Corpus callosum area and brain volume in autism spectrum disorder: quantitative analysis of structural MRI from the ABIDE Database
Abstract
Reduced corpus callosum area and increased brain volume are two commonly reported findings in autism spectrum disorder (ASD). We investigated these two correlates in ASD and healthy controls using T1-weighted MRI scans from the Autism Brain Imaging Data Exchange (ABIDE). Automated methods were used to segment the corpus callosum and intracranial region. No difference in the corpus callosum area was found between ASD participants and healthy controls (ASD 598.53 ± 109 mm(2); control 596.82 ± 102 mm(2); p = 0.76). The ASD participants had increased intracranial volume (ASD 1,508,596 ± 170,505 mm(3); control 1,482,732 ± 150,873.5 mm(3); p = 0.042). No evidence was found for overall ASD differences in the corpus callosum subregions.
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- Authors
- Kucharsky Hiess, R., Alter, R., Sojoudi, S., Ardekani, B. A., Kuzniecky, R., & Pardoe, H. R.
- Affiliations
- NYU Langone Health (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Pardoe, H. R.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2015-06-05
- Volume
- 45
- Issue
- 10
- Pages
- 3107-3114
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W603975957
- Cited by
- 56
- References
- 22
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 1
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amazon Web Services
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- autism spectrum disorder, corpus callosum, intracranial volume, brain volume, corpus callosum segmentation, ABIDE, brain structure
- MeSH terms
- Autism Spectrum Disorder, Adolescent, Corpus Callosum, Female, Humans, Magnetic Resonance Imaging, Male, Organ Size, Case-Control Studies, Young Adult
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