Nutraceutical Potential of Seaweed Polysaccharides: Structure, Bioactivity, Safety, and Toxicity
Abstract
In recent years, marine organisms including seaweeds have been highlighted as potential sources of useful metabolites and bioactive compounds, with vast biological and physiological activities. Seaweeds have long been used as a food source, for medicinal purposes, and as dietary supplements in various Asian countries, and their potential benefits have recently attracted the attention of many Western and European countries. Their commercial value depends on their applications in the food, nutraceutical, and pharmaceutical industries. Seaweeds are considered a potential source of nutraceuticals or functional foods, and analysis of taste‐oriented motives has revealed that seaweeds are preferentially selected over other types of marine foods by seafood consumers and people with high levels of health, education, and living status. It is a general perception that health conscious people prefer environmentally friendly food sources, and present an opportunity to focus on seaweed‐based foods, which have significant nutritional benefits to humans. Among the various bioactive constituents, seaweed polysaccharides have been proven to possess various beneficial properties including anticoagulant, anti‐inflammatory, antioxidant, anticarcinogenic, and antiviral activities. The diversity and composition of seaweed polysaccharides play vital roles in these biological activities. Seaweeds are a rich source of sulfated polysaccharides, which are responsible for much of the bioactivity, as they can interact with various textures and cellular proteins. A number of toxicological assays and clinical trials suggest that the ingestion of seaweeds as functional foods should be considered worldwide to improve immune responses. In this review, different polysaccharides from seaweeds and their compositions and potential nutraceutical applications are discussed.
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Algal food safety incidents occur in Europe, South America, and Asia, causing consumers to face problems.
“Despite edible algae contain plenty of vitamins, micronutrients, and many plant compounds, according to the relevant research reports from Europe, South America, and Asia, the algae food safety situation demonstrates that consumers have to face the problems caused by food safety incidents [25,26,27].”
From Current Status and Future Trends in Removal, Control, and Mitigation of Algae Food Safety Risks for Human Consumption (2022) · cites this paper as [27]
Cites
Alginate: Properties and biomedical applications
Lee, K. Y., & Mooney, D. J. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.06.003 · Cited by 8,218 · see citing works
Bioactive compounds in seaweed: functional food applications and legislation
Holdt, S. L., & Kraan, S. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9632-5 · Cited by 2,135 · see citing works
Alginate Hydrogels as Biomaterials
Augst, A., Kong, H. J., & Mooney, D. J. (2006) · Macromolecular Bioscience · doi:10.1002/mabi.200600069 · Cited by 1,849 · see citing works
Seaweed Ecology and Physiology
Hurd, C. L., Harrison, P. J. H., Bischof, K., & Lobban, C. S. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139192637 · Cited by 1,593 · see citing works
Kuo, C. K., & Ma, P. X. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00201-5 · Cited by 1,497 · see citing works
Carrageenans: Biological properties, chemical modifications and structural analysis – A review
Campo, V. L., Kawano, D. F., da Silva, D. B., & Carvalho, I. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.01.020 · Cited by 1,412 · see citing works
Fucoidan: Structure and bioactivity
Li, B., Lu, F., Wei, X., & Zhao, R. (2008) · Molecules · doi:10.3390/molecules13081671 · Cited by 1,383 · see citing works
Alginate-Based Biomaterials for Regenerative Medicine Applications
Sun, J., & Tan, H. (2013) · Materials · doi:10.3390/ma6041285 · Cited by 1,368 · see citing works
Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026 · see citing works
