The Heavy Burden of Psychiatric Comorbidity in Youth with Autism Spectrum Disorders: A Large Comparative Study of a Psychiatrically Referred Population
Abstract
The objective of the study was to systematically examine patterns of psychiatric comorbidity in referred youth with autism spectrum disorders (ASD) including autistic disorder and pervasive developmental disorder not otherwise specified. Consecutively referred children and adolescents to a pediatric psychopharmacology program were assessed with structured diagnostic interview and measures of psychosocial functioning. Comparisons were made between those youth satisfying diagnostic criteria for ASD and age and sex matched youth without ASD referred to the same clinical program. 9.3% (217/2323) of the referred youth (age range: 3-17 years) met DSM-III-R criteria for ASD. ASD youth suffered from significantly higher number of comorbid disorders than comparisons (6.4 ± 2.7 vs. 5.2 ± 2.9; p < 0.001). Ninety-five percent of the youth with ASD had three or more comorbid psychiatric disorders and 74% had five or more comorbid disorders. ASD youth were also more functionally impaired and required extra-assistance in school and therapeutic interventions at higher rates than age and sex matched non-ASD referred youth. Youth with ASD have high levels of psychiatric comorbidity and dysfunction comparable to the referred population of youth without ASD. These findings emphasize the heavy burden of psychiatric comorbidity afflicting youth with ASD and may be important targets for intervention.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The non-significant diagnosis moderation may be due to the small number of ASD studies (n=6) or high comorbidity shared between both disorders.
“Although this may be due to the small number of ASD studies (n = 6), it may also be due to high-comorbidity shared between both disorders (e.g., Joshi et al. 2010).”
From A meta-analytic review of the efficacy of physical exercise interventions on cognition in individuals with autism spectrum disorder and ADHD (2016) · cites this paper as Joshi et al. 2010
Cites
A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526 · see citing works
Journal of Clinical Psychiatry
(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069 · see citing works
Four Factor Index of Social Status
Paschou, R. (1975) · Cited by 6,989 · see citing works
Four Factor Index of Social Status [1975]
Hollingshead, A. B. (1975) · Cited by 5,151 · see citing works
The Global Assessment Scale: A Procedure for Measuring Overall Severity of Psychiatric Disturbance
Endicott, J. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770060086012 · Cited by 4,982 · see citing works
Scandinavian Journal of Statistics
Rosén, B. G. (2005) · Encyclopedia of Statistical Sciences · doi:10.1002/0471667196.ess2351.pub2 · Cited by 3,608 · see citing works
Mendelson, G. (1995) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048679509064964 · Cited by 2,592 · see citing works
Asperger’s syndrome: a clinical account
Wing, L. (1981) · Psychological Medicine · doi:10.1017/s0033291700053332 · Cited by 1,913 · see citing works
Comorbid psychiatric disorders in children with autism: interview development and rates of disorders
Leyfer, O. T., Folstein, S. E., Bacalman, S., Davis, N. O., Dinh, E., Morgan, J., Tager-Flusberg, H., & Lainhart, J. E. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0123-0 · Cited by 1,637 · see citing works
Risperidone in Children with Autism and Serious Behavioral Problems
McCracken, J. T., McGough, J., Shah, B., Cronin, P., Hong, D., Aman, M. G., Arnold, L. E., Lindsay, R., Nash, P., Hollway, J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013171 · Cited by 1,574 · see citing works
The Assessment of Affective Disorders in Children and Adolescents by Semistructured Interview
Chambers, W. J. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790300064008 · Cited by 1,272 · see citing works
Fombonne, E. (2003) · JAMA · doi:10.1001/jama.289.1.87 · Cited by 604 · see citing works
Herring, S., Gray, K., Taffe, J., Tonge, B., Sweeney, D., & Einfeld, S. (2006) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2006.00904.x · Cited by 588 · see citing works
Lecavalier, L. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0147-5 · Cited by 569 · see citing works
Sukhodolsky, D. G., Scahill, L. D., Gadow, K. D., Arnold, L. E., Aman, M. G., McDougle, C. J., McCracken, J. T., Tierney, E., White, S. W., Lecavalier, L., et al. (2007) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-007-9165-9 · Cited by 524 · see citing works
