Antioxidant effect of the marine algae Chlorella vulgaris against naphthalene-induced oxidative stress in the albino rats
Abstract
Alcoholic extract of the marine algae Chlorella vulgaris was examined for its free radical scavenging effect with reference to naphthalene-induced lipid peroxidation in serum, liver, and kidney of rats. Initially, upon naphthalene intoxication (435 mg/kg body weight, intraperitoneally), the lipid peroxidation activity increased significantly (P < 0.001), and in contrast, the enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymic antioxidants (glutathione, ascorbic acid, and alpha-tocopherol) levels decreased remarkably. When the naphthalene stressed rats were treated with Chlorella vulgaris extract (70 mg/kg body weight, orally), the lipid peroxidation activity reduced significantly (P < 0.001) and the activities of both the enzymic and non-enzymic antioxidants increased reaching near control values. The minimum concentration (70 mg/l) of the extract that exhibited maximum (85%) free radical scavenging activity was chosen for the experimental study. The present results suggest that Chlorella vulgaris extract exerts its chemo-preventive effect by modulating the antioxidants status and lipid peroxidation during naphthalene intoxication.
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The microalgae market is growing due to the increasing demand for beneficial algal food and health products.
“The microalgae market is growing due to the increasing demand for beneficial algal food and health products [147].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [147]
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- Authors
- Vijayavel, K., Anbuselvam, C., & Balasubramanian, M. P.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- University of Madras (IN)
- Corresponding author
- Vijayavel, K.
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2007-04-25
- Volume
- 303
- Issue
- 1-2
- Pages
- 39-44
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- OpenAlex
- W2053484194
- Cited by
- 112
- References
- 29
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 10 · 2020: 14 · 2019: 5 · 2018: 10 · 2017: 7 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular and Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- Chlorella vulgaris, marine algae, naphthalene toxicity, oxidative stress, lipid peroxidation, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, glutathione, vitamin C, alpha-tocopherol, free radical scavenging, chemoprevention, hepatotoxicity, nephrotoxicity
- MeSH terms
- Animals, Antioxidants, Ascorbic Acid, Catalase, Glutathione, Glutathione Peroxidase, Male, Naphthalenes, Plant Extracts, Superoxide Dismutase, Vitamin E, Lipid Peroxidation, Free Radical Scavengers, Rats, Wistar, Reactive Oxygen Species, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Chlorella vulgaris, Rats
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