Structure and Functional Properties of Ulvan, a Polysaccharide from Green Seaweeds
Lahaye, M., & Robic, A. (2007) · Biomacromolecules · doi:10.1021/bm061185q · Cited by 1,024 · see citing works
Wijesekara, I., Pangestuti, R., & Kim, S.-K. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.10.062 · Cited by 992 · see citing works
Metabolites from algae with economical impact
Cardozo, K. H. M., Guaratini, T., Barros, M. P., Falcão, V. D. R., Tonon, Â. P., Lopes, N. P., Campos, S. C. G., Torres, M. A., Souza, A. D. O., Colepicolo, P., et al. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.05.007 · Cited by 960 · see citing works
Alginate composites for bone tissue engineering: A review
Venkatesan, J., Bhatnagar, I., Manivasagan, P., Kang, K., & Kim, S. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.07.008 · Cited by 910 · see citing works
A decade of change in the seaweed hydrocolloids industry
Bixler, H. J., & Porse, H. (2010) · Journal of Applied Phycology · doi:10.1007/s10811-010-9529-3 · Cited by 878 · see citing works
Ale, M. T., Mikkelsen, J. D., & Meyer, A. S. (2011) · Marine Drugs · doi:10.3390/md9102106 · Cited by 779 · see citing works
Berteau, O. (2003) · Glycobiology · doi:10.1093/glycob/cwg058 · Cited by 769 · see citing works
Seaweed in food products: biochemical and nutritional aspects
Mabeau, S., & Fleurence, J. (1993) · Trends in Food Science & Technology · doi:10.1016/0924-2244(93)90091-n · Cited by 622 · see citing works
Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications
Cunha, L., & Grenha, A. (2016) · Marine Drugs · doi:10.3390/md14030042 · Cited by 619 · see citing works
Characterization of polysaccharides extracted from brown seaweeds
Rioux, L.-E., Turgeon, S. L., & Beaulieu, M. (2007) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2007.01.009 · Cited by 604 · see citing works
Carrageenan and its applications in drug delivery
Li, L., Ni, R., Shao, Y., & Mao, S. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.12.008 · Cited by 597 · see citing works
A revised structure for fucoidan may explain some of its biological activities.
Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531 · see citing works
Roberts, J. N., Buck, C. B., Thompson, C. D., Kines, R. C., Bernardo, M., Choyke, P. L., Lowy, D. R., & Schiller, J. T. (2007) · Nature Medicine · doi:10.1038/nm1598 · Cited by 504 · see citing works
Carrageenan is a potent inhibitor of papillomavirus infection
Buck, C. B., Thompson, C. D., Roberts, J. N., Müller, M., Lowy, D. R., & Schiller, J. T. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020069 · Cited by 497 · see citing works
Preparation methods of alginate nanoparticles
Paques, J. P., van der Linden, E., van Rijn, C. J. M., & Sagis, L. M. C. (2014) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2014.03.009 · Cited by 480 · see citing works
Synytsya, A., Kim, W.-J., Kim, S.-M., Pohl, R., Synytsya, A., Kvasnička, F., Čopíková, J., & Il Park, Y. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.01.052 · Cited by 461 · see citing works
‘Green tides’ are overwhelming the coastline of our blue planet: taking the world's largest example
Ye, N., Zhang, X., Mao, Y., Liang, C., Xu, D., Zou, J., Zhuang, Z., & Wang, Q. (2011) · Ecological Research · doi:10.1007/s11284-011-0821-8 · Cited by 455 · see citing works
Marine Bioactive Compounds and Their Health Benefits: A Review
Hamed, I., Özogul, F., Özogul, Y., & Regenstein, J. M. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12136 · Cited by 444 · see citing works
Five Kingdoms: An Illustrated Guide to the Phyla of Life on Earth
Schmid, R., Margulis, L., & Schwartz, K. V. (1988) · Taxon · doi:10.2307/1222104 · Cited by 419 · see citing works
Extraction, structure and biofunctional activities of laminarin from brown algae
Kadam, S. U., Tiwari, B. K., & O'Donnell, C. P. (2015) · International Journal of Food Science & Technology · doi:10.1111/ijfs.12692 · Cited by 393 · see citing works
Review of harmful gastrointestinal effects of carrageenan in animal experiments.