(2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1266 · Cited by 521 · see citing works
High Rates of Psychiatric Co-Morbidity in PDD-NOS
de Bruin, E. I., Ferdinand, R. F., Meester, S., de Nijs, P. F. A., & Verheij, F. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0215-x · Cited by 509 · see citing works
Brereton, A. V., Tonge, B. J., & Einfeld, S. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0125-y · Cited by 506 · see citing works
Blacher, J., & McIntyre, L. L. (2006) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2005.00768.x · Cited by 467 · see citing works
Comorbidity of Asperger syndrome: a preliminary report
Ghaziuddin, M., Weidmer‐Mikhail, E., & Ghaziuddin, N. (1998) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1998.tb01647.x · Cited by 414 · see citing works
Goldstein, S., & Schwebach, A. J. (2004) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000029554.46570.68 · Cited by 412 · see citing works
The Emanuel Miller Memorial Lecture 1991
Gillberg, C. (1992) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1992.tb01959.x · Cited by 409 · see citing works
Gadow, K. D., Devincent, C. J., Pomeroy, J., & Azizian, A. (2005) · Autism · doi:10.1177/1362361305056079 · Cited by 388 · see citing works
Green, J., Gilchrist, A., Burton, D., & Cox, A. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005523232106 · Cited by 378 · see citing works
ROSENBERG, D. R., MacMASTER, F. P., KESHAVAN, M. S., FITZGERALD, K. D., STEWART, C. M., & MOORE, G. J. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200009000-00008 · Cited by 377 · see citing works
Comorbid anxiety symptoms in children with pervasive developmental disorders
Muris, P., Steerneman, P., Merckelbach, H., Holdrinet, I., & Meesters, C. (1998) · Journal of Anxiety Disorders · doi:10.1016/s0887-6185(98)00022-x · Cited by 368 · see citing works
An MRI study of the basal ganglia in autism
Sears, L. L., Vest, C., Mohamed, S., Bailey, J., Ranson, B. J., & Piven, J. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00020-2 · Cited by 364 · see citing works
Rojas, D. C., Peterson, E., Winterrowd, E., Reite, M. L., Rogers, S. J., & Tregellas, J. R. (2006) · BMC Psychiatry · doi:10.1186/1471-244x-6-56 · Cited by 360 · see citing works
Taylor, B. (2002) · BMJ · doi:10.1136/bmj.324.7334.393 · Cited by 345 · see citing works
No evidence for a new variant of measles-mumps-rubella-induced autism
Fombonne, E., & Chakrabarti, S. (2001) · PEDIATRICS · doi:10.1542/peds.108.4.e58 · Cited by 312 · see citing works
Esbensen, A. J., Rojahn, J., Aman, M. G., & Ruedrich, S. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000005999.27178.55 · Cited by 308 · see citing works
ASPERGER'S SYNDROME AND AUTISM: COMPARISON OF EARLY HISTORY AND OUTCOME
Szatmári, P., Bartolucci, G., & Bremner, R. (1989) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1989.tb04066.x · Cited by 296 · see citing works
Psychiatric Symptoms in Preschool Children with PDD and Clinic and Comparison Samples
Gadow, K. D., DeVincent, C. J., Pomeroy, J., & Azizian, A. (2004) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000037415.21458.93 · Cited by 295 · see citing works
The Presentation of Anxiety in Children with Pervasive Developmental Disorders
Weisbrot, D. M., Gadow, K. D., DeVincent, C. J., & Pomeroy, J. C. (2005) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2005.15.477 · Cited by 283 · see citing works
Sterling, L., Dawson, G., Estes, A., & Greenson, J. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0477-y · Cited by 263 · see citing works
Gastrointestinal symptoms in a sample of children with pervasive developmental disorders
Nikolov, R. N., Bearss, K. E., Lettinga, J., Erickson, C., Rodowski, M., Aman, M. G., McCracken, J. T., McDougle, C. J., Tierney, E., Vitiello, B., et al. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0637-8 · Cited by 240 · see citing works
Lee, D. O., & Ousley, O. Y. (2006) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.16.737 · Cited by 239 · see citing works
Scarone, S., Colombo, C., Livian, S., Abbruzzese, M., Ronchi, P., Locatelli, M., Scotti, G., & Smeraldi, E. (1992) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(92)90005-o · Cited by 233 · see citing works
Anxiety and social worries in children with Asperger syndrome
Russell, E., Sofronoff, K., Russell, E., & Sofronoff, K. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01637.x · Cited by 211 · see citing works
