Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening
Abstract
Lipid peroxidation due to oxidative stress (OS) may play an important role in the pathogenesis of chronic systemic inflammatory diseases such as multiple sclerosis (MS). Telomeres, repeated sequences that cap chromosome ends, undergo shortening with each cycle of cell division, resulting in cellular senescence. Research regarding telomere shortening has provided novel insight into the pathogenesis of various diseases. We hypothesized that OS damage leads to inflammatory reactions, which subsequently shortens the telomere length in MS. We enrolled 59 patients with MS, and age- and gender-matched 60 healthy controls. We divided MS subjects into three groups matched for age and gender according to the severity of disability: relatively benign course (BMS), secondary progressive MS, and primary progressive MS (PPMS). We analyzed the telomere length in peripheral blood mononuclear cells and the 8-iso-PGF2α concentration in urine, a reliable and stable marker of lipid peroxidation in vivo. The data showed significant higher levels of urinary 8-iso-PGF2α in MS subjects than in the controls. The lag-time, which represents the direct measurement of the resistance of low-density lipoprotein to oxidation, was shorter in the PPMS subjects than in the groups. Compared to that observed in the controls, the mean telomere length was significantly shorter in the PPMS group, whereas no significant telomere shortening was found between the controls and other subjects. Our data suggest that a decreased telomere length and enhanced lipid peroxidation reflects the severest stage of MS.
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Multiple sclerosis patients have increased markers of oxidative stress and shorter telomeres compared to healthy controls.
“MS patients have increased markers of oxidative stress and shorter telomeres when compared to healthy controls (Guan et al., 2015).”
From Telomeres and cell senescence—size matters not (2017) · cites this paper as Guan et al., 2015
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Telomeres and cell senescence—size matters not
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- Authors
- Guan, J.-Z., Guan, W.-P., Maeda, T., Guoqing, X., GuangZhi, W., & Makino, N.
- Affiliations
- The 309th Hospital of Chinese People's Liberation Army (CN)
- Chinese PLA General Hospital (CN)
- Kyushu University Beppu Hospital (JP)
- Corresponding author
- Maeda, Toyoki
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2014-11-26
- Volume
- 400
- Issue
- 1-2
- Pages
- 183-187
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- OpenAlex
- W2041405406
- Cited by
- 84
- References
- 27
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 8 · 2019: 3 · 2018: 3 · 2017: 10 · 2016: 6 · 2015: 7
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular and Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- multiple sclerosis, oxidative stress, telomere shortening, lipid peroxidation, 8-isoprostane, cellular senescence, primary progressive multiple sclerosis, secondary progressive multiple sclerosis, disability severity, LDL oxidation, peripheral blood mononuclear cells, chronic inflammation
- MeSH terms
- Adult, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Multiple Sclerosis, Lipid Peroxidation, Dinoprost, Oxidative Stress, Telomere Shortening
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