Use of psychotropic medication in children and adolescents with autism spectrum disorders
Abstract
OBJECTIVES: The goal of this study was to examine rates of psychotropic medication use and identify associated child and family characteristics among children and adolescents with autism spectrum disorder (ASD) enrolled in an autism registry maintained by the Autism Treatment Network (ATN). METHODS: The sample, derived from the ATN registry, consists of 2853 children aged 2 to 17 years with diagnoses of ASD supported by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and the Autism Diagnostic Observation Schedule with available data on medication use. As part of initial enrollment in the registry, parents completed questionnaires on current psychotropic medication use, psychiatric and medical conditions, and demographics. RESULTS: Of the 2853 children, 763 (27%) were taking ≥ 1 psychotropic medication; 15% were prescribed 1 medication, 7.4% received 2 medications, and 4.5% received ≥ 3. Among children aged 3 to 5 years, 11% were taking ≥ 1 psychotropic medication; among 6- to 11-year-old children, 46%; and 66% of adolescents aged 12 to 17 years were taking at ≥ 1 psychotropic medication. A parent report of comorbid diagnosis of attention-deficit/hyperactivity disorder, bipolar disorder, obsessive-compulsive disorder, depression, or anxiety was associated with a high rate of use, with 80% receiving ≥ 1 psychotropic medication. Only 15% of children with no comorbid psychiatric disorder were taking psychotropic medication. Psychotropic medication use was also related to sleep and gastrointestinal problems. CONCLUSIONS: The prescription of psychotropic medications in this registry sample is highly related to comorbid psychiatric disorder. Other factors associated with use include medical comorbidities, race, ethnicity, and older age.
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Studies have reported high rates of polypharmacy ranging from 12 to 35% based on the type of studies.
“Studies have reported high rates of polypharmacy ranging from 12 to 35% based on the type of studies [28, 29].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [28]
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- Authors
- Coury, D. L., Anagnostou, E., Manning-Courtney, P., Reynolds, A., Cole, L., McCoy, R., Whitaker, A., & Perrin, J. M.
- Affiliations
- Nationwide Children's Hospital (US)
- University of Toronto (CA)
- Department of Pediatrics, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio;
- University of Colorado Denver (US)
- University of Rochester Medicine (US)
- Oregon Health & Science University (US)
- Columbia University (US)
- Harvard University (US)
- Corresponding author
- Coury, Daniel L.
- Venue
- PEDIATRICS
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2012-11-01
- Volume
- 130
- Issue
- Supplement_2
- Pages
- S69-S76
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2134810756
- Cited by
- 191
- References
- 32
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 15 · 2023: 7 · 2022: 20 · 2021: 13 · 2020: 14 · 2019: 11 · 2018: 16 · 2017: 15 · 2016: 17 · 2015: 19 · 2014: 18 · 2013: 11
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- psychotropic drugs, autism spectrum disorder, children and adolescents, psychiatric comorbidity, attention deficit hyperactivity disorder, bipolar disorder, obsessive-compulsive disorder, depression, anxiety, sleep disorders, gastrointestinal problems
- MeSH terms
- Adolescent, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Humans, Male, Psychotropic Drugs
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