Vickerstaff, S., Heriot, S., Wong, M. L., Lopes, A., & Dossetor, D. R. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0292-x · Cited by 202 · see citing works
Caudate Nucleus Is Enlarged in High-Functioning Medication-Naive Subjects with Autism
Langen, M., Durston, S., Staal, W., Palmen, S. J. M. C., & van Engeland, H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.040 · Cited by 202 · see citing works
Yoshida, Y., & Uchiyama, T. (2004) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-004-0391-1 · Cited by 195 · see citing works
Research Units on Pediatric Psychopharmacology (Rupp) Autism Network
McDougle, C. J., Scahill, L. D., McCracken, J. T., Aman, M. G., Tierney, E., Arnold, L. E., Freeman, B. J., Martin, A., McGough, J. J., Cronin, P., et al. (2000) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(18)30142-1 · Cited by 179 · see citing works
Frazier, J. A., Biederman, J., Bellordre, C. A., Garfield, S. B., GELLER, D. A., Coffey, B. J., & Faraone, S. V. (2001) · Journal of Attention Disorders · doi:10.1177/108705470100400402 · Cited by 162 · see citing works
Self-citationEbert, D., Speck, O., König, A., Berger, T., Hennig, J., & Hohagen, F. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(97)00016-4 · Cited by 154 · see citing works
Validation of the diagnosis of autism in general practitioner records
Fombonne, E. J., Heavey, L., Smeeth, L. L., Rodrigues, L. C., Cook, C., Smith, P. G., Meng, L., & Hall, A. J. (2004) · BMC Public Health · doi:10.1186/1471-2458-4-5 · Cited by 144 · see citing works
Murphy, D., Critchley, H., Schmitz, N., McAlonan, G. M., van Amelsvoort, T., Robertson, D., Daly, E., Rowe, A., Russell, A., Simmons, A., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.885 · Cited by 140 · see citing works
Mania in Children With Pervasive Developmental Disorder Revisited
Wozniak, J. R., Biederman, J., Faraone, S. V., Frazier, J. A., KIM, J., Millstein, R., Gershon, J., Thornell, A., Cha, K., & Snyder, J. B. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/s0890-8567(09)66564-3 · Cited by 137 · see citing works
Self-citationPervasive Developmental Disorder Not Otherwise Specified
Towbin, K. E. (2005) · Wiley eBooks · doi:10.1002/9780470939345.ch6 · Cited by 124 · see citing works
Proton magnetic resonance spectroscopic imaging of the brain in childhood autism
Levitt, J. G., O’Neill, J., Blanton, R. E., Smalley, S. L., Fadale, D., McCracken, J. T., Guthrie, D., Toga, A. W., & Alger, J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00688-7 · Cited by 103 · see citing works
GELLER, D. A., Biederman, J., Faraone, S. V., Bellordre, C. A., Kim, G. S., Hagermoser, L., CRADOCK, K., Frazier, J. A., & Coffey, B. J. (2001) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145701002395 · Cited by 83 · see citing works
Self-citationValidation of DSM-IV Model of Psychiatric Syndromes in Children with Autism Spectrum Disorders
Lecavalier, L., Gadow, K. D., DeVincent, C. J., & Edwards, M. C. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0622-2 · Cited by 79 · see citing works
Treatment of aggression in children and adolescents with autism and conduct disorder.
McDougle, C. J., Stigler, K. A., & Posey, D. J. (2003) · PubMed · Cited by 67 · see citing works
(1996) · Taylor & Francis eBooks · doi:10.4324/9780203294314 · Cited by 67 · see citing works
Behavioral characteristics of 187 young adults with autism
KOBAYASHI, R., & Murata, T. (1998) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.1998.00415.x · Cited by 66 · see citing works
Psychiatric Disorders in Individuals with Pervasive Developmental Disorder
Sverd, J. (2003) · Journal of Psychiatric Practice · doi:10.1097/00131746-200303000-00003 · Cited by 65 · see citing works
‘Schizoid’ Personality in Childhood and Adult Life I: The Vagaries of Diagnostic Labelling
Wolff, S. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.159.5.615 · Cited by 65 · see citing works
‘Schizoid’ Personality in Childhood and Adult Life III: The Childhood Picture
Wolff, S. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.159.5.629 · Cited by 62 · see citing works
Harpaz‐Rotem, I., & Rosenheck, R. A. (2004) · Child Psychiatry & Human Development · doi:10.1023/b:chud.0000020683.08514.2d · Cited by 57 · see citing works
Differentiating the behavioural profile in autism and mental retardation and testing of a screener
Steinhausen, H., & Metzke, C. W. (2004) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-004-0400-4 · Cited by 47 · see citing works
Diagnosis and evaluation of pervasive developmental disorders.
