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Cited by 193Child Nutrition and Feeding IssuesAutism Spectrum Disorder ResearchBone health and osteoporosis research

Reduced bone cortical thickness in boys with autism or autism spectrum disorder

Hediger, Mary L., England, Lucinda J., Molloy, Cynthia A., Yu, Kai F., Manning-Courtney, Patricia, Mills, James L.·2008·Journal of Autism and Developmental Disorders
DOI 10.1007/s10803-007-0453-6
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Abstract

Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4-8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced a progressive fall-off (p = .02): +3.1 +/- 4.7%, -6.5 +/- 4.0%, -16.6 +/- 3.4%, -19.4 +/- 3.7%,-24.1 +/- 4.4%, at ages 4-8, respectively, adjusting for height. The 12% of the boys on casein-free diets had an overall % deviation of -18.9 +/- 3.7%, nearly twice that of boys on minimally restricted or unrestricted diets (-10.5 +/- 1.3%, p < .04), although even for boys on minimally restricted or unrestricted diets the % deviation was highly significant (p < .001). Our data suggest that the bone development of autistic boys should be monitored as part of routine care, especially if they are on casein-free diets.

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Crossref · 10.1007/s10803-007-0453-6

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  • Some studies reported decreased bone development, lower mineral density, and greater risk of fractures in children with ASD compared to controls, linked to lack of calcium and vitamin D in the diet, despite good anthropometric growth.

    “Some studies reported decreased bone development lower mineral density and a greater risk of fractures in children with ASD compared to controls (TDs), linked to a lack of calcium and vitamin D in the diet, despite good anthropometric growth [85,86,87,88].”

    From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [85]

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Authors
Hediger, M. L., England, L. J., Molloy, C. A., Yu, K. F., Manning-Courtney, P., & Mills, J. L.
Affiliations
  • National Institutes of Health (US)
  • Centers for Disease Control and Prevention (US)
  • Cincinnati Children's Hospital Medical Center (US)
Corresponding author
Hediger, Mary L.
ORCID
Venue
Journal of Autism and Developmental Disorders
Publisher
Springer Science and Business Media LLC
Published
2007-09-19
Volume
38
Issue
5
Pages
848-856
ISSN
  • 0162-3257 (ISSN-L)
  • 1573-3432
DOI
10.1007/s10803-007-0453-6
OpenAlex
W2014953581
Cited by
193
References
52
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 4 · 2021: 15 · 2020: 11 · 2019: 13 · 2018: 8 · 2017: 15 · 2016: 5 · 2015: 9 · 2014: 16 · 2013: 20 · 2012: 12
FWCI
7.07
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Autism and Developmental Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • NIH Clinical Center
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (Z01HD008742)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
autism spectrum disorder, skeletal development, casein-free diet, dietary restriction, hand-wrist radiographs, second metacarpal, bone mineralization, children
MeSH terms
Autistic Disorder, Bone Diseases, Child, Child, Preschool, Hand, Humans, Male, Radiography, Metacarpal Bones

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