Tobacman, J. K. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109983 · Cited by 370 · see citing works
Garcia-Vaquero, M., Rajauria, G., O'Doherty, J. V., & Sweeney, T. (2017) · Food Research International · doi:10.1016/j.foodres.2016.11.016 · Cited by 364 · see citing works
Alginates: Biology and Applications
Rehm, B. H. A. (2009) · Microbiology monographs · doi:10.1007/978-3-540-92679-5 · Cited by 357 · see citing works
Zhou, G. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.12.002 · Cited by 339 · see citing works
Leiro, J. M., Castro, R., Arranz, J. A., & Lamas, J. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.02.007 · Cited by 316 · see citing works
A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A. P., & Colliec‐Jouault, S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(00)00314-1 · Cited by 304 · see citing works
Algal Polysaccharides, Novel Applications and Outlook
Kraan, S. (2012) · InTech eBooks · doi:10.5772/51572 · Cited by 291 · see citing works
Seaweed: Chemical composition and potential food uses
Ito, K., & Hori, K. (1989) · Food Reviews International · doi:10.1080/87559128909540845 · Cited by 269 · see citing works
Seaweed: Promising plant of the millennium
Dhargalkar, V. K., & Pereira, N. (2005) · Cited by 269 · see citing works
Ruocco, N., Costantini, S., Guariniello, S., & Costantini, M. (2016) · Molecules · doi:10.3390/molecules21050551 · Cited by 268 · see citing works
Qi, H., Zhang, Q., Zhao, T., Hu, R., Zhang, K., & Li, Z. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.01.076 · Cited by 251 · see citing works
Structural analysis of red seaweed galactans of agar and carrageenan groups
Usov, A. I. (1998) · Food Hydrocolloids · doi:10.1016/s0268-005x(98)00018-6 · Cited by 247 · see citing works
Shanmugam, M., & Mody, K. (2000) · Cited by 228 · see citing works
Study on saccharification techniques of seaweed wastes for the transformation of ethanol
Ge, L., Wang, P., & Mou, H. (2010) · Renewable Energy · doi:10.1016/j.renene.2010.06.001 · Cited by 223 · see citing works
Seaweed polysaccharides and their potential biomedical applications
Venkatesan, J., Lowe, B., Anil, S., Manivasagan, P., Kheraif, A. A. A., Kang, K., & Kim, S. (2015) · Starch - Stärke · doi:10.1002/star.201400127 · Cited by 216 · see citing works
Wang, Y., Han, F., Hu, B., Li, J., & Yu, W. (2006) · Nutrition Research · doi:10.1016/j.nutres.2006.09.015 · Cited by 214 · see citing works
An anticoagulative polysaccharide from an enzymatic hydrolysate of Ecklonia cava
Athukorala, Y., Jung, W.-K., Vasanthan, T., & Jeon, Y.-J. (2006) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2006.03.002 · Cited by 209 · see citing works
Food additive carrageenan: Part II: A critical review of carrageenan<i>in vivo</i>safety studies
Weiner, M. L. (2014) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.861798 · Cited by 192 · see citing works
Sanjeewa, K. K. A., Lee, J.-S., Kim, W.-S., & Jeon, Y. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.09.005 · Cited by 192 · see citing works
Seaweeds for Food and Industrial Applications
Klnc, B., Cırık, S., Turan, G., Tekoğul, H., & Koru, E. (2013) · InTech eBooks · doi:10.5772/53172 · Cited by 184 · see citing works
Alginate based polyurethanes: A review of recent advances and perspective
Zia, K. M., Zia, F., Zuber, M., Rehman, S., & Ahmad, M. N. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.04.076 · Cited by 183 · see citing works
Sanjeewa, K. K. A., Fernando, I. P. S., Kim, E.-A., Ahn, G., Jee, Y., & Jeon, Y.-J. (2017) · Nutrition Research and Practice · doi:10.4162/nrp.2017.11.1.3 · Cited by 171 · see citing works
Sathivel, A., Raghavendran, H. R. B., Srinivasan, P., & Devaki, T. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.07.016 · Cited by 169 · see citing works