Scahill, L. D. (2005) · PubMed · Cited by 35 · see citing works
Hohagen, F., Ebert, D., Speck, O., König, A., Berger, M., & Hennig, J. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)87468-9 · Cited by 34 · see citing works
Sverd, J., Sheth, R., Fuss, J., & Levine, J. (1994) · Child Psychiatry & Human Development · doi:10.1007/bf02250991 · Cited by 17 · see citing works
Flagged first, then by citations
2 of the 67 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Lai, M.-C., Kassee, C., Besney, R., Bonato, S., Hull, L., Mandy, W., Szatmari, P., & Ameis, S. H. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30289-5 · Cited by 1,892 · see citing works
Lord, C., Brugha, T. S., Charman, T., Cusack, J., Dumas, G., Frazier, T., Jones, E. J. H., Jones, R. M., Pickles, A., State, M. W., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0138-4 · Cited by 1,859 · see citing works
Identification, Evaluation, and Management of Children With Autism Spectrum Disorder
Hyman, S. L., Levy, S. E., Myers, S. M., COUNCIL ON CHILDREN WITH DISABILITIES, S. O. D. A. B. P., Kuo, D. Z., Apkon, S., Davidson, L. F., Ellerbeck, K. A., Foster, J. E. A., Noritz, G. H., et al. (2020) · Pediatrics · doi:10.1542/peds.2019-3447 · Cited by 1,548 · see citing works
The health status of adults on the autism spectrum
Croen, L. A., Zerbo, O., Qian, Y., Massolo, M. L., Rich, S., Sidney, S., & Kripke, C. (2015) · Autism · doi:10.1177/1362361315577517 · Cited by 1,110 · see citing works
The Role of Emotion Regulation in Autism Spectrum Disorder
Mazefsky, C. A., Herrington, J., Siegel, M., Scarpa, A., Maddox, B. B., Scahill, L., & White, S. W. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.006 · Cited by 881 · see citing works
Rommelse, N. N. J., Geurts, H. M., Franke, B., Buitelaar, J. K., & Hartman, C. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.015 · Cited by 429 · see citing works
Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., Kotte, A., Stevens, J., Furtak, S. L., Bourgeois, M., et al. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1679-5 · Cited by 419 · see citing works
Self-citationVohra, R., Madhavan, S., Sambamoorthi, U., & Peter, C. C. S. (2013) · Autism · doi:10.1177/1362361313512902 · Cited by 378 · see citing works
Psychiatric Comorbidity and Medication Use in Adults with Autism Spectrum Disorder
Buck, T. R., Viskochil, J., Farley, M., Coon, H., McMahon, W. M., Morgan, J., & Bilder, D. A. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2170-2 · Cited by 323 · see citing works
Chisholm, K., Lin, A. P., Abu-Akel, A. M., & Wood, S. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.012 · Cited by 325 · see citing works
White, S. W., Ollendick, T. H., Albano, A. M., Oswald, D. P., Johnson, C. R., Southam‐Gerow, M. A., Kim, I., & Scahill, L. D. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1577-x · Cited by 314 · see citing works
College students on the autism spectrum
White, S. W., Ollendick, T. H., & Bray, B. C. (2011) · Autism · doi:10.1177/1362361310393363 · Cited by 319 · see citing works
Parental adjustment, marital relationship, and family function in families of children with autism
Gau, S. S., Chou, M. C., Chiang, H., Lee, J.-C., Wong, C., Chou, W., & Wu, Y.-Y. (2011) · Research in Autism · doi:10.1016/j.rasd.2011.05.007 · Cited by 282 · see citing works
Comorbidity in autism spectrum disorder: a literature review
Mannion, A., & Leader, G. (2013) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2013.09.006 · Cited by 271 · see citing works
Black, M. H., Chen, N. T. M., Iyer, K. K., Lipp, O. V., Bölte, S., Falkmer, M., Tan, T., & Girdler, S. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.016 · Cited by 265 · see citing works
White, S. W., Mazefsky, C. A., Dichter, G. S., Chiu, P. H., Richey, J. A., & Ollendick, T. H. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.05.012 · Cited by 252 · see citing works
Anxiety Levels in Children with Autism Spectrum Disorder: A Meta-Analysis
van Steensel, F. J. A., & Heeman, E. J. (2017) · Journal of Child and Family Studies · doi:10.1007/s10826-017-0687-7 · Cited by 245 · see citing works
Emotional and Behavioural Problems in Children with Autism Spectrum Disorder
Maskey, M., Warnell, F., Parr, J. R., Couteur, A. S. L., & McConachie, H. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1622-9 · Cited by 236 · see citing works
An update on pharmacotherapy for autism spectrum disorder in children and adolescents
Ji, N. Y., & Findling, R. L. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000132 · Cited by 217 · see citing works
