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Gain and loss of T cell subsets in old age: age-related reshaping of the T cell repertoire.
Open accessAbstract
The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T cells, thereby compromising the diversity of the T cell pool. Additional infection with latent pathogens such as cytomegalovirus aggravates this process. In this review, we focus on the major age-related changes that occur in the naïve and the antigen-experienced T cell population. We discuss the mechanisms responsible for the generation and maintenance of these subsets and how age-related changes can be delayed or prevented by clinical interventions.
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“Thymic involution leads to the depletion of critical immune cell populations (Arnold, Wolf, Brunner, Herndler‐Brandstetter, & Grubeck‐Loebenstein, 2011)”
From Reversal of epigenetic aging and immunosenescent trends in humans. (2019) · cites this paper as Arnold, Wolf, Brunner, Herndler‐Brandstetter, & Grubeck‐Loebenstein, 2011
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“As a general rule, the frequency of naïve T cells declines with progressive age and the frequency of memory populations increases (Table 1) [15].”
From T-cell aging in rheumatoid arthritis (2014) · cites this paper as [15]
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Self-citation
Metadata
- Authors
- Arnold, C. R., Wolf, J., Brunner, S., Herndler-Brandstetter, D., & Grubeck-Loebenstein, B.
- Affiliations
- Austrian Academy of Sciences (AT)
- Venue
- Journal of Clinical Immunology
- Published
- 2011-01-18
- Volume
- 31
- Issue
- 2
- Pages
- 137-146
- ISSN
- 0271-9142 (ISSN-L)
- 1573-2592
- OpenAlex
- W2058299309
- Cited by
- 170
- References
- 125
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 11 · 2019: 14 · 2018: 11 · 2017: 18 · 2016: 14 · 2015: 15 · 2014: 15 · 2013: 20 · 2012: 18
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- green
- epub.oeaw.ac.at
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Journal of Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Oesterreichisches Musiklexikon online (Institut für kunst- und musikhistorische Forschungen der Österreichischen Akademie der Wissenschaften) (submittedVersion, other-oa)
- Austrian Biographical Dictionary (Austrian Academy of Sciences) (submittedVersion, other-oa)
- ISBN
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- immunosenescence, T cell subsets, T cell receptor repertoire, naive T cells, antigen-experienced T cells, thymus, bone marrow, cytomegalovirus infection, aging, T cell diversity
- MeSH terms
- Aging, Animals, Antigens, Humans, Immunologic Memory, T-Lymphocytes, T-Lymphocyte Subsets, Immunomodulation
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