Ageing and multiple sclerosis

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

Horvath, S., & Raj, K. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0004-3 · Cited by 3,095 · see citing works

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

Montalban, X., Hauser, S. L., Kappos, L., Arnold, D. L., Bar-Or, A., Comi, G., de Seze, J., Giovannoni, G., Hartung, H.-P., Hemmer, B., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606468 · Cited by 1,905 · see citing works

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

Blackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596 · see citing works

Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology

Magliozzi, R., Howell, O. W., Vora, A., Serafini, B., Nicholas, R. S., Puopolo, M., Reynolds, R., & Aloisi, F. (2006) · Brain · doi:10.1093/brain/awm038 · Cited by 1,444 · see citing works

Microglial control of astrocytes in response to microbial metabolites

Rothhammer, V., Borucki, D. M., Tjon, E. C., Takenaka, M. C., Chao, C.-C., Ardura-Fabregat, A., de Lima, K. A., Gutiérrez-Vázquez, C., Hewson, P., Staszewski, O., et al. (2018) · Nature · doi:10.1038/s41586-018-0119-x · Cited by 1,051 · see citing works

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Kappos, L., Bar-Or, A., Cree, B. A. C., Fox, R. J., Giovannoni, G., Gold, R., Vermersch, P., Arnold, D. L., Arnould, S., Scherz, T., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30475-6 · Cited by 942 · see citing works

Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine

Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.-H., May, C., Wilck, N., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.007 · Cited by 927 · see citing works

Review: microglia of the aged brain: primed to be activated and resistant to regulation

Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works

A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

Absinta, M., Maric, D., Gharagozloo, M., Garton, T., Smith, M. D., Jin, J., Fitzgerald, K. C., Song, A., Liu, P., Lin, J.-P., et al. (2021) · Nature · doi:10.1038/s41586-021-03892-7 · Cited by 768 · see citing works

A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: Overview

Marrie, R., Cohen, J., Stüve, O., Trojano, M., Sørensen, P., Reingold, S., Cutter, G., & Reider, N. (2015) · Multiple Sclerosis · doi:10.1177/1352458514564491 · Cited by 762 · see citing works

Subpial Demyelination in the Cerebral Cortex of Multiple Sclerosis Patients

Bø, L., Vedeler, C. A., Nyland, H. I., Trapp, B. D., & Mørk, S. J. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.7.723 · Cited by 757 · see citing works

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

Frischer, J. M., Weigand, S. D., Guo, Y., Kale, N., Parisi, J. E., Pirko, I., Mandrekar, J., Bramow, S., Metz, I., Brück, W., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24497 · Cited by 728 · see citing works

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

Mogilenko, D. A., Shpynov, O., Andhey, P. S., Arthur, L., Swain, A., Esaulova, E., Brioschi, S., Shchukina, I., Kerndl, M., Bambouskova, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2020.11.005 · Cited by 683 · see citing works

Rejuvenation of Regeneration in the Aging Central Nervous System

Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649 · see citing works

Regenerating CNS myelin — from mechanisms to experimental medicines

Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647 · see citing works

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

Duscha, A., Gisevius, B., Hirschberg, S., Yissachar, N., Stangl, G. I., Dawin, E., Bader, V., Haase, S., Kaisler, J., David, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.035 · Cited by 639 · see citing works

The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625 · see citing works

Defective cholesterol clearance limits remyelination in the aged central nervous system

Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M.-T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., et al. (2018) · Science · doi:10.1126/science.aan4183 · Cited by 586 · see citing works

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Khalil, M., Pirpamer, L., Hofer, E., Voortman, M. M., Barro, C., Leppert, D., Benkert, P., Ropele, S., Enzinger, C., Fazekas, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14612-6 · Cited by 572 · see citing works

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Kaufmann, T., van der Meer, D., Doan, N. T., Schwarz, E., Lund, M. J., Agartz, I., Alnæs, D., Barch, D. M., Baur‐Streubel, R., Bertolino, A., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0471-7 · Cited by 559 · see citing works