Maskey, M., Lowry, J., Rodgers, J., McConachie, H., & Parr, J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100374 · Cited by 215 · see citing works
Maddox, B. B., Crabbe, S., Beidas, R. S., Brookman-Frazee, L., Cannuscio, C. C., Miller, J. S., Nicolaidis, C., & Mandell, D. S. (2020) · Autism · doi:10.1177/1362361319882227 · Cited by 203 · see citing works
Adapting psychological therapies for autism
Cooper, K., Loades, M. E., & Russell, A. (2018) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2017.11.002 · Cited by 190 · see citing works
Autism Spectrum Disorder: Defining Dimensions and Subgroups
Ousley, O., & Cermak, T. (2013) · Current Developmental Disorders Reports · doi:10.1007/s40474-013-0003-1 · Cited by 191 · see citing works
Hansen, B. H., Oerbeck, B., Skirbekk, B., Petrovski, B. É., & Kristensen, H. (2018) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2018.1444087 · Cited by 182 · see citing works
Exploring the Relationship Between Anxiety and Insistence on Sameness in Autism Spectrum Disorders
Gotham, K., Bishop, S. L., Hus, V., Huerta, M., Lund, S., Buja, A., Krieger, A., & Lord, C. (2013) · Autism Research · doi:10.1002/aur.1263 · Cited by 176 · see citing works
Brookman-Frazee, L., Stadnick, N., Chlebowski, C., Baker-Ericzén, M., & Ganger, W. (2018) · Autism · doi:10.1177/1362361317712650 · Cited by 174 · see citing works
Brookman-Frazee, L. I., Drahota, A., Stadnick, N. A., & Palinkas, L. A. (2011) · Administration and Policy in Mental Health and Mental Health Services Research · doi:10.1007/s10488-011-0355-y · Cited by 169 · see citing works
Joshi, G., Faraone, S. V., Wozniak, J., Tarko, L., Fried, R., Galdo, M., Furtak, S. L., & Biederman, J. (2017) · Journal of Attention Disorders · doi:10.1177/1087054714543368 · Cited by 155 · see citing works
Self-citationSaghazadeh, A., & Rezaei, N. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.011 · Cited by 146 · see citing works
Tan, B. W. Z., Pooley, J. A., & Speelman, C. P. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2854-x · Cited by 157 · see citing works
“Furthermore, given that comorbidity between the two disorders is reported to be as high as over 80 % of the cases (e.g., Joshi et al. 2010; Mukaddes et al. 2010), it is not known if exercise can be used as an effective intervention in improving aspects of cognitive functions in these clinical…”
BackgroundA Survey on Virtual Reality for Individuals with Autism Spectrum Disorder: Design Considerations
Bozgeyikli, L. “., Raij, A. B., Katkoori, S., & Alqasemi, R. M. (2017) · IEEE Transactions on Learning Technologies · doi:10.1109/tlt.2017.2739747 · Cited by 148 · see citing works
Zerbo, O., Qian, Y., Ray, T., Sidney, S., Rich, S., Massolo, M. L., & Croen, L. (2018) · Autism in Adulthood · doi:10.1089/aut.2018.0004 · Cited by 150 · see citing works
Zheng, Z., Zheng, P., & Zou, X. (2018) · Autism Research · doi:10.1002/aur.1977 · Cited by 144 · see citing works
Association of Comorbid Mood and Anxiety Disorders With Autism Spectrum Disorder
Kirsch, A. C., Huebner, A. R. S., Mehta, S. Q., Howie, F. R., Weaver, A. L., Myers, S. M., Voigt, R. G., & Katusic, S. K. (2020) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2019.4368 · Cited by 139 · see citing works
Conner, C. M., Golt, J., Shaffer, R., Righi, G., Siegel, M., & Mazefsky, C. A. (2021) · Autism Research · doi:10.1002/aur.2450 · Cited by 130 · see citing works
An exploration of concomitant psychiatric disorders in children with autism spectrum disorder
Lecavalier, L., McCracken, C., Aman, M. G., McDougle, C. J., McCracken, J. T., Tierney, E., Smith, T. H., Johnson, C. R., King, B. H., Handen, B. L., et al. (2018) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2018.10.012 · Cited by 129 · see citing works
Prader–Willi syndrome and autism spectrum disorders: an evolving story
Dykens, E. M., Lee, E., & Roof, E. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9092-5 · Cited by 128 · see citing works
Psychopharmacological interventions in autism spectrum disorder
Accordino, R. E., Kidd, C. L., Politte, L. C., Henry, C. A., & McDougle, C. J. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2016.1154536 · Cited by 127 · see citing works
Houghton, R., Ong, R. C., & Bolognani, F. (2017) · Autism Research · doi:10.1002/aur.1848 · Cited by 124 · see citing works
Predicting aggression to others in youth with autism using a wearable biosensor
Goodwin, M. S., Mazefsky, C. A., Ioannidis, S., Deniz Erdogmus, B., & Siegel, M. S. (2019) · Autism Research · doi:10.1002/aur.2151 · Cited by 126 · see citing works