Biorefining of marine macroalgal biomass for production of biofuel and commodity chemicals
Baghel, R. S., Trivedi, N., Gupta, V., Neori, A., Reddy, C. R. K., Lali, A. M., & Jha, B. (2015) · Green Chemistry · doi:10.1039/c4gc02532f · Cited by 169 · see citing works
Opportunities and challenges for seaweed in the biobased economy
van Hal, J. W., Huijgen, W. J. J., & López-Contreras, A. M. (2014) · Trends in biotechnology · doi:10.1016/j.tibtech.2014.02.007 · Cited by 166 · see citing works
Seaweed biorefinery concept for sustainable use of marine resources
Bāliņa, K., Romagnoli, F., & Blumberga, D. (2017) · Energy Procedia · doi:10.1016/j.egypro.2017.09.067 · Cited by 166 · see citing works
Mabeau, S., & Kloareg, B. (1987) · Journal of Experimental Botany · doi:10.1093/jxb/38.9.1573 · Cited by 165 · see citing works
Kang, S., Kim, K., Lee, S., Ahn, G., Cha, S.-H., Kim, A.-D., Yang, X., Kang, M., & Jeon, Y. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.01.052 · Cited by 165 · see citing works
Senni, K., Gueniche, F., Foucault-Bertaud, A., Igondjo-Tchen, S., Fioretti, F., Colliec-Jouault, S., Durand, P., Guezennec, J., Godeau, G., & Letourneur, D. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.11.001 · Cited by 163 · see citing works
Cluzet, S., Ameline-Torregrosa, C., Jacquet, C., Lafitte, C., Fournier, J., MERCIER, L., Salamagne, S., Briand, X., Esquerré‐Tugayé, M., & Dumas, B. (2004) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2004.01197.x · Cited by 159 · see citing works
Immunomodulating Activity of Arabinogalactan and Fucoidan In Vitro
Choi, E., Kim, A.-J., Kim, Y.-O., & Hwang, J. (2005) · Journal of Medicinal Food · doi:10.1089/jmf.2005.8.446 · Cited by 158 · see citing works
Teruya, T., Konishi, T., Uechi, S., Tamaki, H., & Tako, M. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.02.010 · Cited by 156 · see citing works
Ray, B., & Lahaye, M. (1995) · Carbohydrate Research · doi:10.1016/0008-6215(95)00138-j · Cited by 151 · see citing works
Cell Wall Polysaccharides of Marine Algae
Synytsya, A., Čopı́ková, J., Kim, W. J., & Park, Y. I. (2015) · Springer eBooks · doi:10.1007/978-3-642-53971-8_22 · Cited by 142 · see citing works
Ray, B., & Lahaye, M. (1995) · Carbohydrate Research · doi:10.1016/0008-6215(95)00059-3 · Cited by 138 · see citing works
Tanna, B., & Mishra, A. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12396 · Cited by 136 · see citing works
Self-citationSanjeewa, K. K. A., Kang, N., Ahn, G., Jee, Y., Kim, Y.-T., & Jeon, Y. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.02.040 · Cited by 135 · see citing works
Effect of fucoidan on fibroblast growth factor-2-induced angiogenesis in vitro
Matou, S., Helley, D., Chabut, D., Bros, A., & Fischer, A. (2002) · Thrombosis Research · doi:10.1016/s0049-3848(02)00136-6 · Cited by 134 · see citing works
Haneji, K., Matsuda, T., Tomita, M., Kawakami, H., Ohshiro, K., Uchihara, J., Masuda, M., Takasu, N., Tanaka, Y., Ohta, T., et al. (2005) · Nutrition and Cancer · doi:10.1207/s15327914nc5202_9 · Cited by 132 · see citing works
Borazjani, N. J., Tabarsa, M., You, S., & Rezaei, M. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.03.128 · Cited by 131 · see citing works
Barsanti, L. A., & Gualtieri, P. (2014) · CRC Press eBooks · doi:10.1201/b16544 · Cited by 131 · see citing works
Xing, R., Liu, S., Yu, H., et al. (2005) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2005.04.007 · Cited by 130 · see citing works
Effect of low molecular λ-carrageenan from Chondrus ocellatus on antitumor H-22 activity of 5-Fu
Zhou, G.-D., SHENG, W., YAO, W., & WANG, C. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.09.009 · Cited by 129 · see citing works
Blood cholesterol and lipid-lowering effects of carrageenan on human volunteers.