Retinoid X receptor gamma signaling accelerates CNS remyelination

Huang, J. K., Jarjour, A. A., Nait Oumesmar, B., Kerninon, C., Williams, A., Krezel, W., Kagechika, H., Bauer, J., Zhao, C., Evercooren, A. B.-V., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2702 · Cited by 547 · see citing works

Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo

Absinta, M., Sati, P., Masuzzo, F., Nair, G., Sethi, V., Kolb, H., Ohayon, J., Wu, T., Cortese, I. C. M., & Reich, D. S. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2399 · Cited by 534 · see citing works

Regulatory T cells promote myelin regeneration in the central nervous system

Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4528 · Cited by 533 · see citing works

Niche stiffness underlies the ageing of central nervous system progenitor cells

Segel, M., Neumann, B., Hill, M. F. E., Weber, I. P., Viscomi, C., Zhao, C., Young, A., Agley, C. C., Thompson, A. J., Gonzalez, G. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1484-9 · Cited by 532 · see citing works

Age at disability milestones in multiple sclerosis

Confavreux, C., & Vukusic, S. (2006) · Brain · doi:10.1093/brain/awh714 · Cited by 527 · see citing works

Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis

Marrie, R. A., Rudick, R. A., Horwitz, R. I., Cutter, G., Tyry, T. M., Campagnolo, D. I., & Vollmer, T. L. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d6b125 · Cited by 481 · see citing works

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi, C., Marchi, S., Simões, I. C. M., Ren, Z., Morciano, G., Perrone, M., Patalas‐Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., et al. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 467 · see citing works

Increased Relapse Rate in Pediatric-Onset Compared With Adult-Onset Multiple Sclerosis

Gorman, M., Healy, B. C., Polgar‐Turcsanyi, M., & Chitnis, T. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.505 · Cited by 459 · see citing works

Deep gray matter volume loss drives disability worsening in multiple sclerosis

Eshaghi, A., Prados, F., Brownlee, W. J., Altmann, D. R., Tur, C., Cardoso, M. J., Angelis, F. D., van de Pavert, S. H., Cawley, N., Stefano, N. D., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25145 · Cited by 454 · see citing works

Metformin restores CNS remyelination capacity by rejuvenating aged stem cells

Neumann, B., Baror, R., Zhao, C., Segel, M., Dietmann, S., Rawji, K. S., Foerster, S., McClain, C. R., Chalut, K., van Wijngaarden, P., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.08.015 · Cited by 449 · see citing works

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

Chataway, J., Schuerer, N., Alsanousi, A., Chan, D., MacManus, D. G., Hunter, K., Anderson, V. M., Bangham, C. R. M., Clegg, S., Nielsen, C. F., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62242-4 · Cited by 444 · see citing works

Remyelination capacity of the MS brain decreases with disease chronicity

Goldschmidt, T., Antel, J., König, F. B., Brück, W., & Kuhlmann, T. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a8260a · Cited by 411 · see citing works

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

Haider, L., Zrzavy, T., Hametner, S., Höftberger, R., Bagnato, F., Grabner, G., Trattnig, S., Pfeifenbring, S., Brück, W., & Lassmann, H. (2016) · Brain · doi:10.1093/brain/awv398 · Cited by 400 · see citing works

Dynamics of oligodendrocyte generation in multiple sclerosis

Yeung, M. S. Y., Djelloul, M., Steiner, E., Bernard, S., Salehpour, M., Possnert, G., Brundin, L., & Frisén, J. (2019) · Nature · doi:10.1038/s41586-018-0842-3 · Cited by 376 · see citing works

Remyelination in multiple sclerosis: From basic science to clinical translation

Lubetzki, C., Zalc, B., Williams, A., Stadelmann, C., & Stankoff, B. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30140-x · Cited by 350 · see citing works

Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions

Absinta, M., Sati, P., Schindler, M., Leibovitch, E. C., Ohayon, J., Wu, T., Meani, A., Filippi, M., Jacobson, S., Cortese, I. C. M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86198 · Cited by 327 · see citing works

Mitochondrial Dysfunction and Multiple Sclerosis

de Barcelos, I. P., Troxell, R. M., & Graves, J. (2019) · Biology · doi:10.3390/biology8020037 · Cited by 293 · see citing works

Gut Microbiome in Progressive Multiple Sclerosis

Cox, L. M., Maghzi, A. H., Liu, S., Tankou, S. K., Dhang, F. H., Willocq, V., Song, A., Wasén, C., Tauhid, S., Chu, R., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26084 · Cited by 292 · see citing works

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

Fox, R. J., Coffey, C. S., CONWIT, R. A., Cudkowicz, M., Gleason, T., Goodman, A. D., Klawiter, E. C., Matsuda, K., McGovern, M. M., Naismith, R. T., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1803583 · Cited by 285 · see citing works

Age and disability accumulation in multiple sclerosis

Scalfari, A., Neuhaus, A., Daumer, M., Ebers, G. C., & Muraro, P. A. (2011) · Neurology · doi:10.1212/wnl.0b013e318230a17d · Cited by 279 · see citing works

Relapses in multiple sclerosis are age- and time-dependent

Tremlett, H. L., Zhao, Y., Joseph, J. P., & Devonshire, V. A. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.145805 · Cited by 278 · see citing works

Human CD 8 + EMRA T cells display a senescence‐associated secretory phenotype regulated by p38 MAPK

Callender, L. A., Carroll, E. C., Beal, R. W. J., Chambers, E. S., Nourshargh, S., Akbar, A. N., & Henson, S. M. (2017) · Aging Cell · doi:10.1111/acel.12675 · Cited by 266 · see citing works

Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study

Salazar, N., Arboleya, S., Fernández-Navarro, T., Reyes‐Gavilán, C. G. D. L., González, S., & Gueimonde, M. (2019) · Nutrients · doi:10.3390/nu11081765 · Cited by 231 · see citing works

Long-term evolution of multiple sclerosis iron rim lesions in 7 T MRI

Dal‐Bianco, A., Grabner, G., Kronnerwetter, C., Weber, M., Kornek, B., Kasprian, G. J., Berger, T., Leutmezer, F., Rommer, P. S., Trattnig, S., et al. (2020) · Brain · doi:10.1093/brain/awaa436 · Cited by 230 · see citing works

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

Wynne, A. M., Henry, C. J., Huang, Y., Cleland, A., & Godbout, J. P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.05.011 · Cited by 224 · see citing works

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Natrajan, M. S., de la Fuente, A. G., Crawford, A. H., Linehan, E., Núñez, V., Johnson, K. R., Wu, T., Fitzgerald, D. C., Ricote, M., Bielekova, B., et al. (2015) · Brain · doi:10.1093/brain/awv289 · Cited by 217 · see citing works

Testosterone Treatment in Multiple Sclerosis

Sicotte, N. L., Giesser, B. S., Tandon, V., Klutch, R., Steiner, B., Drain, A. E., Shattuck, D. W., Hull, L., Wang, H.-J., Elashoff, R. M., et al. (2007) · Archives of Neurology · doi:10.1001/archneur.64.5.683 · Cited by 215 · see citing works

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis

Elliott, C., Belachew, S. M., Wolinsky, J. S., Hauser, S. L., Kappos, L., Barkhof, F., Bernasconi, C., Fecker, J., Model, F., Wei, W., et al. (2019) · Brain · doi:10.1093/brain/awz212 · Cited by 209 · see citing works

Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study

Maggi, P., Sati, P., Nair, G., Cortese, I. C. M., Jacobson, S., Smith, B., Nath, A., Ohayon, J. M., Pesch, V. V., Perrotta, G., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25877 · Cited by 207 · see citing works

Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

Claes, N., Fraussen, J., Vanheusden, M., Hellings, N., Stinissen, P., Wijmeersch, B. V., Hupperts, R., & Somers, V. A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502448 · Cited by 206 · see citing works

Alterations in Circulating Fatty Acid Are Associated With Gut Microbiota Dysbiosis and Inflammation in Multiple Sclerosis

Saresella, M., Marventano, I., Barone, M., Rosa, F. L., Piancone, F., Mendozzi, L., d’Arma, A., Rossi, V., Pugnetti, L., Roda, G., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01390 · Cited by 202 · see citing works

Sex as a determinant of relapse incidence and progressive course of multiple sclerosis

Kalinčík, T., Vivek, V., Jokubaitis, V., Lechner‐Scott, J., Trojano, M., Izquierdo, G., Lugaresi, A., Grand’Maison, F., Hupperts, R., Oreja‐Guevara, C., et al. (2013) · Brain · doi:10.1093/brain/awt281 · Cited by 199 · see citing works

Telomere biology and age-related diseases

Herrmann, M., Pusceddu, I., März, W., & Herrmann, W. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0870 · Cited by 193 · see citing works

CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia

Parajuli, B., Horiuchi, H., Mizuno, T., Takeuchi, H., & Suzumura, A. (2015) · Glia · doi:10.1002/glia.22892 · Cited by 160 · see citing works

Analyses of immunosenescent markers in patients with autoimmune disease

Thewissen, M. M., Somers, V. A., Venken, K., Linsen, L., van Paassen, P., Geusens, P., Damoiseaux, J. G. M. C., & Stinissen, P. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.01.005 · Cited by 160 · see citing works

Sex Hormones in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis

Voskuhl, R. R., & Palaszynski, K. (2001) · The Neuroscientist · doi:10.1177/107385840100700310 · Cited by 158 · see citing works

Longitudinal Assessment of Multiple Sclerosis with the Brain‐Age Paradigm

Cole, J. H., Raffel, J., Friede, T., Eshaghi, A., Brownlee, W. J., Chard, D., Stefano, N. D., Enzinger, C., Pirpamer, L., Filippi, M., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25746 · Cited by 154 · see citing works

Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin

Franklin, R. J. M., Frisén, J., & Lyons, D. A. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.09.009 · Cited by 154 · see citing works

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Rawji, K. S., Young, A. M. H., Ghosh, T., Michaels, N. J., Mirzaei, R., Kappen, J., Kolehmainen, K. L., Alaeiilkhchi, N., Lozinski, B., Mishra, M. K., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02129-7 · Cited by 153 · see citing works

Correlation between brain volume loss and clinical and MRI outcomes in multiple sclerosis

Radue, E. W., Barkhof, F., Kappos, L., Sprenger, T., Häring, D. A., de Vera, A., von Rosenstiel, P., Bright, J. R., Francis, G., & Cohen, J. A. (2015) · Neurology · doi:10.1212/wnl.0000000000001281 · Cited by 144 · see citing works

Long-term outcome of paediatric-onset multiple sclerosis: a population-based study

Harding, K. E., Liang, K., Cossburn, M., Ingram, G., Hirst, C. L., Pickersgill, T. P., Naudé, J. T. W., Wardle, M., Ben‐Shlomo, Y., & Robertson, N. P. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303996 · Cited by 138 · see citing works

An emerging role for eotaxins in neurodegenerative disease

Huber, A. K., Giles, D. A., Segal, B. M., & Irani, D. N. (2018) · Clinical Immunology · doi:10.1016/j.clim.2016.09.010 · Cited by 133 · see citing works

Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients

Thewissen, M. M., Linsen, L., Somers, V. A., Geusens, P., Raus, J., & Stinissen, P. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.066 · Cited by 131 · see citing works