Mahajan, R., Bernal, M. P., Panzer, R., Whitaker, A. H., Roberts, W., Handen, B. L., Hardan, A. Y., Anagnostou, E. A., & Veenstra-VanderWeele, J. M. (2012) · PEDIATRICS · doi:10.1542/peds.2012-0900j · Cited by 120 · see citing works
Brookman-Frazee, L., Drahota, A., & Stadnick, N. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1406-7 · Cited by 127 · see citing works
Severe mood problems in adolescents with autism spectrum disorder
Simonoff, E. A., Jones, C. R. G., Pickles, A. R., Happe, F. G. E., Baird, G., & Charman, T. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02600.x · Cited by 116 · see citing works
Chandrasekhar, T., & Sikich, L. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.2/tchandrasekhar · Cited by 117 · see citing works
ASD, a Psychiatric Disorder, or Both? Psychiatric Diagnoses in Adolescents with High-Functioning ASD
Mazefsky, C. A., Oswald, D. P., Day, T. N., Eack, S. M., Minshew, N. J., & Lainhart, J. E. (2012) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2012.686102 · Cited by 111 · see citing works
Health Services Utilization Among Children With and Without Autism Spectrum Disorders
Cummings, J. R., Lynch, F. L., Rust, K. C., Coleman, K. J., Madden, J. M., Owen‐Smith, A. A., Yau, V. M., Qian, Y., Pearson, K. A., Crawford, P. M., et al. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2634-z · Cited by 108 · see citing works
Walsh, C., Lydon, S., O’Dowd, E., & O’Connor, P. (2020) · Developmental Neurorehabilitation · doi:10.1080/17518423.2020.1716868 · Cited by 107 · see citing works
Bölte, S., de Schipper, E. J., Robison, J. E., Wong, V. C. N., Selb, M., Singhal, N., de Vries, P. J., & Zwaigenbaum, L. (2013) · Autism Research · doi:10.1002/aur.1335 · Cited by 103 · see citing works
Mansour, R., Dovi, A. T., Lane, D. M., Loveland, K. A., & Pearson, D. A. (2017) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2016.11.009 · Cited by 101 · see citing works
Neurodevelopmental heterogeneity and computational approaches for understanding autism
Jacob, S., Wolff, J. J., Steinbach, M. S., Doyle, C. B., Kumar, V., & Elison, J. T. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0390-0 · Cited by 101 · see citing works
The role of emotion regulation and core autism symptoms in the experience of anxiety in autism
Conner, C. M., White, S. W., Scahill, L., & Mazefsky, C. A. (2020) · Autism · doi:10.1177/1362361320904217 · Cited by 99 · see citing works
Developmental microglial priming in postmortem autism spectrum disorder temporal cortex
Lee, A. S., Azmitia, E. C., & Whitaker‐Azmitia, P. M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.019 · Cited by 96 · see citing works
Griffiths, S., Jarrold, C., Penton‐Voak, I. S., Woods, A. T., Skinner, A., & Munafo, M. R. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3091-7 · Cited by 94 · see citing works
Takara, K., & Kondo, T. (2014) · Annals of General Psychiatry · doi:10.1186/s12991-014-0033-z · Cited by 93 · see citing works
Prevalence of Anxiety in Autism Spectrum Disorders
Kent, R., & Simonoff, E. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805122-1.00002-8 · Cited by 96 · see citing works
Gender Dysphoria in Children with Autism Spectrum Disorder
Hisle-Gorman, E. J., Landis, C. A., Susi, A., Schvey, N. A., Gorman, G. H., Nylund, C. M., & Klein, D. A. (2019) · LGBT Health · doi:10.1089/lgbt.2018.0252 · Cited by 91 · see citing works
Psychiatric problems during the COVID ‐19 pandemic in children with autism spectrum disorder
Vasa, R. A., Singh, V., Holingue, C., Kalb, L. G., Jang, Y., & Keefer, A. J. (2021) · Autism Research · doi:10.1002/aur.2574 · Cited by 86 · see citing works
Mosner, M. G., Kinard, J. L., Shah, J. S., McWeeny, S., Greene, R. K., Lowery, S., Mazefsky, C. A., & Dichter, G. S. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-019-04090-1 · Cited by 84 · see citing works
Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions
McCracken, J. T., Anagnostou, E. A., Arango, C., Dawson, G., Farchione, T. R., Mantua, V., McPartland, J. C., Murphy, D., Pandina, G., & Veenstra-VanderWeele, J. M. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.05.010 · Cited by 87 · see citing works
Vaillancourt, T., Haltigan, J. D., Smith, I. M., Zwaigenbaum, L., Szatmári, P., Fombonne, E. J., Waddell, C., Duku, E., Mirenda, P., Georgiades, S., et al. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000043 · Cited by 82 · see citing works
Nylander, L., Holmqvist, M., Gustafson, L., & Gillberg, C. (2013) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2012.748824 · Cited by 81 · see citing works