Panlasigui, L. N., Baello, O. Q., Dimatangal, J. M., et al. (2003) · PubMed · Cited by 128 · see citing works
Bioactivity of sulfated polysaccharides from the edible red seaweed Mastocarpus stellatus
Gómez‐Ordóñez, E., Jiménez‐Escrig, A., & Rupérez, P. (2014) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2014.01.002 · Cited by 122 · see citing works
Li, C.-M., Gao, Y.-L., Xing, Y., Zhu, H.-B., Shen, J.-Y., & Tian, J.-W. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.05.022 · Cited by 121 · see citing works
Lahaye, M. (1998) · Carbohydrate Research · doi:10.1016/s0008-6215(98)00293-6 · Cited by 120 · see citing works
Hassan, S. M., El-Twab, S. M. A., Hetta, M. H., & Mahmoud, B. (2011) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2011.01.005 · Cited by 117 · see citing works
Tanna, B., Choudhary, B., & Mishra, A. (2018) · Algal Research · doi:10.1016/j.algal.2018.10.019 · Cited by 112 · see citing works
Self-citationLow molecular weight derivatives of different carrageenan types and their antiviral activity
Kalitnik, A. A., Barabanova, A. O., Nagorskaya, V. P., et al. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-012-9839-8 · Cited by 107 · see citing works
Inhibitory Action of Natural Carrageenans on Herpes simplex Virus Infection of Mouse Astrocytes
Carlucci, M. J., Scolaro, L. A., & Damonte, E. B. (1999) · Chemotherapy · doi:10.1159/000007236 · Cited by 106 · see citing works
Berri, M., Slugocki, C., Olivier, M., Helloin, E., Jacques, I., Salmon, H., Demais, H., Goff, M. L., & Collén, P. N. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0822-7 · Cited by 103 · see citing works
Wijesinghe, W. A. J. P., Athukorala, Y., & Jeon, Y. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.05.047 · Cited by 101 · see citing works
A case–control study on seaweed consumption and the risk of breast cancer
Yang, Y. J., Nam, S. J., Kong, G., & Kim, M. K. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509993242 · Cited by 100 · see citing works
Antiviral activity of carrageenan on hepatitis A virus replication in cell culture
Girond, S., Crance, J., van Cuyck‐Gandré, H., RENAUDET, J., & Deloince, R. (1991) · Research in Virology · doi:10.1016/0923-2516(91)90011-q · Cited by 99 · see citing works
Sulfated polysaccharides of the red seaweeds
Usov, A. I. (1992) · Food Hydrocolloids · doi:10.1016/s0268-005x(09)80055-6 · Cited by 99 · see citing works
Chiu, Y.-H., Chan, Y.-L., Li, T., & Wu, C. (2011) · Marine Biotechnology · doi:10.1007/s10126-011-9428-x · Cited by 99 · see citing works
Khotimchenko, Y. S., Ковалев, В. В., Ov, S., & Ziganshina, O. A. (2001) · Russian Journal of Marine Biology · doi:10.1023/a:1013851022276 · Cited by 98 · see citing works
Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats
Raghavendran, H. R. B., Periasamy, S., & Sathyanath, R. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.11.002 · Cited by 97 · see citing works
Patel, M. K., Tanna, B., Mishra, A., & Jha, B. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.06.139 · Cited by 97 · see citing works
Self-citationImmunostimulatory Effect of Laminarin on RAW 264.7 Mouse Macrophages
Lee, J. Y., Kim, Y.-J., Kim, H. J., Kim, Y., & Park, W. (2012) · Molecules · doi:10.3390/molecules17055404 · Cited by 91 · see citing works
Negishi, H., Mori, M., Mori, H., & Yamori, Y. (2013) · Journal of Nutrition · doi:10.3945/jn.113.179036 · Cited by 91 · see citing works