Comorbidity increases the risk of relapse in multiple sclerosis

Kowalec, K., McKay, K. A., Patten, S. B., Fisk, J. D., Evans, C. D., Tremlett, H. L., Marrie, R. A., For the CIHR Team in Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS), CIHR Team in Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS), Blanchard, J., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004716 · Cited by 130 · see citing works

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

Chataway, J., Angelis, F. D., Connick, P., Parker, R. A., Plantone, D., Doshi, A., John, N. A., Stutters, J., MacManus, D. G., Prados, F., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30485-5 · Cited by 126 · see citing works

Evaluating the Risk of Macrovascular Events and Mortality Among People With Multiple Sclerosis in England

Palladino, R., Marrie, R. A., Majeed, A., & Chataway, J. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.0664 · Cited by 120 · see citing works

Remyelination and ageing: Reversing the ravages of time

Neumann, B., Segel, M., Chalut, K. J., & Franklin, R. J. M. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458519884006 · Cited by 113 · see citing works

Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial

Cree, B., Cutter, G., Wolinsky, J. S., Freedman, M. S., Comı, G., Giovannoni, G., Hartung, H.-P., Arnold, D. L., Kühle, J., Block, V. J., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30347-1 · Cited by 113 · see citing works

Chronic White Matter Inflammation and Serum Neurofilament Levels in Multiple Sclerosis

Maggi, P., Kühle, J., Schädelin, S., van der Meer, F., Weigel, M., Galbusera, R., Mathias, A., Lu, P., Rahmanzadeh, R., Benkert, P., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000012326 · Cited by 106 · see citing works

Infection-related health care utilization among people with and without multiple sclerosis

Wijnands, J. M. A., Kingwell, E., Zhu, F., Zhao, Y., Fisk, J. D., Evans, C. D., Marrie, R. A., & Tremlett, H. L. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516681198 · Cited by 106 · see citing works

Sex effects across the lifespan in women with multiple sclerosis

Krysko, K. M., Graves, J. S., Dobson, R., Altıntaş, A., Amato, M. P., Bernard, J. T., Bonavita, S., Bove, R. M., Cavalla, P., Clerico, M., et al. (2020) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286420936166 · Cited by 105 · see citing works

Intracellular and Extracellular Roles of Granzyme K

Bouwman, A. C., van Daalen, K. R., Crnko, S., ten Broeke, T., & Bovenschen, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.677707 · Cited by 104 · see citing works

<i>Cx3cr1-</i> deficient microglia exhibit a premature aging transcriptome

Gyoneva, S., Hosur, R., Gosselin, D., Zhang, B., Ouyang, Z., Cotleur, A. C., Peterson, M., Allaire, N., Challa, R., Cullen, P., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900453 · Cited by 103 · see citing works

Molecular signature of slowly expanding lesions in progressive multiple sclerosis

Jäckle, K., Zeis, T., Schaeren‐Wiemers, N., Junker, A., van der Meer, F., Kramann, N., Stadelmann, C., & Brück, W. (2020) · Brain · doi:10.1093/brain/awaa158 · Cited by 99 · see citing works

The telomere/telomerase system in autoimmune and systemic immune-mediated diseases

Georgin-Lavialle, S., Aouba, A., Mouthon, L., Londono-Vallejo, J. A., Lepelletier, Y., Gabet, A.-S., & Hermine, O. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.04.004 · Cited by 97 · see citing works

Potential role of indolelactate and butyrate in multiple sclerosis revealed by integrated microbiome-metabolome analysis

Levi, I., Gurevich, M., Perlman, G., Magalashvili, D., Menascu, S., Bar, N., Godneva, A., Zahavi, L., Chermon, D., Kosower, N., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100246 · Cited by 97 · see citing works

Exploration of changes in disability after menopause in a longitudinal multiple sclerosis cohort

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Discontinuation of disease-modifying therapy in patients with multiple sclerosis over age 60

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