Anteraper, S. A., Guell, X., D’Mello, A. M., Joshi, N., Whitfield, S., & Joshi, G. (2018) · Brain Connectivity · doi:10.1089/brain.2018.0581 · Cited by 80 · see citing works
Self-citationThe experience and impact of anxiety in autistic adults: A thematic analysis
Robertson, A. E., Stanfield, A. C., Watt, J., Barry, F., Day, M., Cormack, M., & Melville, C. (2018) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2017.11.006 · Cited by 77 · see citing works
Smith, I. C., & White, S. W. (2020) · Autism · doi:10.1177/1362361320908101 · Cited by 77 · see citing works
Zhou, W., Liu, D., Xiong, X., & Xu, H. (2019) · Medicine · doi:10.1097/md.0000000000016794 · Cited by 75 · see citing works
Meilleur, A., Foster, N. E. V., Coll, S.-M., Brambati, S. M., & Hyde, K. L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.013 · Cited by 73 · see citing works
Barriers to Receipt of Services for Young Adults With Autism
Anderson, C., Lupfer, A., & Shattuck, P. T. (2018) · PEDIATRICS · doi:10.1542/peds.2016-4300g · Cited by 74 · see citing works
Park, S. H., Song, Y. J. C., Demetriou, E. A., Pepper, K. L., Norton, A., Thomas, E. E., Hickie, I. B., Hermens, D. F., Glozier, N., & Guastella, A. J. (2019) · Autism · doi:10.1177/1362361318823925 · Cited by 75 · see citing works
Rødgaard, E., Jensen, K. L., Miskowiak, K. W., & Mottron, L. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13345 · Cited by 75 · see citing works
Misdiagnosis versus missed diagnosis: diagnosing autism spectrum disorder in adolescents
Aggarwal, S., & Angus, B. (2015) · Australasian Psychiatry · doi:10.1177/1039856214568214 · Cited by 72 · see citing works
Roux, A. M., Shattuck, P. T., Rast, J. E., Rava, J. A., Edwards, A. D., Wei, X., McCracken, M., & Yu, J. W. (2015) · Autism Research and Treatment · doi:10.1155/2015/391693 · Cited by 73 · see citing works
Brookman-Frazee, L., Roesch, S., Chlebowski, C., Baker-Ericzen, M., & Ganger, W. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0011 · Cited by 71 · see citing works
Psychopharmacological Interventions in Autism Spectrum Disorder
Politte, L. C., Henry, C. A., & McDougle, C. J. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000030 · Cited by 73 · see citing works
Facial Expression Production and Recognition in Autism Spectrum Disorders
Keating, C. T., & Cook, J. L. (2020) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2020.02.006 · Cited by 70 · see citing works
Community Mental Health Services for Autistic Adults: Good News and Bad News
Maddox, B. B., & Gaus, V. L. (2018) · Autism in Adulthood · doi:10.1089/aut.2018.0006 · Cited by 70 · see citing works
Chen, M., Wei, H.-T., Chen, L.-C., Su, T., Bai, Y., Hsu, J.-W., Huang, K., Chang, W.-H., Chen, T., & Chen, Y.-S. (2014) · Research in Autism · doi:10.1016/j.rasd.2014.10.014 · Cited by 68 · see citing works
Kose, L. K., Fox, L., & Storch, E. A. (2017) · Journal of Developmental and Physical Disabilities · doi:10.1007/s10882-017-9559-8 · Cited by 66 · see citing works
Bachmann, C. J., Manthey, T., Kamp-Becker, I., Glaeske, G., & Hoffmann, F. (2013) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2013.05.028 · Cited by 63 · see citing works
Systematic review and guide to management of core and psychiatric symptoms in youth with autism
Ameis, S. H., Kassee, C., Corbett-Dick, P., Cole, L. L., Dadhwal, S., Lai, M., Veenstra-VanderWeele, J. M., & Correll, C. U. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12918 · Cited by 64 · see citing works
Differential diagnosis and comorbidity: distinguishing autism from other mental health issues
Matson, J. L., & Williams, L. W. (2013) · Neuropsychiatry · doi:10.2217/npy.13.1 · Cited by 64 · see citing works
Chiang, H., & Gau, S. S. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12450 · Cited by 63 · see citing works
Visser, J. C., Rommelse, N. N. J., Lappenschaar, M. G. A., Servatius-Oosterling, I. J., Greven, C. U., & Buitelaar, J. K. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.05.022 · Cited by 64 · see citing works
Hara, Y., Ago, Y., Higuchi, M., Hasebe, S., Nakazawa, T., Hashimoto, H., Matsuda, T., & Takuma, K. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.09.013 · Cited by 61 · see citing works
Co-occurring Conditions and Change in Diagnosis in Autism Spectrum Disorders
Close, H. A., Lee, L.-C., Kaufmann, C. N., & Zimmerman, A. W. (2012) · PEDIATRICS · doi:10.1542/peds.2011-1717 · Cited by 61 · see citing works