Liu, J., Kandasamy, S., Zhang, J., Kirby, C. W., Karakach, T. K., Hafting, J. T., Critchley, A. T., Evans, F., & Prithiviraj, B. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0802-5 · Cited by 88 · see citing works
Kim, K.-J., Lee, O.-H., Lee, H.-H., & Lee, B.-Y. (2010) · Toxicology · doi:10.1016/j.tox.2009.11.007 · Cited by 83 · see citing works
Myers, S. P. (2010) · Biologics · doi:10.2147/btt.s8354 · Cited by 83 · see citing works
Abd-Ellatef, G. E. F., Ahmed, O. M., Abdel-Reheim, E. S., et al. (2017) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s125165 · Cited by 83 · see citing works
Zoysa, M. D., Nikapitiya, C., Jeon, Y., Jee, Y., & Lee, J. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9182-7 · Cited by 81 · see citing works
Moroney, N. C., O’Grady, M. N., O’Doherty, J. V., et al. (2012) · Meat Science · doi:10.1016/j.meatsci.2012.05.005 · Cited by 81 · see citing works
Godard, M., Décordé, K., Ventura, E., et al. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.11.084 · Cited by 80 · see citing works
Efficacy of Carraguard®-Based Microbicides In Vivo Despite Variable In Vitro Activity
Turville, S. G., Aravantinou, M., Miller, T., Kenney, J., Teitelbaum, A. M., Hu, L., Chudolij, A., Zydowsky, T. M., Piatak, M., Bess, J. W., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003162 · Cited by 78 · see citing works
Teas, J., Vena, S., Cone, D. L., & Irhimeh, M. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-012-9931-0 · Cited by 77 · see citing works
Carrageenan Induces Cell Cycle Arrest in Human Intestinal Epithelial Cells in Vitro3
Bhattacharyya, S., Borthakur, A., Dudeja, P. K., & Tobacman, J. K. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.469 · Cited by 76 · see citing works
Ghannam, A., Murad, H., Jazzara, M., Odeh, A., & Allaf, A. W. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.11.001 · Cited by 74 · see citing works
Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo
Hwang, P., Yan, M., Lin, H. V., Li, K.-L., & Lin, Y. (2016) · Marine Drugs · doi:10.3390/md14070121 · Cited by 73 · see citing works
Algae, A Possible Source for New Drugs in the Treatment of HIV and Other Viral Diseases
Luescher-Mattli, M. (2003) · Anti-Infective Agents · doi:10.2174/1568012033483051 · Cited by 70 · see citing works
Edible seaweeds of China and their place in the Chinese diet
Bangmei, X., & Abbott, I. A. (1987) · Economic Botany · doi:10.1007/bf02859049 · Cited by 70 · see citing works
Nanri, A., Mizoue, T., Poudel‐Tandukar, K., Noda, M., Kato, M., Kurotani, K., Goto, A., Oba, S., Inoue, M., & Tsugane, S. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.114793 · Cited by 68 · see citing works
Kumar, A., Elavarasan, K., Hanjabam, M. D., Uchoi, D., Tejpal, C. S., Ninan, G., & Zynudheen, A. A. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1310-4 · Cited by 68 · see citing works
Infant, S. S., Jayakumar, K., Mukherjee, A., & Chandrasekaran, N. (2018) · RSC Advances · doi:10.1039/c8ra02616e · Cited by 68 · see citing works
Lee, H. J., Kim, H. C., Vı́tek, L., & Nam, C. M. (2010) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.56.13 · Cited by 61 · see citing works
Miyake, Y., Tanaka, K., Okubo, H., Sasaki, S., & Arakawa, M. (2014) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-14-301 · Cited by 60 · see citing works
HDL in atherosclerosis: actor or bystander?
