Multicenter mapping of structural network alterations in autism
Open accessAbstract
Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions primarily characterized by abnormalities in social cognition. Abundant previous functional MRI studies have shown atypical activity in networks encompassing medial prefrontal cortex (mPFC) and medial parietal regions corresponding to posterior cingulate cortex and precuneus (PCC/PCU). Conversely, studies assessing structural brain anomalies in ASD have been rather inconsistent. The current work evaluated whether structural changes in ASD can be reliability detected in a large multicenter dataset. Our comprehensive structural MRI framework encompassed cortical thickness mapping and structural covariance analysis based on three independent samples comprising individuals with ASD and controls (n = 220), selected from the Autism Brain Imaging Data Exchange open‐access database. Surface‐based analysis revealed increased cortical thickness in ASD relative to controls in mPFC and lateral prefrontal cortex. Clusters encompassing mPFC were embedded in altered inter‐regional covariance networks, showing decreased covariance in ASD relative to controls primarily to PCC/PCU and inferior parietal regions. Cortical thickness increases and covariance reductions in ASD were consistent, yet of variable effect size, across the different sites evaluated and measurable both in children and adults. Our multisite study shows regional and network‐level structural alterations in mPFC in ASD that, possibly, relate to atypical socio‐cognitive functions in this condition. Hum Brain Mapp 36:2364–2373, 2015. © 2015 Wiley Periodicals, Inc.
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- Authors
- Valk, S. L., Di Martino, A., Milham, M. P., & Bernhardt, B. C.
- Affiliations
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience and Autism Spectrum Disorder Research Program at the Child Study Center of NYU Langone Medical Center New York New York USA
- Nathan Kline Institute for Psychiatric Research (US)
- Montreal Neurological Institute and Hospital (CA)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2015-02-25
- Volume
- 36
- Issue
- 6
- Pages
- 2364-2373
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6129398
- OpenAlex
- W1896089105
- Cited by
- 85
- References
- 75
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 14 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 16 · 2016: 13 · 2015: 5
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- NIH (NYU site) (K23MH087770, R21MH084126, R01MH081218, R01HD065282)
- Autism Speaks
- Stavros Niarchos Foundation
- Leon Levy Foundation, an endowment provided by Phyllis Green and Randolph Cowen
- Autism Speaks (PITT site) (04593)
- KO1 NIMH (MH081191)
- NIMH (MH67924)
- NIH (HD55748)
- National Institutes of Health (K08 MH092697, RO1MH080826, P50MH60450, T32DC008553, R01NS34783)
- Autism Speaks Mentor-based Predoctoral Fellowship (USM site) (1677)
- University of Utah Multidisciplinary Research Seed Grant
- NRSA Predoctoral Fellowship (F31 DC010143)
- Ben B. and Iris M. Margolis Foundation
- Jeanne Timmins Costello Award of the Montreal Neurological Institute and Hospital and CIHR
- International Max Planck Research School Stipend, IMPRS NeuroCom
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, brain structural changes, medial prefrontal cortex, posterior cingulate cortex, precuneus, cortical thickness, structural covariance networks, medial parietal cortex, inferior parietal cortex, social cognition, neurodevelopmental disorders
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Brain, Brain Mapping, Child, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Organ Size, Internet, Access to Information, Young Adult, Datasets as Topic
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