Cited by 112Seaweed-derived Bioactive CompoundsAntioxidant Activity and Oxidative StressCancer and biochemical research

Antioxidant effect of the marine algae Chlorella vulgaris against naphthalene-induced oxidative stress in the albino rats

Vijayavel, K., Anbuselvam, C., Balasubramanian, M. P.·2007·Molecular and Cellular Biochemistry

Abstract

Alcoholic extract of the marine algae Chlorella vulgaris was examined for its free radical scavenging effect with reference to naphthalene-induced lipid peroxidation in serum, liver, and kidney of rats. Initially, upon naphthalene intoxication (435 mg/kg body weight, intraperitoneally), the lipid peroxidation activity increased significantly (P < 0.001), and in contrast, the enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymic antioxidants (glutathione, ascorbic acid, and alpha-tocopherol) levels decreased remarkably. When the naphthalene stressed rats were treated with Chlorella vulgaris extract (70 mg/kg body weight, orally), the lipid peroxidation activity reduced significantly (P < 0.001) and the activities of both the enzymic and non-enzymic antioxidants increased reaching near control values. The minimum concentration (70 mg/l) of the extract that exhibited maximum (85%) free radical scavenging activity was chosen for the experimental study. The present results suggest that Chlorella vulgaris extract exerts its chemo-preventive effect by modulating the antioxidants status and lipid peroxidation during naphthalene intoxication.

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Crossref · 10.1007/s11010-007-9453-2

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Authors
Vijayavel, K., Anbuselvam, C., & Balasubramanian, M. P.
Affiliations
  • University of Hawaiʻi at Mānoa (US)
  • University of Madras (IN)
Corresponding author
Vijayavel, K.
Venue
Molecular and Cellular Biochemistry
Published
2007-04-25
Volume
303
Issue
1-2
Pages
39-44
ISSN
  • 0300-8177 (ISSN-L)
  • 1573-4919
OpenAlex
W2053484194
Cited by
112
References
29
Citations by year
2026: 1 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 10 · 2020: 14 · 2019: 5 · 2018: 10 · 2017: 7 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 5
FWCI
4.65
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
Chlorella vulgaris, marine algae, naphthalene toxicity, oxidative stress, lipid peroxidation, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, glutathione, vitamin C, alpha-tocopherol, free radical scavenging, chemoprevention, hepatotoxicity, nephrotoxicity
MeSH terms
Animals, Antioxidants, Ascorbic Acid, Catalase, Glutathione, Glutathione Peroxidase, Male, Naphthalenes, Plant Extracts, Superoxide Dismutase, Vitamin E, Lipid Peroxidation, Free Radical Scavengers, Rats, Wistar, Reactive Oxygen Species, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Chlorella vulgaris, Rats

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