Dietary algae and HIV/AIDS: proof of concept clinical data
Open accessAbstract
Dietary algae have been reported to decrease HIV viral fusion/entry and replication and increase immune response, suggesting that regular consumption of algae by people in Japan, Korea, and Chad could be an important factor in their relatively low HIV/AIDS rates. Five antiretroviral-naïve people with HIV (three females, two males; five African Americans) living in Columbia SC participated in the phase I study of acute toxicity. Subjects were randomly assigned to 5 g day(-1) brown seaweed (Undaria pinnatifida), Spirulina (Arthrospira platensis), or a combination of both. Endpoints included HIV viral load, complete blood count (CBC), metabolic and lipid panel, and quality of life questionnaire data. When no short-term toxicities were observed, six additional subjects (four females, two males; five African Americans, one Latina) were recruited to further evaluate short- and long-term toxicities (phase II). No adverse effects were observed for the 11 subjects in the phase I trial, and quality of life indicators improved at 3 weeks. No significant changes were observed in CBC, metabolic or lipid panel analyses. CD4 cells (milliliters) and HIV-1 viral load remained stable over the first 3-month phase II study period. One subject continued in the study for 13 months and had clinically significant improvement in CD4 (>100 cells mL(-1)) and decreased HIV viral load of 0.5 log(10). Our pilot data suggest that Undaria, Spirulina, and a combination of both were nontoxic and over time may improve clinical endpoints of HIV/AIDS.
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The increase in CD4+ count was always accompanied by a decrease in the viral load.
“In particular, the increase in CD4+ count was always accompanied by a decrease in the viral load [101–103].”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [101]
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- Authors
- Teas, J., & Irhimeh, M. R.
- Affiliations
- University of South Carolina (US)
- The University of Sydney (AU)
- Corresponding author
- Teas, J.
- Venue
- Journal of Applied Phycology
- Published
- 2011-12-29
- Volume
- 24
- Issue
- 3
- Pages
- 575-582
- ISSN
- 0921-8971 (ISSN-L)
- 1573-5176
- PMC
- PMC3354323
- OpenAlex
- W1963862032
- Cited by
- 43
- References
- 32
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 10 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Applied Phycology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- University of South Carolina
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- HIV/AIDS, Undaria pinnatifida, brown algae, Spirulina, Spirulina platensis, HIV-1 viral load, CD4 count, antiretroviral-naive HIV, acute toxicity, quality of life, immune response
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