Asztalos, B. F., & Schaefer, E. J. (2003) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(03)00006-0 · Cited by 59 · see citing works
Niu, J., Xu, C., Lu, X., et al. (2014) · Aquaculture · doi:10.1016/j.aquaculture.2014.08.013 · Cited by 58 · see citing works
Fitton, J. H., Meyers, S., Brooks, L. O., Mulder, A. M., Rolfe, M. I., Baker, D., & Robinson, S. (2016) · Biologics · doi:10.2147/btt.s95165 · Cited by 57 · see citing works
Laminarin Induces Apoptosis of Human Colon Cancer LOVO Cells through a Mitochondrial Pathway
Ji, Y., Ji, C. F., & Zhang, H. (2012) · Molecules · doi:10.3390/molecules17089947 · Cited by 55 · see citing works
Applications of Carrageenan in Advanced Drug Delivery
Guan, J., Li, L., & Mao, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809816-5.00015-3 · Cited by 55 · see citing works
The Preparation and Bioactivity Research of Agaro-Oligosaccharides
Chen, H., Zheng, L., & Yan, X. (2005) · Hrčak Portal of scientific journals of Croatia (University Computing Centre) · Cited by 52 · see citing works
Seaweed Flora of the European North Atlantic and Mediterranean
Pereira, L. (2015) · Springer eBooks · doi:10.1007/978-3-642-53971-8_6 · Cited by 50 · see citing works
Myers, S., O'Connor, J., Fitton, J., Brooks, L., Rolfe, M. I., Connellan, P., Wohlmuth, H., Cheras, P., & Morris, C. (2011) · Biologics : Targets & Therapy · doi:10.2147/btt.s12535 · Cited by 50 · see citing works
Sun, Y., Liu, Y., Jiang, K., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500429r · Cited by 50 · see citing works
Miao, H., Ishai‐Michaeli, R., Peretz, T., & Vlodavsky, I. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041640306 · Cited by 49 · see citing works
Devaki, T., Sathivel, A., & BalajiRaghavendran, H. R. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.09.036 · Cited by 48 · see citing works
Rao, H. B. R., Sathivel, A., & Devaki, T. (2004) · Journal of Medicinal Food · doi:10.1089/jmf.2004.7.495 · Cited by 43 · see citing works
Non-Clinical Safety Evaluation of Intranasal Iota-Carrageenan
Hebar, A., Koller, C., Seifert, J., Chabicovsky, M., Bodenteich, A., Bernkop‐Schnürch, A., Grassauer, A., & Prieschl‐Grassauer, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122911 · Cited by 42 · see citing works
Potentials and possible safety issues of using biorefinery products in food value chains
Lange, L., & Meyer, A. S. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.08.016 · Cited by 38 · see citing works
Novel synthesis of l-iduronic acid using trehalose as the disaccharidic starting material
Hinou, H., Kurosawa, H., Matsuoka, K., et al. (1999) · Tetrahedron Letters · doi:10.1016/s0040-4039(98)02662-8 · Cited by 35 · see citing works
Kolsi, R. B. A., Gara, A. B., Chaaben, R., Feki, A. E., Patti, F. P., Feki, L. E., & Belghith, K. S. (2015) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2015.1105266 · Cited by 31 · see citing works
Violle, N., Rozan, P., Demais, H., Collén, P. N., & Bisson, J. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1276704 · Cited by 29 · see citing works
Fucoidan increases TNF-α-induced MMP-9 secretion in monocytic cell line U937
Jintang, S., Alei, F., Yun, Z., Shanzhen, S., Weixu, H., Meixiang, Y., Fengcai, W., & Xun, Q. (2010) · Inflammation Research · doi:10.1007/s00011-009-0095-6 · Cited by 27 · see citing works
Díaz, A. C., Espino, M. L., Arzoz, N. S., Velurtas, S. M., Ponce, N. M. A., Stortz, C. A., & Fenucci, J. L. (2017) · Latin American Journal of Aquatic Research · doi:10.3856/vol45-issue1-fulltext-10 · Cited by 27 · see citing works
Tanna, B., & Mishra, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812689-9.00002-9 · Cited by 26 · see citing works
Self-citationda Costa, D. S., Araújo, T. S. L., Sousa, N. A., de Souza, L. K. M., Pacífico, D. M., Sousa, F. B. M., Nicolau, L. A. D., Chaves, L. S., Barros, F. C. N., Freitas, A. L. P., et al. (2015) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12531 · Cited by 23 · see citing works
Chang, H., Chen, H.-H., & Hu, H.-H. (2010) · Journal of Texture Studies · doi:10.1111/j.1745-4603.2010.00268.x · Cited by 22 · see citing works