Hickingbotham, M. R., Wong, C., & Bowling, A. B. (2021) · Translational Behavioral Medicine · doi:10.1093/tbm/ibab085 · Cited by 59 · see citing works
Health care access and treatment for children with co-morbid autism and psychiatric conditions
Ahmedani, B. K., & Hock, R. (2012) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-012-0482-0 · Cited by 59 · see citing works
Psychiatric Symptoms in Youth with a History of Autism and Optimal Outcome
Orinstein, A. J., Tyson, K. E., Suh, J., Troyb, E., Helt, M. S., ROSENTHAL, M. A., Barton, M. L., Eigsti, I., Kelley, E. A., Naigles, L., et al. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2520-8 · Cited by 58 · see citing works
Neocerebellar contributions to social perception in adolescents with autism spectrum disorder
Jack, A., & Morris, J. P. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.08.001 · Cited by 58 · see citing works
Giorgi, R. D., Crescenzo, F. D., D’Alò, G. L., Pesci, N. R., Franco, V. D., Sandini, C., & Armando, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091304 · Cited by 58 · see citing works
Orinstein, A. J., Suh, J., Porter, K., Yoe, K. A. D., Tyson, K. E., Troyb, E., Barton, M. L., Eigsti, I., Stevens, M. C. G., & FEIN, D. A. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2409-6 · Cited by 57 · see citing works
Rodriguez, G., Drastal, K. C., & Hartley, S. L. (2020) · Autism · doi:10.1177/1362361320947513 · Cited by 56 · see citing works
Dissecting autism and schizophrenia through neuroimaging genomics
Moreau, C. A., Raznahan, A., Bellec, P., Chakravarty, M. M., Thompson, P. M., & Jacquemont, S. (2021) · Brain · doi:10.1093/brain/awab096 · Cited by 50 · see citing works
Schwartzman, J. M., & Corbett, B. A. (2020) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2020.101613 · Cited by 53 · see citing works
Hillier, A. J., Greher, G. R., Queenan, A., Marshall, S., & Kopec, J. (2015) · Music Education Research · doi:10.1080/14613808.2015.1077802 · Cited by 53 · see citing works
Smith, J., Disalvo, M., Green, A., Ceranoglu, T. A., Anteraper, S., Croarkin, P., & Joshi, G. (2022) · Neuropsychology Review · doi:10.1007/s11065-022-09564-1 · Cited by 47 · see citing works
Self-citationPosserud, M.-B. R., Hysing, M., Helland, W. A., Gillberg, C., & Lundervold, A. J. (2016) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2016.01.002 · Cited by 54 · see citing works
Kurzius‐Spencer, M., Pettygrove, S. D., Christensen, D., Pedersen, A. L., Cunniff, C. M., Meaney, F. J., Soke, G. N., Harrington, R. A., Durkin, M. S., & Rice, S. A. (2018) · Research in Autism · doi:10.1016/j.rasd.2018.09.002 · Cited by 53 · see citing works
Stoppelbein, L., Biasini, F. J., Pennick, M. R., & Greening, L. (2015) · Journal of Child and Family Studies · doi:10.1007/s10826-015-0218-3 · Cited by 53 · see citing works
Joshi, G., Wozniak, J. R., Fitzgerald, M., Faraone, S. V., Fried, R. S., Galdo, M., Furtak, S. L., Conroy, K., Kilcullen, J. R., Belser, A. H., et al. (2018) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-018-3542-9 · Cited by 52 · see citing works
Self-citationSpeech Rate Entrainment in Children and Adults With and Without Autism Spectrum Disorder
Wynn, C. J., Borrie, S. A., & Sellers, T. P. (2018) · American Journal of Speech-Language Pathology · doi:10.1044/2018_ajslp-17-0134 · Cited by 52 · see citing works
- Authors
- Joshi, G., Petty, C., Wozniak, J., Henin, A., Fried, R., Galdo, M., Kotarski, M., Walls, S., & Biederman, J.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Joshi, Gagan
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2010-03-23
- Volume
- 40
- Issue
- 11
- Pages
- 1361-1370
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2058684270
- Cited by
- 464
- References
- 67
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 30 · 2023: 28 · 2022: 37 · 2021: 48 · 2020: 47 · 2019: 40 · 2018: 32 · 2017: 37 · 2016: 20 · 2015: 37 · 2014: 25 · 2013: 21 · 2012: 19
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- autism spectrum disorder, psychiatric comorbidity, pervasive developmental disorder not otherwise specified, autistic disorder, children and adolescents, psychosocial functioning, functional disability, therapeutic interventions, psychiatric referral, pediatric psychopharmacology
- MeSH terms
- Adolescent, Autistic Disorder, Mental Disorders, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Humans, Male, Psychiatric Status Rating Scales, Referral and Consultation, Comorbidity, Case-Control Studies, Cost of Illness, Diagnostic and Statistical Manual of Mental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
