syndrome and high-functioning autism
Russell, A., Mataix‐Cols, D., Anson, M., & Murphy, D. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.186.6.525 · Cited by 233
Use of psychotropic medication in children and adolescents with autism spectrum disorders
Coury, D. L., Anagnostou, E., Manning-Courtney, P., Reynolds, A., Cole, L., McCoy, R., Whitaker, A., & Perrin, J. M. (2012) · PEDIATRICS · doi:10.1542/peds.2012-0900d · Cited by 191
Comorbid psychopathology in adults with Autism Spectrum Disorders and intellectual disabilities
LoVullo, S. V., & Matson, J. L. (2009) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2009.05.004 · Cited by 185
Prosser, H., Moss, S., Costello, H., Simpson, N., Patel, P., & Rowe, S. (1998) · Journal of Intellectual Disability Research · doi:10.1046/j.1365-2788.1998.00146.x · Cited by 182
Medication Patterns in Patients with Autism: Temporal, Regional, and Demographic Influences
Aman, M. G., Lam, K. S. L., & Van Bourgondien, M. E. (2005) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2005.15.116 · Cited by 174
Stanford-Binet Intelligence Scales
(2007) · Sage eBooks · doi:10.4135/9781412952644.n434 · Cited by 167
A public health collaboration for the surveillance of autism spectrum disorders
Rice, C. E., Baio, J., Braun, K. V. N., Doernberg, N. S., Meaney, F. J., Kirby, R. S., & ADDM Network (2007) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2007.00801.x · Cited by 158
New-onset psychiatric disorders in individuals with autism
Hutton, J., Goode, S., Murphy, M., Le Couteur, A., & Rutter, M. (2008) · Autism · doi:10.1177/1362361308091650 · Cited by 139 · cited 4×
“…of sensitivity (62–100 %; Devine et al. 2009; Janssen and Maes 2013), specificity (71–100 %; Devine et al. 2009; Janssen and Maes 2013), internal consistency (.48–.95; Janssen and Maes 2013; Prosser et al. 1998), and inter-rater reliability (.77–.91; Janssen and Maes 2013; Prosser et al. 1998).”
BackgroundMethodInfluentialTrajectory of Behavior and Emotional Problems in Autism
Gray, K. M., Keating, C. M., Taffe, J. R., Brereton, A. V., Einfeld, S., & Tonge, B. J. (2012) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7588-117-2.121 · Cited by 137
Langworthy-Lam, K. S., Aman, M. G., & Van Bourgondien, M. E. (2002) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454602762599853 · Cited by 123
Braun, K. V. N., Pettygrove, S. D., Daniels, J. L., Miller, L. A., Nicholas, J. S., Baio, J., Schieve, L. A., Kirby, R. S., Washington, A., Brocksen, S., et al. (2007) · PubMed · Cited by 121
Melville, C. A., Cooper, S., Morrison, J., Smiley, E., Allan, L., Jackson, A., Finlayson, J., & Mantry, D. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0549-7 · Cited by 121
Psychopathology in Adults with Autism and Intellectual Disability
Tsakanikos, E., Costello, H., Holt, G., Bouras, N., Sturmey, P., & Newton, T. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0149-3 · Cited by 116
Episodic psychiatric disorders in teenagers with learning disabilities with and without autism
Bradley, E. A., & Bolton, P. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.018127 · Cited by 107
Psychiatric comorbidity and medication use in autism: a community survey
Morgan, C., Roy, M., & Chance, P. (2003) · Psychiatric Bulletin · doi:10.1192/pb.27.10.378 · Cited by 83
Mental health aspects of autistic spectrum disorders in children
Skokauskas, N., & Gallagher, L. (2012) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2011.01423.x · Cited by 75
The association between severity of intellectual disability and psychiatric symptomatology
Holden, B., & Gitlesen, J. P. (2004) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2004.00624.x · Cited by 66
(2008) · Örebro University Library (Örebro University) · Cited by 63
Aboraya, A., Tien, A. Y., Stevenson, J., & Crosby, K. (1998) · PubMed · Cited by 60
Miller, J. S., Bilder, D. A., Farley, M. A., Coon, H. H., Pinborough‐Zimmerman, J., Jenson, W. R., Rice, C. E., Fombonne, E. J., Pingree, C., RITVO, E. R., et al. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1566-0 · Cited by 48
Self-citationThe Mini PAS‐ADD Interview Pack
Edwards, N. F. (2003) · Journal of Intellectual Disability Research · doi:10.1046/j.1365-2788.2003.00518.x · Cited by 27
Devine, M., Taggart, L., & McLornian, P. (2009) · British Journal of Learning Disabilities · doi:10.1111/j.1468-3156.2009.00597.x · Cited by 20
Janssen, R., & Maes, B. (2012) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2012.01544.x · Cited by 16
Research works printed but not linked: 1
- World Health Organization. (1992). Schedules for clinical assessment in neuropsychiatry (SCAN-I). Geneva: World Health Organization.
Cited by
Sorted by citations
Lai, M.-C., Kassee, C., Besney, R., Bonato, S., Hull, L., Mandy, W., Szatmari, P., & Ameis, S. H. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30289-5 · Cited by 1,892
Identification, Evaluation, and Management of Children With Autism Spectrum Disorder
Hyman, S. L., Levy, S. E., Myers, S. M., COUNCIL ON CHILDREN WITH DISABILITIES, S. O. D. A. B. P., Kuo, D. Z., Apkon, S., Davidson, L. F., Ellerbeck, K. A., Foster, J. E. A., Noritz, G. H., et al. (2020) · Pediatrics · doi:10.1542/peds.2019-3447 · Cited by 1,798
The health status of adults on the autism spectrum
Croen, L. A., Zerbo, O., Qian, Y., Massolo, M. L., Rich, S., Sidney, S., & Kripke, C. (2015) · Autism · doi:10.1177/1362361315577517 · Cited by 1,110
Hollocks, M. J., Lerh, J. W., Magiati, I., Meiser-Stedman, R., & Brugha, T. S. (2019) · Psychological Medicine · doi:10.1017/s0033291718002283 · Cited by 988
Identifying the lost generation of adults with autism spectrum conditions
Lai, M.-C., & Baron-Cohen, S. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00277-1 · Cited by 756
Metadata
- Authors
- Buck, T. R., Viskochil, J., Farley, M., Coon, H., McMahon, W. M., Morgan, J., & Bilder, D. A.
- Affiliations
- University of Utah (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Bilder, Deborah A.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2014-06-24
- Volume
- 44
- Issue
- 12
- Pages
- 3063-3071
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC4355011
- OpenAlex
- W1997388980
- Cited by
- 323
- References
- 65
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 32 · 2023: 24 · 2022: 27 · 2021: 43 · 2020: 34 · 2019: 50 · 2018: 21 · 2017: 27 · 2016: 19 · 2015: 19 · 2014: 2
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Autism Speaks
- University of Utah
- National Institutes of Health
- National Institute of Mental Health (R01MH094400)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Keywords
- autism spectrum disorder, psychiatric comorbidity, psychotropic drug use, anxiety disorders, depression, intellectual disability, autistic adults, community diagnosis
- MeSH terms
- Adolescent, Adult, Mental Disorders, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Population Surveillance, Psychotropic Drugs, Utah, Cohort Studies, Comorbidity, Young Adult
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