Reversal of brain aging by targeting telomerase: A nutraceutical approach
Open accessAbstract
Telomeres, the protective caps of chromosomes, shorten with age, as telomerase, the enzyme responsible for the compensation of telomere erosion, is inactive in the majority of cells. Telomere shortening and subsequent cell senescence lead to tissue aging and age‑related diseases. Neurodegenerative disorders, characterized by the progressive loss of neurons among other hallmarks of aged tissue, and poor cognitive function, have been associated with a short telomere length. Thus, telomerase activity has emerged as a therapeutic target, with novel agents being under investigation. The present study aimed to examine the effects of a novel natural telomerase activator, ‘Reverse™’, containing Centella asiatica extract, vitamin C, zinc and vitamin D3 on the brains of 18‑month‑old rats. The administration of the ‘Reverse™’ supplement for 3 months restored telomerase reverse transcriptase (TERT) expression in the brains of rats, as revealed by ELISA and immunohistochemistry. In addition, the findings from PCR‑ELISA demonstrated an enhanced telomerase activity in the cerebellum and cortex cells in the brains of rats treated with the ‘Reverse™’ supplement. The histopathological findings confirmed a structural reversibility effect close to the differentiation observed in the young control group of rats treated with two capsules/kg body weight of the ‘Reverse™’ supplement. On the whole, the findings of the present study provide a strong indication that an increased telomerase activity and TERT expression may be achieved not only in the postnatal or embryonic period, but also in the brains of middle‑aged rats through nutraceutical supplementation. The use of the ‘Reverse™’ supplement may thus contribute to the potential alleviation of a number of central nervous system diseases.
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Evidence on nutraceuticals allows projecting a scenario where Alzheimer's disease could have possible preventive treatments and/or a slowing palliative effect in patients who already suffer from it.
“such evidence allows us to project a scenario where AD could have possible preventive treatments and/or have a slowing palliative effect in patients who already suffer from it [73,74,75].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [75]
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- Authors
- Tsoukalas, D., Buga, A., Docea, A., Sarandi, E., Mitrut, R., Renieri, E., Spandidos, D., Rogoveanu, I., Cercelaru, L., Niculescu, M., Tsatsakis, A., & Calina, D.
- Affiliations
- University of Medicine and Pharmacy of Craiova (RO)
- Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- Metabolomic Medicine, Health Clinic for Autoimmune and Chronic Diseases, 10674 Athens, Greece
- Department of Cardiology, University and Emergency Hospital, 050098 Bucharest, Romania
- University of Crete (GR)
- Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- Corresponding author
- Docea, Anca
- ORCID
- Venue
- International Journal of Molecular Medicine
- Publisher
- Spandidos Publications
- Published
- 2021-09-10
- Volume
- 48
- Issue
- 5
- ISSN
- 1107-3756 (ISSN-L)
- 1791-244X
- PMC
- PMC8448543
- OpenAlex
- W3200938121
- Cited by
- 40
- References
- 59
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 16 · 2022: 17
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- International Journal of Molecular Medicine (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- telomerase, telomere shortening, brain aging, nutraceutical supplementation, Centella asiatica extract, telomerase reverse transcriptase, TERT expression, telomerase activity, neurodegenerative diseases, cognitive function, cerebellum, cerebral cortex, age-related diseases
- MeSH terms
- Aging, Animals, Brain, Cerebral Cortex, Male, Rats, Sprague-Dawley, Telomerase, Dietary Supplements, Rats
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