Cited by 170T-cell and B-cell ImmunologyTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Gain and loss of T cell subsets in old age: age-related reshaping of the T cell repertoire.

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Arnold, Christoph R., Wolf, Juliane, Brunner, Stefan, Herndler-Brandstetter, Dietmar, Grubeck-Loebenstein, Beatrix·2011·Journal of Clinical Immunology

DOI 10.1007/s10875-010-9499-x

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Abstract

The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T cells, thereby compromising the diversity of the T cell pool. Additional infection with latent pathogens such as cytomegalovirus aggravates this process. In this review, we focus on the major age-related changes that occur in the naïve and the antigen-experienced T cell population. We discuss the mechanisms responsible for the generation and maintenance of these subsets and how age-related changes can be delayed or prevented by clinical interventions.

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Chen WH, Kozlovsky BF, Effros RB, Grubeck-Loebenstein B, Edelman R, Sztein MB. Vaccination in the elderly: an immunological perspective. Trends Immunol. 2009;30(7):351–9. · DOI

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Authors: Arnold, C. R., Wolf, J., Brunner, S., Herndler-Brandstetter, D., & Grubeck-Loebenstein, B.
Affiliations: Austrian Academy of Sciences (AT)
ORCID: Arnold, Christoph R.
Brunner, Stefan
Venue: Journal of Clinical Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-01-18
Volume: 31
Issue: 2
Pages: 137-146
ISSN: 0271-9142 (ISSN-L)
1573-2592
DOI: 10.1007/s10875-010-9499-x
OpenAlex: W2058299309
Cited by: 170
References: 125
Citations by year: 2026: 3 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 11 · 2019: 14 · 2018: 11 · 2017: 18 · 2016: 14 · 2015: 15 · 2014: 15 · 2013: 20 · 2012: 18
FWCI: 1.60
Type: journal article
Language: en
Open access: green
epub.oeaw.ac.at
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Journal of Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Oesterreichisches Musiklexikon online (Institut für kunst- und musikhistorische Forschungen der Österreichischen Akademie der Wissenschaften) (submittedVersion, other-oa)
Austrian Biographical Dictionary (Austrian Academy of Sciences) (submittedVersion, other-oa)
ISBN
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: immunosenescence, T cell subsets, T cell receptor repertoire, naive T cells, antigen-experienced T cells, thymus, bone marrow, cytomegalovirus infection, aging, T cell diversity
MeSH terms: Aging, Animals, Antigens, Humans, Immunologic Memory, T-Lymphocytes, T-Lymphocyte Subsets, Immunomodulation

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Gain and loss of T cell subsets in old age: age-related reshaping of the T cell repertoire.

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