Ramezanpour, M., Murphy, J., Smith, J., Vreugde, S., & Psaltis, A. J. (2017) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22021 · Cited by 21 · see citing works
Untargeted Metabolomics of Halophytes
Patel, M. K., Mishra, A., & Jha, B. (2016) · CRC Press eBooks · doi:10.1201/9781315372303-18 · Cited by 20 · see citing works
Self-citationJiang, Z., Abu, R., Isaka, S., et al. (2014) · PubMed · Cited by 17 · see citing works
Biological Activity of Algal Sulfated and Nonsulfated Polysaccharides
Rupérez, P., Gómez‐Ordóñez, E., & Jiménez‐Escrig, A. (2013) · Wiley eBooks · doi:10.1002/9781118412893.ch11 · Cited by 16 · see citing works
Effects of Undaria pinnatifida and Laminaria japonica on Rat’s Intestinal Microbiota and Metabolite
Kim, J., Dy, Y., Ja, K., Ey, C., Cy, L., Yh, H., Cw, K., Ss, L., Is, C., & Kk, C. (2016) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000502 · Cited by 15 · see citing works
Photosynthetic Pigments: Perplexing Persistent Prevalence of ‘Superfluous’ Pigment Production
Beale, S. I. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.064 · Cited by 10 · see citing works
Mohankumar, K., Meenakshi, S., Balasubramanian, T., & Manivasagam, T. (2012) · The Egyptian Heart Journal · doi:10.1016/j.ehj.2012.03.003 · Cited by 7 · see citing works
Rodrigues, J. A. G., Vanderlei, E. D. S. O., de Araújo, I. W. F., Quinderé, A. L. G., Coura, C. O., & Benevídes, N. M. B. (2013) · Acta Scientiarum. Technology/Acta scientiarum. Technology · doi:10.4025/actascitechnol.v35i4.15699 · Cited by 7 · see citing works
Polyelectrolyte Complexes Based on Chitosan and Natural Polymers
Mustafa, A., Tomescu, A., Cadar, E., et al. (2017) · European Journal of Formal Sciences and Engineering · doi:10.26417/ejis.v4i1.p100-107 · Cited by 5 · see citing works
Polyelectrolyte Complexes Based on Chitosan and Natural Polymers
Mustafa, A., Tomescu, A., Mustafa, E., et al. (2016) · European Journal of Interdisciplinary Studies · doi:10.26417/ejis.v2i1.p100-107 · Cited by 3 · see citing works
(2009) · Elsevier eBooks · doi:10.1016/b978-0-12-373621-5.x0001-3 · Cited by 3 · see citing works
Myers, S. P., Mulder, A. M., Baker, D. G., et al. (2016) · Dove Medical Press (Taylor and Francis Group) · Cited by 2 · see citing works
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Singh, S., Verma, D. K., Thakur, M., Tripathy, S., Patel, A. R., Shah, N., Utama, G. L., Srivastav, P. P., Benavente-Valdés, J. R., Chávez-González, M. L., et al. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110746 · Cited by 98 · see citing works
Trica, B., Delattre, C., Gros, F., Ursu, A. V., Dobre, T., Djelveh, G., Michaud, P., & Oancea, F. (2019) · Marine Drugs · doi:10.3390/md17070405 · Cited by 92 · see citing works
Wu, G., Zhuang, D., Chew, K. W., Ling, T. C., Khoo, K. S., Van Quyen, D., Feng, S., & Show, P. L. (2022) · Molecules · doi:10.3390/molecules27196633 · Cited by 51 · see citing works
Salvi, K. P., da Silva Oliveira, W., Horta, P. A., Rörig, L. R., & de Oliveira Bastos, E. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02430-2 · Cited by 24 · see citing works
- Authors
- Tanna, B., & Mishra, A.
- Affiliations
- Central Salt and Marine Chemicals Research Institute (IN)
- Corresponding author
- Mishra, Avinash
- Venue
- Comprehensive Reviews in Food Science and Food Safety
- Publisher
- Wiley
- Published
- 2019-04
- Volume
- 18
- Issue
- 3
- Pages
- 817-831
- ISSN
- 1541-4337 (ISSN-L)
- OpenAlex
- W2929935032
- Semantic Scholar
- fe895e93644f68c9ec823d0f173d66f2802f7292
- Cited by
- 329
- References
- 144
- Citations by year
- 2026: 41 · 2025: 51 · 2024: 41 · 2023: 53 · 2022: 61 · 2021: 52 · 2020: 19 · 2019: 11
- FWCI
- 31.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comprehensive Reviews in Food Science and Food Safety (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India (PRIS‐003/2017)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- seaweed polysaccharides, nutraceuticals, sulfated polysaccharides, functional foods, biological activity, antioxidant activity, anti-inflammatory activity, anticoagulant activity, anticarcinogenic activity, antiviral activity, toxicity, dietary supplements, immune response
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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