Brief report: Bone fractures in children and adults with autism spectrum disorders
Open accessAbstract
Peripubertal boys with autism spectrum disorder (ASD) have lower bone mineral density (BMD) than typically developing controls. However, it is not clear whether lower BMD in ASD results in an increased fracture rate. This study examined the rate of fractures in children and adults with and without ASD using a national database of emergency room visits (Nationwide Emergency Department Sample). A higher odds ratio for hip fractures in children and young adults (3-22 years) as well as older adults (23-50 years) with ASD than those without ASD, and a higher odds ratio for forearm and spine fractures in women ages 23-50 with ASD were found. Further studies are necessary to better understand the decreased bone density in ASD and its implications for fracture development.
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Some studies reported decreased bone development, lower mineral density, and greater risk of fractures in children with ASD compared to controls, linked to lack of calcium and vitamin D in the diet, despite good anthropometric growth.
“Some studies reported decreased bone development lower mineral density and a greater risk of fractures in children with ASD compared to controls (TDs), linked to a lack of calcium and vitamin D in the diet, despite good anthropometric growth [85,86,87,88].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [86]
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- Authors
- Neumeyer, A. M., O’Rourke, J. A., Massa, A., Lee, H., Lawson, E. A., McDougle, C. J., & Misra, M.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Neumeyer, Ann M.
- ORCID
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2014-09-06
- Volume
- 45
- Issue
- 3
- Pages
- 881-887
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC4590779
- OpenAlex
- W2056432740
- Cited by
- 77
- References
- 35
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 21 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 4
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Nancy Lurie Marks Family Foundation
- National Institutes of Health
- National Institute of Mental Health (K23MH092560)
- National Center for Research Resources (UL1RR025758)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24HD071843)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, bone fractures, bone mineral density, hip fracture, forearm fractures, spinal fractures, emergency department visits, children and young adults, women, fracture risk
- MeSH terms
- Adolescent, Adult, Child, Child Development Disorders, Pervasive, Female, Humans, Male, Bone Density, Odds Ratio, Fractures, Bone
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