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Cited by 663Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersLanguage Development and Disorders

Localization of white matter volume increase in autism and developmental language disorder

Herbert, Martha R., Ziegler, David A., Makris, Nikos, Filipek, Pauline A., Kemper, Thomas L., Normandin, Joseph J., Sanders, Heather A., Kennedy, David N. +1 more·2004·Annals of Neurology
DOI 10.1002/ana.20032
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Abstract

Increased brain volume in autism appears to be driven mainly by an unexplained white matter enlargement, and we have reported a similar phenomenon in developmental language disorder (DLD). Localization of this enlargement would strongly guide research into its cause, tissue basis, and functional implications. We utilized a white matter parcellation technique that divides cerebral white matter into an outer zone containing the radiate compartment and an inner zone containing sagittal and bridging system compartments. In both high‐functioning autism and DLD, enlargement localized to the radiate white matter (all lobes in autism, all but parietal in DLD), whereas inner zone white matter compartments showed no volume differences from controls. Furthermore, in both autism and DLD, later or longer‐myelinating regions showed greater volume increases over controls. Neither group showed cerebral cortex, corpus callosum, or internal capsule volume differences from control. Radiate white matter myelinates later than deep white matter; this pattern of enlargement thus is consistent with striking postnatal head circumference percentile increases reported in autism. These findings suggest an ongoing postnatal process in both autism and DLD that is probably intrinsic to white matter, that primarily affects intrahemispheric and corticocortical connections, and that places these two disorders on the same spectrum.

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  • The findings are concordant with studies using other imaging methods and support the aberrant connectivity hypothesis in autism.

    “Findings were concordant with studies applying other imaging methods, supporting the aberrant connectivity hypothesis in autism (15-18).”

    From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [15]

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Authors
Herbert, M. R., Ziegler, D. A., Makris, N., Filipek, P. A., Kemper, T. L., Normandin, J. J., Sanders, H. A., Kennedy, D. N., & Caviness, V. S.
Affiliations
  • Harvard University (US)
  • University of California, Irvine (US)
  • Boston University (US)
  • University of Pittsburgh (US)
Corresponding author
Herbert, Martha R.
ORCID
Venue
Annals of Neurology
Publisher
Wiley
Published
2004-03-22
Volume
55
Issue
4
Pages
530-540
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.20032
OpenAlex
W2159813274
Cited by
663
References
50
Citations by year
2026: 1 · 2025: 12 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 17 · 2020: 17 · 2019: 18 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 34 · 2014: 37 · 2013: 44 · 2012: 46
FWCI
28.32
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1k23ns002126-01, 5p01ns027950-04)
  • National Institute on Drug Abuse (DA 09467, DA34189, P01DA009467)
  • National Institute of Neurological Disorders and Stroke (NS34189, NS27950, R01NS034189, NS20489, NS02126)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
Keywords
autism spectrum disorder, specific language impairment, postnatal brain growth, head circumference, corticocortical connections, high-functioning autism
MeSH terms
Autistic Disorder, Brain, Child, Female, Humans, Language Development Disorders, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Multivariate Analysis, Linear Models

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